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| 1 | Role of the Arabidopsis thafiana NAC transcription factors ANAC019 and ANAC055 in regulating jasmonic acid-signaled defense responses显示文摘Jasmonic 酸(JA ) 是对草食动物攻击,病原体感染并且机械伤害调整植物防卫回答的重要植物激素。在这份报告,我们提供了生物化学、基因的证据证明 Arabidopsis thaliana NAC 家庭蛋白质 ANAC019 和 ANAC055 可能作为抄写使活跃之物工作调整辩护基因的导致 JA 的表示。在 JA 发信号的二 NAC 基因的角色与 anac019 anac055 被检验两倍异种并且与转基因的植物 overexpressing ANAC019 或 ANAC055。两倍变异的植物显示出的 anac019 anac055 稀释了导致 JA 的植物的存储 PROTEIN1 (VSP1 ) 和 LIPOXYGENASE2 (LOX2 ) 表示,而二 NAC 基因显示出的转基因的植物 overexpressing 提高了导致 JA 的 VSP1 和 LOX2 表示。二 NAC 基因的 导致JA 的表示取决于 COI1 和 AtMYC2 的功能和发现 ANAC019 的那 overexpression 部分救了 atmyc2-2 异种的JA相关的显型,带了我们到二 NAC 蛋白质 AtMYC2 下游地扮演调整 发信号JA 的防卫回答的一个假设。证实这个想法的进一步的证据来自观察到 necrotrophic 真菌的两倍异种高显示出的 anac019 anac055 的反应类似到 atmyc2-2 异种的。 | Qingyun Bu Hongling Jiang Chang-Bao Li Qingzhe Zhai Jie Zhang Xiaoyan Wu Jiaqiang Sun Qi Xie Chuanyou Li | 2008 | Cell Research2008，18，7： | 60 |
| 2 | Mesozoic contraction deformation in the Yanshan and northern Taihang mountains and its implications to the destruction of the North China Craton显示文摘Mesozoic contraction deformation in the Yanshan and Taihang mountains is characterized by basement-involved thrust tectonics,basement-cored buckling anticlines and ductile thrust and nappe tectonics.Most of these deformations are orientated west-east,west-northwest and northeast to north-northeast.The contraction deformations began in the Permian,continued through the Triassic and Jurassic and terminated in the Early Cretaceous,and constitute an important part of the destruction of the North China Craton.It is estimated,from balanced cross-section reconstructions,that the north-south shortening of the central part of the Yanshan belt before 135 Ma was around 38%.The initial crust thickness,pre-dating the major contraction deformation in late Paleozoic and early Mesozoic,was estimated to be around 35 km based on paleogeographic characteristics.Assuming that the inferred depth of ductile thrusting deformation,20-25 km,was the crust thickness involved in the contraction deformation,and also assuming that the N-S contraction deformation was accommodated by vertical crust thickening,the thickness of the crust after the contraction deformation was expected to be around 47-50 km.This was the approximate crust thickness required for the eclogitization of the lower crust for delamination.The gravity potential accumulated by the isostatic uplift of the thickened crust,together with the decrease in crustal strength caused by the coeval magmatisms associated with the contraction deformation,led to the subsequent extensional collapse of the middle and upper crust although the regional stress regime associated with the plate interactions remained constant.It is inferred that the Mesozoic contraction deformations in the Yanshan and Taihang mountains were not only a significant tectonic process contributing to the destruction of the craton in middle and upper crust but also stimulated delamination at a deep level and the extension of the shallow crust.In other words,both the suspected delamination of the lower crust and upper mantle and the well constrained extension deformations of the shallow crust in the eastern North China Craton during the late Mesozoic are a consequence of crust thickening due to previous contractions.Extensional deformations could be expected to occur independently in the shallow crust,and are not necessarily associated with or responding to delamination at a deep level. | ZHANG ChangHou LI ChengMing DENG HongLing LIU Yang LIU Lei WEI Bo LI HanBin LIU Zi | 2011 | Science China Earth Sciences2011，54，6： | 40 |
