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| 1 | Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy显示文摘Mesenchymal stem cells(MSCs) are a pleiotropic population of cells that are self-renewing and capable of differentiating into canonical cells of the mesenchyme, including adipocytes, chondrocytes, and osteocytes. They employ multi-faceted approaches to maintain bone marrow niche homeostasis and promote wound healing during injury. Biomedical research has long sought to exploit their pleiotropic properties as a basis for cell therapy for a variety of diseases and to facilitate hematopoietic stem cell establishment and stromal reconstruction in bone marrow transplantation. Early results demonstrated their usage as safe, and there was little host response to these cells. The discovery of their immunosuppressive functions ushered in a new interest in MSCs as a promising therapeutic tool to suppress inflammation and down-regulate pathogenic immune responses in graft-versus-host and autoimmune diseases such as multiple sclerosis, autoimmune diabetes, and rheumatoid arthritis. MSCs produce a large number of soluble and membrane-bound factors, some of which inhibit immune responses. However, the full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease. The present review describes the large body of literature that has been accumulated on the fascinating biology of MSCs and their complex effects on immune responses. | Justin D Glenn Katharine A Whartenby | 2014 | World Journal of Stem Cells2014，6，5： | 55 |
| 2 | 上海地区汉族人群杀伤细胞免疫球蛋白样受体基因多样性及单倍型组合研究显示文摘目的 分析上海地区汉族人群杀伤细胞免疫球蛋白样受体 (killer Ig-like receptors,KIR)基因多态性及单倍型 ,为进一步研究不同人群 KIRs与某些疾病的相关性提供线索。方法 采用序列特异性引物 PCR法对 87名无关汉族健康志愿者进行 KIR基因低分辨率检测和单倍型分析。结果 (1)共检出Xv、KIR1D在内的 18个 KIRs基因。 3 DL 3、2 DL 4、3 DL 2和 3 DL 1存在于所有个体 ;较常见为 2 DL 3、Z、2 DL 1、X;其次为 2 DS4、1D、2 DL 5、2 DS1、3 DS1、2 DS5;2 DS2、2 DL 2、2 DS3、Xv频率较低。 (2 )共检出 13种单倍型 ,最常见的是单倍型 2。 (3 )共检出 18种基因型 ,以 AJ(2 ,2 )、AF(1,2 )型最常见 ,其次为 AH(5,2 )、AI(1,5)和 AG(1,1)。另外有 5种基因型 FZ1(2 ,9或 6,16)、FZ2 (1,16或 2 ,15)、FZ3 (6,17)、FZ4(4,13 )和FZ5(2 ,6) ,目前在白人中尚未发现。结论 上海地区汉族人群有其独特的 KIRs基因频率。 | 张磊 Katharine C.Hsu Xiao-Rong Liu 杨珏琴 姚芳娟 许玲娣 Bo Dupont 范丽安 | 2003 | 中华医学遗传学杂志2003，20，5： | 31 |
| 3 | 人类KIR基因PCR-SSP分型及家系研究显示文摘杀伤细胞免疫球蛋白样受体 (KIR )是NK细胞和某些T细胞表面表达的一组特异识别人类主要组织相容性抗原MHCI类分子的受体 ,对NK细胞效应功能的发挥起重要免疫调节作用。KIR由一组位于人类 19q13 4染色体上的多态性丰富的多基因家族所编码 ,其结构和功能具有多样性。每一个体含有不同种类和数目的KIR基因 ,而同一位点的等位基因又具有丰富的多态性 ,目前在低分辨率水平上 ,可检测到包括两个假基因在内的 18个所有已知基因。文章介绍我室建立的在KIR多基因家族多样性研究中所采用的PCR SSP基因分型方法以及单倍型的家系分析。 | 张磊 Katharine C.Hsu LIU Xiao-rong 杨珏琴 姚芳娟 许玲娣 Bo Dupont 范丽安 | 2003 | 上海免疫学杂志2003，23，2： | 27 |
| 4 | Phospho-control of TGF-β superfamily signaling显示文摘转变生长因素的成员 -- 尾(TGF- 尾) 家庭经由 autocrine, paracrine,和内分泌的模式在后生动物的有机体控制大量细胞的回答。因此,发信号的异常 TGF- 尾能在几疾病的致病起一个关键作用,包括癌症。TGF- 尾发信号小径被短 phospho 串联激活,从受体 phosphorylation 到随后的 phosphorylation,下游的信号变换器的激活叫了 R-Smads。R-Smad phosphorylation 状态决定 Smad 复杂集会 / 拆卸,原子进口 / 出口, transcriptional 活动和稳定性,并且因此是在 TGF- 尾发信号的最批评的事件。由特定的磷酸酶的 R-Smads 的 Dephosphorylation 阻止或终止 TGF- 尾发信号,加亮需要认为 Smad (de ) 是 phosphorylation 作为一紧控制了并且动态事件。这篇文章在控制 TGF- 尾发信号和随后的生理的回答的力量和持续时间说明可逆 phosphorylation 的必要角色。 | Katharine H Wrighton Xia Lin Xin-Hua Feng | 2009 | Cell Research2009，19，1： | 25 |
