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| 1 | Construction of chimeric inducible promoters by elicitors of rice fungal blast pathogen and their expression in transgenic rice显示文摘The promoter fragments of wheat GstA1 and potato Gst1 have been amplified by PCR, cloned and fused respectively to the minimal promoter sequence of rice actin gene (Act1)) and its 5’ untranslated leader sequence together with GUS. The constructs with 2 chimeric promoters (WGA and PGA) have been transferred into rice in order to analyze their inducibility patterns in transgenic rice plants. The results show that: WGA and PGA are both inducible by elicitors of Pyricularia oryzae in transgenic rice cells; the intron I of rice Act1 gene is important for the heterogenic expression of monocot and dicot promoter elements in rice; and the Act1 minimal promoter and its 5’untranslated leader sequence produced low level background expression in rice. | LU Huafei MING Xiaotian QU Lijia LIU Meihua LI Jing GU Hongya CHEN Zhangliang | 2000 | Chinese Science Bulletin2000，45，3： | 5 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Optimal control on special Euclidean group via natural gradient algorithm显示文摘Considering the optimal control problem about the control system of the special Euclidean group whose output only depends on its input is meaningful in practical applications. The optimal control considered here is described as the output matrix is as close as possible to the target matrix by adjusting the system input.The geodesic distance is adopted as the measure of the difference between the output matrix and the target matrix, and the trajectory of the control input obtained in the process is achieved. Furthermore, some numerical simulations are shown to illustrate our outcomes based on the natural gradient descent algorithm for optimizing the control system of the special Euclidean group. | Chunhui LI Erchuan ZHANG Lin JIU Huafei SUN | 2016 | Science China(Information Sciences)2016，59，11： | 4 |
| 4 | Research Progress of the Algebraic and Geometric Signal Processing显示文摘The investigation of novel signal processing tools is one of the hottest research topics in modern signal processing community. Among them, the algebraic and geometric signal processing methods are the most powerful tools for the representation of the classical signal processing method. In this paper, we provide an overview of recent contributions to the algebraic and geometric signal processing. Specifically, the paper focuses on the mathematical structures behind the signal processing by emphasizing the algebraic and geometric structure of signal processing. The two major topics are discussed. First, the classical signal processing concepts are related to the algebraic structures, and the recent results associated with the algebraic signal processing theory are introduced. Second, the recent progress of the geometric signal and information processing representations associated with the geometric structure are discussed. From these discussions, it is concluded that the research on the algebraic and geometric structure of signal processing can help the researchers to understand the signal processing tools deeply, and also help us to find novel signal processing methods in signal processing community. Its practical applications are expected to grow significantly in years to come, given that the algebraic and geometric structure of signal processing offer many advantages over the traditional signal processing. | TAO Ran LI Bingzhao SUN Huafei | 2013 | Defence Technology(防务技术)2013，9，1： | 1 |
| 5 | Laguerre Isoparametric Hypersurfaces in R4显示文摘 | Li Tongzhu Sun Huafei | 2011 | Acta Mathematica Sinica English Series2011，28，： | 1 |
| 6 | Potentiating antilymphoma efficacy of chemotherapy using a liposome for integration of CD20 targeting, ultra-violet irradiation polymerizing, and controlled drug delivery显示文摘 | Cong Wu Huafei Li He Zhao Weiwei Zhang Yan Chen Zhanyi Yue Qiong Lu Yuxiang Wan Xiaoyu Tian Anmei Deng | 2014 | Nanoscale Research Letters2014，，： | 1 |
| 7 | An Interactive Assembly Process Planner 显示文摘 | Huafei Liao Linxuan Zhang Tianyuan Xiao Li Zeng Yue Gu | 2004 | Tsinghua Science and Technology (S 1007-0214)2004，9，2： | 1 |
