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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first-line treatment of advanced esophageal squamous cell carcinoma显示文摘Background:Effective therapeutic options are limited for patients with advanced esophageal squamous cell carcinoma(ESCC).The incorporation of an immune checkpoint inhibitor and a molecular anti-angiogenic agent into the commonly adopted chemotherapy may produce synergistic effects.Therefore,we aimed to investigate the efficacy and safety of camrelizumab plus apatinib combined with chemotherapy as the first-line treatment of advanced ESCC.Methods:In this single-arm prospective phase II trial,patients with unresectable locally advanced or recurrent/metastatic ESCC received camrelizumab 200 mg,liposomal paclitaxel 150 mg/m2,and nedaplatin 50 mg/m2 on day 1,and apatinib 250 mg on days 1-14.The treatments were repeated every 14 days for up to 9 cycles,followed by maintenance therapy with camrelizumab and apatinib.The primary endpoint was objective response rate(ORR)according to the Response Evaluation Criteria in Solid Tumors(version 1.1).Secondary endpoints included disease control rate(DCR),progression-free survival(PFS),overall survival(OS),and safety.Results:We enrolled 30 patients between August 7,2018 and February 23,2019.The median follow-up was 24.98 months(95%confidence interval[CI]:23.05-26.16 months).The centrally assessed ORR was 80.0%(95%CI:61.4%-92.3%),with a median duration of response of 9.77 months(range:1.54 to 24.82+months).The DCR reached 96.7%(95%CI:82.8%-99.9%).The median PFS was 6.85 months(95%CI:4.46-14.20 months),and the median OS was 19.43 months(95%CI:9.93 months–not reached).The most common grade 3-4 treatmentrelated adverse events(AEs)were leukopenia(83.3%),neutropenia(60.0%),and increased aspartate aminotransferase level(26.7%).Treatment-related serious AEs included febrile neutropenia,leukopenia,and anorexia in one patient(3.3%),and single cases of increased blood bilirubin level(3.3%)and toxic epidermal necrolysis(3.3%).No treatment-related deaths occurred.Conclusions:Camrelizumab plus apatinib combined with liposomal paclitaxel and nedaplatin as first-line treatment demonstrated feasible anti-tumor activity and manageable safety in patients with advanced ESCC.Randomized trials to evaluate this new combination strategy are warranted.Trial registration:This trial was registered on July 27,2018,at ClinicalTrials.gov(identifier:NCT03603756). | Bo Zhang Ling Qi Xi Wang Jianping Xu Yun Liu Lan Mu Xingyuan Wang Lidan Bai Jing Huang | 2020 | Cancer Communications2020，40，12： | 38 |
| 3 | New chaotic system and its hyperchaos generation显示文摘To seek for lower-dimensional chaotic systems that have complex topological attractor structure with simple algebraic system structure, a new chaotic system of three-dimensional autonomous ordinary differential equations is presented. The new system has simple algebraic structure, and can display a 2-scroll attractor with complex topological structure, which is different from the Lorenz's, Chen's and Lu¨'s attractors. By introducing a linear state feedback controller, the system can be controlled to generate a hyperchaotic attractor. The novel chaotic attractor, hyperchaotic attractor and dynamical behaviors of corresponding systems are further investigated by employing Lyapunov exponent spectrum, bifurcation diagram, Poincar′e mapping and phase portrait, etc., and then verified by simulating an experimental circuit. | Bao Bocheng Liu Zhong Xu Jianping | 2009 | Journal of Systems Engineering and Electronics2009，20，6： | 34 |
| 4 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 5 | An upper ocean response to Typhoon Bolaven analyzed with Argo profiling floats显示文摘In situ observations from Argo profiling floats combined with satellite retrieved SST and rain rate are used to investigate an upper ocean response to Typhoon Bolaven from 20 through 29 August 2012. After the passage of Typhoon Bolaven, the deepening of mixed layer depth(MLD), and the cooling of mixed layer temperature(MLT) were observed. The changes in mixed layer salinity(MLS) showed an equivalent number of increasing and decreasing because the typhoon-induced salinity changes in the mixed layer were influenced by precipitation, evaporation, turbulent