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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization显示文摘 | Yuli Lin Xuguang Yang Wenjie Yue Xiaofei Xu Bingji Li Linlin Zou Rui He | 2014 | Cellular & Molecular Immunology2014，11，4： | 21 |
| 3 | Assessment effect of central venous pressure in fluid resuscitation in the patients with shock: a multi-center retrospective research显示文摘 | HU Bo XIANG Hui LIANG Hui YULi XU Tao YANG Jun-hui DU Zhao-hui LI Jian-guo | 2013 | Chinese Medical Journal2013，，10： | 12 |
| 4 | Geometry-dependent springback behaviors of thin-walled tube upon cold bending显示文摘As one kind of key lightweight components with enormous quantities and diversities, the bent tubular parts have attracted in- creasing applications in aerospace, automobile, etc. Thus, how the inevitable springback behaves under different bending specifications should be fully addressed to efficiently achieve the precision forming of various bent tubes. Taking the medium strength thin-walled 6061-T4 Al-alloy tube as the objective, via the deformation theory of plasticity, explicit/implicit FE method and experimental approaches, we explored and clarified the nonlinear springback rules of the tubes and corresponding mechanisms in universal rotary draw bending regarding angular springback and radius growth by deliberately changing the tube diameter D and wall thickness t. The geometry dependent springback behaviors of thin-walled tube upon cold bending are thus revealed: 1) With the increasing of D, the tangent tensile strain increases and the proportional coefficient decreases, which causes the angular springback to decrease, while the radius springback increases due to the larger bending radius. 2) With the increasing of t, the tangent tensile strain decreases and the proportional coefficient increases, resulting in the increase of both angular springback and radius springback. 3) Under the same D/t, the angular springback varies little, while the radius springback increases with the larger diameter D. 4) The D/t can be used as a reasonable nondimensional index to evaluate the springback angle; as to the radius growth, the individual effects of the D and t should be considered. 5) The verification of the above results was conducted by experiments and analytical analysis. | LI Heng YANG He TIAN YuLi LI GuangJun WANG ZhengHua | 2012 | Science China(Technological Sciences)2012，55，12： | 10 |
| 5 | Quercus yangyiensis sp. nov. from the Late Pliocene of Baoshan, Yunnan and Its Paleoclimatic Significance显示文摘A new Quercus(Fagaceae) morphospecies is described based on well-preserved fossil leaves. The fossils were collected from Yangyi Formation of the Upper Pliocene at the Yangyi coalmine, Baoshan, western Yunnan, China. Details of the microstructure of mesophyll tissue are preserved because lithification of the fossils was not complete. The fossil laminas possess typical characteristics of Quercus sect. Heterobalanus: quite thick and coriaceous cuticle; secondary veins bifurcating near the margin in the middle and top of the leaf; and upper epidermis with adaxial hypodermis. Based on a detailed morphological and anatomical comparison with all living and fossil species of Quercus sect. Heterobalanus, the fossil leaves prove to be different in their sparse and garland-shaped multicellular trichomes on the lower epidermis, and so it is described as a new species Quercus yangyiensis He, Li et Sun sp. nov. The much sparser trichomes of our fossils compare well with those of living Quercus sect. Heterobalanus and indicate a more humid climate during the deposition of the Yangyi Formation in the Late Pliocene. | HE Yuli LI Na WANG Zixi WANG Haofei YANG Guolin XIAO Liang WU Jingyu SUN Bainian | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 6 |
| 6 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 7 | Effect and safety of acupotomy in treatment of knee osteoarthritis:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of acupotomy in treatment of knee osteoarthritis(OA).METHODS: Extensive literature searches were carried out in PubMed, EMBASE, Cochrane Library(Issue 5, 2017), Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database and Wanfang Database. All databases were retrieved from their inception until May 31, 2017.Randomized controlled trials incorporating acupotomy versus intra-articular sodium hyaluronate for knee osteoarthritis were included. According to Cochrane Reviews’ Handbook(5.2), two reviewers screened each article and extracted data independently and were blinded to the findings of each reviewer. Meta-analysis was performed by the Cochrane Collaboration’s RevMan 5.3 software.RESULTS: We identified 12 studies involving 1150 patients aged between 40 and 78 years old. The pooled analysis indicated that acupotomy showed a significant improvement for short-term effect[cure rate: odds ratio(OR) = 2.04, 95% confidence interval(CI)(1.46, 2.85), P < 0.01;total effective rate:OR = 2.25, 95% CI(1.55, 3.28), P < 0.01;pain score:standard mean difference(SMD) =-1.02;95% CI(-1.72,-0.31);P = 0.005;Western Ontario and McMaster Universities Questionnaire(WOMAC) score:SMD =-0.74;95% CI(-1.11,-0.37);P < 0.01];and also for long-term effect [total effective rate:OR = 2.99, 95%CI(1.88, 4.76), Z = 4.64, P < 0.01;pain score: SMD =-1.68;95% CI(-2.14,-1.22);P <0.001;WOMAC score: SMD =-0.91;95% CI(-1.40,-0.41);P < 0.001]. In addition, there was no obvious difference between acupotomy group and control group in adverse events [OR = 2.13, 95% CI(0.14, 32.28), P = 0.58].CONCLUSION: Acupotomy is a safe and effective treatment for KOA. However, due to the methodological deficiency of the included studies, well-designed randomized controlled trials are required to further confirm the findings. | Fang Ting Li Qi Zhou Fanyuan Liu Fushui Liu Zhongyong Zhao Meimei Chen Mei You Jianyu Jin Yuli Xie Jinmei | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 6 |
| 8 | miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity显示文摘As an important component of innate immunity,human circulatingγδT cells function in rapid responses to infections and tumorigenesis.MicroRNAs(miRNAs)play a critical regulatory role in multiple biological processes and diseases.Therefore,how the functions of circulating humanγδT cells are regulated by miRNAs merits investigation.In this study,we profiled the miRNA expression patterns in human peripheralγδT cells from 21 healthy donors and identified 14 miRNAs that were differentially expressed between peripheralαβT cells andγδT cells.Of the 14 identified genes,7 miRNAs were downregulated,including miR-150-5p,miR-450a-5p,miR-193b-3p,miR-365a-3p,miR-31-5p,miR-125b-5p and miR-99a-5p,whereas the other 7 miRNAs were upregulated,including miR-34a-5p,miR-16-5p,miR-15b-5p,miR-24-3p,miR-22-3p,miR-22-5p and miR-9-5p,inγδT cells compared withαβT cells.In subsequent functional studies,we found that both miR-125b-5p and miR-99a-5p downregulatedγδT cell activation and cytotoxicity to tumor cells.Overexpression of miR-125b-5p or miR-99a-5p inγδT cells inhibitedγδT cell activation and promotedγδT cell apoptosis.Additionally,miR-125b-5p knockdown facilitated the cytotoxicity ofγδT cells toward tumor cells in vitro by increasing degranulation and secretion of IFN-γand TNF-α.Our findings improve the understanding of the regulatory functions of miRNAs inγδT cell activation and cytotoxicity,which has implications for interventional approaches toγδT cell-mediated cancer therapy. | Yuli Zhu Siya Zhang Zinan Li Huaishan Wang Zhen Li Yu Hu Hui Chen Xuan Zhang Lianxian Cui Jianmin Zhang Wei He | 2019 | Cellular & Molecular Immunology2019，16，2： | 5 |
| 9 | Exploring Channel Diversity in HF Communication Systems: A Matching-Potential Game Approach显示文摘This paper investigates the channel diversity problem in high frequency(HF) communication systems. Due to the limited HF spectrum resources, a HF communication system with shared channels is considered, where each user equipment(UE) has individual communication demand. In order to maximize the communication probability of the whole system, a matching-potential game framework is designed. In detail, the channel diversity problem is decomposed into two sub-problems. One is channel-transmitter matching problem, which can be formulated as a many-to-one matching game. The other is the transmitter allocation problem which decides the transmission object that each transmitter communicates with under channel-transmitter matching result, and this sub-problem can be modeled as a potential game. A multiple round stable matching algorithm(MRSMA) is proposed, which obtains a stable matching result for the first sub-problem, and a distributed BR-based transmitter allocation algorithm(DBRTAA) is designed to reach Nash Equilibrium(NE) of the second sub-problem. Simulation results verify the effectiveness and superiority of the proposed method. | Wen Li Lang Ruan Yifan Xu Yuli Zhang Yitao Xu Xinhong Shao | 2018 | China Communications2018，15，9： | 4 |
| 10 | Diurnal and seasonal variations in carbon fluxes in bamboo forests during the growing season in Zhejiang province, China显示文摘Bamboo forest is an important forest type in subtropical China and is characterized by fast growth and high carbon sequestration capacity. However, the dynamics of carbon fluxes during the fast growing period of bamboo shoots and their correlation with environment factors are poorly understood. We measured carbon dioxide exchange and climate variables using open-path eddy covariance methods during the 2011 growing season in a Moso bamboo forest(MB, Phyllostchys edulis) and a Lei bamboo forest(LB, Phyllostachys violascens) in Zhejiang province,China. The bamboo forests were carbon sinks during the growing season. The minimum diurnal net ecosystem exchange(NEE) at MB and LB sites were-0.64 and-0.66 mg C m^(-2) s^(-1), respectively. The minimum monthly NEE, ecosystem respiration(RE), and gross ecosystem exchange(GEE) were-99.3 ± 4.03, 76.2 ±2.46, and^(-1)91.5 ± 4.98 g C m^(-2) month^(-1), respectively,at MB site, compared with-31.8 ± 3.44, 70.4 ± 1.41,and^(-1)57.9 ± 4.86 g C m^(-2) month^(-1), respectively, at LB site. Maximum RE was 92.1 ± 1.32 g C m^(-2) month^(-1) at MB site and 151.0 ± 2.38 g C m^(-2) month^(-1) at LB site.Key control factors varied by month during the growing season, but across the whole growing season, NEE and GEE at both sites showed similar trends in sensitivities to photosynthetic active radiation and vapor pressure deficit,and air temperature had the strongest correlation with RE at both sites. Carbon fluxes at LB site were more sensitive to soil water content compared to those at MB site. Both onyear(years when many new shoots are produced) and offyear(years when none or few new shoots are produced)should be studied in bamboo forests to better understand their role in global carbon cycling. | Liang Chen Yuli Liu Guomo Zhou Fangjie Mao Huaqiang Du Xiaojun Xu Pingheng Li Xuejian Li | 2019 | Journal of Forestry Research2019，30，2： | 3 |
| 11 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 12 | Systematic study on the mechanical and electric behaviors of the nonbuckling interconnect design of stretchable electronics显示文摘Recently, we developed a nonbuckling interconnect design that provides an effective approach to simultaneously achieving high elastic stretchability, easiness for encapsulation, and high electric performance for stretchable electronics. This paper aims to systematically study its mechanical and electric behaviors, including comparisons of the nonbuckling and buckling interconnect designs on stretchability, effects of the thickness on electric performance, and modeling and experimental investigations on the finite deformation mechanics. It is found that the results on stretchability depend on the layouts. Long straight segments and small arc radii for nonbuckling interconnects yield an enhancement of stretchability, which is much better than that of buckling designs. On the other hand, shorter straight segments or thicker interconnects are better to lower the resistances of interconnects.Therefore, optimization of the designs needs to balance the requirements of both the mechanical and electric performances. The finite deformation of interconnects during stretching is analyzed. The established analytic model is well validated by both the finite element modeling and experimental investigations. This work is key for providing the design guidelines for nonbucklingbased stretchable electronics. | Hao Liu RiYe Xue JianQiao Hu XueCheng Ping HuaPing Wu MingQi Huang Han Zhang Xu Guo Rui Li YuLi Chen YeWang Su | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 3 |
| 13 | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development显示文摘Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune response.Furthermore,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response.Based on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers.In the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic effects.The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest.For example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion.Furthermore,many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers.Therefore,it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs.In this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs. | Yuli Wang Xingyan Zhang Yuyan Wang Wenjing Zhao Huling Li Lixing Zhang Xinping Li Tiejun Zhang Hongbing Zhang He Huang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 14 | FDI spillovers in an emerging market: the role of foreign firms’ country origin diversity and domestic firms’ absorptive capacity显示文摘 | YanZhang HaiyangLi YuLi Li‐AnZhou | 2010 | Strat Mgmt J2010，，9： | 3 |
| 15 | Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma显示文摘Nanosuspensions,as a new drug delivery system for insoluble drugs,are only composed of a drug and a small amount of stabilizer,which is dispersed in an aqueous solution with high drug-loading,small particle size,high dispersion,and large specific surface area.It can significantly improve the dissolution,bioavailability,and efficacy of insoluble drugs.In this study,paclitaxel nanosuspensions((PTX)NS)were prepared by an ultrasonic precipitation method,with the characteristics of simple preparation and easy repetition.With the help of a homologous targeting mechanism,a kind of glioma C6 cancer cell membrane(CCM)-coated(PTX)NS was developed and modified with DWSW peptide to obtain DWSW-CCM-(PTX)NS with the functions of BBB penetration and tumor targeting.The results showed that the cancer cell membrane could effectively camouflage the nanosuspensions so that it was not cleared by the immune system and could cross the blood-brain-barrier(BBB)and selectively target tumor tissues.Cell uptake experiments and in vivo imaging confirmed that the uptake of DWSW-CCM-(PTX)NS by tumor cells and the distribution in intracranial gliomas increased.Cytotoxicity test and in vivo anti-glioma studies showed that DWSW-CCM-(PTX)NS could significantly inhibit the growth of glioma cells and significantly prolong the survival time of glioma-bearing mice.Finally,the cancer cell membrane coating endowed the nanosuspensions with the biological properties of homologous adhesion and immune escape.This study provides an integrated solution for improving the targeting of nanosuspensions and demonstrates the encouraging potential of biomimetic nanosuspensions applicable to tumor therapy. | Yueyue Fan Yuexin Cui Wenyan Hao Mengyu Chen Qianqian Liu Yuli Wang Meiyan Yang Zhiping Li Wei Gong Shiyong Song Yang Yang Chunsheng Gao | 2021 | Bioactive Materials2021，6，12： | 3 |