| 5 | New policies and strategies to tackle HIV/AIDS in China显示文摘 | ZHAO Yan Katharine E.Poundstone Julio Montaner WU Zun-you | 2012 | Chinese Medical Journal2012，，7： | 7 |
| 6 | 中国部分疾病预防控制机构室内烟草烟雾浓度测定显示文摘目的检测室内工作场所烟草烟雾浓度,评价禁烟政策在降低烟草烟雾暴露中的作用。方法选取10个省市的14个卫生机构的办公楼,调查办公楼内的禁烟规定;用尼古丁作为烟草烟雾的标志物,评估禁烟规定对烟草烟雾暴露的作用。结果14个办公楼中,有4个实行了全面禁烟或部分禁烟规定。有禁烟规定办公楼的办公室的尼古丁浓度80百分位点低于2μg/m3,无禁烟规定办公楼的办公室尼古丁浓度80百分位点为20μg/m3。70%以上的吸烟办公室的尼古丁浓度超过1μg/m3;35%的非吸烟办公室和50%的走廊的尼古丁浓度超过1μg/m3。有1个办公楼在2006年1月1日颁布了禁烟规定,之后其尼古丁浓度大幅度下降:办公室的尼古丁平均值下降到原来的1/4以下,走廊下降到1/8以下。结论工作场所是烟草烟雾暴露的一个重要场所。禁烟或限制吸烟都可以有效降低室内烟草烟雾的暴露。 | 姜垣 李竹 邱五七 常爱玲 李明珠 赵白帆 杨焱 甘泉 Katharine Hammond 胡德伟 | 2007 | 中国慢性病预防与控制2007，15，2： | 5 |
| 7 | Pseudomyxoma peritonei显示文摘Pseudomyxoma peritonei (PMP) is an uncommon 'bor-derline malignancy' generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treat-ment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a 'borderline' peritoneal malignancy. | Katharine E Bevan Faheez Mohamed Brendan J Moran | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 4 |
| 8 | Male horseshoe crabs Limulus polyphemus use multiple sensory cues to locate mates显示文摘The use of multisensory cues to locate mates can increase an organism's success by acting as a back-up plan whenone system fails, by providing additional information to the receiver, and by increasing their ability to detect mates using sensesthat have different ranges in a variable aquatic environment. In this contribution we review the sensory cues that male horseshoecrabs Limulus polyphemus are known to use when locating mates and then provide new data that shed light on this subject. Duringthe breeding season, females migrate into shore during high tides to spawn. Males attach to females as they approach thebeach or are attracted to pairs already spawning. Vision is well established as an important cue in attracting males. Althoughchemoreception is well known in other marine arthropods, and horseshoe crabs have the anatomy available, there are few studieson chemical cues in this species. Experiments are presented here that provide evidence for chemical cue use. We show that the attraction,and retention, of attached and satellite males to actively spawning females and mating pairs involves multimodal | Katharine M.SAUNDERS H.Jane BROCKMANN Winsor H.WATSON Ⅲ Steven H.JURY | 2010 | Current Zoology2010，56，5： | 3 |
| 9 | Plasma Heating Induced by Tadpole-like Downflows in the Flaring Solar Corona显示文摘As one of the most spectacular energy release events in the solar system,solar flares are generally powered by magnetic reconnection in the solar corona.As a result of the re-arrangement of magnetic field topology after the reconnection process,a series of new looplike magnetic structures are often formed and are known as flare loops.A hot diffuse region,consisting of around 5–10 MK plasma,is also observed above the loops and is called a supra-arcade fan.Often,dark,tadpole-like structures are seen to descend through the bright supra-arcade fans.It remains unclear what role these so-called supra-arcade downflows(SADs)play in heating the flaring coronal plasma.Here we show a unique flare observation,where many SADs collide with the flare loops and strongly heat the loops to a temperature of 10–20 MK.Several of these interactions generate clear signatures of quasi-periodic enhancement in the full-Sun-integrated soft X-ray emission,providing an alternative interpretation for quasi-periodic pulsations that are commonly observed during solar and stellar flares. | Tanmoy Samanta Hui Tian Bin Chen Katharine KReeves Mark C.M.Cheung Angelos Vourlidas Dipankar Banerjee | 2021 | The Innovation2021，2，1： | 3 |
