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| 1 | Immunohisto chemical Study on the Effects of Pyrethroids on Gluta-mate and γ-Aminobutyric Acid in Rat Central Nervous System显示文摘Objective\ In order to study the effects of pyrethroids on glutamate (Glu) and gamma aminobutyric acid (GABA) in rat central nervous system. Methods\ Male SD rats were treated with permethrin (7 mg/kg, i.p) or cypermethrin (70 mg/kg, i.p) once a day for 3 days. Glu and GABA immunoreactive cells and transmitters in CNS were studied by immunohistochemical method. Results\ The total number, percentage of positive area and integral optical density of glutamate immunoreactive cell in cerebral cortex, hippocampus decreased significantly in permethrin or cypermethrin, while GABA was enhanced. Cypermethrin is more tent than permethrin on either Glu or GABA. Conclusion\ Disturbance of Glu and GABA is likely to play a role in the development of pyrethroids excitatory neurotoxicity. | Wu Jianping, Lu Chun\+1, Wang Ying, et al. Wu Jianping, Lu Chun\+1, Wang Ying, et al. Institute of Toxicology, Nanjing Medical University, Nanjing\ 210029 Acta Universitatis Medicinalis Nanjing,19(6):450 | 1999 | The Journal of Biomedical Research1999，23，2： | 68 |
| 2 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 3 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 4 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 5 | Adapting liposomes for oral drug delivery显示文摘Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract,difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes. | Haisheng He Yi Lu Jianping Qi Quangang Zhu Zhongjian Chen Wei Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 23 |
| 6 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 7 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 8 | Rattle-Type Silica Colloidal Particles Prepared by a Surface- Protected Etching Process显示文摘This paper explores the capability of the“surface-protected etching”process for the creation of rattle-type SiO_(2)@void@SiO_(2) colloidal structures featuring a mesoporous silica shell and a mesoporous movable silica core.The surface-protected etching process involves stabilization of the particle surface using a polymer ligand,and then selective etching of the interior to form hollow structures.In this paper,this strategy has been extended to the formation of rattle-like structures by etching SiO_(2)@SiO_(2) core shell particles which are synthesized by a two-step sol gel process.The key is to introduce a protecting polymer of polyvinylpyrrolidone(PVP)to the surface of both core and shell in order to tailor their relative stability against chemical etching.Upon reacting with NaOH,the outer layer silica becomes a hollow shell as only the surface layer is protected by PVP and the interior is removed,while the core remains its original size thanks to the protection of PVP on its surface.This process can be carried out at room temperature without the need of additional templates or complicated heterogeneous coating procedures.The etching process also results in the rattle-type colloids having mesoscale pores with two distinct average sizes.In our demonstration of a model drug delivery process,such mesoporous structures show an interesting two-step elution profile which is believed to be related to the unique porous rattle structures. | Qiao Zhang Jianping Ge James Goebl Yongxing Hu Zhenda Lu Yadong Yin | 2009 | Nano Research2009，2，7： | 18 |
| 9 | Trace-element of Tuoyun cli-nopyroxene:Implication for the deep processes of litho-spheric mantle beneath the southwest Tianshan,West China显示文摘Based on the LAM-ICPMS analytic results on the trace elements of clinopyroxenes in peridotitic xenoliths occurring in early-Cretaceous basalts from western Xinjiang, the properties and the deep processes, including partial melting and mantle metasomatism, of the subcontinental lithospheric mantle beneath the Tuoyun Basin are analyzed. In the northern edge of the Tarim Basin (southwest Tian-shan), the Mesozoic subcontinental lithosphere which has experienced the effect of partial melting (<10%) and intricate mantle metasomatism is characterized by Phanerozoic ’ocean-type’ mantle. The superposed influence of SiO2-un-saturated silicate melt and carbonate melt probably results in the metasomatic medium which resembles the hydrous silicated carbonate melt in some aspects. By comparing Tuoyun mantle with Cenozoic main mantle beneath eastern China, the properties are similar, while the former shows finer grain and higher diopside content of the peridotites and more conspicuous modal metasomatism. | ZHENG Jianping LU Fengxiang S.Y.O’Reilly LUO Zhaohua | 2001 | Chinese Science Bulletin2001，46，14： | 13 |
