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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies显示文摘AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats. METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities. CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury. | Mohammed Ibrahim Mohammed Nane Khaja Anjum Aara Aleem Ahmed Khan Mohammed Aejaz Habeeb Yalavarthy Prameela Devi Mangamoori Lakshmi Narasu Chitoor Mohammed Habibullah | 2008 | World Journal of Gastroenterology2008，14，16： | 24 |
| 3 | Current and emerging therapies in unresectable and recurrent gastric cancer显示文摘Gastric cancer is one of the most lethal cancers worldwide despite many advances and options in therapy. As it is often diagnosed at an advanced stage, prognosis is poor with a median overall survival of less than twelve months. Chemotherapy remains the mainstay of treatment for these patients but it confersonly a moderate survival advantage. There remains a need for new targeted treatment options and a way to better define patient populations who will benefit from these agents. In the past few years, there has been a better understanding of the biology, molecular profiling, and heterogeneity of gastric cancer. Our increased knowledge has led to the identification of gastric cancer subtypes and to the development of new targeted therapeutic agents. There are now two new targeted agents, trastuzumab and ramucirumab, that have recently been approved for the treatment of advanced and metastatic gastric cancer. There are also many other actively investigated targets, including epidermal growth factor receptor, the phosphatadylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, c-Met, poly ADP-ribose polymerase, and immune checkpoint inhibition. In this review, we discuss the current management of advanced gastric cancer as well as emerging targeted therapies and immunotherapy. | Erin Jou Lakshmi Rajdev | 2016 | World Journal of Gastroenterology2016，22，20： | 20 |
| 4 | Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity显示文摘Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC. | Michael Hollis Kavitha Nair Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 5 | 基于直流互联的交流电网频率稳定控制研究显示文摘直流互联交流电网已经成为解决大电网互联问题的一种有效手段。互联交流电网的直流联络线可以实现区域备用互补,提高电网运行经济效益,并改善电网受到扰动后的频率波动情况。该文基于直流联络线控制提出一种用于互联交流电网频率支援及恢复策略。该策略可以实现事故时的紧急功率控制,减小交流电网事故后的频率急剧下降和波动。同时,在事故后参与到电网恢复过程,起到保障电网在安全频率范围内运行和加速电网频率恢复的作用。最后,通过仿真软件PSCAD/EMTDC进行仿真验证,结果表明所提策略充分利用了直流调频能力,提高了互联电网的经济性和稳定性。 | 孙凯祺 李可军 Sundaresh Lakshmi 刘奕路 潘久平 孙华东 | 2020 | 中国电机工程学报2020，40，3： | 15 |
| 6 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 7 | Emerging links between type 2 diabetes and Alzheimer's disease显示文摘Type 2 diabetes mellitus and Alzheimer's disease are both associated with increasing age,and each increases the risk of development of the other.Epidemiological,clinical,biochemical and imaging studies have shown that elevated glucose levels and diabetes are associated with cognitive dysfunction,the most prevalent cause of which is Alzheimer's disease.Cross sectional studies have clearly shown such an association,whereas longitudinal studies are equivocal,reflecting the many complex ways in which the two interact.Despite the dichotomy,common risk and etiological factors(obesity,dyslipidemia,insulin resistance,and sedentary habits) are recognized;correction of these by lifestyle changes and pharmacological agents can be expected to prevent or retard the progression of both diseases.Common pathogenic factors in both conditions span a broad sweep including chronic hyperglycemia per se,hyperinsulinemia,insulin resistance,acute hypoglycemic episodes,especially in the elderly,microvascular disease,fibrillar deposits(in brain in Alzheimer's disease and in pancreas in