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| 1 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 2 | An anisotropic propagation technique for synthesizing hyperbranched polyvillic gold nanoparticles显示文摘近来,许多合成过程被学习了开发金 nanostructures 的不规则的 nano 形态学让生物医学的应用程序以便增加 nanoparticle theranostics 的功效,调节 plasmonic 吸收度系列,并且增加通过表面的 biomolecule 察觉的敏感提高的拉曼光谱学。这里,我们报导,一篇小说,非种子调停了能够与超过 50-90 分叉生产 hyperbranched 黄金 nano-polyvilli 的万用的单个壶合成方法在每结构以内从单个起源宣传的 nanowires。这种技术能够完成分叉能被改变孵化,温度,和氢离子集中的持续时间控制的分支繁殖的精确调节。 | Aaron S. Schwartz-Duval Santosh K. Misra Prabuddha Mukhejee Elyse Johnson Alvin S. Acerbo Dipanjan Pan | 2016 | Nano Research2016，9，10： | 2 |
| 3 | 制药企业药品上市前安全风险管理显示文摘1药物警戒的必要性良好的药物警戒是最理想的药品风险管理方式,它可以最大程度的了解某种药品的所有信息,并且发现它潜在的安全问题,甚至有可能发现其预料之外的好处。鉴于这个理念,新化学实体(newchemical entity)在研发初期就必须进行动物和人体安全性测试,以便更好地促进并保护公众健康。中国古话所说的"是药三分毒", | Judith K Jones Elyse E Kingery Jing Tao Jeff J Guo | 2013 | 药物流行病学杂志2013，22，5： | 2 |
| 4 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 5 | 起落架维修显示文摘起落架维修与其他定检一样,其维修间隔也在延长。一般来说,起落架每10年进行一次为期25~40天的翻修。而当这些起落架进行翻修时,航空公司需要给飞机安装上备用起落架进行商业运营。 | Elyse Moody 孙立 | 2011 | 航空维修与工程2011，，3： | 2 |
| 6 | Hepatitis E virus load in swine organs and tissues at slaughterhouse determined by real-time RT-PCR显示文摘 | Danielle Leblanc Elyse Poitras Marie-Josée Gagné Pierre Ward Alain Houde | 2010 | International Journal of Food Microbiology2010，，3： | 1 |
| 7 | Aripiprazole in the treatment of schizophrenia:safety and tolerability in short-term,placebo-controlled trials显示文摘 | Stephen RM Robert DM Elyse S | 2003 | Schizophrenia Research2003，，61： | 1 |
| 8 | Oxidative Stress, Nox Isoforms and Complications of Diabetes—Potential Targets for Novel Therapies显示文摘 | Mona Sedeek Augusto Montezano Richard Hebert Stephen Gray Elyse Marco Jay Jha Mark Cooper Karin Jandeleit-Dahm Ernesto Schiffrin Jennifer Wilkinson-Berka Rhian Touyz | 2012 | Journal of Cardiovascular Translational Research2012，，4： | 1 |
| 9 | 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults显示文摘 | Philip Greenland Joseph S. Alpert George A. Beller Emelia J. Benjamin Matthew J. Budoff Zahi A. Fayad Elyse Foster Mark A. Hlatky John McB. Hodgson Frederick G. Kushner Michael S. Lauer Leslee J. Shaw Sidney C. Smith Allen J. Taylor William S. Weintraub N | 2010 | Journal of the American College of Cardiology2010，，25： | 1 |
| 10 | Affective, normative, and continuance commitment levels across cultures: A meta-analysis显示文摘 | John P. Meyer David J. Stanley Timothy A. Jackson Kate J. McInnis Elyse R. Maltin Leah Sheppard | 2011 | Journal of Vocational Behavior2011，，2： | 1 |
| 11 | The Acute Hemodynamic Effects of MitraClip Therapy显示文摘 | Robert J. Siegel Simon Biner Asim M. Rafique Michael Rinaldi Scott Lim Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow Howard C. Herrmann Elyse Foster Ted Feldman Donald Glower Saibal Kar | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 12 | A relaxation response training for women undergoing breast biopsy: Explo- ring integrated care显示文摘 | Elyse R Park Lara Traeger Jessica Willett | 2013 | The Breast2013，22，5： | 1 |
| 13 | 客舱内饰翻新的发展趋势显示文摘公务机运营商和民用航空公司都需要经过优化的客舱内饰改装包,其中包括使机载娱乐系统具有更好的连通性和更具时尚的内饰等。二者的差别是公务航空不会因为飞机减重而牺牲其舒适性。 | Elyse Moody 孙立 | 2009 | 航空维修与工程2009，，1： | 1 |
| 14 | Pulmonary insufficiency is the nexus of late complications in tetralogy of Fallot显示文摘 | David Gregg Elyse Foster | 2007 | Current Cardiology Reports2007，，4： | 1 |
| 15 | Aripiprazole in the treatment of schizophrenia:safety and tolerability in short-term,placebo-controlled trials显示文摘 | Stepshen RM Robert DM Elyse S | 2003 | Schizophrenia Research2003，61，2： | 1 |
| 16 | Use of sandwich IgG ELISA for the detection and quantification ofadulteration of milk and soft cheese 显示文摘 | Ian P Hurley Robert C Coleman H Elyse Ireland | 2006 | International Dairy Journal2006，16，： | 1 |
| 17 | Novel mutations associated with combined pituitary hormone deficiency显示文摘 | Christopher JR Elyse Pine-Twaddell Sally R | 2011 | J Mol Endocrinol2011，46，3： | 1 |
| 18 | Endovascular Edge-to-Edge Mitral Valve Repair: Short-Term Results in a Porcine Model显示文摘 | Frederick G. St. Goar James I. Fann Jan Komtebedde Elyse Foster Mehmet C. Oz Thomas J. Fogarty Ted Feldman Peter C. Block | 2003 | Circulation: Journal of the American Heart Association2003，，16： | 1 |
| 19 | Acute Neurocardiogenic Injury After Subarachnoid Hemorrhage显示文摘 | Nader M. Banki Alexander Kopelnik Michael W. Dae Jacob Miss Poyee Tung Michael T. Lawton Barbara J. Drew Elyse Foster Wade Smith William W. Parmley Jonathan G. Zaroff | 2005 | Circulation2005，，21： | 1 |
| 20 | Acylphloroglucinol and xanthones from Hypericum ellipticum 显示文摘 | Kylie Manning Elyse Petrunak Michelle Lebo | 2011 | Phytochemistry2011，，： | 1 |
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