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| 1 | Ent-11α-Hydroxy-15-oxo-kaur-16-en-19-oic-acid Inhibits Growth of Human Lung Cancer A549 Cells by Arresting Cell Cycle and Triggering Apoptosis显示文摘Objective: To examine the apoptotic effect of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), a compound isolated from Pteris semipinnata L (PsL), in human lung cancer A549 cells. Methods: A549 cells were treated with 5F (0-80 μg/ml) for different time periods. Cytotoxicity was examined using a MTT method. Cell cycle was examined using propidium iodide staining. Apoptosis was examined using Hoechst 33258 staining, enzyme-linked immunosorbent assay (ELISA) and caspase-3 activity analysis. Expression of representative apoptosis-related proteins was evaluated by Western blot analysis. Reactive oxygen species (ROS) level was measured using standard protocols. Potential interaction of 5F with cisplatin was also examined. Results: 5F inhibited the proliferation of A549 cells in a concentration-and time-dependent manner. 5F increased the accumulation of cells in sub-G1 phase and arrested the cells in the G2 phase. Exposure to 5F induced morphological changes and DNA fragmentation that are characteristic of apoptosis. The expression of p21 was increased. 5F exposure also increased Bax expression, release of cytochrome c and apoptosis inducing factor (AIF), and activation of caspase-3. 5F significantly sensitized the cells to cisplatin toxicity. Interestingly, treatment with 5F did not increase ROS, but reduced ROS production induced by cisplatin. Conclusion: 5F could inhibit the proliferation of A549 cells by arresting the cells in G2 phase and by inducing mitochondrial-mediated apoptosis. | Li Li George G Chen Ying-nian Lu Yi Liu Ke-feng Wu Xian-ling Gong Zhan-ping Gou Ming-yue Li Nian-ci Liang | 2012 | Chinese Journal of Cancer Research2012，24，2： | 10 |
| 2 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 3 | Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer显示文摘 | Zhang XM Miao XP Liang G Hao BT Wang YG Tan W Li Y Guo YL He FC Wei QY Lin DX | 2006 | 中国生物学文摘2006，20，4： | 2 |
| 4 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 5 | Introduction and constitutive expression of rice chitinase gene in bread wheat using biolistic bombardment and the bar gene as a selectable maker显示文摘 | Chen W P Gu X Liang G H Muthukrishnan S Chen P D Liu D J Giu B S | 1998 | Theor Appl Genet1998，97，12： | 2 |
| 6 | Displacement analysis of the general spatial 7-link 7R mechanism 显示文摘 | Lee H Y Liang C G | 1998 | Mechanism and Machine Theory1998，23，3： | 2 |
| 7 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 8 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 9 | Anomalous temperature dependence of photoluminescence in MBE-grown GaInNAs/GaAs QWs 显示文摘 | Liang X G Jiang D S Bian L F | 2002 | Chinese Physics Letter2002，19，： | 2 |
| 10 | Shape- memory effects of radiation crosslinked poly( ε - caprolactone) 显示文摘 | Zhu G Liang G Xu Q | 2003 | Journal of Applied Polymer Science2003，90，6： | 1 |
| 11 | Melatonin in Chinese medicinal herbs显示文摘 | Chen G Huo Y Tan D X Liang Z Zhang W Zhang Y | 2003 | Life Sci2003，73，1： | 1 |
| 12 | Cracks, bifurcation and shear bands propagation in saturated clays显示文摘 | Saada A S Bianchini G F Liang L Q | 1994 | Geotechnique1994，44，1： | 1 |
| 13 | Transfer of a plant chitinese gene into a nitragen-fixing Azospirillum and study of its expression显示文摘 | JAYARAMAN J MUTHUKRISHNAN S LIANG G H | | Can J Microbiol0，50，： | 1 |
| 14 | Unified mechanisms of Ca2 + regulation across the Ca2 + channel family显示文摘 | DEMARIA C D ERICKSON M G | 2003 | Neuron2003，39，6： | 1 |
| 15 | Development of 61-channel digital beam forming (DBF) transmitter array for mobile satellite communication显示文摘 | Liang G Gong W Yu J | | Progress in Electro-magnetics Research0，97，9： | 1 |
| 16 | Derivation and characterization of dispersion of defect modes in photonic band gap from stacks of positive and negative index materials显示文摘 | Chen Yihang Liang G Q Dong Jianwen | 2006 | Phys Lett A2006，351，6： | 1 |
| 17 | Assimilation of enterprise systems : The effect of institutional pressures and the mediating role of top management显示文摘 | Liang H G Saraf N Hu Q | 2007 | MIS Quarterly2007，31，1： | 1 |
| 18 | The putative tumor suppressor micro-RNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2显示文摘 | Friedman JM Liang G Liu CC | 2009 | Cancer Res2009，69，6： | 1 |
| 19 | Laparoscopic versus open colorectal resection for cancer:A meta-analysis of results of randomized controlled trials on recurrence显示文摘 | Liang Y Li G Chen P | 2008 | Eur J Surg Oncol2008，34，11： | 1 |
| 20 | Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c显示文摘 | Liang G Yang J Horton JD Hammer RE Goldstein JL Brown MS | 2002 | J Biol Chem2002，277，11： | 1 |
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