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| 1 | Differential diagnosis in inflammatory bowel disease colitis:State of the art and future perspectives显示文摘Distinction between Crohn's disease of the colonrectum and ulcerative colitis or inflammatory bowel disease(IBD) type unclassified can be of pivotal importance for a tailored clinical management,as each entity often involves specific therapeutic strategies and prognosis.Nonetheless,no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated examinations.Hence,we have performed a literature search to address the problem of differential diagnosis in IBD colitis,revised current and emerging diagnostic tools and refined disease classification strategies.Nowadays,the differential diagnosis is an untangled issue,and the proper diagnosis cannot be reached in up to 10% of patients presenting with IBD colitis.This topic is receiving emerging attention,as medical therapies,surgical approaches and leading prognostic outcomes require more and more disease-specific strategies in IBD patients.The optimization of standard diagnostic approaches based on clinical features,biomarkers,radiology,endoscopy and histopathology appears to provide only marginal benefits.Conversely,emerging diagnostic techniques in the field of gastrointestinal endoscopy,molecular pathology,genetics,epigenetics,metabolomics and proteomics have already shown promising results.Novel advanced endoscopic imaging techniques and biomarkers can shed new light for the differential diagnosis of IBD,better reflecting diverse disease behaviors based on specific pathogenic pathways. | Gian Eugenio Tontini Maurizio Vecchi Luca Pastorelli Markus F Neurath Helmut Neumann | 2015 | World Journal of Gastroenterology2015，21，1： | 13 |
| 2 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 3 | New endoscopic approaches in IBD显示文摘Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular level.This review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD. | Helmut Neumann Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 5 | Advanced colonoscopic imaging using endocytoscopy显示文摘 | Helmut Neumann Shin‐Ei Kudo Ralf Kiesslich Markus F. Neurath | 2015 | Digestive Endoscopy2015，，2： | 2 |
| 6 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 7 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 8 | Confocal Laser Endomicroscopy: Technical Advances and Clinical Applications显示文摘 | Helmut Neumann Ralf Kiesslich Michael B. Wallace Markus F. Neurath | 2010 | Gastroenterology2010，，2： | 1 |
| 9 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 10 | Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14 + Macrophages显示文摘 | Raja Atreya Michael Zimmer Brigitte Bartsch Maximilian J. Waldner Imke Atreya Helmut Neumann Kai Hildner Arthur Hoffman Ralf Kiesslich Andreas D. Rink Tilman T. Rau Stefan Rose–John Hermann Kessler Jan Schmidt Markus F. Neurath | 2011 | Gastroenterology2011，，6： | 1 |
| 11 | Quantitative evaluation of myocardial blush to assess tissue level reperfusion in patients with acute ST-elevation myocardial infarction显示文摘 | Grigorios Korosoglou Andreas Haars Gick Michael Markus Erbacher Stefan Hardt Evangelos Giannitsis Kerstin Kurz Neumann Franz-Josef Helmut Dickhaus Hugo A. Katus Helmut Kuecherer | 2007 | American Heart Journal2007，，4： | 1 |
| 12 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 13 | Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis?显示文摘 | Klaus W Frommer Andreas Sch?ffler Christa Büchler Jürgen Steinmeyer Markus Rickert Stefan Rehart Fabia Brentano Steffen Gay Ulf Müller-Ladner Elena Neumann | 2012 | Annals of the Rheumatic Diseases2012，，10： | 1 |
| 14 | Label-Free Imaging of Inflammatory Bowel Disease Using Multiphoton Microscopy显示文摘 | Sebastian Schürmann Sebastian Foersch Raja Atreya Helmut Neumann Oliver Friedrich Markus F. Neurath Maximilian J. Waldner | 2013 | Gastroenterology2013，，3： | 1 |
| 15 | Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial显示文摘 | Adnan Kastrati Julinda Mehilli Josef Dirschinger Ullrich Schricke Jodi Neverve Jürgen Pache Stefan Martinoff Franz-Josef Neumann Stephan Nekolla Rudolf Blasini Melchior Seyfarth Markus Schwaiger Albert Sch?mig | 2002 | The Lancet2002，，9310： | 1 |
| 16 | Learning curve of virtual chromoendoscopy for the prediction of hyperplastic and adenomatous colorectal lesions: a prospective 2-center study显示文摘 | Helmut Neumann Michael Vieth Lucía C. Fry Claudia Günther Raja Atreya Markus F. Neurath Klaus M?nkemüller | 2013 | Gastrointestinal Endoscopy2013，，1： | 1 |
| 17 | Confocal Laser Endomicroscopy: Technical Advances and Clinical Applications显示文摘 | Helmut Neumann Ralf Kiesslich Michael B. Wallace Markus F. Neurath | 2010 | Gastroenterology2010，，2： | 1 |
| 18 | Productivity increase in Northern Austria Norway spruce forests due to changes in nitrogen cycling and climate显示文摘 | Robert Jandl Markus Neumann Otto Eckmtillner | 2007 | Journal of Plent Nulrition and Soil Science2007，170，1： | 1 |
| 19 | Mo1908 Molecular Imaging With Fluorescent MUC2 Antibodies for Highly Specific Diagnosis of Barrett’s Esophagus显示文摘 | Helmut Neumann Michael Vieth Claudia Günther Markus F. Neurath Raja Atreya | 2013 | Gastroenterology2013，，5： | 1 |
| 20 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
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