type 2 diabetes),altered insulin processing,inflammation,obesity,dyslipidemia,altered levels of insulin like growth factor and occurrence of variant forms of the protein butyrylcholinesterase.Of interest not only do lifestyle measures have a protective effect against the development of cognitive impairment due to Alzheimer's disease,but so do some of the pharmacological agents used in the treatment of diabetes such as insulin(especially when delivered intranasally),metformin,peroxisome proliferator-activated receptors γ agonists,glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors.Diabetes must be recognized as a risk for development of Alzheimer's disease;clinicians must ensure preventive care be given to control and postpone both conditions,and to identify cognitive impairment early to manage it appropriately. | Gumpeny R Sridhar Gumpeny Lakshmi Gumpeny Nagamani | 2015 | World Journal of Diabetes2015，6，5： | 10 |
| 8 | Assessment of heavy metal pollution from the sediment of Tupilipalem Coast,southeast coast of India显示文摘Sediment from twelve stations was sampled from the Tupilipalem Coast, southeast coast of India, and the presence of a set of heavy metals was established including iron(Fe), manganese(Mn), chromium(Cr),copper(Cu), nickel(Ni), lead(Pb), zinc(Zn) and cadmium(Cd). The heavy metals were assessed by factor analysis, the results of which showed positive and/or negative correlations among Fe, Mn, Cr, Cu, Ni, Pb,Zn, and Cd. Factor analysis also indicated that heavy metals in the sediments of the study area have different natural and anthropogenic sources. Similarly, a sediment pollution assessment was done using the Geoaccumulation Index(Igeo), Enrichment Factor(EF), and Pollution Load Index(PLI). The Geoaccumulation Index indicated that the surface sediment of the Tupilipalem Coast was extremely contaminated with Fe, Mn, Cr, Cu, Ni, Pb, and Zn. The calculation of enrichment factors showed a significant enrichment with respect to Pb, Zn, and Cd and a moderate enrichment with Cr, Cu, and Ni. The falling trend of average contents' enrichment factors is Cd > Pb > Zn > Cu > Cr > Ni > Mn > Fe. The PLI values of the Cd show higher(> 1) values due to the influence of distinct external sources like agricultural runoff, industrial activities, and other anthropogenic inputs. Ninety two percent of heavy metals under study showed the highest concentrations at station TP-5 where the Buckingham Canal and other agricultural and aquacultural effluents connect with the Bay of Bengal. This location is the second inlet which is periodically closed and it seemed that these parts of the study area are heavily affected by anthropogenic pollution. | Sreenivasulu Ganugapenta Jayaraju Nadimikeri Sundara Raja Reddy Balam Chinnapolla Lakshmanna Ballari Rajasekhar Madiga Nirmala K Lakshmi Prasad Tella | 2018 | International Journal of Sediment Research2018，33，3： | 8 |
| 9 | Helicobacter pylori eradication in patients with chronic immune thrombocytopenic purpura显示文摘AIM:To assess the effect of Helicobacter pylori(H.pylori)eradication on platelet counts in patients with chronic immune thrombocytopenic purpura(cITP).METHODS:A total of 36 cITP patients were included in the study.The diagnosis of H.pylori was done by rapid urease test and Giemsa staining of the gastric biopsy specimen.All H.pylori positive patients received standard triple therapy for 14 d and were subjected for repeat endoscopy at 6 wk.Patients who continued to be positive for H.pylori on second endoscopyreceived second line salvage therapy.All the patients were assessed for platelet response at 6 wk,3rd and 6th months.RESULTS:Of the 36 patients,17 were positive for H.pylori infection and eradication was achieved in16 patients.The mean baseline