mixing and upwelling of thermocline water. The deepening of the MLD and the cooling of the MLT indicated a significant rightward bias, whereas the MLS was freshened to the left side of the typhoon track and increased on the other side. Intensive temperature and salinity profiles observed by Iridium floats make it possible to view response processes in the upper ocean after the passage of a typhoon. The cooling in the near-surface and the warming in the subsurface were observed by two Iridium floats located to the left side of the cyclonic track during the development stage of the storm, beyond the radius of maximum winds relative to the typhoon center. Water salinity increases at the base of the mixed layer and the top of the thermocline were the most obvious change observed by those two floats. On the right side of the track and near the typhoon center when the typhoon was intensified, the significant cooling from sea surface to a depth of 200×104 Pa, with the exception of the water at the top of the thermocline, was observed by the other Iridium float. Owing to the enhanced upwelling near the typhoon center, the water salinity in the near-surface increased noticeably. The heat pumping from the mixed layer into the thermocline induced by downwelling and the upwelling induced by the positive wind stress curl are the main causes for the different temperature and salinity variations on the different sides of the track. It seems that more time is required for the anomalies in the subsurface to be restored to pretyphoon conditions than for the anomalies in the mixed layer. | LIU Zenghong XU Jianping SUN Chaohui WU Xiaofen | 2014 | Acta Oceanologica Sinica2014，33，11： | 23 |
| 6 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 7 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 8 | Effects of insoluble Zn,Cd,and EDTA on the growth,activities of antioxidant enzymes and uptake of Zn and Cd in Vetiveria zizanioides显示文摘A root-bag experiment was conducted to study the effects of insoluble Zn,Cd,and ethylenediaminetetraacetic acid(EDTA) on the plant growth,activities of antioxidant enzymes,proline,glutathione(GSH),water-soluble proteins and malondialdehyde(MDA) of Vetiveria zizanioides.The V.zizanioides uptake capacity of Zn and Cd also determined.The results showed that plant growth of V.zizanioides was inhibited by Zn and Cd.The shoot dry weight(SDW) and root dry weight(RDW) decrease by 14.2%,14.1%,17.0% and 17.3%,32.5%,35.7%,respectively,compared to the control without EDTA addition.After adding EDTA,shoot and root dry weight decreased over 10% and 15%,respectively.The toxicity from insoluble Zn and Cd in soil on SDW and RDW of V.zizanioides was in order:Zn+Cd > Cd > Zn.The activities of superoxide dismutase(SOD),peroxidase(POD) and catalase(CAT),and contents of MDA and proline increased significantly,while the contents of GSH and water-soluble proteins decreased markedly with increasing Zn and Cd toxicity.With EDTA,shoot and root Zn concentrations increased in the Zn treatment by 7.3% and 37.4%,and Cd concentrations in the combined Zn and Cd treatment increased by 18.6% and 391.9% compared to the treatment without EDTA.However,Zn and Cd concentrations in shoot and roots decreased in the Cd treatment compared to the plants grown in absence of EDTA,with exception of root Cd concentration in the presence of EDTA. | XU Weihong LI Wenyi HE Jianping Balwant Singh XIONG Zhiting | 2009 | Journal of Environmental Sciences2009，21，2： | 16 |
| 9 | Consensus among Chinese experts on standard interventional therapy for deep venous thrombosis of lower extremity(second edition)显示文摘This is an update on the first edition of the expert consensus. This document discusses the indications and contraindications of interventional treatment methods for deep venous thrombosis such as anticoagulation, catheter-directed thrombolysis, percutaneous mechanical thrombectomy, percutaneous transluminal angioplasty and stent implantation. The operational procedures, considerations, preoperative management, and prevention of complications were also updated, supplemented, and revised. Emphasis is placed on the interventional treatment of acute and subacute deep venous thrombosis to effectively reduce the incidence of post-thrombosis syndrome. | Jianping Gu Ke Xu Gaojun Teng | 2018 | Journal of Interventional Medicine2018，1，3： | 16 |
