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| 1 | The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition显示文摘Background: Understanding the composition of the microbial community and its functional capacity during weaning is important for pig production as bacteria play important roles in the pig's health and growth performance. However,limited information is available regarding the composition and function of the gut microbiome of piglets in early-life.Therefore, we performed 16 S rRNA gene and whole metagenome shotgun sequencing of DNA from fecal samples from healthy piglets during weaning to measure microbiome shifts, and to identify the potential contribution of the early-life microbiota in shaping piglet health with a focus on microbial stress responses, carbohydrate and amino acid metabolism.Results: The analysis of 16 S rR NA genes and whole metagenome shotgun sequencing revealed significant compositional and functional differences between the fecal microbiome in nursing and weaned piglets. The fecal microbiome of the nursing piglets showed higher relative abundance of bacteria in the genus Bacteroides with abundant gene families related to the utilization of lactose and galactose. Prevotel a and Lactobacil us were enriched in weaned piglets with an enrichment for the gene families associated with carbohydrate and amino acid metabolism. In addition, an analysis of the functional capacity of the fecal microbiome showed higher abundances of genes associated with heat shock and oxidative stress in the metagenome of weaned piglets compared to nursing piglets.Conclusions: Overal, our data show that microbial shifts and changes in functional capacities of the piglet fecal microbiome resulted in potential reductions in the effects of stress, including dietary changes that occur during weaning.These results provide us with new insights into the piglet gut microbiome that contributes to the growth of the animal. | Robin B.Guevarra Sang Hyun Hong Jin Ho Cho Bo-Ra Kim Jiwon Shin Jun Hyung Lee Bit Na Kang Young Hwa Kim Suphot Wattanaphansak Richard E.Isaacson Minho Song Hyeun Bum Kim | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 16 |
| 2 | Piglet gut microbial shifts early in life:causes and effects显示文摘The gut microbiome has long been known to play fundamentally important roles in the animal health and the well-being of its host. As such, the establishment and maintenance of a beneficial gut microbiota early in life is crucial in pigs, since early gut colonizers are pivotal in the establishment of permanent microbial community structures affecting the health and growth performance of pigs later in life. Emphasizing this importance of early gut colonizers, it is critical to understand the factors impacting the establishment of the piglet gut microbiome at weaning. Factors include, among others, diet, in-feed antibiotics, probiotics and prebiotic administration. The impact of these factors on establishment of the gut microbiome of piglets at weaning includes effects on piglet gut microbial diversity, structure, and succession. In this review, we thoroughly reviewed the most recent findings on the piglet gut microbiome shifts as influenced by weaning, and how these microbiome changes brought about by various factors that have been shown to affect the development of microbiota in piglets. This review will provide a general overview of recent studies that can help to facilitate the design of new strategies to modulate the gut microbiome in order to enhance gastrointestinal health, growth performance and well-being of piglets. | Robin B.Guevarra Jun Hyung Lee Sun Hee Lee Min-Jae Seok Doo Wan Kim Bit Na Kang Timothy J.Johnson Richard E.Isaacson Hyeun Bum Kim | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 13 |
