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| 1 | Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression显示文摘 | Miki Ohta Motoko Seto Hideaki Ijichi Koji Miyabayashi Yotaro Kudo Dai Mohri Yoshinari Asaoka Motohisa Tada Yasuo Tanaka Tsuneo Ikenoue Fumihiko Kanai Takao Kawabe Masao Omata | 2009 | Gastroenterology2009，，1： | 2 |
| 2 | Cancer-derived VEGF plays no role in malignant ascites formation in the mouse显示文摘AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ascites.METHODS: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression knockdown.RESULTS: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ statistically.CONCLUSION: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF. | Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 3 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada Takafumi Sugimoto Shintaro Kondo Miki Ohta Hirotsugu Watabe Shin Maeda Goichi Togo Yutaka Yamaji Keiji Ogura Makoto Okamoto Haruhiko Yoshida Takao Kawabe Tateo Kawase Masao Omata | 2008 | Diseases of the Colon & Rectum2008，，1： | 2 |
| 4 | Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer’s Disease in the Japanese Population显示文摘 | Kouzin Kamino Keiko Nagasaka Masaki Imagawa Hideki Yamamoto Hiroshi Yoneda Akira Ueki Shin Kitamura Kazuhiko Namekata Tetsuro Miki Shigeo Ohta | 2000 | Biochemical and Biophysical Research Communications2000，，1： | 1 |
| 5 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada M.D. Takafumi Sugimoto M.D. Shintaro Kondo M.D. Miki Ohta M.D. Hirotsugu Watabe M.D. Shin Maeda M.D. Goichi Togo M.D. Yutaka Yamaji M.D. Keiji Ogura M.D. Makoto Okamoto M.D. Haruhiko Yoshida M.D. Takao Kawabe M.D. Tateo Kawase M.D. Masao Omat | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 6 | Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition)显示文摘 | Yoshiki Nishizawa Hiroaki Ohta Masakazu Miura Masaaki Inaba Schoichi Ichimura Masataka Shiraki Junichi Takada Osamu Chaki Hiroshi Hagino Saeko Fujiwara Masao Fukunaga Takami Miki Noriko Yoshimura | 2013 | Journal of Bone and Mineral Metabolism2013，，1： | 1 |
| 7 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada M.D. Takafumi Sugimoto M.D. Shintaro Kondo M.D. Miki Ohta M.D. Hirotsugu Watabe M.D. Shin Maeda M.D. Goichi Togo M.D. Yutaka Yamaji M.D. Keiji Ogura M.D. Makoto Okamoto M.D. Haruhiko Yoshida M.D. Takao Kawabe M.D. Tateo Kawase M.D. Masao Omat | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 8 | Histamine enhanced the TNF-α induced expression of E-selectin and ICAM-1 on endothelial cell显示文摘 | Miki I Kusano A Ohta S | 1996 | Cell Immunol1996，171，2： | 1 |
| 9 | Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma显示文摘 | Ryosuke Muroyama Naoya Kato Haruhiko Yoshida Motoyuki Otsuka Masaru Moriyama Yue Wang Run-Xuan Shao Narayan Dharel Yasuo Tanaka Miki Ohta Ryosuke Tateishi Shuichiro Shiina Masashi Tatsukawa Kenichi Fukai Fumio Imazeki Osamu Yokosuka Yasushi Shiratori Masa | 2006 | Journal of Hepatology2006，，6： | 1 |
| 10 | Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression显示文摘 | Dai Mohri Yoshinari Asaoka Hideaki Ijichi Koji Miyabayashi Yotaro Kudo Motoko Seto Miki Ohta Motohisa Tada Yasuo Tanaka Tsuneo Ikenoue Keisuke Tateishi Hiroyuki Isayama Fumihiko Kanai Noriyoshi Fukushima Minoru Tada Takao Kawabe Masao Omata Kazuhiko Koike | 2012 | Journal of Gastroenterology2012，，2： | 1 |
| 11 | Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition)显示文摘 | Yoshiki Nishizawa Hiroaki Ohta Masakazu Miura Masaaki Inaba Schoichi Ichimura Masataka Shiraki Junichi Takada Osamu Chaki Hiroshi Hagino Saeko Fujiwara Masao Fukunaga Takami Miki Noriko Yoshimura | 2013 | Journal of Bone and Mineral Metabolism2013，，： | 1 |
| 12 | Risk assessment for delayed hemorrhagic complication of colonic polypectomy: polyp-related factors and patient-related factors <ce:link locator='fx1'/>显示文摘 | Hirotsugu Watabe Yutaka Yamaji Makoto Okamoto Shintaro Kondo Miki Ohta Tsuneo Ikenoue Jun Kato Goichi Togo Masayuki Matsumura Haruhiko Yoshida Takao Kawabe Masao Omata | 2006 | Gastrointestinal Endoscopy2006，，1： | 1 |
| 13 | Risk assessment for delayed hemorrhagic complication of colonic polypectomy: polyp-related factors and patient-related factors <ce:link locator='fx1'/>显示文摘 | Hirotsugu Watabe Yutaka Yamaji Makoto Okamoto Shintaro Kondo Miki Ohta Tsuneo Ikenoue Jun Kato Goichi Togo Masayuki Matsumura Haruhiko Yoshida Takao Kawabe Masao Omata | 2006 | Gastrointestinal Endoscopy2006，，1： | 1 |
