|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3显示文摘为药抵抗的肿瘤的发展的一个新兴的模型利用作为癌症干细胞(CSC ) 或开始癌症的房间(用户信息控制系统) 知道的自我更新的恶意的祖先的一个水池。这研究的目的是从卵巢的癌症房间线 SKOV3 宣传如此的用户信息控制系统。SKOV3 范围房间在与表皮的生长因素补充的没有浆液的文化系统用 40.0 mol/l cisplatin 和 10.0 mol/l paclitaxel 被选择,基本成纤维细胞生长因素,白血病禁止的因素或标准包含浆液的系统。这些房间在药选择(cisplatin 和 paclitaxel ) 和没有浆液的文化系统下面形成了非支持者范围。选择范围房间对 cisplatin, paclitaxel, adriamycin,和 methotrexate 更抵抗。重要地,范围房间有自强的性质,与干细胞基因 Nanog, Oct4, sox2, nestin, ABCG2, CD133,和干细胞因素受体的高表示 CD117 (c 工具包) 。一致地,流动 cytometric 分析表明范围房间比区分的房间(33%) 有 CD133+/CD117+-positive 房间(71%) 的一个高得多的百分比。而且, SKOV3 范围房间是更多的 tumorigenic。而且, cDNA microarray 和随后的本体论的分析表明分类基因的一个大比例与 angiogenesis,细胞外的矩阵,调停 integrin 的发信号小径,房间粘附,和房间增长有关。从在这个文化系统下面的 SKOV3 房间线的 subpopulation 隔离出现一在为以他们的幸存,自强,和 chemoresistance 学习卵巢的 CSC,并且为开发明确地防碍卵巢的 CSC 的治疗学的药的 vitro 模型合适。 | Li Ma Dongmei Lai Te Liu Weiwei Cheng Lihe Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 18 |
| 2 | Amniotic fluid-derived stem cells mixed with platelet rich plasma for restoration of rat alveolar bone defect显示文摘从羊膜的液体孤立的干细胞作为房间治疗和织物工程的一个有希望的候选人被显示出。然而, maxillofacial 骨头织物工程的地里的羊膜的导出液体的干细胞(AFSC ) 的试验性、现出症状之前的潜的应用仍然是有限的。在这研究,老鼠 AFSC 成功地在 vitro 被收获并且描绘。老鼠 AFSC 显示出典型 fibroblastoid 形态学,稳定的增长活动和多区别潜力。Flow-cytometry 分析为象 CD34 和 CD45 那样的造血的标记证明这些房间为 CD29, CD44,和 CD90 是积极的,当否定时。与血小板富人一起的 AFSCs-premixed 的再生表演在牙槽的骨头缺点的恢复的血浆(PRP ) 胶化进一步用一只修改老鼠被调查颚的牙槽的缺点模型。微型电脑断层摄影术和组织学的检查在操作与控制组作比较以后在 4 和 8 个星期与 PRP 胶化显示出 AFSCs-premixed 的一个优异再生能力。而且,植入的 AFSC 能在缺点地点幸存并且直接参予骨头织物新生。一起拿,这些结果为牙槽的缺点恢复显示了基于 AFSCs 的牙槽的骨头织物工程策略的可行性。 | Minjiao Wang Hongliang Li Jiawen Si Jiewen Dai Jun Shi Xudong Wang Lihe Guo Guofang Shen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 5 |
| 3 | Roles of pre-formed martensite in below-Ms bainite formation,microstructure,strain partitioning and impact absorption energies of low-carbon bainitic steel显示文摘The roles of pre-formed martensite(PM)in below-Ms bainite formation,microstructure,crystallography,strain partitioning and mechanical properties of a low-carbon bainitic steel were investigated using electron-backscattered diffraction,transmission electron microscopy,micro digital image correlation technique and mechanical tests.It is demonstrated that the pre-formation of martensite eliminates the incubation time for bainite transformation at various austempering temperatures below Ms,indicative of its acceleration effect at the early stage of transformation.This effect is mainly attributed to the surfaces or tips of the PM acting as the nuclei of subsequently-formed bainite,with initial bainite tending to form around the PM.However,the finishing time for below-Ms bainite transformation,especially at even lower temperatures,is retarded,owing to the dividing effect of PM on parent austenite grains,the decreasing effect of lowered isothermal temperature on the diffusion rate of carbon atoms and the strengthening effect of lowered isothermal temperature on supercooled austenite.PM and its adjacent bainitic laths have nearly the same crystallographic orientation and belong to the same block.The pre-formation of martensite largely refines the bainitic blocks/laths and retained austenite.The specimens with PM show relatively uniform strain partitioning among various phases,contrasting with the specimens without PM,for which strains are highly concentrated in the bainite region nearby fresh martensite/austenite(M/A)blocks or between adjacent M/A blocks.The impact absorption energies of the specimens with PM,when austempered at 30-60℃ below Ms,are more than twice higher than those of the specimens without PM,at no expense of tensile properties. | Lihe Qian Zhi Li Tongliang Wang Dongdong Li Fucheng Zhang Jiangying Meng | 2022 | Journal of Materials Science & Technology2022，，1： | 4 |