| 3 | Composition ship collision risk based on fuzzy theory显示文摘Despite of modern navigation devices, there are problems in navigation of vessels in waterways due to the geographical structures, disturbances in water, dynamic nature, and heavily environmental influenced sea traffic. Even though all vessels are equipped with modern navigation devices, the accidents are reported caused by various reasons and mainly by human factor according to investigation. We propose an effective and efficient composition collision risk calculation method for finding the collision probability and avoiding the collision between ships in possible collision situations. The proposed composition collision risk calculation method at ship's position using combination of fuzzy and fuzzy comprehensive evaluation methods. The algorithm is straightforward to implement and is shown to be effective in automatic ship handling for ships involved in complex navigation situations. Experiments are carried out with indigenous data and the results show the effectiveness of the proposed approach. | CHEN Shu Rashid Ahmad Byung-Gil Lee Do Hyeun Kim | 2014 | Journal of Central South University2014，21，11： | 3 |
| 4 | Bacteriophage cocktail supplementation improves growth performance,gut microbiome and production traits in broiler chickens显示文摘Background:Effective antibiotic alternatives are urgently needed in the poultry industry to control disease outbreaks.Phage therapy mainly utilizes lytic phages to kill their respective bacterial hosts and can be an attractive solution to combating the emergence of antibiotic resistance in livestock.Methods:Five hundred and four,one-day-old broilers(Ross 308)were allotted to 1 of 4 treatment groups in a completely randomized design.Treatments consisted of CON(basal diet),PC(CON+0.025%Avilamax®),BP 0.05(CON+0.05%bacteriophage),and BP 0.10(CON+0.10%bacteriophage).Results:A significant linear effect on body weight gain(BWG)was observed during days 1–7,days 22–35,and cumulatively in bacteriophage(BP)supplemented groups.The BWG tended to be higher(P=0.08)and the feed intake(FI)was increased(P=0.017)in the PC group over CON group.A greater(P=0.016)BWG and trends in increased FI(P=0.06)were observed in the experiment in birds fed PC than CON diet.At the genus level,the relative abundance of Lactobacillus was decreased in PC(65.28%),while it was similar in BP 0.05 and BP 0.10(90.65%,86.72%)compared to CON(90.19%).At the species level,the relative abundance of Lactobacillus salivarus was higher in BP 0.05(40.15%)and BP 0.10(38.58%)compared to the CON(20.04%)and PC(18.05%).A linear reduction in the weight of bursa of Fabricius(P=0.022)and spleen(P=0.052)was observed in birds fed graded level of BP and an increase(P=0.059)in the weight of gizzard was observed in birds fed PC over BP diets.Linear and quadratic responses were observed in redness of breast muscle color in birds fed graded level of BP.Conclusions:The inclusion of the 0.05%and 0.1%BP cocktail linearly improved broiler weight during the first 7 days,22–35 days and cumulatively,whereas 0.05%BP addition was sufficient for supporting immune organs,bursa and spleen as well as enhancing gut microbiome,indicating the efficacy of 0.05%BP as a substitute antibiotic growth promoter in broiler diets. | Santi Devi Upadhaya Je Min Ahn Jae Hyoung Cho Jin Young Kim Dae Kyung Kang Sung Woo Kim Hyeun Bum Kim In Ho Kim | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 5 | Negative capsule endoscopy without subsequent enteroscopy does not predict lower long-term rebleeding rates in patients with obscure GI bleeding显示文摘 | Jae Jun Park Jae Hee Cheon Hee Man Kim Hyeun Sung Park Chang Mo Moon Jin Ha Lee Sung Pil Hong Tae Il Kim Won Ho Kim | 2010 | Gastrointestinal Endoscopy2010，，6： | 2 |
| 6 | Delayed bone cement displacement following balloon kyphoplasty 显示文摘 | Hee SW Hyeun SK Seok WK | 2008 | J Kore- an Neurosurg Soc2008，43，4： | 1 |
| 7 | The role of bone cement augmentation in the treatment of chronic symp- tomatic osteoporotic compression fracture显示文摘 | Hyeun Sung Kim Sung Hoon Kim Chang I1 J | 2010 | J Korean Neurosurg Soc2010，48，： | 1 |
| 8 | Negative capsule endoscopy without subsequent enteroscopy does not predict lower long-term rebleeding rates in patients with obscure GI bleeding显示文摘 | Jae Jun Park Jae Hee Cheon Hee Man Kim Hyeun Sung Park Chang Mo Moon Jin Ha Lee Sung Pil Hong Tae Il Kim Won Ho Kim | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 9 | Effect of an electrodeposited TiO2 blocking layer on efficiency improvement of dye-sensitized solar cell显示文摘 | Kang-Il Jang Eunpyo Hong Jung Hyeun Kim | 2012 | Korean Journal of Chemical Engineering2012，，3： | 1 |