| 10 | Dynamics analysis of chaotic circuit with two memristors显示文摘Based on Chua’s chaotic oscillation circuit, a fifth-order chaotic circuit with two memristors is designed and its corresponding dimensionless mathematic model is established. By using conventional dynamical analysis methods, stability analysis of the equilibrium set of the circuit is performed, the distribution of stable and unstable regions corresponding to the memristor initial states is achieved, and the complex dynamical behaviors of the circuit depending on the circuit parameters and the memristor initial states are investigated. The theoretical analysis and numerical simulation results demonstrate that the proposed chaotic circuit with two memristors has an equilibrium set located on the plane constituted by the inner state variables of two memristors. The stability of the equilibrium set depends on both the circuit parameters and the initial states of the two memristors. Rich nonlinear dynamical phenomena, such as state transitions, transient hyperchaos and so on, are expected. | BAO BoCheng SHI GuoDong XU JianPing LIU Zhong PAN SaiHu | 2011 | Science China(Technological Sciences)2011，54，8： | 13 |
| 11 | An effective method for improving the accuracy of Argo objective analysis显示文摘基于南船座数据的最佳的插值目的分析,改进被做到广泛地在数据吸收和客观分析系统使用的一个背景错误协变性矩阵的实验公式。明确地,关联的一个评价可伸缩那能有效地改善南船座客观分析的精确性被开发了。这个方法能自动地适应一个变量的坡度变化并且被叫作坡度依赖者关联规模方法。它南船座客观分析上的效果与 Gaussian 脉搏和光谱分析理论上被验证。一个维的模拟实验的结果证明坡度依赖者关联规模能改进客观分析系统的适应性,为充分吸收在有更大的海洋学的坡度的区域的观察的短波信息的分析计划使它可能。新计划在太平洋被用于南船座数据目的分析系统。结果显然被改进。 | ZHANG Chunling XU Jianping BAO Xianwen WANG Zhenfeng | 2013 | Acta Oceanologica Sinica2013，32，7： | 11 |
| 12 | Clearance Influence on Dynamic Response of Intermittent Roller Chain Drive显示文摘The clearances appear in chain link hinges induced by manufacturing tolerance or wear of components are the most important factor that influences the dynamic performance of the intermittent roller chain drives.Due to the existence of the clearances in chain link hinges,the serious impact vibration phenomenon which influences the stability and the position accuracy of the chain drive system would be caused in the intermittent motion.But,the problem may be that a reasonable modeling on the chain with clearances is difficult due to the large clearance's number in chain system and the fact that the clearance' size are different.Currently,the studies on the dynamics of the intermittent roller chain considering the multi-clearance' joints are rare.Most research works have only focused on the constant moving chains.Taking the intermittent roller chain system as an object,this paper designs and builds the experimental device of this kind of mechanical system.The Longitudinal vibration response of the intermittent chain under the different motion laws was tested.The experimental study shows that the clearances presented in chain link hinges can cause severe impact vibration in the intermittent motion of chain.In subsequent work,the dynamic model of the intermittent roller chain system with the multi-clearance' joints was established.By calculating the dynamic response of this kind of mechanical system under the different motion laws,the effect of the clearances on the dynamic response of the intermittent chain drive system was analyzed.The theoretical simulation shows that the serious impact vibration phenomenon of the chain system can be caused by the clearances at the start accelerating period,and the chain drive system is often accompanied by the severe shock and vibration at the moment that the chain moves from the acceleration period to deceleration period.The research conclusions made by the experimental and theoretical studies indicate that the use of motion laws with small and continuous jerk at conversion point can effectively suppress the impact vibration at this point caused by clearances' effect.Additionally,the use of nonsymmetrical motion laws with small jerk approaching the end of the indexing period can obtain a smaller residual vibration.The presented motion law can provide an important reference for the improvement of the dynamic performance of the intermittent chain drive systems. | XU Lixin YANG Yuhu CHANG Zongyu SHEN Zhaoguang LIU Jianping | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 11 |
