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| 1 | Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis显示文摘AIM: To examine the etiology and pathophysiology in human ischemic colitis from the viewpoint of ischemic favors such as hypoxia-inducible factor 1 alpha (HIF-1alpha and vascular endothelial growth factor (VEGF).METHODS: Thirteen patients with ischemic colitis and 21 normal controls underwent colonoscopy. The follow-up colonoscopy was performed in 8 patients at 7 to 10 d after theoccurrence of ischemic colitis. Biopsy samples were subjected to real-time RT-PCR and immunohistochemistry to detect the expression of HIF-1 alpha and VEGF.RESULTS: HIF-1 alpha and VEGF expression were found in the normal colon tissues by RT-PCR and immunohistochemistry.HIF-1 alpha and VEGF were overexpressed in the lesions of ischemic colitis. Overexpressed HIF-1 alpha and VEGF RNA quickly decreased to the normal level in the scar regions at 7 to 10 d after the occurrence of ischemic colitis.CONCLUSION: Constant expression of HIF-1 alpha and VEGF in normal human colon tissue suggested that HIF-1alpha and VEGF play an important role in maintaining tissue integrity. We confirmed the ischemic crisis in ischemic colitis at the molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. These ischemic factors may play an important role in the pathophysiology of ischemic colitis. | Tomoyuki Okuda Takeshi Azuma Masahiro Ohtani Ryuho Masaki Yoshiyuki Ito Yukinao Yamazaki Shigeji Ito Masaru Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 5 |
| 2 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 4 |
| 3 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 4 | Current Immunotherapeutic Approaches in Pancreatic Cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Shintaro Tsukinaga Jimi Mitobe Shunichi Odahara Toyokazu Yukawa Hiroshi Matsudaira Keisuke Nagatsuma Kan Uchiyama Kenichi Satoh Masaki Ito Hideo Komita Hiroshi Arakawa Toshifumi Ohkusa Jianlin Go | 2011 | Clinical and Developmental Immunology2011，，： | 3 |
| 5 | Efficacy of a newly developed dilator for endoscopic ultrasound-guided biliary drainage显示文摘AIM To evaluate the efficacy of a newly developed dilator for endoscopic ultrasound(EUS)-guided drainage(ES Dilator).METHODS Fourteen consecutive patients who had undergone EUSguided choledochoduodenostomy(EUS-CDS) with the ES Dilator were identified from a prospectively maintained database and enrolled in the study group.Fourteen other patients who had undergone EUS-CDS without the dilator just prior to its introduction were analyzed as the control group.A historical cohort study was carried out comparing the two groups.The main outcome measurement was the procedure time.The technical success rate and early AE rate were also compared between the two groups.RESULTS There were no significant differences in age,sex and etiology of biliary obstruction.The utilization rate of a plastic stent was higher in the control group(36% vs 0%).The technical success rate was 100% in both groups.The mean procedure time was significantly shorter in the study group than in the control group(27 ± 7 min vs 44 ± 26 min,P = 0.026).Additionally,there were no patients who required more than 40 min for the procedure in the study group.Early adverse events occurred in 29%(4/14) of the control group whereas none in the study group.The adverse events in all 4 patients was bile peritonitis,including pan-peritonitis in one patient.All patientsrecovered with conservative treatment by medication.CONCLUSION The newly developed dilator was found to be useful for shortening procedure time and would prevent adverse events related to bile leakage in EUS-CDS. | Yoshihide Kanno Kei Ito Shinsuke Koshita Takahisa Ogawa Kaori Masu Yoshiharu Masaki Yutaka Noda | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 2 |
| 6 | Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine显示文摘AIM:To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation.METHODS:Human peripheral blood monocyte-deriveddendritic cells(MoDCs)were stimulated by commensal bacterial strains,including Escherichia coli,Clostridium clostridioforme,Bacteroides vulgatus(B.vulgatus),Fusobacterium varium(F.varium),and Lactobacillus delbrueckii subsp.bulgaricus.After incubation,corticotropin-releasing factor(CRF)and urocortin 1(UCN1)mRNA in the cells was examined by real-time reverse transcription polymerase chain reaction.Supernatants from the cells were tested for CRF and UCN1 using an enzyme-linked immunosorbent assay.RESULTS:Both CRF and UCN1 were significantly augmented by B.vulgatus and F.varium at both the mRNA and protein levels.In particular,B.vulgatus stimulated human MoDCs,resulting in extremely high levels of CRF and UCN1.CONCLUSION:Stimulation of MoDCs by B.vulgatus and F.varium may be associated with CRF/UCN1-related intestinal disorders,such as irritable bowel syndrome