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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 3 | Immunophenotypic subtyping of leukemic cells from Iranian patients with acute lymphoblastie leukaemia: association to disease outeome显示文摘 | Hossein A O Mahdi S Tahereh S | 2007 | Iran J Immunol2007，4，1： | 1 |
| 4 | Selenium capture using sorbent powers: mechanism of sorption by hydrated lime显示文摘 | A Ghosh Dastidar S mahdi | 1996 | Environ Sci Technol1996，30，： | 1 |
| 5 | A Comparison of Oven-cured and Induction-cured Adhesively Bonded Composite Joints显示文摘 | Mahdi S Kim H J Gama B A | 2003 | Journal of Composite Materials2003，37，6： | 1 |
| 6 | Peripartum roboticassisted laparoscopic hysterectomy after second-trimester pregnancy loss with placenta increta显示文摘 | Boes S Mahdi H Khoury F | 2013 | Obstet Gynecol2013，122，2： | 1 |
| 7 | Screening analysis of beer ageing using near infrared spectroscopy and the successive projections algorithm for variable selection显示文摘 | MAHDI G V SEYED S M MARIA L R M | 2012 | Talanta2012，89，1： | 1 |
| 8 | Bad design, bad practices, bad bugs: frustrations in controlling an outbreak of Elizabe- thkingia meningoseptica in intensive care units 显示文摘 | Balm MN Salmon S Jureen R Teo C Mahdi R Seetoh T Teo JT Lin RT Fisher DA | 2013 | J Hosp Infect2013，85，2： | 1 |
| 9 | Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2diabetes显示文摘 | Mahdi T Hanzelmann S Salehi A | 2012 | Cell Metab2012，16，5： | 1 |
| 10 | Secondary outcomes of a pilot randomized trial of azithromycin treatment for asthma显示文摘 | Hahn D L Plane M B Mahdi O S | 2006 | PLOS Clin Trials2006，1，： | 1 |
| 11 | Apoptosis, spermato- genesis and male infertility 显示文摘 | Shukla KK Mahdi AA Rajender S | 2012 | Front Biosci ( Elite Ed)2012，4，： | 1 |
| 12 | Effects of thawing methods on chemical, biochemical, and microbial quality of frozen whole rainbow trout (oncorhynchus mykiss ) 显示文摘 | Seyed R J Masoud R Mahdi S | 2013 | Journal of Aquatic Food Product Technology2013，22，2： | 1 |
| 13 | Emerging group-A rotavirus and a nosocomial outbreak of diarrhoea显示文摘 | Marc-Alain Widdowson Gerard JJ van Doornum Wim HM van der Poel Annette S de Boer Ulrike Mahdi Marion Koopmans | 2000 | 2000 (9236)2000，，9236： | 1 |
| 14 | Effects of preparation conditions on the monodispersity of albumin microspheres 显示文摘 | Ibrahim E - S Safwat S | 1998 | Journal of Microencapsulation1998，15，5： | 1 |
| 15 | Decomposition of 14C-fenitrothion under the influence of UV and sunlight under tropical and subtropical conditions显示文摘 | Zayed S M Mahdy F | 2008 | Cheraosphere2008，70，： | 1 |
| 16 | Methyltrioxorhenium-catalyzed epoxidating in ionic liquids 显示文摘 | GREGORY S OWENS MAHDI M | 2000 | Chem Commun2000，13，： | 1 |
| 17 | Oral iron supplemen?tation leads to oxidative imbalance in anemic women: a prospec?tive study 显示文摘 | Tiwari AK Mahdi AA Chandyan S | 2011 | Clin Nutr2011，30，2： | 1 |
| 18 | Crushing response of composite corrugated tubes to quasi-static axial loading显示文摘 | Elgalai A M Mahdi E Hamouda A M S | 2004 | Composite Structures2004，66，14： | 1 |
| 19 | Effect of the manufacturing process on the interfacial properties and structural performance of multi-functional composite structures显示文摘 | MAHDI S GAMA B A YARLAGADDA S | 2003 | Compos-ites2003，34，： | 1 |
| 20 | Solving flexible job shop sched- uling with multi objective approach显示文摘 | Arash M Kamyar S Mahdi H | 2010 | International Journal of Industrial Engineering & Production Research2010，21，4： | 1 |
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