| 13 | Placement optimization of actuator and sensor and decentralized adaptive fuzzy vibration control for large space intelligent truss structure显示文摘Large space truss structure is widely used in spacecrafts.The vibration of this kind of structure will cause some serious problems.For instance,it will disturb the work of the payloads which are supported on the truss,even worse,it will deactivate the spacecrafts.Therefore,it is highly in need of executing vibration control for large space truss structure.Large space intelligent truss system(LSITS) is not a normal truss structure but a complex truss system consisting of common rods and active rods,and there are at least one actuator and one sensor in each active rod.One of the key points in the vibration control for LSITS is the location assignment of actuators and sensors.The positions of actuators and sensors will directly determine the properties of the control system,such as stability,controllability,observability,etc.In this paper,placement optimization of actuators and sensors(POAS) and decentralized adaptive fuzzy control methods are presented to solve the vibration control problem.The electro-mechanical coupled equations of the active rod are established,and the optimization criterion which does not depend upon control methods is proposed.The optimal positions of actuators and sensors in LSITS are obtained by using genetic algorithm(GA).Furthermore,the decentralized adaptive fuzzy vibration controller is designed to control LSITS.The LSITS dynamic equations with considering those remaining modes are derived.The adaptive fuzzy control scheme is improved via sliding control method.One T-typed truss structure is taken as an example and a demonstration experiment is carried out.The experimental results show that the GA is reliable and valid for placement optimization of actuators and sensors,and the adaptive fuzzy controller can effectively suppress the vibration of LSITS without control spillovers and observation spillovers. | LI DongXu LIU Wang JIANG JianPing XU Rui | 2011 | Science China(Technological Sciences)2011，54，4： | 10 |
| 14 | A New Species of the Asian Toad Genus Megophrys sensu lato(Amphibia: Anura: Megophryidae) from Guizhou Province, China显示文摘We describe a new species of the genus Megophrys sensu lato from Guizhou Province, China. Molecular phylogenetic analyses based on mitochondrial DNA and nuclear DNA sequences all strongly supported the new species as an independent lineage in Megophrys(Panophrys) clade. The new species is distinguished from its congeners by a combination of the following morphological characteristics:(1) small body size with SVL < 38.8 mm in male and SVL < 42.3 mm in female;(2) vomerine teeth absent;(3) tongue not notched behind;(4) a small horn-like tubercle at the edge of each upper eyelid;(5) tympanum distinctly visible, rounded;(6) two metacarpal tubercles in hand;(7) relative finger lengths: II < I < V < III;(8) toes with rudimentary webbing at bases;(9) heels overlapping when thighs are positioned at right angles to the body;(10) tibiotarsal articulation reaching the level between tympanum to eye when leg stretched forward;(11) an internal single subgular vocal sac in male;(12) in breeding male, the nuptial pads with black nuptial spines on the dorsal bases of the first and second fingers. | Shize LI Ning XU Jing LIU Jianping JIANG Gang WEI Bin WANG | 2018 | Asian Herpetological Research2018，9，4： | 10 |
| 15 | China Argo project:progress in China Argo ocean observations and data applications显示文摘This paper reviews the current achievements of the China Argo project. It considers aspects of both the construction of the Argo observing array, float technology, and the quality control and sharing of its data. The developments of associated data products and data applications for use in the fields of ocean, atmosphere, and climate research are discussed, particularly those related to tropical cyclones(typhoons), ocean circulation,mesoscale eddies, turbulence, oceanic heat/salt storage and transportation, water masses, and operational oceanic/atmospheric/climatic forecasts and predictions. Finally, the challenges and opportunities involved in the long-term maintenance and sustained development of the China Argo ocean observation network are outlined.Discussion also focuses on the necessity for increasing the number of floats in the Indian Ocean and for expanding the regional Argo observation network in the South China Sea, together with the importance of promoting the use of Argo data by the maritime countries of Southeast Asia and India. | LIU Zenghong WU Xiaofen XU Jianping LI Hong LU Shaolei SUN Chaohui CAO Minjie | 2017 | Acta Oceanologica Sinica2017，36，6： | 10 |