and inflammatory bowel disease. | Shigeo Koido Toshifumi Ohkusa Shin Kan Kazuki Takakura Keisuke Saito Hideo Komita Zensho Ito Hiroko Kobayashi Shinichiro Takami Kan Uchiyama Hiroshi Arakawa Masaki Ito Masato Okamoto Mikio Kajihara Sadamu Homma Hisao Tajiri | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 7 | Antithrombin Ⅲ injection via the portal vein suppresses liver damage显示文摘AIM:To investigate the effects of antithrombin Ⅲ(AT Ⅲ) injection via the portal vein in acute liver failure.METHODS:Thirty rats were intraperitoneally challenged with lipopolysaccharide(LPS) and D-galactosamine(GalN) and divided into three groups:a control group;a group injected with AT Ⅲ via the tail vein;and a group injected with AT Ⅲ via the portal vein.AT Ⅲ(50 U/kg body weight) was administrated 1 h after challenge with LPS and GalN.Serum levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were analyzed.RESULTS:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control rats.Portal vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin deposition.This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1.CONCLUSION:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities. | Masayuki Miyazaki Masaki Kato Masatake Tanaka Kosuke Tanaka Shinichiro Takao Motoyuki Kohjima Tetsuhide Ito Munechika Enjoji Makoto Nakamuta Kazuhiro Kotoh Ryoichi Takayanagi | 2012 | World Journal of Gastroenterology2012，18，16： | 2 |
| 8 | Immunotherapy synergizes with chemotherapy targeting pancreatic cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Hideo Komita Kan Uchiyama Masaki Ito Jianlin Gong Toshifumi Ohkusa Hisao Tajiri | 2012 | Immunotherapy2012，，1： | 2 |
| 9 | Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions显示文摘 | Shigeo Koido Sadamu Homma Eiichi Hara Yoshihisa Namiki Akitaka Takahara Hideo Komita Eijiro Nagasaki Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri E. Shevach | 2010 | Clinical and Developmental Immunology2010，，： | 2 |
| 10 | Tgf-beta1 induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker on cultured human peritoneal mesothelial cells显示文摘 | Kyuden Y Ito T Masaki T | | 0，，05： | 1 |
| 11 | TGF-betal induced by high glucose is cont rolled by angiotensin-converting enzyme inhibitor and anglotensin II receptor blocker on cultured human peritoneal mesot helial cells显示文摘 | Kyuden Y Ito T Masaki T | 2005 | Perit Dial Int2005，25，5： | 1 |
| 12 | Combined Transplantation of Pancreatic Islets and Adipose Tissue-Derived Stem Cells Enhances the Survival and Insulin Function of Islet Grafts in Diabetic Mice显示文摘 | Yoshiaki Ohmura Masahiro Tanemura Naomasa Kawaguchi Tomohiko Machida Tsukasa Tanida Takashi Deguchi Hiroshi Wada Shogo Kobayashi Shigeru Marubashi Hidetoshi Eguchi Yutaka Takeda Nariaki Matsuura Toshinori Ito Hiroaki Nagano Yuichiro Doki Masaki Mori | 2010 | Transplantation2010，，12： | 1 |
| 13 | Regression of B-Cell Lymphoma of the Liver with Hepatitis C Virus Infection After Treatment with Pegylated Interferon-α and Ribavirin显示文摘 | Yayoi Oda Tadayuki Kou Masaki Watanabe Yojiro Sakuma Nori Taguchi Yoko Kato Yasushi Kudo Atsushi Yamauchi Yasushi Sugiura Shinya Ohashi Masanori Asada Toyokazu Fukunaga Kiyotaka Kawaguchi Hiroaki Ito Takefumi Nakamura Shujiro Yazumi | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 14 | TGF-betal induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker on cultured human peritoneal mesothelial cells显示文摘 | Kyuden Y Ito T Masaki T | 2005 | Perit Dial Int2005，25，5： | 1 |
| 15 | Tgf-beta1 induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin Ⅱ receptor blocker on cultured human peritoneal mesothelial cells显示文摘 | Kyuden Y Ito T Masaki T | 2005 | Perit Dial Int2005，25，5： | 1 |
| 16 | Estimation of automotive tire force characteristics using wheel velocity显示文摘 | Eiichi Ono Katsuhiro Asano Masaru Sugai Shoji Ito Masaki Yamamoto Mamoru Sawada Yoshiyuki Yasui | 2003 | Control Engineering Practice2003，，12： | 1 |
| 17 | Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions显示文摘 | Shigeo Koido Eiichi Hara Sadamu Homma Yoshihisa Namiki Hideo Komita Akitaka Takahara Eijiro Nagasaki Masaki Ito Yukiko Sagawa Makoto Mitsunaga Kan Uchiyama Kenichi Satoh Seiji Arihiro Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2010 | Clinical Immunology2010，，3： | 1 |
| 18 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 1 |
| 19 | Tgf-betal induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin 1I receptor blocker on cultured human peritoneal mesothelial cells显示文摘 | KYUDEN Y ITO T MASAKI T | 2005 | Petit Dial Int2005，25，5： | 1 |
| 20 | Tomato FRUITFULL homologues act in fruit ripening via forming MADS-box transcription factor complexes with RIN显示文摘 | Yoko Shima Mamiko Kitagawa Masaki Fujisawa Toshitsugu Nakano Hiroki Kato Junji Kimbara Takafumi Kasumi Yasuhiro Ito | 2013 | Plant Molecular Biology2013，，4： | 1 |
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