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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | American Gastroenterological Association Institute Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation During Immunosuppressive Drug Therapy显示文摘 | K. Rajender Reddy Kimberly L. Beavers Sarah P. Hammond Joseph K. Lim Yngve T. Falck-Ytter | 2015 | Gastroenterology2015，，1： | 3 |
| 3 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 3 |
| 4 | Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions显示文摘 | Sang Hoon Ahn Henry L. Y. Chan Pei-Jer Chen Jun Cheng Mahesh K. Goenka Jinlin Hou Seng Gee Lim Masao Omata Teerha Piratvisuth Qing Xie Hyung Joon Yim Man-Fung Yuen | 2010 | Hepatology International2010，，1： | 3 |
| 5 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 2 |
| 6 | Randomized Controlled Trial of Danoprevir Plus Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients with HCV Genotype 1 Infection显示文摘 | P. Marcellin C. Cooper L. Balart D. Larrey T. Box E. Yoshida E. Lawitz P. Buggisch P. Ferenci M. Weltman E. Labriola-Tompkins S. Le Pogam I. Nájera D. Thomas G. Hooper N.S. Shulman Y. Zhang M.T. Navarro C.Y. Lim M. Brunda N.A. Terrault E.S. Yetzer | 2013 | Gastroenterology2013，，： | 2 |
| 7 | Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy显示文摘 | Virginia Hernández-Gea Moira Hilscher Raphael Rozenfeld Maribel P. Lim Natalia Nieto Sabine Werner Lakshmi A. Devi Scott L. Friedman | 2013 | Journal of Hepatology2013，，1： | 2 |
| 8 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 9 | Successful withdrawal of antiviral treatment in kidney transplant recipients with chronic hepatitis B viral infection显示文摘 | J.‐H. Cho J.‐H. Lim G.‐Y. Park J.‐S. Kim Y.‐J. Kang O. Kwon J.‐Y. Choi S.‐H. Park Y.‐L. Kim H.‐K. Kim S. Huh C.‐D. Kim | 2014 | Transpl Infect Dis2014，，2： | 2 |
| 10 | 糖筛查试验异常但口服葡萄糖耐量试验正常患者的特点:与正常及妊娠期糖尿病患者的比较显示文摘Objective: The purpose of this study was to evaluate the characteristics and outcomes of patients who had abnormal glucose challenge test results and subsequent normal oral glucose tolerance test results and to assess whether such patients are at agreater risk than normal pregnant patients for adverse perinatal outcome. Study design: In this retrospective cohort study that was conducted between June and December 2003, 101 pregnant women (group A) had an abnormal glucose challenge test result and a normal oral glucose tolerance test result. Data were also collected on 2 control groups: 100 pregnant women with normal glucose challenge test results (group B) and all 76 pregnant women who were diagnosed with gestational diabetes mellitus during this period of time (group C). Patients with multiple pregnancies, chronic hypertension, pregestational diabetes mellitus, or any other maternal or fetal problems that were diagnosed before 24 weeks (when the glucose challenge test was performed) were excluded from the study groups. The following data were collected and analyzed: maternal age, maternal weight and height, parity and gravidity, diabetes mellitus in first-degree relatives, medical and obstetric history, ethnicity,complications during the third trimester of pregnancy, birth- weight, gestational age at delivery, mode of delivery, Apgar scores, cord blood gas results, maternal complications of labor and during the postpartum period, and infant admission to then eonatal intensive care unit. For comparison between groups,we used the Student t test, 1-way analysis of variance, the chis-quaretest, and stepwise logistic regression. Results: Patients in groups A and C were significantly older compared with group B (29.2 ± 5.6 years and 30.4 ± 5.5 years, respectively, vs 24.8± 5.5 years; P < .01), had a lesser rate of primiparity (48% and 31% , respectively, vs 24% ; P < .05), had