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| 1 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 2 | Changing trends of surgical treatment of hilar bile duct cancer:clinical and experimental perspectives显示文摘HISTORICAL POINT OF VIEWCarcinoma of the confluence of the hepatic ductshas been thought to be a rare disease until recently.Carcinoma of the large hepatic ducts was rarelydiagnosed correctly premorterned.Because of itsdeeply seated location,resection was once thoughtto be impossible.In 1957,Altemeier reported | Huang ZQ Zhou NX Wang DD Lu JG Chen MY | 2000 | World Journal of Gastroenterology2000，6，6： | 2 |
| 3 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 4 | 伴枕叶第4层细胞缺失的局灶性皮层发育不良Ⅲd型的临床病理变异:12例伴早期缺血缺氧损伤儿童患者的研究显示文摘背景局灶性皮层发育不良(Focal cortical dysplasia,FCD)名词首次由Taylor等于1971年报道使用,如今被广泛用于诊断各种大脑皮层和皮层下白质的癫痫脑组织病理,包括皮层构层异常、细胞形态异常、灰白质边界模糊和白质异常等。2011年国际抗癫痫联盟(ILAE)提出了一个新的FCD分类标准共识以区分临床病理学亚型,如'孤立'的FCDⅠa-c型和Ⅱa-b型,'混合的'FCDⅢa-d型。FCDⅠ型和Ⅲ型组织病理学分化的变异依然存在。 | 卢德宏 Wang DD Piao YS Blumcke I | 2017 | 癫痫杂志2017，3，6： | 2 |
| 5 | X-ray CT metal artifacts reduction using wavlets: An application for imaging total hip prostheses显示文摘 | Zhao SY Robertson DD Wang G | 2000 | IEEE Transactions on Medical Imaging2000，19，12： | 1 |
| 6 | In vivo degradation of three-dimensional silk fibroin scaffolds显示文摘 | Wang Y Rudym DD Walsh A | | 0，，24： | 1 |
| 7 | Detailed methylation pat-terns and protein expression profiles of MGMT in colorectal carci-noma surgical margins显示文摘 | Zhang DD Bai YF Wang Y | 2008 | Clin Biochem2008，41，12： | 1 |
| 8 | The pivotal role ofc-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells 显示文摘 | Li DD Wang LL Deng R | 2009 | Oncogene2009，28，6： | 1 |
| 9 | Immunobiology of hepatitis C virus (HCV) infection: the role of CD4 T cells in HCV infection显示文摘 | Eckels DD Wang H Bian TH | 2000 | Immunol Rev2000，174，1： | 1 |
| 10 | Mutations in immunodominant T cell epitopes derived from the non-structural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition显示文摘 | Wang H Eckels DD | 1999 | J Immunol1999，162，7： | 1 |
| 11 | Decreased expression of auto- phagy-related proteins in malignant epithelial ovarian cancer显示文摘 | Shen Y Li DD Wang LL | 2008 | Autophagy2008，4，8： | 1 |
| 12 | Fragmented QRS on surface electrocardiogram is not a reliable predictor of myocardial scar, angio- graphic coronary disease or long term adverse outcomes显示文摘 | Wang DD Tibrewala A Ngnygen P | 2014 | Cardiovasc Diagn Ther2014，4，4： | 1 |
| 13 | Warfarin resistance in Rattus losea in Guangdong province, China(In pressing) 显示文摘 | Wang JS Feng ZY Yao DD | 2008 | Pest Bioehem Physiol2008，91，2： | 1 |
| 14 | Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants显示文摘 | Yu H Wang DD Wang Y Liu T Lee FS Chen ZY | 2012 | J Neurosci2012，32，12： | 1 |
| 15 | Defining the role of GABA in cortical development显示文摘 | Wang DD Kriegstein AR | 2009 | J Physiol2009，587，9： | 1 |
| 16 | Transformation of polychlorinated biphenyls by persulfate at ambient temperature显示文摘 | Fang GD Dionysiou DD Zhou DM Wang Y Zhu XD Fan JX Cang L Wang YJ | 2013 | Chemosphere2013，90，： | 1 |
| 17 | KISS-1 represses 92-kDa type Ⅳ collagenase expression by down-regulating NF-κB binding to the promoter as a consequence of Iκ Bα-induced block of p65/p50 nuclear translocation 显示文摘 | Yan C Wang H Boyd DD | 2001 | J Biol Chem2001，276，2： | 1 |
| 18 | Immunobiology of hepatitis C virus (HCV) infection:the role of CD4+ T cells in HCV infection显示文摘 | Wang HR Bian TH | 2000 | Immunol Rev2000，174，： | 1 |
| 19 | KISS-1 represses 92-kDa type Ⅳ collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa-induced block of p65/pS0 nuclear translocation 显示文摘 | Yan C Wang H Boyd DD | 2001 | J Biol Chem2001，276，2： | 1 |
| 20 | A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo 显示文摘 | Meng H Swartz DD Wang Z | 2006 | Neurosurgery2006，59，： | 1 |
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