| 4 | Effects of biological activity, light, temperature and oxygen on phosphorus release processes at the sediment and water interface of Taihu Lake, China显示文摘 | Xia Jiang Xiangcan Jin Yang Yao Lihe Li Fengchang Wu | 2008 | Water Research2008，，8： | 2 |
| 5 | A new approach to measure melamine, cyanuric acid, and melamine cyanurate using surface enhanced Raman spectroscopy coupled with gold nanosubstrates 显示文摘 | Li Lihe Yang Liu Meng Shilin | 2008 | Food Qna12008，，2： | 1 |
| 6 | Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas显示文摘 | Liyu Li Jianjun Hou Xinjie Liu Yujia Guo Yun Wu Lihe Zhang Zhenjun Yang | 2014 | Biomaterials2014，，： | 1 |
| 7 | Loss of silencing activity caused by 5′-terminal modification with D-/L-isonucleotide(isoNA) or locked nucleic acid(LNA) could not be restored by 5′-terminal phosphorylation显示文摘In this study,a series of 5′-phosphorylated siRNAs with D-/L-isonucleotide(isoNA)or locked nucleic acid(LNA)incorporated at the 5′-terminus were synthesized.It was found that after incorporating either isoNA or LNA at the 5′-terminus of the antisense strand or sense strand,the silencing activity of modified strands has been inhibited,which cannot be recovered by phosphorylation at the 5′-terminus;however,the silencing activity of unmodified strand to its own target was increased.This work indicates that the isoNA and LNA modification at 5′-terminus can interfere with the strand selection during the RISC assembling process,and the disturbance of the 5′-phosporylation should not be the only viable mechanism. | HUANG Ye CHEN Zhuo WANG Zhuo LI YaTing CHEN Yue YANG ZhenJun ZHANG LiHe | 2014 | Science China Chemistry2014，57，2： | 1 |
| 8 | Synthesis and activity of novel indole derivatives as inhibitors of CD38显示文摘CD38 is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues,regulating a wide range of physiological functions.Beginning with the previously reported compound 1,an inhibitor of human CD38 NADase,we synthesized a series of indole-based NH-substituted derivatives with modifications on alkyl chains,changes in substituent groups on aromatic rings,and differences in carbon chain lengths.Compounds 10,13,16 and 34 exhibited moderate inhibition of human CD38 NADase.Analysis of the structure-activity relationships showed that the phenylpropionyl moiety was very important for the inhibitory activity.This study provides information for the rational design of CD38 inhibitors. | Dongying Wu Kaiyiu Ting Yaokai Duan Na Li Jianguo Li Liangren Zhang Honcheung Lee Lihe Zhang | 2013 | Acta Pharmaceutica Sinica B2013，3，4： | 1 |
| 9 | Mercury contaminated and its potential health effects in a lead-zinc mining area in the karst region of Guangxi, China 显示文摘 | DENG Ghaohing ZHANG Chaolan LI Lihe | 2011 | Appl Geochem2011，26，2： | 1 |
| 10 | Regularity theory in Orlicz spaces for elliptic equations in Reifenberg domains显示文摘 | Huilian Jia Dongsheng Li Lihe Wang | 2007 | Journal of Mathematical Analysis and Applications2007，，2： | 1 |
| 11 | Existence of an Endogenous Glutamate and Aspartate Transporter in Chinese Hamster Ovary Cells显示文摘中国仓鼠卵巢房间出现内长高亲密关系 Na+ 依赖充斥使挫折运输活动。这项运输活动是类似于战略上在中央神经系统表示的一个 glut 使挫折 transporter 家庭的运动联盟者并且是 pharmacologically 不同的充斥使挫折 transporter-1 或有刺激性的氨基酸搬运人 1。象 transporter 一样的 glutamate/aspartate transporter (GLAST ) 的 cDNA 被获得并且分析。推出的氨基酸顺序高证明到人,老鼠,和老鼠 GLAST.We 的类似断定象 GLAST 一样充斥使挫折 transporter 在可能交谈的中国仓鼠卵巢房间存在内长高亲密关系 Na+ 依赖充斥在这些房间明显的使挫折运输活动。 | Xunhe JI Yuhua JIN Yaoyue CHEN Chongyong LI Lihe GUO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 1 |
