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| 1 | Modeling soil conservation, water conservation and their tradeoffs: A case study in Beijing显示文摘Natural ecosystems provide society with important goods and services. With the rapid increase in human populations and excessive utilization of natural resources, humans frequently enhance the production of some services at the expense of the others. Although the need for tradeoffs between conservation and development is urgent, the lack of efficient methods to assess such tradeoffs has impeded progress. Three land use strategy scenarios (development scenario, plan trend scenario and conservation scenario) were created to forecast potential changes in ecosystem services from 2007 to 2050 in Beijing, China. GIS-based techniques were used to map spatial and temporal distribution and changes in ecosystem services for each scenario. The provision of ecosystem services differed spatially, with significant changes being associated with different scenarios. Scenario analysis of water yield (as average annual yield) and soil retention (as retention rate per unit area) for the period 2007 to 2050 indicated that the highest values for these parameters were predicted for the forest habitat under all three scenarios. Annual yield/retention of forest, shrub, and grassland ranked the highest in the conservation scenario. Total water yield and soil retention increased in the conservation scenario and declined dramatically in the other two scenarios, especially the development scenario. The conservation scenario was the optimal land use strategy, resulting in the highest soil retention and water yield. Our study suggests that the evaluation and visualization of ecosystem services can effectively assist in understanding the tradeoffs between conservation and development. Results of this study have implications for planning and monitoring future management of natural capital and ecosystem services, which can be integrated into land use decision-making. | Yang Bai Zhiyun Ouyang Hua Zheng Xiaoma Li Changwei Zhuang Bo Jiang | 2012 | Journal of Environmental Sciences2012，24，3： | 21 |
| 2 | Cloning, expression, and protective immunity in mice of a gene encoding the diagnostic antigen P-29 of Echinococcus granulosus显示文摘Taeniid 绦虫包虫 granulosus 是包虫病的原因的代理人,有世界范围的分发的重要动物病。在这研究,诊断抗原 P-29 从 E 被克隆。granulosus 并且在 Escherichia 表示了 coli。顺序分析证明 EgP-29 包含 717-bp 开的读框架并且与 27.1 kDa 的预言的分子的重量编码 238 氨基酸残余的蛋白质。recombinant EgP-29 (rEgP-29 ) 能在西方的弄污与反老鼠 sera 被认出。特定的抗体被连接酶的 immunosorbent 试金检测。老鼠与 rEgP-29 种牛痘并且与 E intraperitoneally 质问了。granulosus protoscoleces 揭示了 96.6% 的重要保护的免疫(P < 0.05 ) ,与控制组相比。因此, rEgP-29 蛋白质是一个有希望的候选人让一支有效疫苗阻止第二等的包虫病。 | Zhiyun Shi Yana Wang Zongji Li Zhaoyu Li Yang Bo Rui Ma Wei Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 19 |
| 3 | Response of runoff and soil loss to reforestation and rainfall type in red soil region of southern China显示文摘To evaluate the long-term effects of reforestation types on soil erosion on degraded land, vegetation and soil properties under conventional sloping farmland (CSF) and three different reforestation types including a Pinus massoniana secondary forest (PSF), an Eucommia ulmoides artificial economic forest (EEF) and a natural succession type forest (NST), were investigated at runoff plot scale over a six-year period in a red soil region of southern China. One hundred and thirty erosive rainfall events generating runoff in plots were grouped into four rainfall types by means of K-mean clustering method. Erosive rainfall type I is the dominant rainfall type. The amount of runoff and the soil loss under erosive rainfall type III were the most, followed by rain-fall type II, IV and I. Compared with CSF treatment, reforestation treatments decreased the average annual runoff depth and the soil loss by 25.5%-61.8% and 93.9%- 96.2% during the study period respectively. Meanwhile, runoff depth at PSF and EEF treatments was significantly lower than that in