| 10 | Isolation and Identification of a Specific cDNA Mapping to the Bam HI-I2 and -LFragments within the Inverted Repeats ofUnique Long Re-gion (IRL) in the Genom e ofMarek′s Disease Herpesvirus (MDV) Oncogenic Strain Beijing-1显示文摘Objective\ To understand the transcription of BamHI L DNA fragment from genome of strong virulent GA strain of Marek′s disease herpesvirus (MDV) in lymphoblastoid tumor tissue induced by oncogenic strain Beijing 1 (a specific local strain in China) of MDV. Methods\ Two oligonucleotide primers were synthesized according to the reported sequence of \%meq\% gene an ideal oncogenic candidate and our previously determined sequence of BamHI L fragment of Marek′s disease herpesvirus (MDV), respectively. Reverse transcriptase PCR(RT PCR) assay was performed by using these primers and the mRNA as a template which was isolated from visceral lymphoblastoid tumors obtained from chickens artificially infected with strain Beijing 1 of oncogenic MDV. Southern blot molecular hybridization was further carried out to detect the product of RT PCR with digoxigenin labeled nucleotide probe from BamHI I2 and L fragment in the gene library of MDV strain GA, respectively. Results\ Two probes could simultaneously hybridize this cDNA amplified by RT PCR with a length of about 730 bp. Conclusion\ It is suggested that \%meq\% transcription could extend from the right hand end of BamHI I2 to the adjacent BamHI L, and the BamHI L region was likely to be transcribed in MDV induced lymphoblastoid tumors. | Lu Chun, Wu Jianping, Zhang Xunhai, et al. Lu Chun, Wu Jianping, Zhang Xunhai, et al. Department of Microbiology and Immunology, Nanjing Medical University, Nanjing\ 210029 Acta Universitatis Medicinalis Nanjing, 19(6):447 | 1999 | The Journal of Biomedical Research1999，23，2： | 13 |
| 11 | China Argo project:progress in China Argo ocean observations and data applications显示文摘This paper reviews the current achievements of the China Argo project. It considers aspects of both the construction of the Argo observing array, float technology, and the quality control and sharing of its data. The developments of associated data products and data applications for use in the fields of ocean, atmosphere, and climate research are discussed, particularly those related to tropical cyclones(typhoons), ocean circulation,mesoscale eddies, turbulence, oceanic heat/salt storage and transportation, water masses, and operational oceanic/atmospheric/climatic forecasts and predictions. Finally, the challenges and opportunities involved in the long-term maintenance and sustained development of the China Argo ocean observation network are outlined.Discussion also focuses on the necessity for increasing the number of floats in the Indian Ocean and for expanding the regional Argo observation network in the South China Sea, together with the importance of promoting the use of Argo data by the maritime countries of Southeast Asia and India. | LIU Zenghong WU Xiaofen XU Jianping LI Hong LU Shaolei SUN Chaohui CAO Minjie | 2017 | Acta Oceanologica Sinica2017，36，6： | 10 |
| 12 | Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin显示文摘Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of biomacromolecules. In this study, two vitamins, thiamine and niacin, are employed to decorate liposomes loaded with insulin, thus facilitating oral absorption via vitamin ligand–receptor interactions. Both vitamins are conjugated with stearamine, which works to anchor the ligands to the surface of liposomes.Liposomes prepared under optimum conditions have a mean particle size of 125–150 nm and an insulin entrapment efficiency of approximately 30%–36%. Encapsulation into liposomes helps to stabilize insulin due to improved resistance against enzymatic disruption, with 60% and 80% of the insulin left after 4 h when incubated in simulated gastric and intestinal fluids, respectively, whereas non-encapsulated insulin is broken down completely at 0.5 h. Preservation of insulin bioactivity against preparative stresses is validated by intra-peritoneal injection of insulin after release from various liposomes using the surfactant Triton X-100. In a diabetic rat model chemically induced by streptozotocin, both thiamine-and niacindecorated liposomes showed a comparable and sustained mild hypoglycemic effect. The superiority of decorated liposomes over conventional liposomes highlights the contribution of vitamin ligands. It is concluded that decoration of liposomes with thiamine or niacin facilitates interactions with gastrointestinal vitamin receptors and thereby facilitates oral absorption of insulin-loaded liposomes. | Haisheng He Yi Lu Jianping Qi Weili Zhao Xiaochun Dong Wei Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 8 |