| 16 | Dynamic changes and convergence of China's regional green productivity:A dynamic spatial econometric analysis显示文摘Low-carbon economic development is at the heart of the post-pandemic green recovery scheme worldwide.It requires economic recovery without compromising on the environment,implying a critical role that green productivity plays in achieving the carbon neutrality goal.Green productivity measures the quality of economic growth with consideration for energy consumption and environmental pollution.This study employs the slacks-based measure directional distance function(SBM-DDF)approach and the Malmquist-Luenberger(ML)index to calculate green productivity and its components of 30 provinces in China between 2001 and 2018.Using a spatial panel data model,we empirically analyzed the conditionalβ-convergence of China's green productivity.We found that overall,since 2001,China's green productivity has demonstrated a continuous upward trend.When taking into account spatial factors,China's green productivity demonstrates a significant conditionalβ-convergence.In terms of regional effects,the results indicate that the green productivity of the eastern and western regions demonstrates club convergence,implying a more balanced green economic development.Moreover,the convergence rate of China's green productivity increases with the addition of environmental regulation variable,and so the corresponding convergence time decreases.It indicates that environmental regulations help to facilitate the convergence of China's green productivity,narrowing the gap between the regional green economic development.The findings provide guideline for achieving a low-carbon development and carbon neutrality from a regional green productivity perspective. | Xu-Quan ZHAI Rui XUE Bin HE Dong YANG Xiang-Yu PEI Xian LI Yuli SHAN | 2022 | Advances in Climate Change Research2022，13，2： | 2 |
| 17 | Noninvasive preimplantation genetic testing in assisted reproductive technology:current state and future perspectives显示文摘Invasive genetic screening of pre-implantation embryos via biopsied trophectoderm(TE)cells has been in use for more than 20 years,while its benefits in selecting euploid embryos remain controversial.Recent advances in the ability to process embryonic cell-free DNA(cfDNA)from blastocoel fluid(BF)and spent culture media(SCM)of blastocysts in a manner similar to that of a biopsied TE sample provide a potential alternative holding great promise for obtaining cytogenetic information of the embryos without intrusive biopsy of traditional biopsy-based pre-implantation genetic testing(PGT).Several studies have reported even higher diagnostic accuracy in non-invasive PGT(ni-PGT)than conventional PGT.However,there are still several technical challenges to be overcome before ni-PGT can be accepted as a reliable genomic information source of embryo.In this review,we have summarized the emergence and current state of ni-PGT,and discussed our own perspectives on their limitations and future prospect.There is still a long way to go before truly wide clinical application of ni-PGT. | Jingyi Li Yifeng Liu Yuli Qian Dan Zhang | 2020 | Journal of Genetics and Genomics2020，47，12： | 2 |
| 18 | Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid显示文摘Laser flash photolysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) experiments were carried out to study the photosensitive damage induced by pazufloxacin(PAX) and the protection of lysozyme(Lyso) by ferulic acid(FCA), an active antioxidant. Transient absorption spectra revealed electron transfer from Lyso and FCA to 3PAX*, with respective bimolecular reaction rate constants of 6.3×107 and 1.4×1010 dm3/(mol s). A pulse radiolysis study was also performed to investigate the formation of Lyso radical cations. Results showed that FCA effectively inhibited the cross-linking of protein induced by fluoroquinolones. Finally, a mechanism of the protective effect of FCA on Lyso was proposed. | Yulie Xu Yancheng Liu Haixia Li Peng Zhang Jianfeng Zhao Wenfeng Wang | 2015 | Science China Chemistry2015，58，3： | 2 |
| 19 | Pulse radiolysis of sparfloxacin in neutral aqueous solution显示文摘 | LIU Yancheng LI Haixia CUI Rongrong TANG Ruizhi XU Yulie WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 20 | Pulse radiolysis and laser flash photolysis study of balofloxacin显示文摘 | XU Yulie LIU Yancheng LI Haixia ZHANG Peng TANG Ruizhi CAO Xiyan WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
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