NST treatment, but no significant difference existed in soil erosion modulus among the three reforestation treatments. This is mainly due to the improved vegetation properties (i.e., vegetation coverage, biomass of above- and below-ground and litter-fall mass) and soil properties (i.e., bulk density, total porosity, infiltration rate and organic carbon content) in the three reforestation treatments compared to CSF treatment. The PSF and EEF are recommended as the preferred reforestation types to control runoff and soil erosion in the red soil region of southern China, with the NST potentially being used as an important supplement. | Zhigang Huang Zhiyun Ouyang Fengrui Li Hua Zheng Xiaoke Wang | 2010 | Journal of Environmental Sciences2010，22，11： | 18 |
| 4 | Soil microbial community structure and function responses to successive planting of Eucalyptus显示文摘Many studies have shown soil degradation after the conversion of native forests to exotic Eucalyptus plantations. However, few studies have investigated the long-term impacts of short-rotation forestry practices on soil microorganisms. The impacts of Eucalyptus successive rotations on soil microbial communities were evaluated by comparing phospholipid fatty acid(PLFA) abundances,compositions, and enzyme activities of native Pinus massoniana plantations and adjacent 1st, 2nd, 3rd, 4th generation Eucalyptus plantations. The conversion from P. massoniana to Eucalyptus plantations significantly decreased soil microbial community size and enzyme activities, and increased microbial physiological stress. However, the PLFA abundances formed '∪' shaped quadratic functions with Eucalyptus plantation age. Alternatively, physiological stress biomarkers, the ratios of monounsaturated to saturated fatty acid and Gram+ to Gram- bacteria, formed '∩' shaped quadratic functions, and the ratio of cy17:0 to 16:1ω7c decreased with plantation age. The activities of phenol oxidase, peroxidase, and acid phosphatase increased with Eucalyptus plantation age, while the cellobiohydrolase activity formed '∪' shaped quadratic functions. Soil N:P, alkaline hydrolytic nitrogen, soil organic carbon, and understory cover largely explained the variation in PLFA profiles while soil N:P, alkaline hydrolytic nitrogen, and understory cover explained most of the variability in enzyme activity. In conclusion, soil microbial structure and function under Eucalyptus plantations were strongly impacted by plantation age. Most of the changes could be explained by altered soil resource availability and understory cover associated with successive planting of Eucalyptus. Our results highlight the importance of plantation age for assessing the impacts of plantation conversion as well as the importance of reducing disturbance for plantation management. | Falin Chen Hua Zheng Kai Zhang Zhiyun Ouyang Huailin Li Bing Wu Qian Shi | 2013 | Journal of Environmental Sciences2013，25，10： | 12 |
| 5 | Progress in high-speed train technology around the world显示文摘This is a review of high-speed train development in the sense of technology advances all over the world.Three generations of high-speed trains are classified according to their technical characteristics and maximum operating speed.Emphasis is given to the newly developed high-speed train in China,CRH380.The theoretical foundations and future development of CRH380 are briefly discussed. | Li ZHOU Zhiyun SHEN | 2011 | Journal of Modern Transportation2011，19，1： | 9 |
