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| 1 | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals显示文摘Arginine(ARG) exerts many beneficial effects on animal body and enhanced angiogenesis, lactogenesis, which finally leads to the improvement in nitrogen(N) metabolism, reproduction, lactation, immunity and growth. Unfortunately, unprotected ARG will be degraded in the rumen and its price is high, thus feeding rumen-protected ARG seems to be uneconomical. Alternatively, N-carbamoyl glutamate(NCG) is structural analogue of N-acetyl glutamate, cofactor of cabamoyl phosphate synthetase 1, is lower in rumen degradation compared to ARG. Additionally, rumen epithelial and duodenal cells have potentially utilized the NCG for ureagenesis. Supplementation of NCG to high yielding dairy cows increased plasma concentration of ARG and nitric oxide, decreased the plasma ammonia N and improved lactation performance and N utilization. Supplementation of NCG enhanced pregnancy rates in rats, improved litter size and fetal survival rate, thereby improved the reproductive performance of sows. Oral NCG supplementation increases plasma ARG and somatotropin levels, and increased growth rate and muscle protein synthesis in nursing piglets. The NCG is potential a relatively cheaper source of feed additive to offer vital compensation over oral administration of ARG, resulting in improved ruminant animal health and production. In this article, we reviewed the mechanism of ARG biosynthesis by NCG and their significance in growth, reproduction, milk production and N utilization in ruminant animals. | Bahram Chacher Hongyun Liu Diming Wang Jianxin Liu | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 15 |
| 2 | Effect of Mo on High-Temperature Fatigue Behavior of 15CrNbTi Ferritic Stainless Steel显示文摘In order to understand the effect of Mo element on the high-temperature fatigue behavior of 15 CrNbTi ferritic stainless steel, the stress-controlled fatigue tests have been performed for both 15 CrNbTi and 15Cr0.5MoNbTi ferritic stainless steels at 800 °C in laboratory air. The fatigue test results indicate that the fatigue resistance of 15Cr0.5MoNbTi steel is manifestly higher than that of 15 CrNbTi steel at the maximum stress below 57 MPa; the 15Cr0.5MoNbTi steel possesses a fatigue limit of 35 MPa, which is higher than that of 15 CrNbTi steel. The TEM observations reveal that the Mo element can suppress the formation of coarsened Fe3Nb3 C precipitates and result in the fatigue resistance enhancement.The dislocation networks formed during the cyclic load favor to improve the fatigue resistance of 15Cr0.5MoNbTi steel at800 °C. | Tianlong Liu Lijia Chen Hongyun Bi Xin Che | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 10 |
| 3 | Effects of recrystallization on the low cycle fatigue behavior of directionally solidified superalloy DZ40M显示文摘The effects of recrystallization on low cycle fatigue behavior were investigated on directionally solidified Co-base superalloy DZ40M. Opti-cal microscopy and SEM were used to examine the microstructure and fracture surface of the specimens. The mechanical testing results demonstrated that the low cycle fatigue property of DZ40M significantly decreased with the partial recrystallization. Fatigue cracks initiate near the carbides and the grain boundaries with slip-bands. Both the fatigue crack initiation and propagation can be accelerated with the oc-currences of recrystallized grain boundaries. | ZHAO Yang WANG Lei LI Hongyun YU Teng LIU Yang | 2008 | Rare Metals2008，27，4： | 8 |
| 4 | miR-146a-5p acts as a negative regulator of TGF-β signaling in skeletal muscle after acute contusion显示文摘成长证据在表明小径的应力建议 microRNAs (miRNAs ) 的重要性。转变生长因素 --(TGF-) 是在尖锐殴打以后支持骨胳的肌肉纤维变性的发展的有势力 cytokine。然而, miRNAs 怎么涉及 TGF- 发信号并且授与 TGF 的坚韧性 -- 导致的 fibrotic 反应尚待充分被阐明。这里,我们证明 miR-146a-5p (miR-146 ) 层次在尖锐肌肉殴打以后在一个 fibrotic 老鼠模型被减少。它也被发现那个 TGF- 处理减少在在一个剂量依赖者和时间依赖者举止的 vitro 的 miR-146 的表示。另外, Smad3 和 Samd4 的 overexpression,在 TGF- 发信号的二个关键播放器,在肌肉房间压制了 miR-146 的表达式。miR-146 的 Overexpression 在 vitro 并且在 vivo 禁止了纤维变性标记的表情。而且,在肌肉房间的 miR-146 的表示的增加能在纤维变性标记的表情上稀释 TGF- 的效果。机械学的分析表明 Smad4 是在肌肉房间的 miR-146 的一个直接目标。而且, miR-146 的 anti-fibrotic 效果能被 Smad4 的 overexpression 在 vivo 堵住。这些结果建议 Smad4 由在骨胳的肌肉的 miR-146 是下面调整的。一起拿,我们的结果显示 anti-fibrotic miR-146 是 TGF- 发信号的一个部件。它由 Smad 蛋白质是下面调整的,并且能禁止 Smad4 的表示。我们的学习建议 miR-146 可能有一个治疗学的潜力在损害以后减少骨胳的肌肉纤维变性。 | Yaying Sun Yan Li Hui Wang Hongyun Li Shaohua Liu Jiwu Chen Hao Ying | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 5 |
