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| 1 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 2 | Measurement and modeing of PS/Supercritical CO2 solution viscosities 显示文摘 | Minhee Lee Park C B Costas Tzoganakis | 1999 | Polymer Engineering and Science1999，39，1： | 1 |
| 3 | Measurements And Modeling of PS/Supercridcal CO2 Solution Viscosities显示文摘 | Lee Minhee Park Chul B Tzoganakis Costas | 1999 | Polymer Engineering and Science1999，39，1： | 1 |
| 4 | Ckl-Line Measurement of PS/COe Solution Viscosities 显示文摘 | Lee Minhee Park Chul B Tzoganakis Costas | 1997 | Annual Technical Conference - ANTEC Conference Proceedings Materials1997，2，： | 1 |
| 5 | 显示文摘 | Minhee Lee Niko G Gubernator | 2010 | J Am Chem Soc2010，132，： | 1 |
| 6 | Application of nonionic surfactant-enhanced in situ flushing to a diesel contaminated site 显示文摘 | Lee Minhee Kang Hyunmin Do Wonhong | 2005 | Water Research2005，39，： | 1 |
| 7 | Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells显示文摘 | Jeong Goo Lee MinHee K. Ko EunDuck P. Kay | 2011 | Experimental Eye Research2011，，1： | 1 |
| 8 | The role of critical shear stress on acute coronary syndrome显示文摘 | F. Jung O.K. Baskurt Jongyoun Kim Hyemoon Chung Minhee Cho Byoung-Kwon Lee Ali Karimi Sehyun Shin | 2013 | Clinical Hemorheology and Microcirculation2013，，1： | 1 |
| 9 | , Remediation of heavy metal contaminated groundwater originated from abandoned mine using lime and calcium carbonate显示文摘 | Minhee Lee In Sung Paik Insu Kim | 2007 | Journal of Hazardous Materials2007，144，12： | 1 |
| 10 | A study of a method for distribution analysis of skin color显示文摘 | Seunghan Ha Minhee Lee | 2009 | Skin Res Technol2009，15，： | 1 |
| 11 | Extrusion of PE/PS Blends with Supercritical Carbon Dioxide 显示文摘 | Minhee Lee Costas Tzoganakis Chul B Park | 1998 | Poly Eng Sci1998，38，7： | 1 |
| 12 | Measurement and Modeling of PS/Supercritical CO2 Solution Viscosities 显示文摘 | Minhee Lee Chul B Park Costas Tzoganakis | 1999 | Poly Eng Sci1999，39，1： | 1 |
| 13 | A high‐fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity‐resistant BALB/c mice显示文摘 | Heesook Park Minhee Kim Gyoo Taik Kwon Do Young Lim Rina Yu Mi‐Kyung Sung Ki Won Lee James W. Daily Jung Han Yoon Park | 2011 | Mol Carcinog2011，，11： | 1 |
| 14 | Application of nonionic surfactant-enhanced in situ flushing to a diesel contaminated site显示文摘 | Minhee Lee Hyunmin Kang Wonhong Do | 2004 | Water Research2004，，1： | 1 |
| 15 | Measurement and Modeling of PS/Supercritical CO2 Solution Viscosities显示文摘 | Minhee Lee Chu113 Park Costas Tzoganakis | 1999 | Polymer Engineering and Science1999，39，1： | 1 |
| 16 | The effectiveness of surfactants for remediation of organic pollutants in the unsaturated zone显示文摘 | Lee Minhee and Fountain John C | 1999 | Soil Contamination1999，8，： | 1 |
| 17 | A comparison of some imidazoles in the curing of epoxy resin显示文摘 | YOUNG ROK HAMA SUN HEE KIM a YOUNG JAE SHIN b DONG HO LEE a MINHEE YANG a JI HYE MIN a JAE SUP SHIN a * | 2010 | Journal of Industrial and Engineering Chemistry2010，16，： | 1 |
| 18 | Microencapsulation of imidazole curing agent for epoxy resin显示文摘 | YOUNG ROK HAMA DONG HO LEE SUN HEE KIM YOUNG JAE SHIN MINHEE YANG JAE SUP SHIN | 2010 | Journal of Industrial and Engineering Chemistry2010，16，5： | 1 |
| 19 | Extrusion of PE/PS blends with supercritical carbon dioxide 显示文摘 | Minhee Lee Costas Tzoganakis Chul B Park | 1998 | Polymer Engineering and Science1998，38，7： | 1 |
| 20 | Biosorption of cadmium, copper, and lead ions from aqueous solutions by Ralstonia sp. and Bacillus sp. isolated from diesel and heavy metal contaminated soil显示文摘 | Aejung Choi Sookyun Wang Minhee Lee | 2009 | Geosciences Journal2009，，4： | 1 |
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