| 13 | Regional eco-efficiency evaluation and spatial pattern analysis of the Yangtze River Economic Zone显示文摘The environmental ecology of the Yangtze River Economic Zone(YREZ)faces ecological function decline,deterioration and degradation under intense human activities,long-term development and utilization and its economy has developed rapidly over recent decades.Eco-efficiency is considered as a measure of coordinated development of economy,resources,environment and ecology,and is currently considered a very important issue.In this paper,based on the slack-based measure and data envelope analysis model,we take 129 prefecture-level cities of the YREZ as the study unit and measure the eco-efficiency of the YREZ in 2000,2005,2010 and 2015,which considers undesired output.The evaluation of the status quo of the regional eco-efficiency development was carried out at provincial,prefectural and city scales.The spatial autocorrelation test model and standard deviation ellipse were used to analyze the spatially distributed characteristics and the evolutionary regularity of eco-efficiency.Our study suggested that the eco-efficiency value varied significantly at different spatiotemporal scales and the overall distribution presented an'N-shaped'pattern,the value is the largest downstream and the smallest upstream.Regional eco-efficiency presented certain volatility in growth and a clear spatial positive agglomeration trend from 2000 to 2015.The spatial distribution of each agglomeration area was also significantly different,forming some high-high agglomeration areas at the center of the shaft with Shanghai and surrounding cities,and some low-low agglomeration areas at the center with middle reaches and upstream cities.The low-high over-aggregation and high-low polarization clusters were fewer.At the same time,with the change of the research period,the degree of positive agglomeration became increasingly pronounced and the eco-efficiency gap of the neighborhoodunit reduced.The regional eco-efficiency value of the YREZ presented a spatial distribution pattern in the northeast-southwest axis and the evolutionary pattern of the regional eco-efficiency similarly showed a northeast-southwest orientation. | HA Lin TU Jianjun YANG Jianping XU Chunhai PANG Jiaxing LU Debin YAO Zuolin ZHAO Wenyu | 2020 | Journal of Geographical Sciences2020，30，7： | 8 |
| 14 | Garnet-bearing Granulite Facies Rock Xenoliths from Late Mesozoic Volcaniclastic Breccia, Xinyang, Henan Province显示文摘This paper presents the primary results of petrologic,mineralogical and petrochemical studies of garnet beating granulite facies rock xenoliths from Xinyang, Henan Province. These xenoliths, which are found in a pipe of late Mesozoic volcaniclastic breccia, are of high density (3.13-3.30 g/cm3) and high seismic velocity (Vp = 7.04-7.31 km/s), being products of underplating of basaltic magmas and had experienced granulite facies metamorphism. The underplating and metamorphism took place before the eruption of the host rock. Petrographical studies and equilibrium T-P calculations show that these xenoliths were captured at a 49 km depth and experienced at least a 16 km uplift before they were captured. The dynamics of the uplift could be related to the continent-continent collision between the North China plate and the Yangtze plate during the Triassic. | ZHENG Jianping, SUN Min, LU Fengxiang, WANG Chunyangand ZHONG Zengqiu Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China Department of Earth Sciences, The University of Hong Kong, China | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 7 |
| 15 | Effect and quantitative evaluation of CO_2 derived from organic matter in coal on the formation of tight sandstone reservoirs显示文摘Tight reservoirs are widely distributed, especially in coal measure strata. Identification of the densification mechanism of the tight sandstone reservoirs is critical in effectively exploring and exploiting tight gas/oil resources. In this study, the gas formation from type Ⅲ organic matter in coal was kinetically modeled for the whole diagenetic stage, from the shallow buried biogas generation stage to the deep buried thermal gas generation stage. The results demonstrated that during hydrocarbon formation, quantities of non-hydrocarbon gases, such as CO2 , were generated. The proportion of CO2 is about 50%-70% of that of the C1-5 , which far exceeds the CO2 content (0-5%) in the natural gas in the sedimentary basins. Geological case study analysis showed that a considerable part of the 'lost' gaseous CO2 was converted into carbonate cement under favorable environments. Under the ideal conditions, the volume of the carbonate cement transformed from total CO 2 generated by 1 m 3 coal (Junggar Basin Jurassic, TOC 67%) can amount to 0.32 m 3 . Obviously, this process plays a very important role in the formation of tight sandstone reservoirs in the coal measures. Our results also show that the kinetic generation processes of C1-5 and CO2 are asynchronous. There are two main stages of CO2 generation, one at the weak diagenetic stage and the other at the over-mature stage, which are different from large-scale multi-stage hydrocarbon gas generation. Therefore, we can understand the mechanism of tight gas charging by determining the filling time for a tight gas reservoir and the key period of CO2 generation. Further analysis and correlation studies of a specific region are of great significance for determining the mechanism and modeling gas charging in tight reservoirs. It should be noted that the formation of tight sandstone reservoirs is the combined result of complex organic-inorganic and water-rock-hydrocarbon interactions. The details of spatial and temporal distributions of the carbonate cement derived from the organic CO2 , which combines with metal ions (Ca/Mg/Fe) in the formation water, should be further investigated. | SHUAI YanHua ZHANG ShuiChang GAO Yang LU Hong CHEN JianPing MI JingKui LIU JinZhong HU GuoYi | 2013 | Science China Earth Sciences2013，56，5： | 7 |