platelet count in the eradicated patients was 88615.38±30117.93/mm3and platelet count after eradication at 6 wk,3 mo and6 mo was 143230.77±52437.51/mm3(P=0.003),152562.50±52892.3/mm3(P=0.0001),150187.50±41796.68/mm3(P=0.0001)respectively and in the negative patients,the mean baseline count was71000.00±33216.46/mm3 and at 6 wk,3rd and 6th month follow up was 137631.58±74364.13/mm3(P=0.001),125578.95±71472.1/mm3(P=0.005),77210.53±56892.28/mm3(P=0.684)respectively.CONCLUSION:Eradication of H.pylori leads to increase in platelet counts in patients with cITP and can be recommended as a complementary treatment with conventional therapy. | Ravinder Naik Noonavath Chandrasekharan Padma Lakshmi Tarun Kumar Dutta Vikram Kate | 2014 | World Journal of Gastroenterology2014，20，22： | 6 |
| 10 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 11 | 妊娠性高血压视网膜变化的临床研究(英文)显示文摘目的:研究妊娠性高血压(PIH)患者视网膜变化的患病率,视网膜变化与疾病严重程度的相关性。方法:横断面研究。共收集2014-12/2015-05妊娠性高血压患者100例。所有患者均行眼底检查。单眼或双眼眼底发生变化视为阳性。妊娠性高血压分级为轻度子痫前期(血压>140/90~160/90 mmHg),重度子痫前期(血压>160/90 mmHg)和子痫前期(重度子痫前期和抽搐)。结果:患者平均年龄为23.05(19~34)岁。妊娠期为28~41wk。其中62例初产妇以及38例经产妇。轻度子痫前期,重度子痫前期和子痫前期患者占比分别为62%,26%,12%。8例患者发生视网膜变化。观察得出:高血压性视网膜病变Ⅰ级(1%),Ⅱ级(0%),Ⅲ级(2%),Ⅳ级(2%),浆液性视网膜脱离(1%)和中心性浆液性脉络膜视网膜病变(2%)。视网膜变化与PIH严重程度呈正相关,有统计学意义(P=0.0001)。结论:8%的PIH患者视网膜发生变化,视网膜变化与PIH严重程度呈正相关。 | sahana raviraj manipur pavana acharya kavitha chikkanayakanahalli venugopal lakshmi bomalapura ramamurthy | 2017 | 国际眼科杂志2017，17，6： | 4 |
| 12 | Er^(3+)/Yb^(3+)/Li^+/Zn^(2+):Gd_2(MoO_4)_3 upconverting nanophosphors in optical thermometry显示文摘Er^(3+)-Yb^(3+)-Li^+:Gd_2(MoO_4)_3 and Er^(3+)-Yb^(3+)-Zn^(2+):Gd_2(MoO_4)_3 nanophosphors, synthesized by chemical co-precipitation technique were characterized through XRD,FESEM,dynamic light scattering(DLS),diffuse reflectance, photoluminescence, photometric and decay time analysis. The enhancement of about~28, ~149 and ~351 times in the green upconversion emission band is observed for the optimized Er^(3+)-Yb^(3+),Er^(3+)-Yb^(3+)-Li^+ and Er^(3+)-Yb^(3+)-Zn^(2+):Gd_2(MoO_4)_3 nanophosphors in comparison to the singly Er^(3+) doped nanophosphors. The electric dipole-dipole interaction is found to be responsible for the concentration quenching. The temperature dependent behaviour of the two green thermally coupled levels of the Er^(3+) ions based on the fluorescence intensity ratio technique was studied. The maximum sensor sensitivity ~38.7 × 10^(-3) K^(-1) at 473 K for optimized Er^(3+)-Yb^(3+)-Zn^(2+) codoped Gd_2(MoO_4)_3 nanophosphors is reported with maximum population redistribution ability~88% among the ~2H_(11/2) and ~4S_(3/2) levels. | Anita Kumari Lakshmi Mukhopadhyay Vineet Kumar Rai | 2019 | Journal of Rare Earths2019，37，3： | 4 |
| 13 | Design,synthesis and in vitro antibacterial activities of methyl-4-((substituted phenyl)[6H-indolo(2,3-b)quinoxalin-6-yl]methyl-amino)benzoate derivatives显示文摘一系列新 methyl-4-(( 代替的苯基)[6H-indolo (2,3-b ) quinoxalin-6yl ] methylamino ) 安息香酸盐衍生物被综合了并且为他们 9 个不同细菌的种类上的抗菌剂活动的 assayed。在屏蔽混合物之中, 2e2g 展出了与标准药相比的禁止的活动采用了的有势力,值得进一步的调查。 | Yellajyosula Lakshmi Narasimha Murthy Nagalakshmi Karthikeyan Govindh Boddeti Bhagavathula S.Diwakar E.Rajendra Singh | 2011 | Chinese Chemical Letters2011，22，5： | 4 |
