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| 1 | Screen efficiency comparisons of decision tree and neural network algorithms in machine learning assisted drug design显示文摘In view of huge search space in drug design, machine learning has become a powerful method to predict the affinity between small molecular drug and targeting protein with the development of artificial intelligence technology. However, various machine learning algorithms including massive different parameters make the prediction framework choice to be quite difficult. In this work, we took a recent drug design competition(from XtalPi company on the DataCastle platform) as the typical case to find the optimized parameters for different machines learning algorithms and the most effective algorithm. After the parameter optimizations, we compared the typical machine learning methods as decision tree(XGBoost, LightGBM) and artificial neural network(MLP, CNN) with root-mean-square error(RMSE) and coefficient of determination(R^2) evaluation. As a result, decision tree is more effective than the neural network as LightGBM>XGBoost>CNN>MLP in the affinity prediction of the specific drug design problem with ~160000 samples. For a much larger screening task in a more complicated drug design study, the sophisticated neural network model may go beyond the decision tree algorithm after generalization enhancing and overfitting reducing. The advanced machine learning methods could extract more information of protein-ligand bindings than traditional ones and improve the screen efficiency of drug design up to 200–1000 times. | Qiumei Pu Yinghao Li Hong Zhang Haodong Yao Bo Zhang Bingji Hou Lin Li Yuliang Zhao Lina Zhao | 2019 | Science China Chemistry2019，62，4： | 5 |
| 2 | Restless legs syndrome following the use of ziprasidone: a case report显示文摘Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of RLS.We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate.The patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/day.Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded.Clinicians should be aware of the potential for ziprasidone-induced RLS.Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS. | Cuizhen Zhu Ran Bi Yuliang Hu Hui Zhou Daomin Zhu Brian Isaacson Qingwei Li Yezhe Lin | 2020 | General Psychiatry2020，33，2： | 3 |
| 3 | Heterostructured ZnFe_2O_4/Fe_2TiO_5/TiO_2 Composite Nanotube Arrays with an Improved Photocatalysis Degradation Efficiency Under Simulated Sunlight Irradiation显示文摘To improve the visible light absorption and photocatalytic activity of titanium dioxide nanotube arrays(TONTAs), ZnFe_2O_4(ZFO) nanocrystals were perfused into pristine TONTA pipelines using a novel bias voltageassisted perfusion method. ZFO nanocrystals were well anchored on the inner walls of the pristine TONTAs when the ZFO suspensions(0.025 mg m L^(-1)) were kept under a60 V bias voltage for 1 h. After annealing at 750 °C for2 h, the heterostructured ZFO/Fe_2 TiO_5(FTO)/TiO_2 composite nanotube arrays were successfully obtained. Furthermore, Fe^(3+)was reduced to Fe^(2+)when solid solution reactions occurred at the interface of ZFO and the pristine TONTAs. Introducing ZFO significantly enhanced thevisible light absorption of the ZFO/FTO/TONTAs relative to that of the annealed TONTAs. The coexistence of type I and staggered type II band alignment in the ZFO/FTO/TONTAs facilitated the separation of photogenerated electrons and holes, thereby improving the efficiency of the ZFO/FTO/TONTAs for photocatalytic degradation of methylene blue when irradiated with simulated sunlight. | Kun Xiong Kunzhou Wang Lin Chen Xinqing Wang Qingbo Fan Jérémie Courtois Yuliang Liu Xianguo Tuo Minhao Yan | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 4 | Development of powdery mildew resistant derivatives of wheat variety Fielder for use in genetic transformation显示文摘Genetic transformation is widely used to improve target traits and to study gene function in wheat.However,transformation efficiency depends on the physiological status of the recipient genotype and that