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| 1 | Osteoblastic glucocorticoid signaling exacerbates high-fat-diet-induced bone loss and obesity显示文摘Chronic high-fat diet(HFD)consumption not only promotes obesity and insulin resistance,but also causes bone loss through mechanisms that are not well understood.Here,we fed wild-type CD-1 mice either chow or a HFD(43%of energy from fat)for 18 weeks;HFD-fed mice exhibited decreased trabecular volume(-28%)and cortical thickness(-14%)compared to chow-fed mice.In HFD-fed mice,bone loss was due to reduced bone formation and mineral apposition,without obvious effects on bone resorption.HFD feeding also increased skeletal expression of sclerostin and caused deterioration of the osteocyte lacunocanalicular network(LCN).In mice fed HFD,skeletal glucocorticoid signaling was activated relative to chow-fed mice,independent of serum corticosterone concentrations.We therefore examined whether skeletal glucocorticoid signaling was necessary for HFD-induced bone loss,using transgenic mice lacking glucocorticoid signaling in osteoblasts and osteocytes(HSD2^(OB/OCY)-tg mice).In HSD2^(OB/OCY)-tg mice,bone formation and mineral apposition rates were not suppressed by HFD,and bone loss was significantly attenuated.Interestingly,in HSD2^(OB/OCY)-tg mice fed HFD,both Wnt signaling(less sclerostin induction,increased P | Sarah Kim Holger Henneicke Lauryn L.Cavanagh Eugenie Macfarlane Lee Joanne Thai Daphne Foong Sylvia J.Gasparini Colette Fong-Yee Michael M.Swarbrick Markus J.Seibel Hong Zhou | 2021 | Bone Research2021，9，4： | 2 |
| 2 | Understanding and managing the possible adverse effects associated with bevacizumab显示文摘 | STACY S. SHORD LINDA R. BRESSLER LAURYN A. TIERNEY SANDRA CUELLAR AMINA GEORGE | 2009 | American Journal of Health-System Pharmacy2009，，11： | 1 |
| 3 | From music making to speaking: Engaging the mirror neuron system in autism显示文摘 | Catherine Y. Wan Krystal Demaine Lauryn Zipse Andrea Norton Gottfried Schlaug | 2010 | Brain Research Bulletin2010，，3： | 1 |
| 4 | Synthesis fluorine-18 radiolabeling and biological evaluation of N- (( E )-4-fluorobut-2-en-l-yl )-2-carbomethoxy-3显示文摘 | Jeffrey S S Lauryn M D Ping C | 2010 | Journal of Medicinal Chemistry2010，53，： | 1 |
| 5 | High-Temperature High-Efficiency Solar Thermoelectric Generators显示文摘 | Lauryn L. Baranowski Emily L. Warren Eric S. Toberer | 2014 | Journal of Electronic Materials2014，，6： | 1 |
| 6 | Paced mating behavior in the naturally cycling and the hormone treated female rat显示文摘 | LAURYN R Z ERICA M B ANN S C | 2000 | Physiology Behav2000，70，： | 1 |
| 7 | andgottfried Schla- ug Melodic Intonation Therapy:Shared Insights on How it is Done and Why it Might Help 显示文摘 | Andrea Norton Lauryn Zipse Sarah Marchina | 2009 | Ann N Y Acad Sci2009，，1169： | 1 |
| 8 | 超越实用:Facebook的品牌挑战显示文摘那是个让全世界都关注的估值数字:500亿美元。对于只有十年历史的Facebook来说,从新英格兰的一个大学宿舍走出到现在成为全世界估值最高的公司之一,这个成绩实在不赖。 | Lauryn Bennett | 2011 | 新营销2011，，12： | 0 |
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