| 14 | Comparative evaluation of roundabout capacities under heterogeneous traffic conditions显示文摘In heterogeneous traffic conditions, roundabout capacity is described by vehicle and driver characteristics which are different from traffic conditions in homogeneous conditions. In the present study, the capacity of the roundabout is determined using various capacity formulas such as gap acceptance models given by Highway Capacity Manual 2010(US), German model(2001); empirical regression models given by TRRL(UK) and weaving models given by IRC: 65–1976(India). In addition,microscopic simulation model like VISSIM(PTV Germany) is also used to derive capacity values. Unlike the other capacity estimation models, VISSIM is helpful in estimating capacity values using geometric and driver characteristics and it can also simulate heterogeneous traffic condition accurately. Capacity is estimated after calibrating the simulation model(VISSIM) developed for the roundabout. This is achieved by incorporating different vehicle classes to represent the heterogeneous traffic environment, driver gap acceptance, and lane changeparameters. All the required inputs were extracted from the video using semi-automatic data collection methods. Data are used for the estimation of capacity values from different methods mentioned above and for the calibration and validation of simulation model. The capacity values estimated form various formulas except German model are distinctly different from the field values and they are either overestimating or underestimating. Analysis of these observations reveals that the capacity values from VISSIM and German models are nearly matching with the field capacity. | Ramu Arroju Hari Krishna Gaddam Lakshmi Devi Vanumu K.Ramachandra Rao | 2015 | Journal of Modern Transportation2015，23，4： | 4 |
| 15 | In Silico Characterization and Homology Modeling of Thylakoidbound Ascorbate Peroxidase from a Drought Tolerant Wheat Cultivar显示文摘Ascorbate peroxidase,a haem protein (EC 1.11.1.11),efficiently scavenges hydrogen peroxide (H2O2) in cytosol and chloroplasts of plants.In this study,a fulllength coding sequence of thylakoid-bound ascorbate peroxidase cDNA (TatAPX) was cloned from a drought tolerant wheat cultivar C306.Homology modeling of the TatAPX protein was performed by using the template crystal structure of chloroplastic ascorbate peroxidase from tobacco plant (PDB: 1IYN).The model structure was further refined by molecular mechanics and dynamic methods using various tools such as PROCHECK,ProSA and Verify3D.The predicted model was then tested for docking with H2O2,the substrate for TatAPX enzyme.The results revealed that Arg233 and Glu255 in the predicted active site of the enzyme are two important amino acid residues responsible for strong hydrogen bonding affinity with H2O2,which might play an important role in scavenging of H2O2 from the plant system. | A. Katiyar S.K. Lenka K. Lakshmi V. Chinnusamy K.C. Bansal | 2009 | Genomics, Proteomics & Bioinformatics2009，7，4： | 3 |
| 16 | Molecular alterations in colitis-associated colorectal neoplasia: Study from a low prevalence area using magnifying chromo colonoscopy显示文摘 | Bhadravathi Marigowda Shivakumar Balasubramanian Lakshman Kumar Ganesh Bhat Deepak Suvarna Lakshmi Rao C. Ganesh Pai Kapaettu Satyamoorthy | 2011 | Journal of Crohn’s and Colitis2011，，6： | 3 |
| 17 | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies显示文摘膝关节骨性关节炎(OA)是世界上最常见的关节炎,其发病率逐年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA的方法虽取得了一定疗效,但仍没有一种方法可达到全膝关节置换术(TKA)的治疗效果。TKA主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生技术,以推迟甚至消除患者对TKA的需求。一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展。单独或联合应用先进的生物材料和干细胞治疗膝关节OA可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA疼痛和软骨损害的发病机制,并探讨了该病的最新治疗策略及其局限性。 | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin | 2017 | Engineering2017，3，1： | 3 |