| 6 | Effects of spatial resolution of remotely sensed data on estimating urban impervious surfaces显示文摘Impervious surfaces are the result of urbanization that can be explicitly quantified,managed and controlled at each stage of land development.It is a very useful environmental indicator that can be used to measure the impacts of urbanization on surface runoff,water quality,air quality,biodiversity and microclimate.Therefore,accurate estimation of impervious surfaces is critical for urban environmental monitoring,land management,decision-making and urban planning.Many approaches have been developed to estimate surface imperviousness,using remotely sensed data with various spatial resolutions.However,few studies,have investigated the effects of spatial resolution on estimating surface imperviousness.We compare medium-resolution Landsat data with high-resolution SPOT images to quantify the imperviousness in Beijing,China.The results indicated that the overall 91% accuracy of estimates of imperviousness based on TM data was considerably higher than the 81% accuracy of the SPOT data.The higher resolution SPOT data did not always predict the imperviousness of the land better than the TM data.At the whole city level,the TM data better predicts the percentage cover of impervious surfaces.At the sub-city level,however,the ring belts from the central core to the urban-rural peripheral,the SPOT data may better predict the imperviousness.These results highlighted the need to combine multiple resolution data to quantify the percentage of imperviousness,as higher resolution data do not necessarily lead to more accurate estimates.The methodology and results in this study can be utilized to identify the most suitable remote sensing data to quickly and efficiently extract the pattern of the impervious land,which could provide the base for further study on many related urban environmental problems. | Weifeng Li Zhiyun Ouyang Weiqi Zhou Qiuwen Chen | 2011 | Journal of Environmental Sciences2011，23，8： | 8 |
| 7 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 8 | Spatial and seasonal variability of CO_2 flux at the air-water interface of the Three Gorges Reservoir显示文摘Difusive carbon dioxide(CO2) emissions from the water surface of the Three Gorges Reservoir, currently the largest hydroelectric reservoir in the world, were measured using floating static chambers over the course of a yearlong survey. The results showed that the average annual CO2 flux was(163.3 ± 117.4) mg CO2/(m2·hr) at the reservoir surface, which was larger than the CO2 flux in most boreal and temperate reservoirs but lower than that in tropical reservoirs. Significant spatial variations in CO2 flux were observed at four measured sites, with the largest flux measured at Wushan(221.9 mg CO2/(m2·hr)) and the smallest flux measured at Zigui(88.6 mg CO2/(m2·hr)); these diferences were probably related to the average water velocities at diferent sites. Seasonal variations in CO2 flux were also observed at four sites, starting to increase in January, continuously rising until peaking in the summer(June-August) and gradually decreasing thereafter. Seasonal variations in CO2 flux could reflect seasonal dynamics in pH, water velocity,and temperature. Since the spatial and temporal variations in CO2 flux were significant and dependent on multiple physical, chemical,and hydrological factors, it is suggested that long-term measurements should be made on a large spatial scale to assess the climatic influence of hydropower in China, as well as the rest of the world. | Le Yang Fei Lu Xiaoke Wang Xiaonan Duan Lei Tong Zhiyun Ouyang Hepeng Li | 2013 | Journal of Environmental Sciences2013，25，11： | 7 |
| 9 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 10 | Molecular distribution and seasonal variation of hydrocarbons in PM_(2.5) from Beijing during 2006显示文摘正常(n) 链烷和多不的芳香的烃(哼) 在 2006 从北京在 PM2.5 被收集并且分析了使用一种热 desorption-GC/MS 技术。n 链烷的年度平均集中并且哼 282 是 ????????????? ? ㈠ ?? 朠洯″ ???? ?? | Yushan Li Junji Cao Jianjun Li Jiamao Zhou Hongmei Xu Renjian Zhang Zhiyun Ouyang | 2013 | Particuology2013，11，1： | 5 |
| 11 | Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years显示文摘Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins.Two cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation.NSAIDs are the most frequent choices for treatment of inflammation.Nevertheless,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal.Recently,more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles.In this review,we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021.It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research. | Zhiran Ju Menglan Li Junde Xu Daniel C.Howell Zhiyun Li Fen-Er Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 4 |