| 10 | Differential Scanning Calorimetry of Phenol - formaldehyde (PF) Adhesives显示文摘 | P BYUNG R B HYEUN Y SKIM | 1999 | Journal of Wood Chemistry and Technology1999，19，3： | 1 |
| 11 | Anti inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirslum chanroenicum显示文摘 | Hyun L Nun H S Hyeun W C | 2008 | Biol Pharm Bull2008，31，11： | 1 |
| 12 | Carbon dioxide gas sensor using a graphene sheet显示文摘 | YOON HYEUN JOONG JUN DO HAN YANG JINHO | 2011 | Sensors and Actuators B: Chemical2011，157，： | 1 |
| 13 | Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs显示文摘Background:This study was conducted to investigate the effects of each phytogenic feed additive(PFA;PFA1,bitter citrus extract;PFA2,a microencapsulated blend of thymol and carvacrol;PFA3,a mixture of bitter citrus extract,thymol,and carvacrol;PFA4,a premixture of grape seed,grape marc extract,green tea,and hops;PFA5,fenugreek seed powder)on the growth performance,nutrient digestibility,intestinal morphology,and immune response in weaned pigs infected with Escherichia coli(E.coli).Results:A total of 634-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment groups.The seven treatments were as follows:1)NC;basal diet without E.coli challenge,2)PC;basal diet with E.coli challenge,3)T1;PC+0.04%PFA1,4)T2;PC+0.01%PFA2,5)T3;PC+0.10%PFA3,6)T4;PC+0.04%PFA4,7)T5;PC+0.10%PFA5.The experiments lasted in 21 d,including 7 d before and 14 d after the first E.coli challenge.In the E.coli challenge treatments,all pigs were orally inoculated by dividing a total of 10 mL of E.coli F18 for 3 consecutive days.The PFA-added groups significantly increased(P<0.05)average daily gain and feed efficiency and decreased(P<0.05)the fecal score at d 0 to 14 post-inoculation(PI).Tumor necrosis factorαwas significantly lower(P<0.05)in the PFA-added groups except for T1 in d 14 PI compared to the PC treatment.The T3 had a higher(P<0.05)immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 PI.Also,T3 showed significantly higher(P<0.05)villus height:crypt depth and claudin 1 expression in ileal mucosa,and significantly downregulated(P<0.05)the expression of calprotectin compared to the PC treatment.Conclusions:Supplementation of PFA in weaned pigs challenged with E.coli alleviated the negative effects of E.coli and improved growth performance.Among them,the mixed additive of bitter citrus extract,thymol,and carvacrol showed the most effective results,improving immune response,intestinal morphology,and expression of tight junctions. | Se Yeon Chang Min Ho Song Ji Hwan Lee Han Jin Oh Yong Ju Kim Jae Woo An Young Bin Go Dong Cheol Song Hyun AhCho Seung Yeol Cho Dong Jun Kim Mi Suk Kim Hyeun Bum Kim Jin Ho Cho | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 1 |
| 14 | Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter,tylosin显示文摘 | Hyeun B K Klaudyna B Bryan A | 2012 | PNAS2012，109，15： | 1 |
| 15 | Antiinflammatory activity of naturally occurring flavone and flavonol glycosides显示文摘 | Song Jin Lee Kun Ho Son Hyeun Wook Chang Jae Chul Do Keun Young Jung Sam Sik Kang Hyun Pyo Kim | 1993 | Archives of Pharmacal Research1993，，1： | 1 |
| 16 | Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity显示文摘 | Ju Sun Kim Jin Cheul Kim Sang Hee Shim Eun Ju Lee Wen Yi Jin Kihwan Bae Kun Ho Son Hyun Pyo Kim Sam Sik Kang Hyeun Wook Chang | 2006 | Archives of Pharmacal Research2006，，： | 1 |
| 17 | Radial basis function based adaptive fuzzy systems and their applications to system identification and prediction显示文摘 | Cho Kwang Bo Wang Bo Hyeun | 1996 | Fuzzy sets and systems1996，83，3： | 1 |
| 18 | Ballon kyphoplasty in severe osteo- porotic compression fracture : is it a contraindication 显示文摘 | Hyeun SK Chang I J Seok WK | 2007 | Neurosurgery2007，60，5： | 1 |
| 19 | Radial basis function based adaptive fuzzy systems and their applications to system identification and prediction显示文摘 | Kwang Bo Cho Bo Hyeun Wang | 1996 | Fuzzy Sets and Systems1996，83，： | 1 |
| 20 | 显示文摘 | Hyeun Hwa So | 2006 | Proteomics2006，6，： | 1 |
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