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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 3 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 4 | Low-cost and high-strength Mg-Al-Ca-Zn-Mn wrought alloy with balanced ductility显示文摘A novel low-cost Mg-Al-Ca-Zn-Mn-based alloy was developed to simultaneously improve its strength and ductility.The high yield strength of 411 MPa and the high elongation to failure of~8.9%have been achieved in the as-extruded Mg-1.3Al-1.2Ca-0.5Zn-0.6Mn(wt%)sample.Microstructure characterizations showed that the high strength is mainly associated with the ultra-fined dynamically recrystallized(DRXed)grains.Moreover,high-density dislocations in the un-DRXed region and nano-precipitates are distributed among theα-Mg matrix.The high ductility property can be ascribed to the high volume fraction of DRXed grains with a much randomized texture,as well as the formations of high-density subgrains in the un-DRXed grain regions. | Kun Yang Hucheng Pan Sen Du Man Li Jingren Li Hongbo Xie Qiuyan Huang Huajun Mo Gaowu Qin | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 5 | Temperature elevated N ion implantation of Ti6A14V alloys using the plasma source显示文摘Specimens of Ti6A14V alloy were implanted with nitrogen ions of 4× 1018 cm-2 at temperatures from 100 to 600℃. Auger Electron Spectroscopy (AES), microhardness measurements and pin-on-disk wear testing, Scanning Electron Mi- croscopy (SEM), and Glancing angle X-ray Diffraction. (XRD) were utilized to evaluate the surface property improvements. The thickness of implanted layers increased by about an order of magnitude when the temperature was elevated from 100 to 6000℃. Higher surface hardness and wear resistance were also obtained in the high tempera-ture implantation. The XRD image showed the presence of nitrides of titanium at the implanted surface. | ZHAO Qing, ZHENG Yong-Zhen, Mo Zhi-Tao, TONG Hong-Hui, GENG Man (Southwestern Institute of Physics, Chengdu 610041 | 2001 | Nuclear Science and Techniques2001，12，3： | 2 |
| 6 | Negative capsule endoscopy without subsequent enteroscopy does not predict lower long-term rebleeding rates in patients with obscure GI bleeding显示文摘 | Jae Jun Park Jae Hee Cheon Hee Man Kim Hyeun Sung Park Chang Mo Moon Jin Ha Lee Sung Pil Hong Tae Il Kim Won Ho Kim | 2010 | Gastrointestinal Endoscopy2010，，6： | 2 |
| 7 | Negative capsule endoscopy without subsequent enteroscopy does not predict lower long-term rebleeding rates in patients with obscure GI bleeding显示文摘 | Jae Jun Park Jae Hee Cheon Hee Man Kim Hyeun Sung Park Chang Mo Moon Jin Ha Lee Sung Pil Hong Tae Il Kim Won Ho Kim | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 8 | De novo hepatitis B virus infection after pediatric liver transplantations with hepatitis B core antibody‐positive donors: A single‐center 20‐yr experience显示文摘 | Yeoun Joo Lee Seak Hee Oh Kyung Mo Kim Seung Min Song Jung‐Man Namgoong Dae Yeon Kim Sung‐Gyu Lee | 2015 | Pediatr Transplantation2015，，3： | 1 |
| 9 | Synthesis and blue light-emitting properties of 4,4'-bis(diphenylamino)-quinque(p-phenyl)s显示文摘An excellent organic blue light-emitting diode based on 4,40-bis(diphenylamino)-quinque( p-phenylene)s (OPP(5)-NPh) with a maximum luminance of up to 5000 cd/m2 and a luminanous efficiency of 1.3 cd/A was reported. This diode was made by using a wide band-gap hole-blocking layer, F-TBB instead of PBD in the OLED devices. We attribute the good performance to the one trade-off involved in the use of F-TBB to obtain higher luminance is the increased turn-on voltages and slightly decreased device efficiencies. | Zhong Hui Li Mo Jun Xiong Man Shing Wong | 2007 | Chinese Chemical Letters2007，18，7： | 1 |
| 10 | Clinical features and predictors of clinical outcomes in K orean patients with C rohn’s disease: A K orean A ssociation for the S tudy of I ntestinal D iseases multicenter study显示文摘 | Chang Mo Moon Dong Il Park Eun Ran Kim Young‐Ho Kim Chang Kyun Lee Suck‐Ho Lee Jae Hak Kim Kyu‐Chan Huh Sung‐Ae Jung Soon Man Yoon Hyun Joo Song Hyun Joo Jang You Sun Kim Kang‐Moon Lee Jeong Eun Shin | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 11 | Expression, secretion and functional characterization of three laccases in E. coli显示文摘Endocrine Disrupting Chemicals(EDCs)are a group of molecules that can influence hormonal balance,causing disturbance of the reproductive system and other health problems.Despite the efforts to eliminate EDC in the environment,all current approaches are inefficient and expensive.In previous research,studies revealed that laccase-producing microorganisms may be a potential candidate for EDC degradation,as laccases have been found to be able to degrade many kinds of EDCs effectively and steadily.Here,we created two recombinant laccases,each fused with secretion peptide,Novel Signal Peptide 4(NSP4),and expressed them in Escherichia coli(E.coli,BL21),together with one laccase without secretion peptide.We first optimized the culture condition of expressing these laccases.Then,we test the activity of the recombinant laccases of decolorizing of a synthetic dye,indigo carmine.Finally,we confirmed the secreted can degrade one of the EDCs,β-estradiol,showing the potential of using the laccase secretion system to degrade toxic compounds. | Yating Mo Hou Ip Lao Sau Wa Au Ieng Chon Li Jeremy Hu Hoi Man Yuen Wai Man Cheong Owen Lok In Lo Leo Chi U.Seak | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 1 |