greater body mass index (30.8 ± 5 kg/m2 and 31.3 ± 6 kg/m2, respectively,vs 29.2 ± 4.4 kg/m2; P < .01), had a greater rate of previous gestational diabetes mellitus (6% and 20% , respectively, vs 0% ; P < .05), and had a greater rate of first-degree family members with diabetes mellitus (21% and 21% , respectively,vs 3% ; P < .01). None of the outcome parameters was statistically significant when group A was compared with group B. Conclusion: Patients with an abnormal glucose challenge test result and a subsequent normal oral glucose tolerance test result have different maternal characteristics and backgrounds compared with patients in whom both test results are normal,yet both groups have normal outcomes. We should continue to consider patients who have an abnormal glucose challenge test result and subsequent normal oral glucose tolerance test result as low-risk; however, these findings may represent an indication of an increased likelihood for the development of overt diabetes mellitus later in life. | Dudhbhai M. Lim L. Bombard A. Z.Weiner 李奎 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，9： | 1 |
| 11 | Longitudinal Studies of a B Cell–Derived Signature of Tolerance in Renal Transplant Recipients显示文摘 | K. A. Newell A. Asare I. Sanz C. Wei A. Rosenberg Z. Gao S. Kanaparthi S. Asare N. Lim M. Stahly M. Howell S. Knechtle A. Kirk W. H. Marks T. Kawai T. Spitzer N. Tolkoff‐Rubin M. Sykes D. H. Sachs A. B. Cosimi W. J. Burlingham D. Phippard L. A. Turka | 2015 | American Journal of Transplantation2015，，11： | 1 |
| 12 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 1 |
| 13 | The Acute Hemodynamic Effects of MitraClip Therapy显示文摘 | Robert J. Siegel Simon Biner Asim M. Rafique Michael Rinaldi Scott Lim Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow Howard C. Herrmann Elyse Foster Ted Feldman Donald Glower Saibal Kar | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 14 | Surgical Outcome of Bone Anchored Hearing Aid (Baha) Implant Surgery: A 10 Years Experience显示文摘 | A. Asma M. A. Ubaidah Siti Salbiah Hasan W. H. Wan Fazlina B. Y. Lim L. Saim B. S. Goh | 2013 | Indian Journal of Otolaryngology and Head & Neck Surgery2013，，3： | 1 |
| 15 | Molecular identification of Cryptosporidium parvum from avian hosts显示文摘 | J. X. QUAH S. AMBU Y. A. L. LIM M. A. K. MAHDY J. W. MAK | 2011 | Parasitology2011，，5： | 1 |
| 16 | Uveitis and Gender: The Course of Uveitis in Pregnancy显示文摘 | Nathalie P. Y. Chiam Lyndell L. P. Lim H. Nida Sen | 2014 | Journal of Ophthalmology2014，，： | 1 |
| 17 | Natural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review显示文摘 | Rachel L. McIntosh Sophie L. Rogers Lyndell Lim Ning Cheung Jie Jin Wang Paul Mitchell Jonathan W. Kowalski Hiep P. Nguyen Tien Yin Wong | 2010 | Ophthalmology2010，，6： | 1 |
| 18 | Natural History of Branch Retinal Vein Occlusion: An Evidence-Based Systematic Review显示文摘 | Sophie L. Rogers Rachel L. McIntosh Lyndell Lim Paul Mitchell Ning Cheung Jonathan W. Kowalski Hiep P. Nguyen Jie Jin Wang Tien Yin Wong | 2010 | Ophthalmology2010，，6： | 1 |
| 19 | The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection显示文摘 | Edward J. Gane Young-Suk Lim Stuart C. Gordon Kumar Visvanathan Eric Sicard Richard N. Fedorak Stuart Roberts Benedetta Massetto Zhishen Ye Stefan Pflanz Kimberly L. Garrison Anuj Gaggar G. Mani Subramanian John G. McHutchison Shyamasundaran Kottilil Brad | 2015 | Journal of Hepatology2015，，2： | 1 |
| 20 | Longitudinal Strain Delay Index by Speckle Tracking Imaging: A New Marker of Response to Cardiac Resynchronization Therapy显示文摘 | Pascal Lim Adisai Buakhamsri Zoran B. Popovic Neil L. Greenberg Dimpi Patel James D. Thomas Richard A. Grimm | 2008 | Circulation2008，，11： | 1 |
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