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| 1 | Clinical significance of serum procalcitonin in patients with ulcerative colitis显示文摘AIM:To investigate the association of procalcitonin(PCT)with ulcerative colitis(UC)activity.METHODS:Serum PCT levels,C-reactive protein(CRP)levels,the erythrocyte sedimentation rate,and the white blood cell count were analyzed in 18 patients with UC and 11 healthy volunteers.Serum PCT levels were analyzed by an electrochemiluminescence immunoassay.Severity assessments were based on Truelove and Witts’severity index.Correlation of serum PCT and CRP levels with UC activity was examined.Moreover,we assessed serum PCT and CRP levels in patients with a Mayo endoscopic subscore.RESULTS:Serum PCT levels in severe UC patients(n=7)(0.096±0.034 ng/mL)were significantly higher than in mild-to-moderate UC patients(n=11)(0.033±0.012 ng/mL)and healthy volunteers(n=11)(0.035±0.005 ng/mL)(P=0.0005 and P<0.0001,respectively).In addition,there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy volunteers.Interestingly,patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT(0.075±0.043 ng/mL)compared with patients with a subscore of 2 points(0.03±0.011 ng/mL)(P=0.0302).Moreover,CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 points.CONCLUSION:Serum PCT levels were significantly correlated with UC activity. | Shigeo Koido Toshifumi Ohkusa Kazuki Takakura Shunichi Odahara Shintaro Tsukinaga Toyokazu Yukawa Jimi Mitobe Mikio Kajihara Kan Uchiyama Hiroshi Arakawa Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，45： | 15 |
| 2 | Current Immunotherapeutic Approaches in Pancreatic Cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Shintaro Tsukinaga Jimi Mitobe Shunichi Odahara Toyokazu Yukawa Hiroshi Matsudaira Keisuke Nagatsuma Kan Uchiyama Kenichi Satoh Masaki Ito Hideo Komita Hiroshi Arakawa Toshifumi Ohkusa Jianlin Go | 2011 | Clinical and Developmental Immunology2011，，： | 3 |
| 3 | Difl'eencee in protein con- tent, amylose content and palatability in relation to location of gains within rice panicle显示文摘 | Matsue Y Odahara K Hiramatsu M | 1994 | Jpn J Crop Sci1994，63，： | 1 |
| 4 | Detection of exag- gerated blood pressure response using laboratory of physical science protocol and risk of future hypertension显示文摘 | Odahara T Irokawa M Karasawa H etal | 2010 | Occup Health2010，52，5： | 1 |
| 5 | Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy显示文摘AIM: To investigate the association of plasma levels of interleukin(IL)-6 and-8 with Wilms' tumor 1(WT1)-specific immune responses and clinical outcomes in patients with pancreatic ductal adenocarcinoma(PDA) treated with dendritic cells(DCs) pulsed with three types of major histocompatibility complex classⅠand Ⅱ-restricted WT1 peptides combined with chemotherapy.METHODS: During the entire treatment period, plasma levels of IL-6 and-8 were analyzed by ELISA. The induction of WT1-specific immune responses was assessed using the WT1 peptide-specific delayed-type hypersensitivity(DTH) test.RESULTS: Three of 7 patients displayed strong WT1-DTH reactions throughout long-term vaccination with significantly decreased levels of IL-6/-8 after vaccinations compared with the levels prior to treatment. Moreover, overall survival(OS) was significantly longer in PDA patients with low plasma IL-6 levels(< 2 pg/m L) after 5 vaccinations than in patients with high plasma IL-6 levels(≥ 2 pg/m L)(P = 0.025). After disease progression, WT1-DTH reactions decreased severely and were ultimately negative at the terminal stage of cancer. The decreased levels of IL-6/-8 observed throughout long-term vaccination were associated with WT1-specific DTH reactions and long-term OS.CONCLUSION: Prolonged low levels of plasma IL-6/-8 in PDA patients may be a prognostic marker for the clinical outcomes of chemoimmunotherapy. | Shintaro Tsukinaga Mikio Kajihara Kazuki Takakura Zensho Ito Tomoya Kanai Keisuke Saito Shinichiro Takami Hiroko Kobayashi Yoshihiro Matsumoto Shunichi Odahara Kan Uchiyama Hiroshi Arakawa Masato Okamoto Haruo Sugiyama Kazuki Sumiyama Toshifumi Ohkusa Shigeo Koido | 2015 | World Journal of Gastroenterology2015，21，39： | 1 |