| 18 | Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides显示文摘Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 and cathelicidin B1, have been identified in chickens. As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. Additionally, a tissue-specific regulatory pattern was evident for all four cathelicidins during the first 28 days after hatching. The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. | Mallika Achanta Lakshmi T Sunkara Gan Dai Yugendar R Bommineni Weiyu Jiang Guolong Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 19 | 非负载和氧化铝负载的纳米CeO_2-ZrO_2和CeO_2-Te_2O_3固溶体催化CO氧化(英文)显示文摘Ceria-zirconia(CZ)and ceria-terbia(CT)and alumina-supported ceria-zirconia(CZA)and ceria-terbia(CTA)solid solutions were synthesized by coprecipitation and deposition precipitation methods,respectively.Structural characteristics and catalytic activity of the synthesized samples have been investigated using X-ray diffraction(XRD),high resolution transmission electron microscopy(HRTEM),X-ray photoelectron spectroscopy(XPS),Raman spectroscopy(RS),and Brunauer-Emmett-Teller(BET)surface area measurements.To evaluate the catalytic properties,total oxygen storage capacity and CO oxidation activity measurements were carried out.The XRD analyses revealed the formation of Ce0.75Zr0.25O2 phase for CZ and Ce0.5Zr0.5O2 and Ce0.6Zr0.4O2 phases for CZA samples,respectively.While the formation of only Ce0.8Tb0.2O2-δphase was noted for both CT and CTA samples.All the supported and unsupported samples adopted a fluorite-type structure and exhibited cell parameters with respect to Vegard's rule.The HRTEM results indicated well-dispersed particles of the size around 5 nm.The RS measurements suggested the presence of oxygen vacancies due to defective structure formation.The XPS studies revealed the presence of cerium in both Ce 4+ and Ce 3+ oxidation states in different proportions.It was found that CO oxidation for CTA occurs at very much lower temperature than CT,CZ,and CZA samples.Details of these findings by correlating with the structural characterization studies are consolidated. | M.Reddy BENJARAM Thrimurthulu GODE Lakshmi KATTA | 2011 | 催化学报2011，32，5： | 3 |
| 20 | Role of post-translational modification of the Y box binding protein 1 in human cancers显示文摘Y box binding protein-1(YBX1)belongs to a DNA-and RNA-binding family of transcription factors,containing the highly conserved cold shock domain(CSD).YBX1 is involved in a number of cellular functions including transcription,translation,DNA damage repair etc.,and it is upregulated during times of environmental stress.YBX1 is localized in both the cytoplasm and the nucleus.There,its nuclear translocation is observed in a number of cancers and is associated with poor prognosis and disease progression.Additionally,YBX1 expression is upregulated in a variety of cancers,pointing towards its role as a potential oncogene.Under certain circumstances,YBX1 also promotes the expression of multidrug resistance 1(MDR1)gene,which is involved in the development of drug resistance.Thus,it is critical to understand the mechanism of YBX1 regulation and its downstream effects on promoting cancer development.A number of recent studies have highlighted the mechanisms of YBX1 regulation.Mass spectrometric analyses have reported several post-translational modifications that possibly play an important role in modulating YBX1 function.Phosphorylation is the most widely occurring post-translational modification in YBX1.In vivo analyses of sites like S102 and more recently,S165 illustrate the relationship of post-translational regulation of YBX1 in promoting cell proliferation and tumor growth.This review provides a comprehensive and up-to-date account of post-translational modifications identified in YBX1.This knowledge is a key in allowing us to better understand the mechanism of YBX1 regulation,which will aid in development of novel therapeutic strategies to target YBX1 in many types of cancer in the future. | Lakshmi Prabhu Antja-Voy Hartley Matthew Martin Fadumo Warsame Emily Sun Tao Lu | 2015 | Genes & Diseases2015，2，3： | 3 |
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