| 12 | Evaporative enrichment of stable isotopes(δ^(18)O and δD) in lake water and the relation to lake-level change of Lake Qinghai, Northeast Tibetan Plateau of China显示文摘Stable isotopic compositions(δ18O and δD) have been utilized as a useful indicator for evaluating the current and historical climatic and environmental changes. Therefore, it is vital to understand the relationship between the stable isotopic contents in lake water and the variations of lake level, particularly in Lake Qinghai, China. In this study, we analyzed the variations of isotope compositions(δ18O, δD and d-excess) in lake water and precipitation by using the samples that were collected from Lake Qinghai region during the period from 2009 to 2012. The results showed that the average isotopic contents of δ18O and δD in lake water were higher than those in precipitation, which were contrary to the variations of d-excess. The linear regression correlations between δ18O and δD in lake water and precipitation showed that the local evaporative line(LEL) in lake water(δD=5.88δ18O–2.41) deviated significantly from the local meteoric water line(LMWL) in precipitation(δD=8.26δ18O+16.91), indicating that evaporative enrichment had a significant impact on isotopic contents in lake water. Moreover, we also quantified the E/I ratio(evaporation-to-input ratio) in Lake Qinghai based on the lake water isotopic enrichment model derived from the Rayleigh equation. The changes of E/I ratios(ranging from 0.29 to 0.36 between 2009 and 2012) clearly revealed the shifts of lake levels in Lake Qinghai in recent years. The average E/I ratio of 0.40 reflected that water budget in Lake Qinghai was positive, and consistent with the rising lake levels and the increasing lake areas in many lakes of the Tibetan Plateau. These findings provide some evidences for studying the hydrological balance or water budget by using δ18O values of lake sedimentary materials and contribute to the reconstruction of paleolake water level and paleoclimate from an isotopic enrichment model in Lake Qinghai. | WU Huawu LI Xiaoyan LI Jing JIANG Zhiyun LI Guangyong LIU Lei | 2015 | Journal of Arid Land2015，7，5： | 4 |
| 13 | Porous cobalt oxide nanowires: Notable improved gas sensing performances显示文摘The porous Co3O4 nanowires have been successfully synthesized via modified template method. A possible growth mechanism governing the formation of such 1D nanowires is proposed. The as-prepared products have been characterized by X-ray Powder Diffraction (XRD), Extended X-ray Absorption Fine-structure (EXAFS), High-resolution Transmission Electron Microscopy (HRTEM) and N2 adsorption/desorption analysis. Our systematic studies have revealed that the porous Co3O4 nanowires show excellent gas sensing performances, which demonstrate the potential application of the 1D nanostructured Co3O4 in the detection of the ethanol gas as a sensor material. The improved performances are owing to its large specific surface area and porous morphology. | MA MaiXia PAN ZhiYun GUO Lin LI JingHong WU ZiYu YANG ShiHe | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 14 | The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation显示文摘由葡萄糖 transporter GLUT4 的刺激胰岛素的葡萄糖举起在整个身体的葡萄糖动态平衡起一个中央作用,哪个导致类型 2 糖尿病的 dysregulation。然而,调整刺激胰岛素的葡萄糖举起的分子的部件和机制仍然保持大部分不清楚。这里,我们证明 Axin 与 ADP-ribosylase tankyrase 交往 2 (TNKS2 ) 并且 kinesin 马达蛋白质 KIF3A,响应胰岛素形成为 GLUT4 translocation 关键的第三的建筑群。特定到血浆膜的复杂稀释刺激胰岛素的 GLUT4 translocation 的单个部件击倒。重要地, TNKS2 −/− 老鼠展出减少的胰岛素敏感和更高的血葡萄糖层次什么时候在 fasting 以后的 re-fed。机械学地,我们证明当胰岛素不在时, Axin, TNKS 和 KIF3A 与 trans-Golgi 网络上的 GLUT4 是 co 局部性的。胰岛素处理压制 TNKS 的 ADP-ribosylase 活动,导致在自动数据处理 ribosylation 和 ubiquitination 的减小 Axin 和 TNKS,和建筑群的并发的稳定。Akt 的抑制,胰岛素发信号的主要受动器 kinase,废除调停胰岛素的复杂稳定。我们因此阐明了直接在刺激胰岛素的 GLUT4 translocation 与马达蛋白质 kinesin 被联系的新蛋白质建筑群。 | Hui-Ling Guo Cixiong Zhang Qi Liu Qinxi Li Guili Lian Di Wu Xuebin Li Wei Zhang Yuemao Shen Zhiyun Ye Slau-Yong Lin Sheng-Cai Lin | 2012 | Cell Research2012，22，8： | 4 |