| 3 | An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV显示文摘Severe fever with thrombocytopenia syndrome(SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus,SFTSV,named after the disease.The transmission vectors and animal hosts of SFTSV are unclear.Ticks are the most likely transmission vectors and domestic animals,including goats,dogs,and cattle,are potential amplifying hosts of SFTSV.The clinical symptoms of SFTS are nonspecific,but major symptoms include fever,gastrointestinal symptoms,myalgia,dizziness,joint pain,chills,and regional lymphadenopathy.The most common abnormalities in laboratory test results are thrombocytopenia(95%),leukocytopenia(86%),and elevated levels of serum alanine aminotransferase,aspartate aminotransferase,creatine kinase,and lactate dehydrogenase.The fatality rate for SFTS is 12% on average,and the annual incidence of the disease is approximately five per 100000 of the rural population. | ZHANG XiaoShuang LIU Yan ZHAO Li LI Bing YU Hao WEN HongLing YU Xue-Jie | 2013 | Science China(Life Sciences)2013，56，8： | 28 |
| 4 | Analysis of extrapolation cascadic multigrid method(EXCMG)显示文摘Based on an asymptotic expansion of finite element,a new extrapolation formula and extrapolation cascadic multigrid method(EXCMG)are proposed,in which the new extrapolation and quadratic interpolation are used to provide a better initial value on refined grid.In the case of triple grids,the error of the new initial value is analyzed in detail.A larger scale computation is completed in PC. | CHEN ChuanMiao HU HongLing XIE ZiQing LI ChenLiang | 2008 | Science China Mathematics2008，51，8： | 23 |
| 5 | A Transcriptional Network Promotes Anthocyanin Biosynthesis in Tomato Flesh显示文摘Dietary anthocyanins are important health-promoting antioxidants that make a major contribution to the quality of fruits. It is intriguing that most tomato cultivars do not produce anthocyanins in fruit. However, the purple tomato variety Indigo Rose, which has the dominant Aft locus combined with the recessive atv locus from wild tomato species, exhibits light-dependent anthocyanin accumulation in the fruit skin. Here, we report that Aft encodes a functional anthocyanin activator named SlAN2-like, while atv encodes a nonfunctional version of the anthocyanin repressor SlMYBATV. The expression of SlAN2-like is responsive to light, and the functional SlAN2-like can activate the expression of both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator in the activation of anthocyanin biosynthesis. We further showed that cultivated tomatoes contain nonfunctional alleles of SlAN2-like and therefore fail to produce anthocyanins. Consistently, expression of a functional SlAN2-like gene driven by the fruit-specific promoter in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high-level accumulation of anthocyanins in both the peel and flesh. Taken together, our study exemplifies that efficient engineering of complex metabolic pathways could be achieved through tissue-specific expression of master transcriptional regulators. | Chuanlong Sun Lei Deng Minmin Du Jiuhai Zhao Qian Chen Tingting Huang Hongling Jiang Chang-Bao Li Chuanyou Li | 2020 | Molecular Plant2020，13，1： | 17 |
| 6 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 7 | Efficient generation of pink-fruited tomatoes using CRISPR/Cas9 system显示文摘Tomato(Solanum lycopersicum)is the leading vegetable crop worldwide and an essential component of a healthy diet(Lin et al.,2014;Du et al.,2017).Fruit color is regarded as one of the most important commercial traits in tomato(The Tomato Genome Consortium,2012).Consumers in different regions have different color preferences.For example,European and | Lei Deng Hang Wang Chuanlong Sun Qian Li Hongling Jiang Minmin Du Chang-Bao Li Chuanyou Li | 2018 | Journal of Genetics and Genomics2018，45，1： | 13 |