is affected by several factors including powdery mildew(PM)infection.The widely used recipient variety Fielder is very susceptible to PM.Therefore,it would be beneficial to develop PM resistant derivatives with high regeneration ability for use in genetic transformation.In the present study PM resistant lines CB037 and Pm97033 carrying genes Pm21 and PmV,respectively,were backcrossed to Fielder with selection for PM resistance.Five lines,NT89,NT90,NT154,and WT48 with Pm21 and line FL347 with PmV were developed,identified by molecular markers and genomic in situ hybridization(GISH)or fluorescent in situ hybridization(FISH),and further subjected to detailed assessment of agronomic traits and regeneration ability following genetic transformation capacity.Lines FL347,WT48,NT89 and NT154 assessed as being equal to,or superior,to Fielder in regeneration and transformation ability are recommended as suitable materials for the replacement of Fielder for wheat gene transfer and genome editing study. | Xiaona Liang Xiaomin Bie Yuliang Qiu Ke Wang Zujun Yang Yuqi Jia Zhiying Xu Mei Yu Lipu Du Zhishan Lin Xingguo Ye | 2023 | The Crop Journal2023，11，2： | 2 |
| 5 | Micros true ture and Elec tron Conduction Mechanism of Hydrogenated Nano-crystalline Silicon Films显示文摘The hydrogeunted nano-crystalline silicou(nc-Si:H)fims have been deposited with plasma cnl hanced chenuical vapor depositioi method.The microstrncture of tluese films las bcen studied by trausnission electrol microscopy and high resolution trans-mission electron nicroscopy.The nc-Si:H filuus slow fiber tex ture structure.The fractal dimeision of this structure lus bccn cnlculated witl it Fouricr filtered inuage.The relatiouship betwecn conductivity and temperature las also been studied and the mechnnisi of clectron conuduction is cdiscussed. | HE Yuliang(Y.L.HE) CHU Yining(Y.M.CHU) LIN Hongyi(H.Y.LIN) JIANG Shusheng(S.S.JIANG) | 1993 | Chinese Physics Letters1993，10，9： | 2 |
| 6 | The machine protection system for CSNS显示文摘Background The China Spallation Neutron Source(CSNS)accelerator consists of an 80 MeV H-LINAC,a 1.6 GeV rapid cycling synchrotron(RCS)and two beam transport lines.The uncontrolled beam may permanently damage the components or lead to very high residual radiation dose along the beam line.So the equipment protection must be deliberately designed and implemented.Purpose The machine protection system(MPS)protects components from being damaged by the beam.The response time requirement for the CSNS MPS is less than 20 ms,so the PLC(programmable logic controller)was adopted to implement the interlock logic.Methods The MPS was implemented as a two-tier architecture system,and developed through utilizing PLC and Experimental Physics and Industrial Control System(EPICS)software toolkits.The application logic was taken into careful consideration during the implementation stage.An embedded CPU module can function as an IOC accessing PLC I/O modules through the sequence CPU,with an embedded Linux operation system.Results The interlock logic and heartbeat functions were tested with all functions ok.Time consumption has been measured thoroughly since the important requirement,which is around 15 ms to stop the beam.Conclusions MPS was completed in Sep.2017 and then put into operation.It has been operating smoothly for more than 3 years.MPS has played an important role in every stage of CSNS’s commissioning and operation and achieved high reliability during the user’s experiment operation.The accelerator recently runs stably with low equipment failure. | Kang Mingtao Zhang Yuliang Jin Dapeng He Yongcheng Zhan Mingchuan Zhu Peng Wu Xuan Guo Fengqin Wang Lin | 2021 | Radiation Detection Technology and Methods2021，5，2： | 1 |
| 7 | Study on the internal reflection of the multimode-interference-type device显示文摘 | Yang Lin Liu Yuliang Wang Qiming | 2004 | Optical Engineering2004，43，10： | 1 |
| 8 | Engineering behaviors of reinforced gabion retaining wall based on laboratory test显示文摘 | LIN Yuliang YANG Guolin LI Yun | 2010 | Journal of Central South University of Teetmology2010，17，6： | 1 |