| 15 | Stable Lithium-Carbon Composite Enabled by Dual-Salt Additives显示文摘Lithium metal is regarded as the ultimate negative electrode material for secondary batteries due to its high energy density.However,it suffers from poor cycling stability because of its high reactivity with liquid electrolytes.Therefore,continuous efforts have been put into improving the cycling Coulombic efficiency(CE)to extend the lifespan of the lithium metal negative electrode.Herein,we report that using dual-salt additives of LiPF_(6) and LiNO_(3) in an ether solvent-based electrolyte can significantly improve the cycling stability and rate capability of a Li-carbon(Li-CNT)composite.As a result,an average cycling CE as high as 99.30% was obtained for the Li-CNT at a current density of 2.5 mA cm^(-2) and an negative electrode to positive electrode capacity(N/P)ratio of 2.The cycling stability and rate capability enhancement of the Li-CNT negative electrode could be attributed to the formation of a better solid electrolyte interphase layer that contains both inorganic components and organic polyether.The former component mainly originates from the decomposition of the LiNO_(3) additive,while the latter comes from the LiPF_(6)-induced ring-opening polymerization of the ether solvent.This novel surface chemistry significantly improves the CE of Li negative electrode,revealing its importance for the practical application of lithium metal batteries. | Lei Zheng Feng Guo Tuo Kang Yingzhu Fan Wei Gu Yayun Mao Ya Liu Rong Huang Zhiyun Li Yanbin Shen Wei Lu Liwei Chen | 2021 | Nano-Micro Letters2021，13，7： | 3 |
| 16 | Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus显示文摘Severe fever with thrombocytopenia syndrome(SFTS)is an emerging hemorrhagic fever disease caused by SFTSV,a newly discovered phlebovirus that is named after the disease.Currently,no effective vaccines or drugs are available for use against SFTSV infection,as our understanding of the viral pathogenesis is limited.Bortezomib(PS-341),a dipeptideboronic acid analog,is the first clinically approved proteasome inhibitor for use in humans.In this study,the antiviral efficacy of PS-341 against SFTSV infection was tested in human embryonic kidney HEK293T(293T)cells.We employed four different assays to analyze the antiviral ability of PS-341 and determined that PS-341 inhibited the proliferation of SFTSV in 293T cells under various treatment conditions.Although PS-341 did not affect the virus absorption,PS-341 treatment within a non-toxic concentration range resulted in a significant reduction of progeny viral titers in infected cells.Dual-luciferase reporter assays and Western blot analysis revealed that PS-341 could reverse the SFTSV-encoded nonstructural protein(NS)mediated degradation of retinoic acid-inducible gene-1(RIG-I),thereby antagonizing the inhibitory effect of NSs on interferons and blocking virus replication.In addition,we observed that inhibition of apoptosis promotes virus replication.These results indicate that targeting of cellular interferon pathways and apoptosis during acute infection might serve as the bases of future therapeutics for the treatment of SFTSV infections. | Sihua Liu Hongyun Liu Keke Zhang Xueping Li Yuqin Duan Zhiyun Wang Tao Wang | 2019 | Virologica Sinica2019，34，5： | 3 |