| 8 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 9 | Mesenchymal stem cells and immune disorders: from basic science to clinical transition显示文摘As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i.e., multilineage differentiation, secretome, and immunomodulation. Specifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e.,“subtotipotent stem cell” hypothesis, MSC system, and “Yin and Yang” balance of MSC regulation, which may bring new insights into our understanding of MSCs. Furthermore, we analyzed data from the Clinical Trials database (http://gffzzd3f38a9638994581hkfqnnw0opowb6v00.ffgz.tsg.suse.edu.cn) on registered clinical trials using MSCs to treat a variety of immune diseases, such as graft-versus-host disease, systemic lupus erythematosus, and multiple sclerosis. In addition, we highlighted MSC clinical trials in China and discussed the challenges and future directions in the field of MSC clinical application. | Shihua Wang Rongjia Zhu Hongling Li Jing Li Qin Han Robert Chunhua Zhao | 2019 | Frontiers of Medicine2019，13，2： | 12 |
| 10 | Analyses of trends and causes for variations in runoff and sediment load of the Yellow River显示文摘Due to the impacts of globe climate change and human activities,dramatic variations in runoff and sediment load were observed for the Yellow River.Analyses of nearly 65 years' data measured at main hydrologic-stations on the Yellow River from 1950 to 2014 indicated that,except for the Tangnaihai station in the head region,sharp downward trends existed in both the annual runoff and annual sediment load according to the Mann-Kendal trend test;and their abrupt changes occurred in 1986 and in1980,respectively,according to the rank sum test.Factors affecting the changes in the runoff and sediment load were very complicated.Results indicated that the reducing precipitation and the increasing water consumption were the main causes for the runoff decline,while the impoundment of the Longyangxia Reservoir and its combined operation with the Liujiaxia Reservoir exerted a direct bearing on the abrupt change in the annual runoff.In addition to the sediment load decrease associated with the runoff reduction,the reduced storm intensity,the conducted soil erosion control,and the constructed dam buildings all played an important role in the trends and abrupt changes of sediment load decline. | Hongling Shi Chunhong Hu Yangui Wang Cheng Liu Huimei Li | 2017 | International Journal of Sediment Research2017，32，2： | 11 |
| 11 | The Arabidopsis P450 protein CYP82C2 modulates jasmonateinduced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis显示文摘Jasmonic 酸(JA ) 是对草食动物和一些微生物引起的病原体调整大量植物防卫回答的一个丰满的导出酸的发信号分子。分子的基因研究证实了 JA 也在植物开发的几个方面执行一个关键角色。这里,我们描述 Arabidopsis 变异的 jasmonic acid-hypersensitive1-1 (jah1-1 ) 的描述,它在 JA 回答的几个方面是有缺点的。尽管异种在根生长抑制展出增加的敏感到 JA,它显示出 JA 可诱导的防卫基因和减少的抵抗的减少的表示到 necrotrophic 真菌 Botrytis cinerea。基因克隆研究显示这些缺点被一个变化在细胞色素 P450 蛋白质 CYP82C2 引起。我们提供证明的证据到 B 的 jah1-1 异种的损害抵抗。cinerea 被导致 JA 的防卫基因的减少的表示伴随并且减少了导致 JA 的吲哚 glucosinolates (IG ) 的累积。相反地,提高的抵抗到 B。在 CYP82C2-overexpressing 植物的 cinerea 被导致 JA 的防卫基因的增加的表示伴随并且提高了导致 JA 的 IG 的层次。我们证明 CYP82C2 影响 IG biosynthetic 先锋的导致 JA 的累积色氨酸(Trp ) ,然而并非导致 JA 的 IAA 或导致病原体的 camalexin。一起,我们 CYP82C2 可以在导出 Trp 的第二等的代谢物的新陈代谢扮演在下面的一个假设在 JA 在哪个铺平调节的结果支持被提高。jah1-1 异种应该因此在向理解位于调停 JA 的微分回答的复杂性下面的机制的未来研究是重要的,它是重要的让植物使他们的生长适应千变万化环境。 | Fang Liu Hongling Jiang Songqing Ye Wen-Ping Chen Wenxing Liang Yingxiu Xu Bo Sun Jiaqiang Sun Qiaomei Wang Jerry D Cohen Chuanyou Li | 2010 | Cell Research2010，20，5： | 10 |