| 9 | Development of a haploid inducer by editing HvMTL in barley显示文摘The doubled-haploid technique mediated by parthenogenesis and androgenesis in plants can directly generate homozygous diploid lines after chromosome doubling with colchicine in one or two generations,and this method undoubtedly shortens the breeding process and improves breeding efficiency in crops.Previously,haploid plants were mainly induced by anther culture or microspore culture via androgenesis(Ohnoutkova et al.,2019).In wheat(Triticum aestivum),haploids can also be induced by maize(Zea mays)pollen and chromosome elimination via parthenogenesis(Liu et al.,2020b).However,the aforementioned induction methods are genotype-dependent,require complex manipulations,and are both time-consuming and inefficient.Therefore,it is necessary to develop new techniques or germplasm for simple and efficient haploid induction. | Huali Tang Yuliang Qiu Wanxin Wang Mei Yu Yanan Chang Zhiyang Han Lipu Du Zhishan Lin Ke Wang Xingguo Ye | 2023 | Journal of Genetics and Genomics2023，50，5： | 1 |
| 10 | Silicon-on-insulator 1×2 Y-junction Optical Switch Basedon Waveguide-vanishing Effect | ZHAO Cezhou (Microelectron. Institute,Xidian University,Xi’an 710071,CHN) LIU Enke,LI Guozheng,LIU Yuliang (Depart.of Electron.Eng.,Xi’an Jiaotong University,Xi’an 710049,CHN) GUO Lin (Sichuan Institute of Solid State Circuits,Chongqing 630060,CH | 1997 | Semiconductor Photonics and Technology1997，3，2： | 1 |
| 11 | Impact modeling ofthe weld line of tailor-welded blank显示文摘 | Shi Yuliang Lin Zhongqin Zhu Ping | 2008 | Materials and Design2008，29，： | 1 |
| 12 | Fabrication of thermooptic variable optical attenuators based on multi- mode interference coupler principle显示文摘 | Lin Yang Yuliang Liu Yi Cheng | 2003 | Optical Engineering Letters2003，42，： | 1 |
| 13 | Simulation and fabrication of thermo-optic variable optical attenuators based on multimode interference coupler显示文摘 | Lin Yang Yuliang Liu Fang Li | 2002 | International Journal of Modem Physics B2002，16，： | 1 |
| 14 | Nucleation and growth of Fe-rich phases in Al-5Ti-1B modified Al-Fe alloys investigated using synchrotron X-ray imaging and electron microscopy显示文摘Plate-like Fe-rich intermetallic phases directly influence the mechanical properties of recycled Al alloys;thus, many attempts have been made to modify the morphology of these phases. Through synchrotron X-ray imaging and electron microscopy, the underlying nucleation and growth mechanisms of Fe-rich phases during the solidification of Al-5 Ti-1 B-modified Al-2 Fe alloys were revealed in this study. The results showed that the Al-5 Ti-1 B grain refiner as well as the applied pressure both resulted in reduction of the size and number of primary Al_(3)Fe phases and promoted the formation of eutectic Al_(6)Fe phases.The tomography results demonstrated that Al-5 Ti-1 B changed the three-dimensional(3 D) morphology of primary Fe-rich phases from rod-like to branched plate-like, while a reduction in their thickness and size was also observed. This was attributed to the fact that Ti-containing solutes in the melts inhibit the diffusion of Fe atoms and the Al_(3)Fe twins produce re-entrant corner on the twin boundaries along the growth direction. Moreover, the TiB_(2) provides possible nucleation sites for Al_6Fe phases. The nucleation mechanism of Fe-rich phases is discussed in terms of experimental observations and crystallography calculations. The decrease in the lattice mismatch between TiB_(2) and Al_(6)Fe phases was suggested, which promoted the transformation of Al_(3)Fe to Al_(6)Fe phases. | Yuliang Zhao Weiwen Zhang Dongfu Song Bo Lin Fanghua Shen Donghai Zheng ChunXiao Xie Zhenzhong Sun Yanan Fu Runxia Li | 2021 | Journal of Materials Science & Technology2021，，21： | 0 |