| 8 | Synergistic anti-tumor therapy by a homotypic cell membranecloaked biomimetic nanocarrier with exceptionally potent activity against hepatic carcinoma显示文摘Hepatic carcinoma(HC)is the sixth most frequently occurring malignancies and the third leading cause of cancer death worldwide.Sepantronium bromide(YM155)is a small molecule inhibitor of survivin,which has broad-spectrum anticancer therapeutic effects in various xenograft models.However,several-day continuous infusion is required to achieve greater antitumor efficacy because of rapid elimination from the blood circulation.Herein,a SMMC-7721 cancerous cyto-membrane-cloaked drug delivery system(DDS)(named as iM7721@GQD-YM),was developed for co-encapsulation of YM155 and graphene quantum dots(GQDs).Cytomembrane coating endowed iM7721@GQD-YM with effective targeting for homologous HC cells,excellent biocompatibility and favorable immunocompatibility for in vivo application.Surface decoration of iRGD peptide further enhanced its tumor targeting activity by iRGD-integrin recognition.In addition,under the irradiation of near-infrared ray(NIR),GQDs can directly kill tumors through photothermal effect and cause cell membrane rupture,accurately releasing YM155 at tumor sites.The physicochemical properties,in vivo and ex vivo anti-tumor efficacy,and mechanisms of iM7721@GQD-YM nanoparticles(NPs)were systematically investigated in this work.The experimental results clearly indicate that the versatile biomimetic DDS holds great potential for the treatment of HC,which merits further investigation in both pre-clinical and clinical studies. | Shini Feng Pinyue Ni Yan Gong Bijiang Geng Hui Li Chenlin Miao Ruyu Fan Levon Galstyan Dengyu Pan Fuxue Chen Huafei Li | 2022 | Nano Research2022，15，9： | 1 |
| 9 | Suppression of charge recombination by application of CueZnSnS4-graphene counter electrode to thin dye-sensitized solar cells显示文摘 | Yan Li Huafei Guo Xiuqin Wang Ningyi Yuan Jianning Ding | 2016 | Science Bulletin2016，61，15： | 1 |
| 10 | Circulating cell-free DNA for cancer early detection显示文摘Effective screening modalities are currently available for only a small subset of cancers,and they generally have suboptimal performance with complicated procedures.Therefore,there is an urgent need to develop simple,accurate,and non-invasive methods for early detection of cancers.Genetic and epigenetic alterations in plasma circulating cell-free DNA(cfDNA)have shown the potential to revolutionize methods of early detection of cancers and facilitate subsequent diagnosis to improve survival of patients.The medical interest in cfDNA assays has been inspired by emerging single-and multi-early detection of cancers studies.This review summarizes current technological and clinical advances,in the hopes of providing insights into the development and applications of cfDNA assays in various cancers and clinical scenarios.The key phases of clinical development of biomarkers are highlighted,and the future developments of cfDNA-based liquid biopsies in early detection of cancers are outlined.It is hoped that this study can boost the potential integration of cfDNA-based early detection of cancers into the current clinical workflow. | Qiang Gao Qiang Zeng Zhijie Wang Chengcheng Li Yu Xu Peng Cui Xin Zhu Huafei Lu Guoqiang Wang Shangli Cai Jie Wang Jia Fan | 2022 | The Innovation2022，3，4： | 1 |
| 11 | Detection and classification of breast lesions using multiple information on contrast-enhanced mammography by a multiprocess deep-learning system: A multicenter study显示文摘Objective: Accurate detection and classification of breast lesions in early stage is crucial to timely formulate effective treatments for patients. We aim to develop a fully automatic system to detect and classify breast lesions using multiple contrast-enhanced mammography(CEM) images.Methods: In this study, a total of 1,903 females who underwent CEM examination from three hospitals were enrolled as the training set, internal testing set, pooled external testing set and prospective testing set. Here we developed a CEM-based multiprocess detection and classification system(MDCS) to perform the task of detection and classification of breast lesions. In this system, we introduced an innovative auxiliary feature fusion(AFF)algorithm that could intelligently incorporates multiple types of information from CEM images. The average freeresponse receiver operating characteristic score(AFROC-Score) was presented to validate system’s detection performance, and the performance of classification was evaluated by area under the receiver operating characteristic curve(AUC). Furthermore, we assessed the diagnostic value of MDCS through visual analysis of disputed cases,comparing its performance and efficiency with that of radiologists and exploring whether it could augment radiologists’ performance.Results: On the pooled external and prospective testing sets, MDCS always maintained a high standalone performance, with AFROC-Scores of 0.953 and 0.963 for detection task, and AUCs for classification were 0.909[95% confidence interval(95% CI): 0.822-0.996] and 0.912(95% CI: 0.840-0.985), respectively. It also achieved higher sensitivity than all senior radiologists and higher specificity than all junior radiologists on pooled external and prospective testing sets. Moreover, MDCS performed superior diagnostic efficiency with an average reading time of 5 seconds, compared to the radiologists’ average reading time of 3.2 min. The average performance of all radiologists was also improved to varying degrees with MDCS assistance.Conclusions: MDCS demonstrated excellent