| 5 | Effect of dietary phosphorus content on milk production and phosphorus excretion in dairy cows显示文摘Background:Phosphorus(P) supplementation is costly and can result in excess P excretion.This study investigated the effects of reducing dietary P on milk production and P excretion in dairy cows over a full lactation.Method:Forty-five multiparous Holstein dairy cows were divided into 15 blocks according to expected calving date and previous milk yield,and assigned randomly to one of the three dietary treatments:0.37,0.47,and 0.57%P(DM basis);these P levels represent the NRC recommendations,Chinese recommendations,and the amount of dietary P commonly fed by Chinese dairy farmers,respectively.Average daily feed intake was calculated from monthly data on feed offered and refused.Milk yields of individual cows were recorded weekly,and milk samples were taken for analysis of protein,fat,solids-not-fat,lactose,and somatic cell count.Blood samples were collected on days-6,-3,0,3,6 relative to calving,and then monthly throughout lactation,and analyzed for P and Ca concentrations.Spot samples of feces and urine were collected for 3 consecutive d during weeks 12,24,and 36,and P concentrations were analyzed.Reproduction and health data were recorded.Results:Dietary P did not affect dry matter intake or milk yield(P> 0.10).Milk fat content was slightly higher in cows fed 0.37%P than in cows fed 0.47%P(P = 0.05).Serum concentrations of P and Ca did not reflect dietary P content(P> 0.10).Fecal and urinary P both declined linearly(P< 0.05) as dietary P decreased from 0.57 to0.37%.Fecal P content was 25%less when dietary P was 0.37%compared to 0.57%.Health events and reproductive performance were not associated with dietary P content(P> 0.05).Conclusions:Lowering dietary P from 0.57 to 0.37%did not negatively affect milk production,but did significantly reduce P excretion into environment. | Chong Wang Zhen Liu Diming Wang Jianxin Liu Hongyun Liu Zhiguo Wu | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 5 |
| 6 | PTEN-L promotes type I interferon responses and antiviral immunity显示文摘Phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human cancer.Our previous work has demonstrated that PTEN also plays a vital role in type I interferon responses and antiviral innate immunity.Recently,a translational variant of PTEN with a long N-terminal extension(PTEN-L)has been discovered that is secreted into the extracellular environment and enters recipient cells,where it exerts a phosphatase function antagonistic to PI3K/Akt signaling and tumorigenesis.In this study,we demonstrate that PTEN-L promotes type I interferon responses and antiviral innate immunity during viral infection in a phosphatase activity-dependent manner.Compared with canonical PTEN,PTEN-L also exerts its antiviral function when it is applied exogenously in protein form.This finding was confirmed in cell cultures and mouse infection models.Furthermore,PTEN-L enhances the responses of both type I interferon and proinflammatory cytokines,thus suggesting that PTEN-L might possess additional functions compared with those of PTEN.Thus,the antiviral function of PTEN-L may open an avenue for the use of PTEN-L in antiviral therapy,particularly in patients with PTEN-deficient tumors. | Yuanyuan Cao Hongyun Wang Liu Yang Zhen Zhang Chenlin Li Xu Yuan Lang Bu Lang Chen Yu Chen Chun-Mei Li Deyin Guo | 2018 | Cellular & Molecular Immunology2018，15，1： | 3 |