| 15 | The phase behavior of n-ethylpyridinium tetrafluoroborate and sodium-based salts ATPS and its application in 2-chlorophenol extraction显示文摘In this paper,the aqueous two-phase systems(ATPS)containing n-ethylpyridinium tetrafluoroborate([EPy]BF_(4)),sodium-based salts,and water were studied and the extraction efficiency of 2-chlorophenol was measured to study the ATPS performance in extracting phenolic compounds.The binodal curves of[EPy]BF_(4)+sodium carbonate(Na_(2)CO_(3))ATPS and[EPy]BF_(4)+sodium dihydrogen phosphate(NaH_(2)PO_(4))ATPS have been determined at 308.15 K,318.15 K,and 328.15 K and atmospheric pressure.After getting good correlation with Merchuk equation,the binodal curves together with gravimetric method were used to calculate the tie-lines data.Furthermore,the reliability of tie-lines data was verified using Othmer-Tobias and Bancroft equations.Then,the salt influence and temperature influence on the phase behavior were discussed and the results show the salt-outing ability of Na_(2)CO_(3) is better than NaH_(2)PO_(4).With the aim of studying the ATPS performance in extracting phenolic compounds,extraction efficiency for 2-chlorophenol at different temperatures were studied and the results show that[EPy]BF_(4)+Na_(2)CO_(3) ATPS is preferred than[EPy]BF_(4)+NaH_(2)PO_(4) ATPS in applications. | Shuai Xu Qi Zhu Shaojie Xu Manjing Yuan Xuliang Lin Wenjing Lin Yanlin Qin Yuliang Li | 2021 | Chinese Journal of Chemical Engineering2021，34，5： | 0 |
| 16 | Experimental Investigation on Compressive Properties of Fiber Recycled Aggregate Concrete显示文摘This paper presents an experimental study to explore the compressive properties of fiber recycled aggregate concrete.A total of 75 specimens with the replacement rate of recycled coarse aggregate and fiber type were conducted under a uniaxial compressive test.The failure modes,stress-strain whole curves,peak stress,peak strain,and energy dissipation capacity were systematically observed and revealed.Test results indicate that steel fiber has the best modification effect on energy dissipation capacity and the toughness index of recycled concrete,corresponding to the enhancement of 81.75% and 22.90% on average.The addition of polyvinyl alcohol fiber can effectively improve the compressive strength and energy dissipation capacity of recycled aggregate concrete by 28.49% and 29.43% on average,respectively.The compressive strength and energy dissipation capacity of recycled aggregate concrete is increased by an average of 16.5% and 24.4% by incorporating carbon fiber.The energy dissipation capacity of recycled aggregate concrete is increased by an average of 13.5% with the incorporation of polypropylene fiber.However,the addition of carbon fiber results in a slight reduction of toughness by 16.97%,and the effect of polyvinyl alcohol fiber on the energy dissipation capacity is limited.Besides,with the increase in replacement rate,the compressive strength and the energy dissipation capacity of recycled coarse aggregate concrete with fiber decreased,and toughness first decreased and then increased.Finally,based on the analysis of test data,a segment-based stress-strain model of fiber recycled aggregate concrete was proposed,which shows good agreement with the test results. | Guiwu Lin Kaige Liu Yuliang Chen Yunpeng Ji Rui Jiang | 2023 | Journal of Renewable Materials2023，11，11： | 0 |
| 17 | Evaluation of the Integrated Information System for Brucellosis Case Diagnosis and Management-Inner Mongolia Autonomous Region,China,2019显示文摘What is already known about this topic?Wulanchabu City Center for Endemic Disease Prevention and Control had established and used a Brucellosis Integrated Information System(BIIS)since 2013.However,it had not been systematically evaluated and promoted so far.What is added by this report?The BIIS had significantly improved the efficiency of brucellosis reporting and provided convenience for follow-up management of cases,which was valuable for finishing completely routine therapy.However,the stability of the system needs to be improved.What are the implications for public health practice?The results of the BIIS assessment demonstrated its advantages and disadvantages,which could provide some evidence for its implementation in other areas of China. | Shuaibing Dong Hai Jiang Mengguang Fan Yuexi Li Cuihong Zhang Shenghong Lin Yuliang Zhu Na Ta Jianke Guo Zijun Wang Lijie Zhang Liping Wang | 2021 | China CDC weekly2021，3，6： | 0 |
