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4篇 您的检索式：作者名="Andrea Califano"

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		题名	作者	年代	出处	被引量
	1	肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.	Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone	2010	中华神经外科疾病研究杂志2010，9，1：	16
	2	Cross-species analysis of genome-wide regulatory networks identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy显示文摘	Alvaro Aytes Antonina Mitrofanova Celine Lefebvre Mariano J. Alvarez Mireia Castillo-Martin Tian Zheng James A. Eastham Anuradha Gopalan Kenneth J. Pienta Michael M. Shen Andrea Califano Cory Abate-Shen	2014	Cancer Cell2014，，：	1
	3	Laparo-endoscopic single site cholecystectomy versus standard laparoscopic cholecystectomy: results of a pilot randomized trial显示文摘	Marco Maria Lirici Andrea Domenico Califano Pierluigi Angelini Francesco Corcione	2011	The American Journal of Surgery2011，，1：	1
	4	B-Raf Activation Cooperates with PTEN Loss to Drive c-Myc Expression in Advanced Prostate Cancer显示文摘	Jingqiang Wang Takashi Kobayashi Nicolas Floc’h Carolyn Waugh Kinkade Alvaro Aytes David Dankort Celine Lefebvre Antonina Mitrofanova Robert D. Cardiff Martin McMahon Andrea Califano Michael M. Shen Cory Abate-Shen	2012	Cancer Research2012，，18：	1

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