| 17 | Quality control of cell-based high-throughput drug screening显示文摘The pharmaceutical industry is presently suffering difficult times due to low productivity of new molecular entities.As a major source of drug leads,high-throughput screening(HTS)has been often criticized for its‘dead end’lead compounds.However,the fruitful achievements resulting from HTS technology indicate that it remains a feasible way for drug innovation.Because of increasing considerations of earlier stage ADMET(absorption,distribution,metabolism,excretion and toxicity)in drug development,cell-based HTS is highly recommended in modern drug discovery for its ability to detect more biologically relevant characteristics of compounds in living systems.This review provides a systematic and practical description of vital points for conducting high quality cell-based HTS,from assay development to optimization,compound management,data analyses,hit validation as well as lead identification.Potential problems and solutions are also covered. | Zhiyun Zhang Ni Guan Ting Li Dale E.Mais Mingwei Wang | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 18 | Novel Organic Dyes Based on Bulky Tri(triphenylamine)-Substituted Styrene for Dye-Sensitized Solar Cells显示文摘三个新奇施主--领受人( D --一)当有各种各样的结合的连接器(苯, thiophene 和呋喃)的施主被综合,没有金属的器官的染料( TB , TS 和 TF )基于 tri ( triphenylamine )代替了苯乙烯,描绘并且为敏化染料的太阳能电池( DSSC )的申请使用了。分别地,在一样下面,状况,与 TB 敏化的 DSSC 的 photo-to-electrical 变换效率, TS 和 TF 到达 1.84% , 4.10% 和 4.52% 它比与一个 triphenylamine 单位与 R1 (5.02%) 敏化的低。结果建议这些笨重基于施主的 sensitizers 对 DSSC 相反。 | Zhang Zhiyun Han Jinlong Li Xin Cai Shengyun Su Jianhua | 2012 | Chinese Journal of Chemistry2012，30，12： | 2 |
| 19 | The mechanisms of melanogenesis inhibition by glabridin:molecular docking,PKA/MITF and MAPK/MITF pathways显示文摘Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins.However,the underlying mechanism(s)remain not completely understood.The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 murine melanoma cells and in UVA radiation induced hyperpigmentation model of BALB/c mice as well.Molecular docking simulations revealed that between catalytic core residues and the compound.The treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor(MC1R),microphthalmia-associated transcription factor(MITF),tyrosinase(TYR),TYR-related protein-1(TRP-1)and TRP-2 in B16 cells.Both PKA/MITF and MAPK/MITF signaling pathways were found to be involved in the suppression of melanogenesis by glabridin in B16 cells.Also in vivo glabridin therapy significantly reduced hyperpigmentation,epidermal thickening,roughness and inflammation induced by frequent UVA exposure in mice skins,thus beneficial for skin healthcare.These data further look insights into the molecular mechanisms of melanogenesis suppression by glabridin,rationalizing the application of the natural compound for skin healthcare. | Chunxing Pan Xiaoying Liu Yating Zheng Zejun Zhang Yongliang Li Biao Che Guangrong Liu Lanyue Zhang Changzhi Dong Haji Akber Aisa Zhiyun Du Zhengqiang Yuan | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 20 | Influence of Nitrogen Flow Rate on the Microstructure and Properties of N and Me (Me=Cr,Zr) Co-doped Diamond-like Carbon Films显示文摘In this paper,Me (Me=Cr,Zr) and N co-doped diamond like carbon (DLC-MeN) composite films were prepared on cemented carbide substrates by pulsed bias arc ion plating.The effect of nitrogen flow rates on the microstructure and properties of the films were investigated by X-ray photoelectron spectroscopy (XPS),Raman spectra,grazing incident X-ray diffraction (GIXRD),high resolution transmission electron microscopy (HRTEM) and nano-indentation.Raman,GIXRD and HRTEM results show that the deposited films are nanocomposite films with MeN nanocrystalline phase embedded within DLC amorphous matrix,which are vital for the mechanical properties of the films.The nitrogen flow rate has significant effect on the compositions and structures and hence on the hardness and elastic modulus of the films,and increasing nitrogen flow rate decreases drastically the hardness and elastic modulus of the films. | Zhiyun Han,Hongkai Li,Guoqiang Lin and Chuang Dong Key Laboratory for Material Modification by Laser,Ion and Electron Beams,Dalian University of Technology,Dalian 116085,China | 2010 | Journal of Materials Science & Technology2010，26，11： | 2 |
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