|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hydrogen peroxide primes heart regeneration with a derepression mechanism显示文摘当成年的人的心很限制了再生潜力时,成年 zebrafish 心能充分在 20% 室的切除术以后再生。尽管以前的报告建议象 FGF 和 PDGF 那样的发展发信号小径在成年的心新生被再使用,内在的细胞内部的机制仍然保持大部分未知。这里,我们显示出那 H 2 O 2 充当新奇 epicardial 和心肌的信号在成年 zebrafish 为新生告知心。未经触动的心的实时成像揭示了高度局部性的 H 2 O 2(~ 30 μ M ) 在在切除术地点的心外膜和邻近的紧缩的心肌层的生产。减少的 H 2有 Duox 禁止者 diphenyleneiodonium (点每英寸)或 apocynin 的 O 2形成,或清除 H 2当时,由过氧化氢酶 overexpression 的 O 2显著地损害了心脏的新生外长的 H 2 O 2在心脏的新生上救了点每英寸的禁止的效果,显示那 H 2 O 2是在这个过程的一个必要、足够的信号。机械学地,提高了 H 2 O 2 使动摇氧化还原作用敏感的磷酸酶 Dusp6 并且因此增加了 Erk1/2 的 phosphorylation。当 dusp6 的转基因的 overexpression 损害了心脏的新生时, Dusp6 禁止者 BCI 完成了类似的支持 regenerative 效果。H 2 O 2 在招募起一个双作用通过二条相对独立的小径的有免疫力的房间和支持的心新生。我们结束那 H 2 潜在地从 Duox/Nox2 产生的 O 2 由解开通过包含 Dusp6 的 derepression 机制发信号的地图 kinase 在 zebrafish 支持心新生。 | Peidong Han Xiao-Hai Zhou Nannan Chang Cheng-Lu Xiao Shouyu Yah He Ren Xin-Zhuang Yang Mei-Ling Zhang Qing Wu Boyang Tang Ju-Peng Diao Xiaojun Zhu Chuanmao Zhang Chuan-Yun Li Heping Cheng Jing-Wei Xiong | 2014 | Cell Research2014，24，9： | 10 |
| 2 | Landslides Triggered by the 2020 Qiaojia M_(w)5.1 Earthquake, Yunnan, China: Distribution, Influence Factors and Tectonic Significance显示文摘On May 18, 2020, an M_(w)5.1 earthquake occurred in Qiaojia County, Yunnan Province, China. This moderate-sized event triggered massive coseismic landslides, resulting in some damage. In this work, through visual interpretation of high-resolution(0.8–2 m) Gaofen satellite images before and after the earthquake, 167 landslides were delineated, 18 of which were inspected in the field. Using the landslide number density(LND) and landslide area percentage(LAP), we characterized the spatial distribution of these landslides, and analyzed their possible influence factors and tectonic significance. The results show that these landslides are distributed mostly in the NW-SE direction, roughly parallel to the long axis of seismic intensity zones and the strike of the Xiaohe-Baogunao fault(XBF). The LND and LAP decrease with increasing distances to the fault and from the epicenter to fault ends of the XBF. These permit to suggest that the seismogenic fault of the Qiaojia earthquake is likely a hidden branch of the XBF. All of the landslides induced by this event occurred in the region with the seismic intensity of six degrees or greater of the 2014 M_(w)6.2 Ludian earthquake. Therefore, it was inferred that the 2020 Qiaojia earthquake was probably the subsequent release of accumulated elastic strain after the 2014 Ludian earthquake in a same tectonic stress regime. | Xiangli He Chong Xu Wenwen Qi Yuandong Huang Jia Cheng Xiwei Xu Qi Yao Yongkun Lu Boyang Dai | 2021 | Journal of Earth Science2021，32，5： | 2 |
| 3 | Excretion of manure-borne estrogens and androgens and their potential risk estimation in the Yangtze River Basin显示文摘The Yangtze River is the longest river in China, and the river basin spans one fifth of the area of the whole country. Based on statistical data, the excretion of manure-borne steroid hormones, including steroid estrogens(SEs) and steroid androgens(SAs), in 10 provinces of China within the region has been estimated. The potential environmental and ecological risk of manure-borne steroid estrogens to the surface water in this region was also assessed. The manure-borne SE and SA excretions in the 10 provinces and municipalities vary in the order: Sichuan > Hunan > Hubei > Yunnan > Jiangsu > Anhui > Jiangxi >Chongqing > Qinghai > Shanghai. The highest increase of manure-borne SEs(1434.3 kg)and SAs(408.5 kg) was found in Hunan and Hubei provinces, respectively, and the total excretion in 2013 was 65% more than 15 years earlier in these two provinces. However, the emissions in Anhui and Shanghai decreased in this 15 year period of time. Swine urine,chicken feces, cattle urine, and laying hen feces were considered the dominant sources of manure-borne E1, βE2, αE2, and SAs, respectively. Although Jiangsu province did not have the largest excretion of manure-borne SEs, it had the highest level of predicted17β-estradiol equivalency(EEQs) value of 16.65 ng/L in surface water because of the limited surface water resources. According to the lowest observable effect level of 10 ng/L for17β-estradiol, the manure-borne SEs in Jiangsu province might potentially pose ecological risk to its wild aquatic organisms. | Yanxia Li Shiying Gao Shufang Liu Bei Liu Xuelian Zhang Min Gao Linjie Cheng Boyang Hu | 2015 | Journal of Environmental Sciences2015，27，11： | 2 |
