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| 1 | Application of semi-analytical finite element method to analyze the bearing capacity of asphalt pavements under moving loads显示文摘便于长期的基础结构财产管理系统,决定人行道的适用的能力是必要的。当前以一种静止方式进行如此的大小是普通的,然而,有静止装载的评估不对应于现实向最近的年里的连续、高的速度大小的一个趋势能被观察。计算程序 SAFEM 与在动人的负担下面评估沥青的动态反应的目的被开发并且基于一个半分析的元素方法。在这个研究工程, SAFEM 与商业有限元素软件 ABAQUS 和领域大小相比验证计算精确性。虽然自称拥有比 ABAQUS 远短的一计算时间, SAFEM 的计算精确性被发现足够高可行。因此, SAFEM 看起来是一条可行途径在动态负担下面决定人行道的动态反应并且是一个有用工具让基础结构政府分析忍受能力的人行道。 | Pengfei LIU Dawei WANG Frederic OTTO Markus OESER | 2018 | Frontiers of Structural and Civil Engineering2018，12，2： | 3 |
| 2 | 盾构术:12年实践后的逐步手术方案显示文摘在2010年首次发表的盾构术,现已获得了全世界的科学和临床认可。为了解决这一创新技术在种植美学可能出现的并发症,我们结合在过去十年的经验提出了一个全面的逐步方案。首先是去除牙冠,之后就可以在牙根处预备种植床。在拔除腭侧根片后,根据机械或生物“锁定”原理预备唇侧根片。机械“锁定”包括植体和根片的直接接触,而生物“锁定”是通过促进了根片与牙槽骨固连以防止其冠向移位。根片的冠部需要预备成凹形,高度终止于颊侧骨板上0.5mm。随后植入植体,并制作个性化愈合帽。根据基本的生物和机械原理进行的盾构术可以提供高度美观和可预测的结果。 | Philip Staehler Sophia M.Abraha Joel Bastos Otto Zuhr Markus Hiirzeler 罗启培(译) 张新春(审) | 2020 | 中国口腔医学继续教育杂志2020，23，5： | 2 |
| 3 | Diagnosis of Creutzfeldt- Jakob disease by two - dimensional gel eletrophoresis of cerebrospinal fluid显示文摘 | Inga Zerr Monika Bodemer Markus Otto | 1996 | The lancet1996，348，9031： | 1 |
| 4 | 测定血清S100蛋白用于诊断克-雅病:前瞻性病例对照研究显示文摘目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患者、其他疾病引起的痴呆患者及对照组血清 S100浓度。结果:224例疑为 CJD 的患者中,65例经病理证实确诊;6例有基因突变而肯定诊断;43例很可能患 CJD;36例可能患 CJD;74例患有其他疾病。108例为肯定或很可能 CJD 患者,其血清 S100浓度中位数为395 pg/ml(SD 387 pg/ml)。这明显高于患其他疾病的74例患者(S100浓度中位数为109pg/ml,SDl77pg/ml;P=0.0001)。以213pg/ml为界值,S100测定用于 CJD 诊断的敏感性为77.8%(95%的可信区间为66.8%~85.2%),特异性为81.1%(70.3%~89.3%)。在 Kaplan-Meier 曲线上,不同浓度 S100患者的存活时间差异有显著性(P=0.023)。结论:S100血清浓度测定是一种有价值的工具,在 CJD 的鉴别诊断中,较测定脑脊液更有价值。尚需更多的研究以确定连续测定是否有助于提高此病的诊断准确性。 | Markus Otto Jens Wiltfang Ekkehard Schtz Ingo Zerr Anke Otto Annette Pfahlberg Olaf Gefeller Manfred Uhr Armin Giese Thomas Weber Hans A Kretzschmar Sigrid Poser 张星虎 | 1998 | 英国医学杂志中文版1998，0，1： | 1 |
| 5 | The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: critical elements in design and execution显示文摘 | Otto Zuhr Daniel B?umer Markus Hürzeler | 2014 | J Clin Periodontol2014，，： | 1 |
| 6 | Neuroflament light and heterogeneity of disease progression in amyotrophic lateral sclerosis:development and validation of a prediction model to improve interventional trials显示文摘Background:Interventional trials in amyotrophic lateral sclerosis(ALS)sufer from the heterogeneity of the disease as it considerably reduces statistical power.We asked if blood neuroflament light chains(NfL)could be used to antici‑pate disease progression and increase trial power.Methods:In 125 patients with ALS from three independent prospective studies-one observational study and two interventional trials-we developed and externally validated a multivariate linear model for predicting disease pro‑gression,measured by the monthly decrease of the ALS Functional Rating Scale Revised(ALSFRS-R)score.We trained the prediction model in the observational study and tested the predictive value of the following parameters assessed at diagnosis:NfL levels,sex,age,site of onset,body mass index,disease duration,ALSFRS-R score,and monthly ALSFRS-R score decrease since disease onset.We then applied the resulting model in the other two study cohorts to assess the actual utility for interventional trials.We analyzed the impact on trial power in mixed-efects models and compared the performance of the NfL model with two currently used predictive approaches,which anticipate disease progression using the ALSFRS-R decrease during a three-month observational period(lead-in)or since disease onset(ΔFRS).Results:Among the parameters provided,the NfL levels(P<0.001)and the interaction with site of onset(P<0.01)contributed signifcantly to the prediction,forming a robust NfL prediction model(R=0.67).Model application in the trial cohorts confrmed its applicability and revealed superiority over lead-in andΔFRS-based approaches.The NfL model improved statistical power by 61%and 22%(95%confdence intervals:54%-66%,7%-29%).Conclusion:The use of the NfL-based prediction model to compensate for clinical heterogeneity in ALS could signif‑cantly increase the trial power.NCT00868166,registered March23,2009;NCT02306590,registered December 2,2014. | Simon Witzel Felix Frauhammer† Petra Steinacker David Devos Pierre‑François Pradat Vincent Meininger Stefen Halbgebauer Patrick Oeckl Joachim Schuster Simon Anders Johannes Dorst Markus Otto Albert C.Ludolph | 2021 | Translational Neurodegeneration2021，10，3： | 1 |