| 18 | Fast Segmentation Method of Sonar Images for Jacket Installation Environment显示文摘It has remained a hard nut for years to segment sonar images of jacket installation environment,most of which are noisy images with inevitable blur after noise reduction.For the purpose of solutions to this problem,a fast segmen-tation algorithm is proposed on the basis of the gray value characteristics of sonar images.This algorithm is endowed with the advantage in no need of segmentation thresholds.To realize this goal,we follow the undermentioned steps:first,calcu-late the gray matrix of the fuzzy image background.After adjusting the gray value,the image is divided into three regions:background region,buffer region and target regions.Afterfiltering,we reset the pixels with gray value lower than 255 to binarize images and eliminate most artifacts.Finally,the remaining noise is removed by morphological processing.The simulation results of several sonar images show that the algorithm can segment the fuzzy sonar images quickly and effectively.Thus,the stable and feasible method is testified. | Hande Mao Hongzhe Yan Lei Lin Wentao Dong Yuhang Li Yuliang Liu Jing Xue | 2023 | Intelligent Automation & Soft Computing2023，，5： | 0 |
| 19 | Technique research of embedded event receiver for BEPC-II显示文摘Purpose The event receiver is an important component of the BEPC-II timing system.It receives event codes from the event generator and then generates triggers and interrupts.The currently applied event receiver is implemented in a single FPGA board,which has to work in conjunction with a single-board computer and an external bus chassis.With the rapid development of System-on-Chip(SoC)technology,combining them in one SoC is more efficient,more integrated,and cheaper.Thereby,an embedded event receiver based on ZYNQ SoC is proposed.Methods and Results In this paper,some key techniques of embedded event receiver have been researched.These techniques have been implemented in an embedded event receiver prototype named ER-Z.And the function test results show that ER-Z has the ability to receive event codes and handle them through interrupts while attaching timestamps with event clock precision.The performance test results show that the average interrupt latency is less than 30μs and the average AXI-Lite read latency is less than 170 ns. | Zhao Zhang Zhi Liu Sinong Cheng Ge Lei Yuliang Zhang Peng Zhu Guanglei Xu Lin Wang | 2023 | Radiation Detection Technology and Methods2023，7，1： | 0 |
| 20 | The run management system for CSNS显示文摘Purpose In order to increase CSNS beam power from 100 to 500 kW,the linac injection energy needs to be increased from 80 to 300 MeV.The combined layout of superconducting spoke cavities and elliptical cavities will be adopted to accelerate H−beam to 300 MeV.In this paper,a compact single spoke cavity withΦ50-mm beam aperture was proposed,with the RF performance of the spoke cavity optimized to Ep/Eacc<5,Bp/Eacc<9,as well as the good multipacting behavior.Methods CST Microwave Studio was used to optimize the RF performance(Epeak/Eacc,Bpeak/Eacc,R/Q)with cavity geometry parameters.After electromagnetic design was finished,multipacting behavior was studied with CST Particle Studio module,and cavity shape modification was made to get a reasonablevalue.Results The simulation got optimum results of Epeak/Eacc=4.97 and Bpeak/Eacc=8.42 mT/(MV/m),and themax is 1.52 at Eacc=7.74 MV/m.Conclusion A 648 MHzβg=0.4 single spoke cavity with beam apertureΦ50 mm was proposed in the paper.This compact cavity may be a very promising option for CSNS linac upgrading.In addition to the optimization of the RF parameters,the multipacting behavior of the cavity is also studied,and cavity shape is optimized to reducevalue. | Yuliang Zhang Mingtao Kang Dapeng Jin Yongcheng He Peng Zhu Xuan Wu Fengqin Guo Lin Wang Wenchun Gao Gang Li | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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