| 16 | Examples of unusual ionospheric observations by the CSES prior to earthquakes显示文摘The CSES(China seismic electromagnetic satellite) was launched on February 2, 2018 in a circular polar orbit at an altitude of~507 km. One of the main objectives of CSES is to search for and characterize ionospheric perturbations that can be associated with seismic activities, to better understand the generation mechanism of such perturbations. Its scientific payload can measure a broad frequency range of electromagnetic waves and some important plasma parameters. This paper is a first-hand study of unusual observations recorded by the CSES over seismic regions prior to four earthquakes with M >7.0 since the satellite's launch. CSES detectors measured irregularities near the epicenter of these four earthquakes. It is already clear that data from instruments onboard the CSES will be of significant help in studies of characteristics of ionospheric perturbations related to earthquakes and their generation mechanisms. | Rui Yan XuHui Shen JianPing Huang Qiao Wang Wei Chu DaPeng Liu YanYan Yang HengXin Lu Song Xu | 2018 | Earth and Planetary Physics2018，2，6： | 7 |
| 17 | 16 × 16 silicon Mach–Zehnder interferometer switch actuated with waveguide microheaters显示文摘We experimentally demonstrate a 16 × 16 reconfigurably nonblocking optical switch fabric using a Benes architecture. The switch fabric consists of 56 2 × 2 Mach–Zehnder interferometer based elementary switches, with each integrated with a pair of waveguide microheaters. The average on-chip insertion loss is ~5.2 dB for both of the 'all-cross' and the 'all-bar' states, with a loss variation of 1 dB over all routing paths. The cross talk for all switching states is better than -30 d B. The switching time of the switch element is about 22 μs. The switching functionality is verified by transmission of a 40 Gb∕s quadrature phase-shift keying optical signal. | Shuoyi Zhao Liangjun Lu Linjie Zhou Dong Li Zhanzhi Guo Jianping Chen | 2016 | Photonics Research2016，4，5： | 7 |
| 18 | Effect of Landform on Seasonal Temperature Structures across China in the Past 52 Years显示文摘The data of 160 national meteorological observatory stations including the long-term monthly temperature data in China were analyzed to study the seasonal variation of the spatial temperature structures across China in the past half century. It is found that temperature structures differ between seasons: a latitude temperature pattern in winter and a landform temperature pattern in summer, which indicate that the effect of landform on temperature structure is much stronger in summer than that in winter and the effect of latitudinal temperature is much stronger in winter than that in summer. The mechanisms of the seasonal difference in temperature structures are also discussed in this paper. | LU Aigang PANG Deqian GE Jianping HE Yuanqing PANG Hongxi YUAN Lingling | 2006 | Journal of Mountain Science2006，3，2： | 7 |
| 19 | CL and FTIR analysis on the diamonds in Wafangdian, Liaoning Province显示文摘The CL images show that the internal structures of the diamonds in Wafangdian, Liaoning Province is classified as three types: simple growth girdle zone, multi-stage growth complex girdle zone, and rare agate-like structure. These internal features reflect the complexity of growth processes of the diamonds. The FTIR analyses in micro area on diamond plates reveal the heterogeneity of the impurities of nitrogen and hydrogen. The variety of nitrogen contents and nitrogen aggregation states have been revealed not only in different diamonds from one kimberlite pipe but also in different zones of one diamond. The extent of conversion A defects to the aggregated B form is a function of the nitrogen aggregation temperature (TNA), mantle residence time (tMR), and nitrogen concentration of diamond. The interval of 0.6-0.7Ga from core to rim of diamond growth is obtained by using the FTIR curves and some geological data. The long period of diamond growth is identical with the feature in CL image. | CHEN Meihua LU Fengxiang DI Jingru ZHENG Jianping | 2000 | Chinese Science Bulletin2000，45，21： | 6 |
| 20 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
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