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| 1 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 2 | Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women显示文摘AIM: To evaluate the association between the severity of liver steatosis and metabolic syndrome in apparently healthy Korean adults.METHODS: We examined 1 022 men and women, aged 30-79 years, who participated in a health screening test.A standard interview, anthropometrics, biochemical studies,and abdominal ultrasonography were conducted for each participant. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel Ⅲ, with a modification for the waist circumference cut-off level. The severity of liver steatosis was evaluated using liver ultrasonography, and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GT) levels were determined.RESULTS: Ultrasonographic liver steatosis was strongly associated with metabolic syndrome and common metabolic abnormalities. Compared with people without steatosis, people with mild, moderate, and severe steatosis had adjusted odds ratios for metabolic syndrome of 1.72(95%CI, 1.01-2.94), 2.89 (1.75-4.76) and 3.53 (1.25-9.98)in men, and 2.86 (1.64-5.01), 3.19 (1.80-5.65) and 3.70(0.82-16.73) in women, respectively. The serum AST level was not associated with metabolic syndrome. The serum ALT and γ-GT levels were significantly associated with metabolic syndrome in men but not in women.CONCLUSION: The occurrence of metabolic syndrome shows a stronger association with the severity of ultrasonographic steatosis than with the serum liver enzyme levels. The degree of fatty infiltration detected on ultrasonography can be used as an indicator of liver dysfunction attributable to metabolic abnormalities. | Hyeon Chang Kim Sung Hee Choi Hae Won Shin Jae Youn Cheong Kwan Woo Lee Hyun Chul Lee Kap Bum Huh Dae Jung Kim | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 3 | Tin oxide-based methane gas sensor promoted by alumina-supported Pd catalyst显示文摘 | Jae Chang Kim Hee Kwon Jun Jeung-Soo Huh | 1997 | Sensors and Actuators B1997，，： | 1 |
| 4 | Radiation therapy for abdominal lymph node metastasis from hepatocellular carcinoma显示文摘 | Young Je Park Do Hoon Lim Seung Woon Paik Kwang Cheol Koh Joon Hyoek Lee Moon Seok Choi Byung Chul Yoo Hee Rim Nam Dong Ryul Oh Won Park Yong Chan Ahn Seung Jae Huh | 2006 | Journal of Gastroenterology2006，，11： | 1 |
| 5 | Local radiotherapy for patients with unresectable hepatocellular carcinoma显示文摘 | Won Park Do Hoon Lim Seung Woon Paik Kwang Cheol Koh Moon Seok Choi Cheol Keun Park Byung Chul Yoo Jeong Eun Lee Min Kyu Kang Young Je Park Hee Rim Nam Yong Chan Ahn Seung Jae Huh | 2005 | International Journal of Radiation Oncology Biology Physics2005，，4： | 1 |
| 6 | miR‐206 regulates brain‐derived neurotrophic factor in Alzheimer disease model显示文摘 | Soon‐Tae Lee Kon Chu Keun‐Hwa Jung Jin Hee Kim Ji‐Young Huh Hyejin Yoon Dong‐Kyu Park Ji‐Yeon Lim Jeong‐Min Kim Daejong Jeon Hoon Ryu Sang Kun Lee Manho Kim Jae‐Kyu Roh | 2012 | Ann Neurol2012，，2： | 1 |
| 7 | Predictive factors of gastroduodenal toxicity in cirrhotic patients after three-dimensional conformal radiotherapy for hepatocellular carcinoma显示文摘 | Haeyoung Kim Do Hoon Lim Seung Woon Paik Byung Chul Yoo Kwang Gheol Koh Joon Hyoek Lee Moon Seok Choi Won Park Hee Chul Park Seung Jae Huh Doo Ho Choi Yong Chan Ahn | 2009 | Radiotherapy and Oncology2009，，2： | 1 |
| 8 | Tinoxide-based methane gas sensor promoted by alumina-supported Pd catalyst显示文摘 | Jae Chang Kim Hee Kwon Jun Jeung-Soo Huh | 1997 | Sensors and Actuators B1997，45，： | 1 |
| 9 | Phase II Study of Consolidation Chemotherapy After Concurrent Chemoradiation in Cervical Cancer: Preliminary Results显示文摘 | Chel Hun Choi Jeong-Won Lee Tae-Joong Kim Woo Young Kim Hee Rim Nam Byoung-Gie Kim Seung Jae Huh Je-Ho Lee Duk-Soo Bae | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，3： | 1 |
| 10 | 基于辣椒基因组测序探究辣味在种群中的进化显示文摘辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。 | Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰 张西露 | 2014 | 辣椒杂志2014，0，2： | 0 |
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