| 10 | 钩端螺旋体病(综述)显示文摘钩端螺旋体病是一种人畜共患病,由感染了钩端螺旋体属众多致病血清型中的任何一个后引发,本病遍及世界各地。钧端螺旋体病几乎会影响所有哺乳动物,且具有较为广泛的临床症状,从轻度、亚临床感染到多器官衰竭和死亡。1病因钩端螺旋体是一种极难培养且生长缓慢的需氧型革兰氏阴性螺旋体原虫,能够引发特征性的螺旋样死亡。钩端螺旋体的分类很复杂,且可能会造成混淆。 | 夏俊花(译) 韩浩月(图) Katharine F.Lunn Thomas J.Divers 陈建康(校) | 2017 | 国外畜牧学(猪与禽)2017，0，3： | 3 |
| 11 | Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation显示文摘 | Xiaolei Qiu Katharine Brown Matthew D. Hirschey Eric Verdin Danica Chen | 2010 | Cell Metabolism2010，，6： | 2 |
| 12 | 岩石的晶体粒度分布(CSD)和结晶作用的动力学与力学(Ⅱ Makaopuhi熔岩湖)显示文摘已把晶体粒度分布(CSD)理论用于夏威夷Kilauea火山Makaopuhi熔岩湖的岩心标本,采用稳态晶体布居平衡方程式: n=n^0exp(-L/Gr)测定了斜长石和Fe—Ti氧化物粒度分布范围并计算和分析了布居密度(n)ln(n)与晶体粒度(L)曲线的斜率确定参数Gr,即平均晶体生长速度(G)和平均晶体生长时间(r)的乘积;截距为J/G,J为成核速率。已知温度—深度分布为实际生长时间(r)提供了估计值,使我们可以确定与任何动力学模式无关的成核与生长速率。斜长石生长速率象斜长石成核速率那样(33.9~1.6×10^(-3)/cm^3)随结晶度增高而降低(9.9~5.4×10^(-11)cm/s)。铁铁矿生长与成核速率也随结晶度升高而降低(分别为4.9~3.4×10^(-10)cm/s和15—2.2×10^(-3)/cm^3s,J=7.6×10^(-2)/cm^3/s)。把布居密度函数矩用来检查结晶速率随时间的变化。初步结果暗示在接近50%结晶作用之后总晶体体积和时间近似呈线性关系;为了确定整个结晶史,对晶体<50%的物质必须有完整的一套样品,计算的结晶速率和实验数据对比说明熔岩湖的结晶作用发生于过冷却值极小的条件下。这种解释与以前提出岩浆冷却的热模型是一致的,该模型的热耗是通过保持平衡冷却的潜热产量平衡的。 | Katharine V.Cashman Bruce D.Marsh | 1992 | 世界地质1992，11，3： | 2 |
| 13 | Successful treatment of intravenously abused oral Opana ER‐induced thrombotic microangiopathy without plasma exchange显示文摘 | Peter John Miller Andrew Matthew Farland Mary Ann Knovich Katharine Marie Batt John Owen | 2014 | Am. J. Hematol2014，，： | 2 |
| 14 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 15 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 16 | α-Fetoprotein, free β-human chorionic gonadotropin, and dimeric inhibin A produce the best results in a three-analyte, multiple-marker screening test for fetal Down syndrome显示文摘 | Katharine D. Wenstrom John Owen D.C. Chu Larry Boots | 1997 | American Journal of Obstetrics and Gynecology1997，，5： | 2 |
| 17 | 猪钩端螺旋体病显示文摘据报道,问号钩端螺旋体(Leptospira interrogans)(波摩纳血清型、黄疸出血血清型、犬型血清型、哈勒焦血清型和布拉迪斯拉发血清型)、博氏钩端螺旋体(Leptospira borgpetersenii)(赛罗血清型和塔拉索夫血清型)以及Leptospira kirschneri(感冒伤寒型血清型)均可感染猪(图1,图2)。 | 唐彩琰(译) 韩浩月(图) Katharine F.Lunn Thomas J.Divers 陈建康(校) | 2017 | 国外畜牧学(猪与禽)2017，0，3： | 2 |
| 18 | 以语言为基础的辅助沟通系统评估模式构建显示文摘辅助沟通系统评估是个复杂且跨专业的过程,过去发表的多个辅助沟通系统评估模式多着重在维持基本沟通需求,而没有将目标放在尽可能发挥个案潜能、将沟通效度最大化。本文介绍的辅助沟通系统评估模式是建立在交互式沟通目标、详细的认知、语言、感觉、运动能力评估、以及循证实践上,内容包含以循证为基础的各项辅助沟通组成元素介绍。希望藉此提供一个结构化的辅助沟通系统评估模式,可帮助在康复科、语言康复及其他相关专业耕耘的人士在临床工作有架构可循,进而加强信心、提供完善的评估服务给个案。 | Szu-Han Kay Chen Katharine Joan Hill 孙克兴 褚立希 | 2012 | 中国康复理论与实践2012，18，10： | 2 |
| 19 | Structural relationship between the two IgY of the duck,Anas platyrhynchos:molecular genetic evidence显示文摘 | Katharine E Magor Gregory W Warr | 1992 | J Immunol1992，149，8： | 1 |
| 20 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
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