| 6 | Difference in protein content, amylose content and palatability in relation to location grains within rice panicle 显示文摘 | Matsue Y Odahara K Hiramatsu M | 1994 | Japanese Journal of Crop Science1994，63，： | 1 |
| 7 | Differences in amylose content,amylographic characteristics and storage proteins of grains on primary and secondary rachis branches in rice 显示文摘 | Matsue Y Odahara K Hiramatsu M | 1995 | Japanese Journal of Crop Science1995，64，： | 1 |
| 8 | Differences in amylase content, amylographic characteristics and storage protein of grains on primary and secondary rachis branches in rice显示文摘 | Matsue Y Odahara K Hiramatsu M | 1995 | Japanese Journal of Crop Science1995，64，： | 1 |
| 9 | Change in the respiration system of Candida albicans in the lag and log growth phase 显示文摘 | Ogasawara A Odahara K Toume M | 2006 | Biol Pharm Bull2006，29，3： | 1 |
| 10 | Vitamin A prevents the decline in immunoglobulin A and Th2 cytokine levels in small intestinal mueosa of protein-malnourished miee显示文摘 | Nikawa T Odahara K Koizumi H | 1999 | J Nutr1999，129，5： | 1 |
| 11 | Molecular phylogeography and ge-netic diversity of East Asian goats显示文摘 | Lin BZ Odahara S Ishida M | | 0，，01： | 1 |
| 12 | Vitamin A prevents the decline in immunoglobulin A and Th2 cytokine levels in small intestinal mucosa of protein-malnourished mice显示文摘 | Nikawa T Odahara K Koizumi H | 1999 | J Nutr1999，129，5： | 1 |
| 13 | Differences in amylase content, amylographic characteristics and storage protein of grains on primary and secondary rachis branches in rice 显示文摘 | MATSUE Y ODAHARA K HIRAMATSU M | 1995 | Japan J Crop Sci1995，64，： | 1 |
| 14 | Studies on Relationship between the Palatability of Rice and Protein Content 显示文摘 | MATSUE Y ODAHARA K HIRAMATSU M | 2005 | Crop Sci2005，6，3： | 1 |
| 15 | Studies on relationship between the palatability of rice and protein content显示文摘 | odahara K Hiradmatsu M | 1995 | Japanese Journal of Crop Science1995，64，3： | 1 |
| 16 | Differences in protein content, amylose content and palatability in relation to location of grains within rice panicle显示文摘 | Yuji Matsue Koji Odahara Michikazq Hiramatsu | 1994 | Crop Science1994，63，2： | 1 |
| 17 | Differences in amylose content, amylographic characteristics and storage proteins of grain on primary and secondary rachis branches in rice 显示文摘 | Matasue Y Odahara K Hiramatsu M | 1995 | Jpn J Crop Sci1995，64，3： | 1 |
| 18 | CF4 decomposition of flue gas from semiconductor process using inductively coupled plasma 显示文摘 | Kuroki T Mine J Odahara S | 2005 | IEEE Transactions on Industry Applications2005，41，1： | 1 |
| 19 | Differences in amylase content,amylographic characteristics and storage protein of grains on primary and secondary rachis branches in rice显示文摘 | Matsue Y Odahara K Hiramatsu M | 1995 | Japanese Journal of Crop Science1995，64，： | 1 |
| 20 | Differences in am-ylase content,amylographic characteristics and storage protein of grains on primary and secondary rachis branches in rice显示文摘 | MATSUE Y ODAHARA K HIRAMATSU M | 1995 | Japa-nese Journal of Crop Science1995，64，： | 1 |
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