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| 1 | Three-Dimensional TIN Algorithm for Digital Terrain Modeling显示文摘The problem of taking an unorganized point cloud in 3D space and fitting a polyhedral surface to those points is both important and difficult. Aiming at increasing applications of full three dimensional digital terrain surface modeling, a new algorithm for the automatic generation of three dimensional triangulated irregular network from a point cloud is pro- posed. Based on the local topological consistency test, a combined algorithm of constrained 3D Delaunay triangulation and region-growing is extended to ensure topologically correct reconstruction. This paper also introduced an efficient neighbor- ing triangle location method by making full use of the surface normal information. Experimental results prove that this algo- rithm can efficiently obtain the most reasonable reconstructed mesh surface with arbitrary topology, wherein the automati- cally reconstructed surface has only small topological difference from the true surface. This algorithm has potential applica- tions to virtual environments, computer vision, and so on. | ZHU Qing ZHANG Yeting LI Fengchun | 2008 | Geo-Spatial Information Science2008，11，2： | 6 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | A necessary and sufficient condition for a surface sum of two handlebodies to be a handlebody显示文摘The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,2.Suppose that S is incompressible in both H1 and H2.Then H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2. | Fengchun Lei He Liu Fengling Li Andrei Vesnin | 2020 | Science China Mathematics2020，63，10： | 2 |
| 6 | Analysis of the Stability and Mechanical Characteristics of the Jointed Surrounding Rock and Lining Structure of a Deeply Buried Hydraulic Tunnel显示文摘On-site monitoring and numerical simulation have been combined to analyze the stability of the jointed surrounding rock and the stress inside the lining structure of a sample deeply buried hydraulic tunnel.We show that the deformation around the tunnel was mainly concentrated in the range 51.37 mm∼66.73 mm,the tunnel circumference was dominated by shear failure,and the maximum plastic zone was about 3.90 m.When the shotcrete treatment was performed immediately after the excavation,the deformation of the surrounding rock was reduced by 58.94%∼76.31%,and the extension of the plastic zone was relatively limited,thereby leading to improvements in terms of the stability of surrounding rock.When the support was provided at different time points,the stress of the surrounding rock in the shallow part of the tunnel was improved everywhere.In the tunnel section with high ground stress and joint development,when 10 cm steel fiber concrete spray layer and 40 cm C25 concrete secondary lining were used,the maximum tensile stress on the lining structure was 0.89 MPa,i.e.,it was less than the tensile strength of concrete,which indicates that the internal force of the lining can meet the overall requirements. | Changchang Li Zuguo Mo Haibo Jiang Fengchun Yang | 2022 | Fluid Dynamics & Materials Processing2022，18，1： | 2 |
| 7 | China's battery electric vehicles lead the world:achievements in technology system architecture and technological breakthroughs显示文摘Developing new energy vehicles has been a worldwide consensus,and developing new energy vehicles characterized by pure electric drive has been China's national strategy.After more than 20 years of high-quality development of China's electric vehicles(EVs),a technological R&D layout of“Three Verticals and Three Horizontals”has been created,and technological advantages have been accumulated.As a result,China's new energy vehicle market has ranked first in the world since 2015.To systematically solve the key problems of battery electric vehicles(BEVs)such as“driving range anxiety,long battery charging time,and driving safety hazards”,China took the lead in putting forward a“system engineering-based technology system architecture for BEVs”and clarifying its connotation.This paper analyzes the research status and progress of the three core components of this architecture,namely,“BEV platform,charging/swapping station,and real-time operation monitoring platform”,and their key technological points.The three major demonstration projects of the 2008 Beijing Olympic Games,the 2022 Beijing Winter Olympics,and the intelligent and connected autonomous battery electric bus project are discussed to specify the applications of BEVs in China.The key research directions for upgrading BEV technologies remain to be further improving the vehicle-level all-climate environmental adaptability and all-day safety of BEVs,systematically solving the charging problem of BEVs and improving their application convenience,and safeguarding safety with early warning and implementing active/passive safety protection for the whole life cycle of power batteries on the basis of BEVs'operation big data.BEVs have acquired new technological features such as intelligent and networked technology empowerment,extensive integration of control-by-wire systems,a platform of chassis hardware,and modularization of functional software. | Hongwen He Fengchun Sun Zhenpo Wang Cheng Lin Chengning Zhang Rui Xiong Junjun Deng Xiaoqing Zhu Peng Xie Shuo Zhang Zhongbao Wei Wanke Cao Li Zhai | 2022 | Green Energy and Intelligent Transportation2022，1，1： | 2 |
| 8 | Heegaard genera of high distance are additive under annulus sum 显示文摘 | Li Fengling Yang Guoqiu Lei Fengchun | 2010 | Topology and its Application2010，，： | 1 |
| 9 | Structure and wear-resistance of an Fe-VC surface composite produced in situ 显示文摘 | Wang Yisan Li Fengchun | 1999 | Materials and Design1999，20，： | 1 |
| 10 | In situ production of Fe–VC and Fe–TiC surface composites by cast-sintering显示文摘 | Yisan Wang Xinyuan Zhang Guangting Zeng Fengchun Li | 2001 | Composites Part A2001，，2： | 1 |
| 11 | Structure and wear-resistance of an Fe-VC surface composite produced in situ显示文摘 | Yisan Wang Fengchun Li Guangting Zeng Daoli Feng | 1999 | Materials and Design1999，，1： | 1 |
| 12 | Study on an Fe-TiC Surface Composite Produced in Situ显示文摘 | Zhang Xinyuan Li Fengchun Zeng Guangting | 1999 | Materials and Design1999，，20： | 1 |
| 13 | In Situ Production of Fe-VC and Fe-TiC Surface Composites by Cast-sintering显示文摘 | Wang Yisan Zhang Xinyuan Zeng Guangting Li Fengchun | 2000 | Composites(Part A)2000，32，： | 1 |
| 14 | The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous γδ T-cell lymphoma may mimic those of rheumatic diseases: a report of 11 cases显示文摘 | Lin Yi Shi Qun Zheng Wenjie Zhang Wen Li Jian Zhao Yan Zhang Fengchun | 2013 | Clinical Rheumatology2013，，8： | 1 |
| 15 | Death causes and pathogens analysis of systemic lupus erythematosus during the past 26 years显示文摘 | Yunyun Fei Xiaochun Shi Fengying Gan Xuemei Li Wen Zhang Mengtao Li Yong Hou Xuan Zhang Yan Zhao Xiaofeng Zeng Fengchun Zhang | 2014 | Clinical Rheumatology2014，，1： | 1 |
| 16 | Study on an Fe-TiC surface composite produced in situ显示文摘 | WANG Yisan LI fengchun ZENG Guangting | 1999 | Materials and Design1999，20，10： | 1 |
| 17 | Sol-gel Glass-coated Zinc Oxide for Varistor Applications显示文摘 | Lingbing Kong Fengchun Li Liangying Zhang Xi Yao | 1998 | Journal of Materials Science Letters1998，，9： | 1 |
| 18 | Structure and wear-resistance of an Fe-VC surface composite produced in situ显示文摘 | Wang Yisan Li Fengchun Huang Wen | 1999 | Materials and Design1999，20，11： | 1 |
| 19 | Study on an Fe-TiC surface composite produced in situ 显示文摘 | Wang Yisan Zhang Xinyuan Li Fengchun | 1999 | Materials & Design1999，20，5： | 1 |
| 20 | Structure and wear-resistance of an Fe-VC surface composite produced in s itu显示文摘 | Li Fengchun Zeng Guangting | 1999 | Materials and Design1999，20，： | 1 |
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