| 12 | Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene显示文摘Hemagglutinin-neuramidinase (HN ) ,纽卡斯尔疾病导出病毒的蛋白质,不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动,劈开那些受体的一个部件的能力, N-acetylneuraminic 酸(NAcneu, sialic ) 。包括人,在哺乳动物的种类的这蛋白质有有趣的反肿瘤以及有免疫力的刺激性质,这被知道。在癌症基因治疗探索 HN 基因的使用,我们构造了表示 HN 蛋白质(vFV-HN ) 的一个 recombinant 家禽痘病毒并且在 vivo 并且在 vitro 把 recombinant 病毒的 theanti 肿瘤活动与野类型的家禽痘病毒(FPV ) 的作比较。这里,我们发现尽管 B16 房间对野类型的家禽痘病毒的基础细胞毒素的效果有点抵抗,有 vFV-HN 的感染引起了显著细胞毒素的效果并且,与 vFV-HN 使免疫的忍受肿瘤的老鼠的幸存显著地与独自与 FPV 使免疫的老鼠的幸存相比被增加。而且,有 vFV-HNelicited 的老鼠的免疫 B16 肿瘤特定的细胞毒素的 T 淋巴细胞(CTL ) 回答和在 vivo 的 bothCD4+ 和 CD8+ T 房间人口的同种细胞的扩大。另外,从老鼠的淋巴节点的 T 房间种牛痘, Th1 cytokine IL-2 和 IFN-v 高级的 vFV-HN 藏匿了,显示肿瘤房间的回归与 Th1 类型主导的有免疫力的回答有关。这些结果证明有 vFV-HN 的种痘可以是为癌症基因治疗的潜在的策略。 | LI Xiao JIN Ningyi LIAN Hai GUAN Goufang SUN Lili LI Xue mei ZHENG Hongling | 2006 | Chinese Science Bulletin2006，51，22： | 9 |
| 13 | The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses显示文摘在真核细胞的房间的送信人 RNA (mRNA ) 周转以弄短开始 poly 在 3 鈥 ? 结束的(A) 尾巴,一个过程叫了 deadenylation。在酵母, deadenylation 反应被 CCR4 和联系 CCR4 的因素主要调停 1 (CAF1 ) ,描述得好的蛋白质建筑群的二个部件 CCR4 不说出。我们这里报导那 AtCAF1a 和 AtCAF1b,酵母 CAF1 基因的通常认为的 Arabidopsis 相当或相同的事物,部分面对咖啡因或在高温度补充酵母 caf1 异种的生长缺点。AtCAF1a 和 AtCAF1b 的表示被多重压力相关的荷尔蒙和刺激导致。在 vitro 的 AtCAF1a 和在预言的活跃地点的点变化破坏这项活动。破坏 AtCAF1a 或 AtCAF1b 的表示的 T-DNA 插入异种在压力相关的 mRNAs 的 deadenylation 是有缺点的,显示二 AtCAF1 蛋白质涉及在 vivo 的调整 mRNA deadenylation。有趣地, AtCAF1a 和 AtCAF1b 表演的单个、双的异种减少了表示致病相关( PR )基因 PR1 和 PR2 并且更产生 Pseudomonas syringae pv 西红柿 DC3000 ( Pst DC3000 )感染,而转基因的植物过去表示的 AtCAF1a 表演提高了 PR1 和 PR2 的表示并且增加了抵抗到一样的病原体。我们的结果在到病原体感染的调整 mRNA deadenylation 和防卫回答建议 AtCAF1 蛋白质的角色。 | Wenxing Liang Changbao Li Fang Liu Hongling Jiang Shuyu Li Jiaqiang Sun Xiaoyan Wu Chuanyou Li | 2009 | Cell Research2009，19，3： | 8 |
| 14 | Rapid breeding of pink-fruited tomato hybrids using the CRISPR/Cas9 system显示文摘As one of the most important vegetables,tomato (Solanum lycopersicum) is extensively produced and consumed worldwide and substantially contributes to human nutrition and health (The Tomato Genome Consortium,2012).Although red tomatoes are the most common,pink tomatoes are more popular in Asia,particularly in China and Japan,because of their better taste (Ballester et al.,2010;Zhu et al.,2018).Compared with red tomatoes,pink tomatoes fail to accumulate the yellow-colored flavonoid pigment,naringenin chalcone (NarCh),in their peels,resulting in a colorless peel phenotype (Adato et al,2009;Ballester et al.,2010). | Tianxia Yang Lei Deng Wei Zhao Ruoxi Zhang Hongling Jiang Zhibiao Ye Chang-Bao Li Chuanyou Li | 2019 | Journal of Genetics and Genomics2019，46，10： | 8 |
| 15 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 16 | Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways显示文摘Spaceflight-associated immune system weakening ultimately limits the ability of humans to expand their presence beyond the earth's orbit. A mechanistic study of microgravity-regulated immune cell function is necessary to overcome this challenge. Here, we demonstrate that both spaceflight (real) and simulated microgravity significantly reduce macrophage differentiation, decrease macrophage quantity and functional polarization, and lead to metabolic reprogramming, as demonstrated by changes in gene expression profiles. Moreover, we identified RAS/ERK/NFκB as a major microgravity-regulated pathway. Exogenous ERK and NFκB activators significantly counteracted the effect of microgravity on macrophage differentiation. In addition, microgravity also affects the p53 pathway, which we verified by RT-qPCR and Western blot. Collectively, our data reveal a new mechanism for the effects of microgravity on macrophage development and provide potential molecular targets for the prevention or treatment of macrophage differentiation deficiency in spaceflight. | Lu Shi Hongling Tian Peng Wang Ling Li Zhaoqi Zhang Jiayu Zhang Yong Zhao | 2021 | Cellular & Molecular Immunology2021，18，6： | 7 |