| 12 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 13 | Studies of substrate binding region of mEAAC1 and mASCT1 by constructing chimeras显示文摘The cDNA chimeras between two subtypes of mouse excitatory amino acid transporter family, mouse excitatory amino acid carrier 1 (mEAAC1) and mouse alanine serine cysteine transporter 1 (mASCT1), were constructed by recombinant PCR. After transcription in vitro, the cRNA was injected and expressed in Xenopus laevis oocytes. 3H-Glu and 3H-Ser were used as isotopic tracer to measure the flux of amino acids. The results showed that there might not be the key amino acids responsible for substractive specificity in the NH2-terminal and its adjacent regions of these two transporters, which probably supported the formation of the substrata binding sites. | Jing Li Jibin Peng Jian Fei Fang Huang Quanbao Gu Lihe Guo | 1999 | Chinese Science Bulletin1999，44，6： | 0 |
| 14 | REGULARITY OF POISSON EQUATION IN SOME LOGARITHMIC SPACE显示文摘在这笔记,泊松方程的整齐?有躺在对数函数空间 L p (LogL ) 的 f 的螖 u = f 一(惟)(1 < p < 鈭?鈭 ? R ) 被学习。笔记的结果概括 W 2,在 L p 的泊松方程的 p 估计(惟) 。 | Jia Huilian Li Dongsheng Wang Lihe | 2007 | Applied Mathematics(A Journal of Chinese Universities)2007，22，1： | 0 |
| 15 | Investigation of the effect of 2'-substitution of NMN analogues on CD38 NADase inhibitory activity显示文摘CD38是一种烟酰胺腺嘌呤二核苷酸(NAD)代谢酶,可以催化生成不同的钙信号信使。它的酶抑制剂对于CD38调控的信号通路和生理功能的进一步研究有重要作用。为了深入了解2'位取代基对烟酰胺单核苷酸(NMN)类似物抑制CD38酶活性的影响,本文研究了一种2'位有两个取代基的新NMN类似物,同时使用分子动力学模拟和量子化学计算方法探索2'位取代基影响活性的原因。结果表明2'位有两个取代基时,会干扰核苷酸C1'与CD38之间共价键的形成。本研究将有助于全面理清NMN类似物作为CD38酶抑制剂的构效关系。 | Jianguo Li Fen Pei Wenjie Zhu Hongwei Jin Yongjuan Zhao Liangren Zhang Honcheung Lee Lihe Zhang | 2015 | Journal of Chinese Pharmaceutical Sciences2015，24，8： | 0 |
| 16 | Using a Particle Tracking Method to Quantify Groundwater Circulation rates: a Case Study in the Ordos Plateau显示文摘Groundwater is a valuable resource in many areas, and commonly plays a key role in economic development. Therefore, groundwater circulation rates at different depths are key issues for groundwater development and management in the Ordos Plateau. In this study, a particle tracking method was used to quantify circulation rates in the Ordos plateau. The results show that groundwater mainly circulates in shallow groundwater systems up to 400m depth. The results of this study can be used to develop effective programs for groundwater management and development.. | Lihe Yin Hongyun Ma Jiaqiu Dong Xiaoyong Wang Ying Li | 2013 | Journal of Groundwater Science and Engineering2013，1，1： | 0 |
| 17 | ROLLING MILL SYSTEM DYNAMIC DESIGN显示文摘It is studied how the aluminum foil chatter mark is produced and controlled The stableness of hydraulic AGC system,fluid vibration of capsule system,and electromechanical coupling of AC/AC VVVF system and de coupling are also studied It is shown that rolling mill design should go to system dynamic design from traditional design The framed drawing of system dynamic design program is presented. | Li Mouwei, Liu Hongfei, Zhang Yang, Zhao Yongzhong (College of Mechanical Engineering,University of Science and Technology Beijing) Wany Yide, Li Aiqun, Pei Quanren (Taiyuan Iron and Steel(Group)Ltd.) Zhao Liangmo, Zou Lihe, Zhou Binsheng (Northeast Light | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 0 |