| 7 | Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus显示文摘Severe fever with thrombocytopenia syndrome(SFTS)is an emerging hemorrhagic fever disease caused by SFTSV,a newly discovered phlebovirus that is named after the disease.Currently,no effective vaccines or drugs are available for use against SFTSV infection,as our understanding of the viral pathogenesis is limited.Bortezomib(PS-341),a dipeptideboronic acid analog,is the first clinically approved proteasome inhibitor for use in humans.In this study,the antiviral efficacy of PS-341 against SFTSV infection was tested in human embryonic kidney HEK293T(293T)cells.We employed four different assays to analyze the antiviral ability of PS-341 and determined that PS-341 inhibited the proliferation of SFTSV in 293T cells under various treatment conditions.Although PS-341 did not affect the virus absorption,PS-341 treatment within a non-toxic concentration range resulted in a significant reduction of progeny viral titers in infected cells.Dual-luciferase reporter assays and Western blot analysis revealed that PS-341 could reverse the SFTSV-encoded nonstructural protein(NS)mediated degradation of retinoic acid-inducible gene-1(RIG-I),thereby antagonizing the inhibitory effect of NSs on interferons and blocking virus replication.In addition,we observed that inhibition of apoptosis promotes virus replication.These results indicate that targeting of cellular interferon pathways and apoptosis during acute infection might serve as the bases of future therapeutics for the treatment of SFTSV infections. | Sihua Liu Hongyun Liu Keke Zhang Xueping Li Yuqin Duan Zhiyun Wang Tao Wang | 2019 | Virologica Sinica2019，34，5： | 3 |
| 8 | Constraints on the utilization of cereal straw in lactating dairy cows:A review from the perspective of systems biology显示文摘Cereal straw,a human inedible crop byproduct,can be used as a roughage source in ruminants.However,the nutrition density and palatability are very low,limiting its efficient utilization in animal production.This review aims to systematically provide an overview of the limitations of cereal straws,which is crucial for developing new strategies to enhance the efficient use of cereal straws by lactating dairy cows.Evolutionary molecular biology makes it possible to comprehensively understand the limitations of using cereal straw as a roughage source in dairy cows by different techniques,e.g.,multi-omics.Main constraints for utilization of cereal straw and stover in lactating dairy cows include low contents of easily fermented carbohydrates(pectin)and essential amino acids(Met,Phe,and branched-chain amino acids),high content of lignin and silica,and low nutrient digestibility.These cause insufficient supply of the precursors for milk synthesis and result in increased loss of nutrients in feces and urine.Several molecular mechanisms are revealed by multi-omics techniques,including changed amino acid and glucose metabolism,altered rumen microbial composition and function,and differential expression of miRNAs,mRNA,and protein in multi-organs that are associated with milk synthesis.These can be targets of approaches to improve the utilization of cereal straw by dairy cows.In addition,much attention should be given to the efficient countermeasures,including pretreatments by fibrolytic enzymes or steam explosion,dietary formulations such as supplement of pectin,methionine,and branched-chain amino acids,and feeding with other functional feedstuffs,which may improve the feeding and economic value of cereal straw for lactating dairy cows.The newly revealed functional genes(such as BAG3 in the rumen,PC in the liver,CSN1S2 in the mammary gland)and biomarkers(hippuric acid)as well as the integrative signaling and metabolic pathways(phenylalanine metabolism)related to the shortages of cereal straws could be used as nutritional or genetic regulatory targets to improve dairy cow production. | Bing Wang Huizeng Sun Diming Wang Hongyun Liu Jianxin Liu | 2022 | Animal Nutrition2022，，2： | 3 |
| 9 | Biomarker and pathway analyses of urine metabolomics in dairy cows when corn stover replaces alfalfa hay显示文摘Background: Alfalfa hay and corn stover are different type of forages which can significantly impact a cow's lactation performance, but the underlying metabolic mechanism has been poorly studied. We used biomarker and pathway analyses to characterize related biomarkers and pathways based on urine metabolomics data from different forage treatments. Urine was col ected from 16 multiparous Holstein dairy cows fed alfalfa hay(AH, high-quality forage, n = 8) and corn stover(CS, low-quality forage, n = 8) respectively. Gas chromatography–time of flight/mass spectrometry(GC-TOF/MS) was