| 4 | Carbon dots-confined CoP-CoO nanoheterostructure with strong interfacial synergy triggered the robust hydrogen evolution from ammonia borane显示文摘Ammonia borane(NH_(3)BH_(3),AB) is promising for chemical hydrogen sto rage;however,current systems for rapid hydrogen production are limited by the expensive noble metal catalysts required for AB hydrolysis.Here we report the design and synthesis of a highly efficient and robust non-noble-metal catalyst for the hydrolysis of AB at 298 K(TOF=89.56 molH_(2) min^(-1) molCo^(-1)).Experiments and density functional theory calculations were performed to explore the catalyst’s hybrid nanoparticle heterostructure and its catalytic mechanism.The catalyst comprised nitrogen-doped carbon dots confining CoO and CoP,and exhibited strong interface-induced synergistic catalysis for AB hydrolysis that effectively decreased the energy barriers for the dissociation of both AB and water molecules.The co-doping of N and P introduced numerous defects,and further regulated the reactivity of the carbon layers.The heterogeneous interface design technique presented here provides a new strategy for developing efficient and inexpensive non-noblemetal catalysts that may be applicable in other fields related to energy catalysis. | Han Wu Yaojia Cheng Boyang Wang Yao Wang Min Wu Weidong Li Baozhong Liu Siyu Lu | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 5 | Infrared LSS-Target Detection Via Adaptive TCAIE-LGM Smoothing and Pixel-Based Background Subtraction显示文摘Infrared small target detection is a significant and challenging topic for daily security. This paper proposes a novel model to detect LSS-target (low altitude, slow speed, and small target) under the complicated background. Firstly, the fundamental constituents of an infrared image including the complexity and entropy are calculated, which are invoked as adaptive control parameters of smoothness. Secondly, the adaptive L0 gradient minimization smoothing based on texture complexity and information entropy (TCAIE-LGM) is proposed in order to remove noises and suppress low-amplitude details in infrared image abstraction. Finally, difference of Gaussian (DoG) map is incorporated into the pixel-based adaptive segmentation (PBAS) background modeling algorithm, which can differ LSS-target from the sophisticated background. Experimental results demonstrate that the proposed novel model has a high detection rate and produces fewer false alarms, which outperforms most state-of-the-art methods. | Yanfeng WU Yanjie WANG Huiyuan LUO Boyang CHENG Haijiang SUN | 2019 | Photonic Sensors2019，9，2： | 1 |
| 6 | Development of a new pre- Derivatization LC method for analysis of branched- Chain and aromatic amino acids in rat plasma and to monitor their dynamic variation as a resuh of acute hepatic Injury显示文摘 | Jiye Cheng Fang Feng Boyang Zhuang | 2009 | Vieweg Teubner2009，，： | 1 |
| 7 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 8 | Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis显示文摘Subarachnoid hemorrhage is associated with high morbidity and mortality and lacks effective treatment.Pyroptosis is a crucial mechanism underlying early brain injury after subarachnoid hemorrhage.Previous studies have confirmed that tumor necrosis factor-stimulated gene-6(TSG-6)can exert a neuroprotective effect by suppressing oxidative stress and apoptosis.However,no study to date has explored whether TSG-6 can alleviate pyroptosis in early brain injury after subarachnoid hemorrhage.In this study,a C57BL/6J mouse model of subarachnoid hemorrhage was established using the endovascular perforation method.Our results indicated that TSG-6 expression was predominantly detected in astrocytes,along with NLRC4 and gasdermin-D(GSDMD).The expression of NLRC4,GSDMD and its N-terminal domain(GSDMD-N),and cleaved caspase-1 was significantly enhanced after subarachnoid hemorrhage and accompanied by brain edema and neurological impairment.To explore how TSG-6 affects pyroptosis during early brain injury after subarachnoid hemorrhage,recombinant human TSG-6 or a siRNA targeting TSG-6 was injected into the cerebral ventricles.Exogenous TSG-6 administration downregulated the expression of NLRC4 and pyroptosis-associated proteins and alleviated brain edema and neurological deficits.Moreover,TSG-6 knockdown further increased the expression of NLRC4,which was accompanied by more severe astrocyte pyroptosis.In summary,our study revealed that TSG-6 provides neuroprotection against early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome activation-induced astrocyte pyroptosis. | Mingxiang Ding Lei Jin Boyang Wei Wenping Cheng Wenchao Liu Xifeng Li Chuanzhi Duan | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 9 | Dirac points and the transition towards Weyl points in three-dimensional sonic crystals显示文摘A four-fold-degenerate three-dimensional(3D)Dirac point,represents a degenerate pair of Weyl points carrying opposite chiralities.Moreover,3D Dirac crystals have shown many exotic features different from those of Weyl crystals.How these features evolve from 3D Dirac to Weyl crystals is important in research on 3D topological matter.Here,we realized a pair of 3D acoustic Dirac points from band inversion in a hexagonal sonic crystal and observed the surface states and helical interface states connecting the Dirac points.Furthermore,each Dirac point can transition into a pair of Weyl points with the introduction of chiral hopping.The exotic features of the surface states and interface states are inherited by the resulting Weyl crystal.Our work may serve as an ideal platform for exploring exotic physical phenomena in 3D topological semimetals. | Boyang Xie Hui Liu Hua Cheng Zhengyou Liu Jianguo Tian Shuqi Chen | 2020 | Light(Science & Applications)2020，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员