| 7 | Methylene blue–aided cholangioscopy unravels the endoscopic features of ischemic-type biliary lesions after liver transplantation显示文摘 | Arthur Hoffman Ralf Kiesslich Christian Moench Fernando Bittinger Gerd Otto Peter R. Galle Markus F. Neurath | 2007 | Gastrointestinal Endoscopy2007，，5： | 1 |
| 8 | Elevated Serum Levels of Astroglial S100β in Patients with Liver Cirrhosis Indicate Early and Subclinical Portal-Systemic Encephalopathy显示文摘 | Jens Wiltfang Wilhelm Nolte Markus Otto Jens Wildberg Erik Bahn Hans Reiner Figulla Lars Pralle Heinz Hartmann Eckhard Rüther Giuliano Ramadori | 1999 | Metabolic Brain Disease1999，，4： | 1 |
| 9 | Treatment of chyloperitoneum after extended lymphatic dissection during duodenopancreatectomy显示文摘 | Otto Kollmar Martin K. Schilling Markus W. Büchler | 2000 | International Journal of Pancreatology2000，，1： | 1 |
| 10 | Assessment of right ventricular systolic function: Comparison between cardiac magnetic resonance derived ejection fraction and pulsed-wave tissue Doppler imaging of the tricuspid annulus显示文摘 | Andreas Wahl Fabien Praz Markus Schwerzmann Harald Bonel Simon C. Koestner Roger Hullin Jean-Paul Schmid Thomas Stuber Etienne Delacrétaz Otto M. Hess Bernhard Meier Christian Seiler | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 11 | Midterm follow-up after DC-BEAD?-TACE of Hepatocellular Carcinoma (HCC)显示文摘 | Marijke Skowasch Jens Schneider Gerd Otto Arndt Weinmann Markus Alexander Woerns Christoph Dueber Michael Bernhard Pitton | 2012 | European Journal of Radiology2012，，12： | 1 |
| 12 | Flupirtine as Neuroprotective Add-On Therapy in Autoimmune Optic Neuritis显示文摘 | Muriel B. S?ttler Sarah K. Williams Clemens Neusch Markus Otto Jens R. Pehlke Mathias B?hr Ricarda Diem | 2008 | The American Journal of Pathology2008，，5： | 1 |
| 13 | Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain显示文摘 | Katharine Walker Stephen J. Medhurst Bruce L. Kidd Markus Glatt Mick Bowes Sadhana Patel Kara McNair Adam Kesingland Jonathan Green Otto Chan Alyson J. Fox Laszlo A. Urban | 2002 | Pain2002，，3： | 1 |
| 14 | FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0显示文摘 | Ronald Boellaard Mike J. O’Doherty Wolfgang A. Weber Felix M. Mottaghy Markus N. Lonsdale Sigrid G. Stroobants Wim J. G. Oyen Joerg Kotzerke Otto S. Hoekstra Jan Pruim Paul K. Marsden Klaus Tatsch Corneline J. Hoekstra Eric P. Visser Bertjan Arends Fred J | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，1： | 1 |
| 15 | Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia‐reperfusion injury in heart显示文摘 | Rianne Nederlof Otto Eerbeek Markus W Hollmann Richard Southworth Coert J Zuurbier | | Br J Pharmacol0，，8： | 1 |
| 16 | Productivity increase in Northern Austria Norway spruce forests due to changes in nitrogen cycling and climate显示文摘 | Robert Jandl Markus Neumann Otto Eckmtillner | 2007 | Journal of Plent Nulrition and Soil Science2007，170，1： | 1 |
| 17 | Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment显示文摘 | Doris Bach Julia Fuereder Michael Karbiener Marcel Scheideler Anna Lena Ress Daniel Neureiter Ralf Kemmerling Otto Dietze Markus Wiederstein Frieder Berr Kristjan Plaetzer Tobias Kiesslich Martin Pichler | 2013 | Journal of Photochemistry & Photobiology B: Biology2013，，： | 1 |
| 18 | Kinetics of serum neuron-specific enolase and prolactin in patients after simple epileptic seizures显示文摘 | Tumani H Otto Markus Gafeller Olaf | 1999 | Epilepsia1999，40，6： | 1 |
| 19 | The influence of asymmetric quadriceps loading on patellar tracking — An in vitro study显示文摘 | Andrea Lorenz Otto Müller Philipp Kohler Markus Wünschel Nikolaus Wülker Ulf G. Leichtle | 2012 | The Knee2012，，6： | 1 |
| 20 | 美学区域种植二期手术时软组织美学处理:一项新技术显示文摘种植体支持修复体的美学效果日益受到关注.尤其是美学区域的单颗牙种植修复。由于拔牙后组织形态发生了变化.为了达到理想的美学效果.在种植术前、术中或术后常常需要进行组织增量手术。本文介绍一种二期手术时进行的改良软组织增量手术。该技术采用改良卷曲瓣联合邻牙隧道技术以及腭侧滑行瓣冠向复位技术.使种植体周围软组织能够达到足够的增量效果.避免了手术瘢痕.获得协调的外形结构。 | Markus B. HUrzeler Sebastian von Mohrensch Idt Otto Zuhr 蒋析(译) 陈波(审) | 2011 | 中国口腔医学继续教育杂志2011，14，1： | 0 |
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