performed to identify metabolites in urine and the metaboanalyst online platform was used to do biomarker and pathway analysis.Results: Hippuric acid(HUA) and N-methyl-glutamic(NML-Glu) indicated the most significant difference between the two diets, when statistical y validated by biomarker analysis. HUA was also validated by standard compound quantitative method and showed significant higher concentration in CS group than AH group(2.8282 vs. 0.0005 mg/mL; P < 0.01).The significant negative correlation between milk yield and HUA(R^2= 0.459; P < 0.01) and significant positive correlation between milk yield and NML-Glu(R^2= 0.652; P < 0.01) were characterized. The pathway analysis revealed that these different metabolites were involved in 17 pathways including 7 influential pathways(pathway impact value > 0): Tyr metabolism, starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism, galactose metabolism,Phe, Tyr and Try biosynthesis, purine metabolism, and glycerolipid metabolism. Based on the metabolome view map,the Phe, Tyr and Try biosynthesis pathway exhibited the highest impact value(0.50), and the Holm-Bonferroni multiple testing-based analysis revealed the most significant difference in the Tyr metabolism pathway(Holm P = 0.048).Conclusions: The identified HUA and NML-Glu may serve as potential biomarkers for discriminating CS and AH diets and could be used as candidates for milk yield related mechanistic investigations. Integrated network pathways associated with related metabolites provide a helpful perspective for discovering the effectiveness of forage quality in lactation performance and provides novel insights into developing strategies for better utilization of CS and other low-quality forage in China. | Huizeng Sun Bing Wang Jiakun Wang Hongyun Liu Jianxin Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 10 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 11 | A critical review on lead migration, transformation and emission control in Chinese coal-fired power plants显示文摘Coal is widely utilized as an important energy source,but coal-fired power plant was considered to be an important anthropogenic lead emission source.In the present study,the distribution characteristics of lead in coal and combustion by-products are reviewed.Specifically,lead is mainly transferred to ash particles and the formation and migration mechanisms of particulate lead are summarized.Also,targeted measures are proposed to control the formation of fine particulate lead as well as to increase the removal efficiency during the low-temperature flue gas clean process.In detail,interactions between gaseous lead and some coal-bearing minerals or added adsorbents could obviously suppress the formation of fine particulate lead.On the other hand,some efforts(including promoting capture of fine particles,reducing resistivity of particles and strengthening the gas-liquid contact)could be made to improve the fine particulate lead removal capacity.Notably,the formation mechanism of fine particulate lead is still unclear due to the limitations of research methods.Some differences in the removal principles of fine particles and particulate lead make the lead emission precisely control a great challenge.Finally,the environmental potential risk of lead emission from flue gas and ash residues is addressed and further discussed. | Yicheng Wang Hongyun Hu Xinye Wang Huimin Liu Lu Dong Guangqian Luo Yongchun Zhao Hong Yao | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 12 | Structure and magnetostriction of Tb_(0.4)Nd_(0.6)(Fe_(0.8)Co_(0.2))_(1.90) alloy prepared by solid-state synthesis显示文摘Mechanical alloying (MA) and subsequent solid sintering process was used to prepare the Nd-containing magnetostrictive Tb0.4Nd0.6(Fe0.8Co0.2)1.90 alloy. The structure, thermal stability and phase transformation were investigated as functions of composition, milling process and annealing temperature. An amorphous phase was formed by high-energy ball milling for 5 h with the ball-to-powder weight ratio of 20:1, which crystallized into MgCu2-type and PuNi3-type crystalline structure with different annealing temperatures. The magnetoelastic properties were investigated by means of a standard strain technique. The high Nd-content (Tb,Nd)(Fe,Co)2 Laves phase for the composition Tb0.4Nd0.6(Fe0.8Co0.2)1.90 was synthesized by MA process plus annealing at 500 ℃ for 30 min. | Liu Jinjun Wang Rong Yin Hongyun Liu Xincai Si Pingzhan Du Juan | 2012 | Rare Metals2012，31，6： | 2 |