| 16 | Cd uptake in rice cultivars treated with organic acids and EDTA显示文摘A pot experiment was conducted to examine the activity of antioxidant enzymes, the content of malondialdehyde (MDA), proline and protein, and Cd uptake in different rice cultivars exposed to Cd (0, 1 and 5 mg/kg) in the presence of organic acids and ethylenediamine tetraacetic acid (EDTA). The results showed the increase in activity of dismutase (SOD), contents of proline and protein but a decline in activities of peroxidase (POD) and catalase (CAT), and MDA content for cultivars Xiushui63 and IIyou527. The resistance to Cd was higher in Xiushui63 than that in IIyou527 under the same Cd treatment. Cadmium contents in grain, straw and roots of both cultivars were markedly reduced in the presence of organic acids and EDTA. Grain Cd contents was the highest for plants treated with organic acids, followed by organic acids + 1/2EDTA, and the lowest with EDTA; Cd contents in straw and root were the lowest for plants treated with organic acids, followed by organic acids + 1/2EDTA, and the highest with EDTA treatment when exposed to Cd. | Weihong Xu Yangrui Li Jianping He Qifu Ma Xiaojing Zhang Guiqing Chen Huixian Wang Haibo Zhang | 2010 | Journal of Environmental Sciences2010，22，3： | 9 |
| 17 | Conventional versus drug-eluting bead transarterial chemoembolization:A better option for treatment of unresectable hepatocellular carcinoma显示文摘Transarterial chemoembolization(TACE) is a minimally invasive procedure involving intra-arterial catheter-based chemotherapy to selectively administer high doses of cytotoxic drugs to the tumor bed along with ischemic necrosis induced by arterial embolization.Chemoembolization forms the essential core of management in patients with hepatocellular carcinoma(HCC) who are not suitable for curative therapies such as transplantation,resection,or percutaneous ablation.TACE of hepatic cancer(s) has proven to be helpful in achieving local tumor control,and has supported the ability to prevent tumor progression,prolong patient life,and manage patient symptoms.Recent data have demonstrated that,in patients with single-nodule HCC ≤3 cm without vascular invasion,the 5-year overall survival with TACE was found to be comparable with hepatic resection and radiofrequency ablation.Used for several years,Lipiodol continues to play a vital role as a tumor-seeking and radiopaque drug delivery vector in interventional oncology.Efforts have been made to enhance the administration of chemotherapeutic agents to tumors.Compared with conventional TACE,drug-eluting bead TACE is a fairly new drug delivery embolization technique that permits fixed dosing and has the ability to provide sustained release of anticancer agents over a period of time.The present review discusses the basic procedure of TACE and its properties,and the effectiveness of conventional and drug-eluting bead chemoembolization systems currently available or presently undergoing clinical evaluation. | Murtuza Razi Gu Jianping He Xu Mohammed Jameeluddin Ahmed | 2021 | Journal of Interventional Medicine2021，4，1： | 9 |
| 18 | The Impacts of Permafrost Change on NPP and Implications:A Case of the Source Regions of Yangtze and Yellow Rivers显示文摘This paper studies the relationship between net primary productivity (NPP) and annual average air temperature (GT) at 0cm above ground in permafrost regions by using revised Chikugo NPP model,cubic spline interpolating functions,and non-linear regression methods.The source regions of the Yangtze and Yellow Rivers were selected as the research areas.Results illustrate that:(1) There is significant non-linear relationship between NPP and GT in various typical years;(2) The maximum value of NPP is 6.17,5.87,7.73,and 5.41 DM·t·hm-2 ·a-1 respectively,and the corresponding GT is 