| 14 | Neurolytic celiac plexus block reduces occurrence and duration of terminal delirium in patients with pancreatic cancer显示文摘 | Young-Chang P. Arai Makoto Nishihara Kunio Kobayashi Tamotsu Kanazawa Nobuhiko Hayashi Yukio Tohyama Kikuyo Nishida Maki Arakawa Chiharu Suzuki Akiko Kinoshita Miki Kondo Satuki Matsubara Nami Yokoe Ruiko Hayashi Aya Ohta Jun Sato Takahiro Ushida | 2013 | Journal of Anesthesia2013，，1： | 1 |
| 15 | Hepatoma-derived growth factor expression as a prognostic marker in cervical cancer显示文摘AIM: To examine the association of hepatoma-derived growth factor(HDGF) expression with the prognosis of patients with cervical cancer of the uterus(CC). METHODS: HDGF is a unique nuclear growth factor, and it may play an important role in the development and progression of carcinoma. HDGF expression in 88 CC patients aged 23 to 76 years(median, 54 years) was analyzed by immunohistochemistry. A rabbit polyclonal antibody against the C-terminal amino acids(aa 231-240) of the human HDGF sequence was used as primary antibody at a dilution of 1:5000. This specific anti-HDGF antibody was purified using C-terminal peptide-conjugated Sepharose columns. Staining of endothelial cells in the noncancerous areas of each specimen was used as an internal positive control. Samples with more than 80% of tumor cells showing positive immunoreactivity in both the nucleus and cytoplasm were regarded as HDGF index level 2, more than 80% positive immunoreactivity in either the nucleus or cytoplasm as level 1, and less than 80% in both the nucleus and cytoplasm as level 0. The chisquare test and Fisher's exact probability test were used to examine the relationship between HDGF expression and clinicopathologic parameters, and statistical significance was examined by the log-rank test. Multivariate analysis of factors related to survival was performed using Cox's proportional hazards regression model. Statistical significance was set at P < 0.05. RESULTS: The five-year overall survival rate was 82.9%. Fourteen patients died due to tumors, nine of whom had tumor recurrence at 2-21 mo(median, 10 mo) after surgery. Tumor recurrence in five patients was determined at the time of the patients' deaths. Nineteen cases were regarded as HDGF index level 0, 11 as level 1, and 58 as level 2. Patients with level 2 expression showed higher rates of histological classification of keratinized squamous cell carcinomaand adenosquamous carcinoma(44.8% of level 2 patients and 13.3% in levels 0 and 1), deep invasion(p T2-4 in 65.5% of level 2 patients, and 30.0% in levels 0 and 1), the presence of lymphatic invasion(50.0% in level 2, and 20.0% in levels 0 and 1), and the presence of lymph node metastasis(37.9% in level 2, and 6.7% in levels 0 and 1). Patients with an HDGF index of level 2 CC showed poorer 5-year overall survival rates than those with level 0 or 1 CC(74.0% and 100%, respectively, P = 0.0036). Univariate analysis revealed that histological classification(P = 0.04), depth of tumor invasion(P = 0.0001), vascular invasion(P = 0.004), and lymph node metastasis(P = 0.0001) were significant factors affecting overall survival in addition to HDGF expression. Multivariate analysis revealed HDGF expression level and lymph node metastasis as independent prognostic factors for overall survival(P = 0.0148 and P = 0.0197, respectively). The prognostic significance of HDGF was further analyzed in p T1 and p T2-4 patient groups, respectively. Among patients with p T1 CC, one the 39 analyzed patients died during the study, and no difference was observed among patients with HDGF index level 0, 1, or 2 CC. However, prognostic significance of the HDGF index was observed in the p T2-4 patient group, in which the mortality rates of patients with HDGF index level 2 CC and those with level 0 or 1 CC significantly differed(P = 0.0463). CONCLUSION: The HDGF expression level is of prognostic significance in CC. | Misa Song Miki Tomoeda Yu-Feng Jin Chiaki Kubo Hidenori Yoshizawa Masanori Kitamura Shigenori Nagata Yukinobu Ohta Shoji Kamiura Hideji Nakamura Yasuhiko Tomita | 2015 | World Journal of Obstetrics and Gynecology2015，4，1： | 0 |
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