| 13 | Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles显示文摘As well-known persistent organic pollutants(POPs), organofluorine pollutants such as perfluorooctane sulfonate(PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles,trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles(PTFEPMMA NPs) were synthesized with various fluorine contents(PTFE-PMMA-1 NPs 12.0 wt.%,PTFE-PMMA-2 NPs 6.1 wt.% and PTFE-PMMA-3 NPs 5.0 wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine(F) contents and Fcontaining side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose(50 μg/m L) for 24 hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species(ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials(ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications. | Xue Wang Wenge Cheng Qiuyuan Yang Hongyun Niu Qian Liu Yun Liu Ming Gao Ming Xu An Xu Sijin Liu Xiaoyu Huang Yuguo Du | 2018 | Journal of Environmental Sciences2018，30，7： | 2 |
| 14 | Functional characterization of oligopeptide transporter 1 of dairy cows显示文摘Background: It is wel known that peptides play a vital role in the nutrition and health of dairy cows. Bovine oligopeptide transporter 1(bP epT 1) is involved in the peptide transport process in the gastrointestinal tracts of dairy cows. However,little information is known in the characteristics of bP epT 1. Therefore, the purpose of this study was to characterize bP epT 1 functional y using a mammalian cel expression system. The uptake of radiolabeled dipeptide glycyl-sarcosine([3 H]-Gly-Sar)into the bP epT 1-transfected Chinese hamster ovary cel s was measured at various pH and substrate concentrations and with or without 15 other smal peptides that contained Met or Lys.Results: Western blot results showed that the abundance of bP epT 1 protein in the jejunum and ileum are the highest in the gastrointestinal tract of dairy cows. The uptake of [3 H]-Gly-Sar by b Pep T1-Chinese hamster ovary cells was dependent on time, p H, and substrate concentration, with a low Kmvalue of 0.94 ± 0.06 mmol/L and a maximum velocity of 20.80 ± 1.74 nmol/(mg protein · 5 min). Most of the di-and tripeptides were the substrates of b Pep T1,based on substrate-competitive studies. However, bP epT 1 has a higher affinity to the peptides with shorter chains, greater hydrophobicity, and negative or neutral charges.Conclusions: These results demonstrated for the first time the functional characteristics of bP epT 1, and they provide a new insight and better understanding into its vital role in absorbing a wide range of peptides from the digestive tract of dairy cows. | Qingbiao Xu Zhixuan Liu Hongyun Liu Fengqi Zhao Xinbei Huang Yueming Wu Jianxin Liu | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 2 |
| 15 | Optimal time for subarachnoid transplantation of neural progenitor cells in the treatment of contusive spinal cord injury显示文摘This study aimed to identify the optimal neural progenitor cell transplantation time for spinal cord injury in rats via the subarachnoid space. Cultured neural progenitor cells from 14-day embryonic rats, constitutively expressing enhanced green fluorescence protein, or media alone, were injected into the subarachnoid space of adult rats at 1 hour (acute stage), 7 days (subacute stage) and 28 days (chronic stage) after contusive spinal cord injury. Results showed that grafted neural progenitor cells migrated and aggregated around the blood vessels of the injured region, and infiltrated the spinal cord parenchyma along the tissue spaces in the acute stage transplantation group. However, this was not observed in subacute and chronic stage transplantation groups. O4- and glial fibrillary acidic protein-positive cells, representing oligodendrocytes and astrocytes respectively, were detected in the core of the grafted cluster attached to the cauda equina pia surface in the chronic stage transplantation group 8 weeks after transplantation. Both acute and subacute stage