7.1,10.0,21.2,and 8.9 o C respectively in 1980,1990,2000 and 2007;(3) In 1980,the sensitivity of NPP to GT is higher than in 1990,2000 and 2007.This tendency shows that the NPP presents change from fluctuation to an adaptation process over time;(4) During 1980~2007,the accumulated NPP was reduced to 8.05,and the corresponding carrying capacity of theoretical livestock reduced by 11%;(5) The shape of the demonstration region of ecological compensation system,livelihood support system,and science appraisal system in the source regions of Yangtze and Yellow Rivers are an important research for increasing the adaptation capacity and balancing protection and development. | FANG Yiping QIN Dahe DING Yongjian YANG Jianping XU Keyan | 2011 | Journal of Mountain Science2011，8，3： | 9 |
| 19 | Investigation on Uniaxial Tensile Instability of USIBOR1500 Steel Sheets at Elevated Temperature显示文摘In the sheet forming process with stretch, diffuse instability and localized instability usually occur in the process one after another. The necking rate has a great impact on the instability process and the forming limits of the rate sensitive material, such as USIBOR1500 steel sheets at elevated temperature. The available reports about this steel mainly focus on hot uniaxial tensile, martensitic transformation and forming process, but there are few investigations on instability behavior and forming limits. Based on Inoue Kachiro’s flow stress constitutive model at elevated temperature, combined with Swift’s diffuse instability rule and Hill’s localized instability rule, the relation is theoretically deduced between the diffuse necking rate along with the localized necking rate and the exponent of strain rate sensitivity together with the strain rate in the case of the USIBOR1500 steel sheets at elevated temperature. According to the time–temperature characteristics of the hot stamping process, tensile tests of the steel sheets were carried out on Gleeble3800, and the stress–strain curves were obtained at different temperatures and different strain rates. Then the values of the exponent of strain rate sensitivity and the hardening exponent were obtained through fitting the curves by least squares. The tests also helped to provide the distribution laws of the major strain of the specimens and the uniform strains as well as the necking width. The uniform strains obtained from the tests are matched well with the theoretical calculations. | MIN Junying LIN Jianping TIAN Haobin SUN Guohua XU Zhou | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 9 |
| 20 | Features of the fault system and its relationship with migration and accumulation of hydrocarbon in Liaodong Bay显示文摘The fault system of Liaodong Bay developed extensively under the control of the Tanlu Fault.The fault system can be grouped into strike-slip faults of grade I,trunk faults of grade II and branch faults (induced faults) of grade III respectively based on its developmental scale.The faults of grade I and II were deep,early and large while the faults of grade III were shallow,late and small.The formation,evolution and distribution features played a significant role in controlling the migration of oil and gas in both horizontal and vertical directions.The fluid transfer in the fault system occurred in the process of faulting.The strike-slip and trunk faults moved actively forming predominant pathways for oil and gas migration.The branch faults,with weak activity,generally controlled the development of traps and were beneficial for the accumulation and preservation of oil and gas.The faults of grade I and II formed the major migration pathways for oil and gas,but their fault activity rates appeared to vary along their strikes.The zones with a relatively low fault activity rate might be favorable for oil and gas accumulation.When the activities of strike-slip,trunk,and branch faults came to a halt,the fault seal behavior had a vitally important effect on the accumulation of oil and gas.The controlling role of the fault over fluid distribution was further analyzed by calculating the fault activity quantitatively. | Xu Guosheng Ma Ruolong Gong Deyu Zhou Donghong Li Jianping Guo Yonghua Yuan Haifeng Wu Changrong | 2011 | Petroleum Science2011，8，3： | 8 |
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