| 12 | Pneumoslide- M technique for rapid detection of atypical pathogens in critically ill children with lower respiratory tract infections显示文摘 | Sally AF Azza MO E man AE | 2006 | Journal of Medical Sciences2006，6，5： | 1 |
| 13 | 3D anchoring structured for LiFe_(0.5)Mn_(0.5)PO_(4)@cornstalk-C cathode materials显示文摘The organic carbon source coating LiFe_(x)Mn_(1-x)PO_(4)suffers from the problem of non-uniform carbon cladding.Too thick carbon cladding layer instead hinders the de-embedding of lithium ions.In this paper,we choose cornstalk as the carbon source,then LiFe_(0.5)Mn_(0.5)PO_(4)@cornstalk-C(LFMP@C-C)with 3D anchoring structure is prepared by the solvothermal method.The results show that the LFMP with cornstalk as the carbon source has better performance compared to the sucrose-coated LFMP material(LFMP@C).The discharge capacity of LFMP@C-C is 116 mAh/g for the first cycle at 1 C and the capacity retention rate is 94.0%after 500 cycles,and the discharge capacity of LFMP@C-C is more than 17.17%higher than that of LFMP@C. | Guangliang Zhang Riran Zang Man Mo Zhijie Fang Yangxian Huang Kunsong Hu Jiali Huang Xinxiang Liu Lingyun Huang Guohui Kang Weijian Li Haiqing Zhan Xianquan Ming Guanhan Huang Guiliang Li Feng Zhan | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 14 | IOTA-Based Data Encryption Storage and Retrieval Method显示文摘At present,the traditional blockchain for data storage and retrieval reflects the characteristics of slow data uploading speed,high cost,and transparency,and there are a lot of corresponding problems,such as not supporting private data storage,large data operation costs,and not supporting Data field query.This paper proposes a method of data encryption storage and retrieval based on the IOTA distributed ledger,combined with the fast transaction processing speed and zero-value transactions of the IOTA blockchain,through the Masked Authenticated Messaging technology,so that the data is encrypted in the data stream.The form is stored in the distributed ledger,quickly retrieved through the field index mechanism established by the data form,and the data operation is carried out on the chain.Experimental results show that this system has high storage,encryption and retrieval performance,and good practicability. | Hongchao Ma Yi Man Xiao Xing Zihan Zhuo Mo Chen | 2021 | Journal of Quantum Computing2021，3，3： | 0 |
| 15 | Chidamide combined with traditional chemotherapy for primary cutaneous aggressive epidermotropic CD8+cytotoxic T-cell lymphoma:A case report显示文摘BACKGROUND Traditional chemotherapy has benefited many patients with non-Hodgkin's lymphoma,but results in a very poor response in patients with rare lymphomas or refractory lymphomas.Previous studies have shown that chidamide has potential anti-lymphoma activity and reverses lymphoma cell chemoresistance to increase the chemosensitivity of lymphoma cells to traditional chemotherapy.CASE SUMMARY A 14-year-old boy was admitted to our hospital with a 5-d history of generalized erythema,papules,and blisters.Initially,the disease was refractory to potent antiallergic and anti-infective treatment,and his condition progressively worsened.Skin biopsy revealed primary cutaneous aggressive epidermotropic CD8+cytotoxic T-cell lymphoma.Considering that the disease is extremely rare in clinical practice,existing case reports have shown poor efficacy with traditional chemotherapy alone.We recommend chidamide combined with traditional chemotherapy for treatment.The regimen was as follows:Chidamide 30 mg/biw,cyclophosphamide 1100 mg/d1,pirarubicin 70 mg/d1,vincristine 2 mg/d1,dexamethasone 20 mg/d1-5,etoposide 100 mg/d1-5,in a 21 d cycle.The treatment effect was considerable,and complete remission was achieved after 4 cycles of treatment,after which the patient completed a total of 6 cycles of treatment.Subsequently,the patient regularly took chidamide 20 mg/biw as maintenance therapy for 1 year.To date,the patient has been disease-free for 3 years.CONCLUSION This case suggests that the combination of chidamide and traditional chemotherapy is effective in primary cutaneous aggressive epidermotropic CD8+cytotoxic T-cell lymphoma. | Zhen-Dong He Hai-Yan Yang Sheng-Sheng Zhou Man Wang Qin-Li Mo Feng-Xiang Huang Zhi-Gang Peng | 2022 | World Journal of Clinical Cases2022，10，4： | 0 |
| 16 | Electrochemical Radical Borylation of Aryl Iodides显示文摘Herein,we report the first electrochemical strategy for the borylation of aryl iodides via a radical pathway using current as a driving force.A mild reaction condition allows an assorted range of readily available aryl iodides to be proficiently converted into synthetically valuable arylboronic esters under transition metal catalyst-free conditions.Moreover,this method also shows good functional group tolerance.Initial control mechanistic experiments reveal the formation of aryl radical as a key intermediate and the current plays an important role in the generation of radical intermediate. | Junting Hong Qianyi Liu Feng Li Guangcan Bai Guoquan Liu Man Li Onkar S.Nayal Xuefeng Fu Fanyang Mo | 2019 | Chinese Journal of Chemistry2019，37，4： | 0 |
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