| 17 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 18 | China organic-rich shale geologic features and special shale gas production issues显示文摘The depositional environment of organic-rich shale and the related tectonic evolution in China are rather different from those in North America.In China,organic-rich shale is not only deposited in marine environment,but also in non-marine environment:marine-continental transitional environment and lacustrine environment.Through analyzing large amount of outcrops and well cores,the geologic features of organic-rich shale,including mineral composition,organic matter richness and type,and lithology stratigraphy,were analyzed,indicating very special characteristics.Meanwhile,the more complex and active tectonic movements in China lead to strong deformation and erosion of organic-rich shale,well-development of fractures and faults,and higher thermal maturity and serious heterogeneity.Co-existence of shale gas,tight sand gas,and coal bed methane(CBM)proposes a new topic:whether it is possible to co-produce these gases to reduce cost.Based on the geologic features,the primary production issues of shale gas in China were discussed with suggestions. | Yiwen Ju Guochang Wang Hongling Bu Qingguang Li Zhifeng Yan | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，3： | 5 |
| 19 | Relationship between chronic diarrhea with normal colonoscopy findings and terminal ileum lesions显示文摘 | LI Hongling WANG Changcheng LIU Shuqing XU Dongsheng ZHANG Ju CHEN hongmei | 2014 | Chinese Medical Journal2014，，16： | 4 |
| 20 | Comparison of thermal and light performance in two typical Chinese solar greenhouses in Beijing显示文摘Solar greenhouses have been used for producing vegetables in northern China during early spring,late autumn or over-winter.To improve the thermal performance of solar greenhouses,a traditional type and a retrofitted design were comparatively evaluated.In the retrofitted design,three adjustments were incorporated:the material and structure of the walls,south-facing roof angle,and structure of the north-facing back-roof.The results indicated that the thermal and light performance of the retrofitted greenhouse was much better than that of the traditional greenhouse.Specifically,the daily mean temperature,minimum air temperature,and soil temperature inside the greenhouses after retrofit ting were increased by 1.3,2.4,and 1.9℃,respectively,meanwhile,the daily total solar radiation and PAR were increased by 28.2%and 9.2%,respectively.The wall temperature and its daily variation range were reduced with increasing depth and height.The characteristic analysis of heat storage and release indicated that higher locations have longer heat storage,and shorter heat release time in vertical direction,as well as a lower ratio of heat release to storage.In horizontal direction,the western wall has the shortest heat storage time but the highest heat release flux density.Altogether,the heat storage time of the wall is 1.5 h less than that of the soil.The heat storage flux density of the wall is 1.5 times of that of the soil,but the heat release flux is only 61%of the soil’s value.The total wall heat storage is half of that of the soil in the greenhouse;the total wall heat release amount is only a quarter of that of the soil.Therefore,the thermal environment of solar greenhouses can be further improved by improving the thermal insulation properties of the wall. | Fan Xu Chao Shang Hongling Li Xuzhang Xue Weituo Sun Hong Chen Yinkun Li Zhenhe Zhang Xinxu Li Wenzhong Guo | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 4 |
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