transplantation groups were negative for O4 and glial fibrillary acidic protein cells. Basso, Beattie and Bresnahan scale score comparisons indicated that rat hind limb locomotor activity showed better recovery after acute stage transplantation than after subacute and chronic transplantation. Our experimental findings suggest that the subarachnoid route could be useful for transplantation of neural progenitor cells at the acute stage of spinal cord injury. Although grafted cells survived only for a short time and did not differentiate into astrocytes or neurons, they were able to reach the parenchyma of the injured spinal cord and improve neurological function in rats. Transplantation efficacy was enhanced at the acute stage in comparison with subacute and chronic stages. | Yan Liu Ying Zhou Chunli Zhang Feng Zhang Shuxun Hou Hongbin Zhong Hongyun Huang | 2013 | Neural Regeneration Research2013，8，5： | 2 |
| 16 | Sirolimus combined with oseltamivir and corticosteroid treatment for a puerpera with severe pneumonia caused by 2009 pandemic H1N1:A case report显示文摘Severe pneumonia in patients infected with the 2009 pandemic H1N1(pH1N1)virus was partially attributed to excessive immune response.Anti-virus treatment for these patients was insufficient.Here we reported the therapy effect of sirolimus,an immunosuppressor,combined with oseltamivir and corticosteroid for a puerpera with severe pneumonia caused by pH1N1 virus.This patient has infected with the pH1N1 virus in late pregnancy,and antiviral therapy was not implemented timely.She developed severe pneumonia and ARDS rapidly and need receive a cesarean section on the 39th week after pregnancy.After giving birth to a healthy baby,she received a combination of oseltamivir,sirolimus and corticosteroid,and improved in the following days.Moreover,the cytokines in serum and viral loads in BALF decreased significantly.She recovered without infectious symptoms and was discharged.Sirolimus combined with oseltamivir and corticosteroid is likely responsible for lowering the viral loads,reducing the patient's cytokine level,and further improving her clinical outcomes.It provides evidence that adjuvant treatment was beneficial to patients with severe pneumonia induced by the pH1N1 virus. | Lijun Suo Xiaofeng Yu Yongfeng Hu Hongyun Cao Xiaohui Zou Peiquan Wang Tao Xu Xiangzhi Zhou Yexin Wu Lili Ren Bo Liu Bin Cao | 2021 | Biosafety and Health2021，3，6： | 2 |
| 17 | Natural nanomaterial as hard template for scalable synthesizing holey carbon naonsheet/nanotube with in-plane and out-of-plane pores for electrochemical energy storage显示文摘Tuning porous structure of carbon nanomaterials has been found to be important for their performance enhancement in electrochemical energy storage applications. In this work we employed a natural nanomaterial kaolinite, which is abundant and cheap, as hard template to synthesis porous carbon nanomaterial. By tuning the structure of hard template kaolinite, we have achieved a template directed formation of holey carbon nanosheet/nanotube materials. This carbon nanomaterials with hierarchical in-plane and out-of-plane pores have shown electrochemical energy storage capacity of 286 F/g(equal to 314 F/cm^3) at 0.1 A/g and 85 F/g(equal to 93 F/cm^3) at 100 A/g, which is comparable to variety of reported carbon based electrochemical energy storage electrode materials. | Yijie Zhang Luhua Lu Zhao Zhang Zhu Shu Kai Dai Jinghai Liu Ying Chen Hongyun Jin Shuen Hou | 2018 | Chinese Chemical Letters2018，29，4： | 2 |
| 18 | Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura显示文摘 | Hongyun Liu Xianfeng Ouyang Yiqing Li Hua Zeng Xiuju Wang Shuangfeng Xie Danian Nie Jie Xiao Jing Wei Yudan Wu Songmei Yin Liping Ma | 2013 | Thrombosis Research2013，，： | 2 |
| 19 | Independent Association between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis显示文摘 | Hongyun Lu Hong Liu Fang Hu Lingling Zou Shunkui Luo Liao Sun Kaori Minehira | 2013 | International Journal of Endocrinology2013，，： | 1 |
| 20 | Estab-lishment and characterization of a lactating bovine mamma-ry epithelial cell model for the study of milk synthesis显示文摘 | ZHAO Ke LIU Hongyun ZHOU Miaomiao | | 0，，7： | 1 |
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