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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | An Efficient Method for the Synthesis of Acyl-diazenes Using NaNO_2/NaHSO_4·H_2O显示文摘 | Jian Ping LI*, Ping LIU, Yu Lu WANG College of Chemistry & Environmental Science, Henan Normal University, Xinxiang 453002 Key Laboratory of Environmental Science and Technology of High Education of Henan Province, Xinxiang 453002 | 2003 | Chinese Chemical Letters2003，14，7： | 7 |
| 3 | Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene显示文摘A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu:Pd atomic ratios were prepared by conventionally sequential impregnation(CSD)and modified sequential impregnation(MSI)of Cu and Pd for selective hydrogenation of acetylene.Characterization indicates that the supported copper(I)nitrate in the PdCu bimetallic catalysts prepared by MSI can be directly reduced to Cu metal particles due to the hydrogen spillover from Pd to Cu(NO3)2 crystals.In addition,for the catalysts prepared by MSI,Pd atoms can form PdCu alloy on the surface of metal particles,however,for the catalysts prepared by CSI,Pd tends to migrate and exist below the surface layer of Cu.Reaction results indicate that compared with CSI,the MSI method enables samples to possess preferable stability as well as comparable reaction activity.This should be due to the MSI method in favor of the formation of PdCu alloy on the surface of metal particles.Moreover,even Pd loading is super low,<0.045 wt-%in this study,by through adjusting Cu loading to an appropriate value,attractive reactivity and selectivity still can be achieved. | Xinxiang Cao Tengteng Lyu Wentao Xie Arash Mirjalili Adelaide Bradicich Ricky Huitema Ben W.-L.Jang Jong K.Keum Karren More Changjun Liu Xiaoliang Yan | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 4 |
| 4 | A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study显示文摘Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is limited.The objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after surgery.Methods:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December 2006.The endpoint of this study was OS.The nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical usefulness.The nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),respectively.Results:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),respectively.Encouragingly,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup analyses.Decision curve analysis indicated that the nomogram was clinically useful and applicable.Conclusions:The study presents a nomogram that incorporates clinicopathological predictors,which can accurately predict the OS of adult ACC patients after surgery.This model and the corresponding risk classification system have the potential to guide therapy decisions after surgery. | Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao Weibin Xie Xiong Chen Chenyi Liao Hao Yu Xinxiang Fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv Haide Qin Jian Huang Tianxin Lin | 2019 | Cancer Communications2019，39，1： | 3 |
| 5 | Effects of Exposure to Trinitrotoluene on Male Reproduction显示文摘A cross-sectional study was performed in 2 plants located in Henan Province in 1990 for observing the reproductive and sexual functions of male workers exposed to trinitrotoluene(TNT).The TNT concentrations in the workplace air,excpet the packing site,were found to have exceeded MAC(1mg/m^3).TNT exposed maled workers complained of more sexual disorders such as impotence,the loss of libido and sexual hypoesthesia than the control group.Compared with the control group,the volume of semen and percentage of motile spermatozoa were found to have significantly decreased.and the sperm malformation incidence increased significantly in TNT exposed workers.The serum testosterone content in TNT exposed male workers was significantly decreased too. | LI YI, JIANG QUAN-GUAN, YAO SHOU-QI, LIU WEI, TIAN GAO-JUN,AND GUI JING-WEIDepartment of Occupational Health, School of Public Health, Beijing Medical University, Beijing ^Hebi Institute of Occupational Health, Henan Province Anyang Institute of Occupational Health, Henan Province Xinxiang Institute of Occupational Health, Henan Province, China Prof. Jiang Quan-guan, Department of Occupational Health, School of Public Health, Beijing Medical University, Beijing 100083 China. | 1993 | Biomedical and Environmental Sciences1993，6，2： | 3 |
| 6 | Comparison of transperitoneal and retroperitoneal laparoscopic nephrectomy for renal cell carcinoma: a systematic review and meta‐analysis显示文摘 | Xinxiang Fan Kewei Xu Tianxin Lin Hao Liu Zi Yin Wen Dong Hai Huang Jian Huang | 2012 | BJU Int2012，，： | 2 |
| 7 | A Mild Oxidant for the Regeneration of Carbonyl Compounds from Oximes in Nonaqueous Condition显示文摘Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. The reaction proved to be mild and selective. | Qing Zhi ZHANG*, Shen Song ZHANG, Xin Ming LIU, Jin Ming ZHANG College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453002 | 2001 | Chinese Chemical Letters2001，12，2： | 1 |
| 8 | Synergetic effect of Pd and Ag dispersed on AI203 in the selective hydrogenation of acet- ylene显示文摘 | Zhang Qianwen Li Jia Liu Xinxiang | 2000 | Applied Catalysis A2000，197，2： | 1 |