performance in the detection and classification of breast lesions,and greatly enhanced the overall performance of radiologists. | Yuqian Chen Zhen Hua Fan Lin Tiantian Zheng Heng Zhou Shijie Zhang Jing Gao Zhongyi Wang Huafei Shao Wenjuan Li Fengjie Liu Simin Wang Yan Zhang Feng Zhao Hao Liu Haizhu Xie Heng Ma Haicheng Zhang Ning Mao | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 12 | Analysis of surface cracking in water-cooled rolls and heat transfer between furnace chamber and rolls in a direct flame furnace显示文摘In the direct fired furnace of a continuous annealing line,seal rolls are susceptible to deformation that leads to surface defects of steel strips. According to failure analysis,the reasons include improper structural design and heat imbalance. An improved design has been proposed to reduce stress concentration and thermal radiation. A heat transfer model has been employed to determine the proper water flow rate for roll cooling. Industrial application proves that seal rolls with the new design has less deformation and longer service life. | LIU Yimin LIU Huafei LI Jun | 2015 | Baosteel Technical Research2015，9，1： | 0 |
| 13 | Heisenberg Uncertainty Principle for n-Dimen-sional Linear Canonical Transforms显示文摘The uncertainty principle proposed by German physicist Heisenberg in 1927 is a basic principle of quantum mechanics and signal processing.Since linear canonical transformation has been widely used in various fields of signal processing recently and Heisenberg uncertainty principle has been endowed with new expressive meaning in linear canonical transforms domain,in this manuscript,an improved Heisenberg uncertainty principle is obtained in linear canonical trans-forms domain. | Yonggang Li Chuan Zhang Huafei Sun | 2021 | Journal of Beijing Institute of Technology2021，30，3： | 0 |
| 14 | Principal whitened gradient-projection algorithm for distribution control显示文摘In this paper,we use an information geometric algorithm to solve the distribution control problem.The new designed algorithm is called principal whitened gradient-projection algorithm.In the principal natural gradient step,we use principal whitened gradient algorithm to obtain an optimal trajectory of the weight vector on the B-spline manifold from the viewpoint of information geometry.In the projection step,we project the selected points on B onto M.The coordinates of the projections on M give the trajectory of the control input u. | ZHANG ShiCheng Sun HuaFei LI ChunHui | 2013 | Science China(Information Sciences)2013，56，3： | 0 |
| 15 | Characterization and performance of V2Os/CeO2 for NH3-SCR of NO at low temperatures显示文摘A series of CeO2 supported V205 catalysts with various loadings were prepared with different calcination temperatures by the incipient impregnation. The catalysts were evaluated for low temperature selective catalytic reduction (SCR) of NO with ammonia (NH3). The effects of 02 and SO2 on catalytic activity were also studied. The catalysts were characterized by specific surface areas (SBET) and X-ray diffraction (XRD) methods. The experimental results showed that NO conversion changed significantly with the different V205 loading and calcination temperature. With the V205 loading increasing from 0 to 10wt%, NO conversion increased significantly, but decreased at higher loading. The optimum calcination temperature was 400℃. The best catalyst yielded above 80% NO conversion in the reaction temperature range of 160℃-300℃. The formation of CeVO4 on the surface of catalysts caused the decrease of redox ability. | Caiting LI Qun LI Pei LU Huafei CUI Guangming ZENG | 2012 | Frontiers of Environmental Science & Engineering2012，6，2： | 0 |
| 16 | Large-Area Monolayer n-Type Molecular Semiconductors with Improved Thermal Stability and Charge Injection显示文摘We fabricated monolayer n-type two-dimensional crystalline semiconducting films with millimeter-sized areas and remarkable morphological uniformity using an antisolvent-confined spin-coating method.The antisolvent can cause a downstream Marangoni flow,which improves the film morphologies.The deposited crystalline monolayer films exhibit excellent thermal stabilities after annealing,which reveals the annealing-induced enhancement of crystallinity.The transistors based on the n-type monolayer crystalline films show linear output characteristics and superior electron mobilities.The improved charge injection between monolayer films and Au electrodes results from the energy level shift as the films decrease to the monolayer,which leads to a lower injection barrier.This work demonstrates a promising method for fabricating air-stable,low-cost,high-performance,and large-area organic electronics. | Sai Jiang Lichao Peng Xiaosong Du Qinyong Dai Jianhang Guo Jianhui Gu Jian Su Ding Gu Qijing Wang Huafei Guo Jianhua Qiu Yun Li | 2023 | Chinese Physics Letters2023，40，3： | 0 |
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