| 18 | Production Performance of Different Generations of Muchuan Blackbone Chicken显示文摘In order to formulate feasible conservation measures and develop and utilize Muchuan black-bone chicken rationally,two generations of Muchuan black-bone chicken were bred,and their production performance and slaughter traits( at the age of 300 d) were compared. The results showed that the reproductive performance,slaughter performance and body size of the Muchuan black-bone chicken of Generation 1( G_1)were all improved compared with those of the Generation 0( G_0)( P <0. 05). At the age of 300 d,the live weight,carcass weight,and leg muscle weight of the G_1 were significantly higher than those of the G_0( P <0. 05); and the chest width of the cocks of the G_1 was significantly higher than that of the G_0( P <0. 05). It suggests that after rigorous selection and utilization of modern poultry breeding techniques,the reproductive performance,slaughter performance and survival rate of Muchuan black-bone chicken can be improved significantly. | Mohan QIU Zengrong ZHANG Xiaosong JIANG Huarui DU Qingyun LI Chunlin YU Xia XIONG Lihe ZOU Chaowu YANG | 2018 | Asian Agricultural Research2018，10，8： | 0 |
| 19 | Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates显示文摘Oleanolic acid(OA) and echinocystic acid(EA), two naturally occurring pentacyclic oleanane triterpenes,are gaining increasing attention due to their promising pharmacological activities. Conjugation with amphiphilic α(β)-cyclodextrin(CD) via 'click chemistry' can improve their solubility and anti-HCV entry potency. In the present work,four water-soluble β-CD-pentacyclic triterpene conjugates were designed and synthesized, in which OA and EA was coupled to one of the primary hydroxyl groups of β-CD via ester and amide bonds. The structures of the conjugates were unambiguously determined by ~1H NMR, ^(13)C NMR and HRMS or MALDI-TOF-MS. All the conjugates showed lower hydrophobicity(AlogP) than their parent compounds and no significant cytotoxicity was found to HL-60, A549, Hela and Bel-7402 cells at concentrations up to 10 μmol/L. Further anti-HCV entry activity and mechanism studies are under way in our laboratory. | Pingxuan Jiao Shouxin Wang Shuobin Liang Man Li Qianqian Gao Dezhong Ji Yingying Chen Haiwei Li Fuxiang Ran Yongmin Zhang Lihe Zhang Demin Zhou Sulong Xiao | 2019 | Chinese Chemical Letters2019，30，3： | 0 |
| 20 | Robust cooperative multi-agent reinforcement learning via multi-view message certification显示文摘Many multi-agent scenarios require message sharing among agents to promote coordination,hastening the robustness of multi-agent communication when policies are deployed in a message perturbation environment.Major relevant studies tackle this issue under specific assumptions,like a limited number of message channels would sustain perturbations,limiting the efficiency in complex scenarios.In this paper,we take a further step in addressing this issue by learning a robust cooperative multi-agent reinforcement learning via multi-view message certification,dubbed CroMAC.Agents trained under CroMAC can obtain guaranteed lower bounds on state-action values to identify and choose the optimal action under a worst-case deviation when the received messages are perturbed.Concretely,we first model multi-agent communication as a multi-view problem,where every message stands for a view of the state.Then we extract a certificated joint message representation by a multi-view variational autoencoder(MVAE)that uses a product-of-experts inference network.For the optimization phase,we do perturbations in the latent space of the state for a certificate guarantee.Then the learned joint message representation is used to approximate the certificated state representation during training.Extensive experiments in several cooperative multi-agent benchmarks validate the effectiveness of the proposed CroMAC. | Lei YUAN Tao JIANG Lihe LI Feng CHEN Zongzhang ZHANG Yang YU | 2024 | Science China(Information Sciences)2024，67，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员