| 9 | Synthesis of three-dimensional hierarchical cobalt hydroxide microstructures显示文摘β-Co(OH)2 with three-dimensional (3-D) structures was prepared by a simple hydrothermal method. It was found that the amount of cetyltrimethylammonium bromide (CTAB), the pH value, and the reaction time all had an important influence on the formation of this morphology. The products were characterized by X-ray diffraction, energy-dispersive X-ray analysis, and scanning electron microscopy. A possible mechanism of the formation of the 3-D microstructures of β-Co(OH)2 was proposed. | SONG XuChun1, ZHAO Yang2, ZHENG YiFan3, YANG E1 & LIU ZhiSheng1 1Institute of Physical Chemistry, Department of Chemistry, Fujian Normal University, Fuzhou 350007, China 2Department of Chemistry, Henan Normal University, Xinxiang 453007, China 3College of Chemical Engineering & Materials Science, Zhejiang University of Technology, Hangzhou 310014, China | 2010 | Science China Chemistry2010，53，4： | 1 |
| 10 | Synergetic effect of Pd and Ag dispersed on Al2O3 in the seletive hydrogenation of acetylene显示文摘 | Zhang Qianwen Li Jia Liu Xinxiang | 2000 | Applied Catalysis A:General2000，197，： | 1 |
| 11 | Synergetic Effect of Pd and Ag Dispersed on Al2O3 in the Selective Hydro- genation ofAcetylene显示文摘 | Zhang Qianwen Li Jia Liu Xinxiang | 2000 | Appl Catal A2000，197，： | 1 |
| 12 | Developing an efficient and visible prime editing system to restore tobacco 8-hydroxy-copalyl diphosphate gene for labdane diterpene Z-abienol biosynthesis显示文摘Prime editing(PE)is a versatile CRISPR-Cas based precise genome-editing platform widely used to introduce a range of possible base conversions in various organisms.However,no PE systems have been shown to induce heritable mutations in tobacco,nor in any other dicot.In this study,we generated an efficient PE system in tobacco that not only introduced heritable mutations,but also enabled anthocyanin-based reporter selection of transgene-free T_(1) plants.This system was used to confer Zabienol biosynthesis in the allotetraploid tobacco cultivar HHDJY by restoring a G>T conversion in the NtCPS2 gene.High levels of Z-abienol were detected in the leaves of homozygous T_(1) plants at two weeks after topping.This study describes an advance in PE systems and expands genome-editing toolbox in tobacco,even in dicots,for use in basic research and molecular breeding.And restoring biosynthesis of Z-abienol in tobacco might provide an efficient way to obtain Z-abienol in plants. | Jianduo Zhang Lu Zhang Chengwei Zhang Yongxing Yang Huayin Liu Lu Li Shengxue Zhang Xianggan Li Xinxiang Liu Ya Liu Jin Wang Guangyu Yang Qingyou Xia Weiguang Wang Jinxiao Yang | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 13 | Comparison of transperitoneal and retroperitoneal laparoscopic nephrectomy for renal cell carcinoma: a systematic review and meta‐analysis显示文摘 | Xinxiang Fan Kewei Xu Tianxin Lin Hao Liu Zi Yin Wen Dong Hai Huang Jian Huang | 2012 | BJU Int2012，，4： | 1 |
| 14 | Synergetic effect of Pd and Ag dispersed on Al2 O3 in the selective hydrogenation of acet- ylene显示文摘 | Zhang Qianwen Li Jia Liu Xinxiang | 2000 | Applied Catalysis A2000，197，2： | 1 |
| 15 | Thermodynamic parameters of interaction of HC1 with alcohols in water Ⅲ.HCl-ethanol-water system at 278.15-318.15 K显示文摘Pt,H2(g,p0)HCl(mE)|AgCl-AgPt, H2(g, p0)|HCl(mE), EtOH(mN)|AgCl-Ag have been measured at 10 degree intervals from 278.15 to 318.15 K, where EtOH refers to ethanol, mE=0.005-0.1 mol.kg-1, mN=0.4-1.0 mol.kg-1. The salting constant kS of EtOH by HCl and the thermodynamic parameters of interaction, fEN(gEN> hEN, sEN] cP,EN)> of EtOH with HCI in water have been evaluated. It has been shown that kS>0, gEN>0,hEN>0, SEN>0 ,and cp,EN<0.The signs of these parameters and the temperature dependence of them have been discussed on the basis of structural interaction and the group additivity models. | ZHUO, Ke-Lei WANG, Jian-Ji LIU, Wen-Bin LU, Jin-SuoDepartment of Chemistry, Henan Normal University, Xinxiang, Henan 453002, China | 1996 | Chinese Journal of Chemistry1996，14，3： | 1 |
| 16 | Use of the dnaj gene for the detection and identification of all Legiormlla pneumophila serogroups and description of the primers used to detect 16SrDNA gene sequences of major members of the genus Legiormlla显示文摘 | Hongsheng Liu Ying Li Xinxiang Huang | 2003 | Microbiol Immuno12003，47，11： | 1 |
| 17 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 18 | Gemcitabine Compared With Gemcitabine and S-1 Combination Therapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis显示文摘 | Doudou Li Changhao Chen Yu Zhou Rufu Chen Xinxiang Fan Zhuofei Bi Zhihua Li Yimin Liu | 2015 | Medicine2015，，35： | 1 |
| 19 | Synergetic effect of Pd and Ag dispersed on Al2O3 in the seletive hydrogenation of acetylene显示文摘 | Zhang Qianwen Li Jia Liu Xinxiang | 2000 | Applied Catalysis A:General2000，197，： | 1 |
| 20 | Synergetic effect of Pd and Ag dispersed on A12 03 in the selective hydrogenation of acetylene 显示文摘 | ZHANG Qianwen LI Jia LIU Xinxiang | 2000 | Applied Catalysis A : General2000，，197： | 1 |
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