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| 1 | Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis显示文摘AIM: To evaluate whether Helicobacter pylori(H. pylori) eradication therapy benefits patients with functional dyspepsia(FD).METHODS: Randomized controlled trials(RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English(up to May 2015) were identified by searching Pub Med, EMBASE, and The Cochrane Library. Pooled estimates were measured using the fixed or random effect model. Overall effect was expressed as a pooled risk ratio(RR) or a standard mean difference(SMD). All data were analyzed with Review Manager 5.3 and Stata 12.0.RESULTS: This systematic review included 25 RCTs with a total of 5555 patients with FD. Twenty-three of these studies were used to evaluate the benefits of H. pylori eradication therapy for symptom improvement; the pooled RR was 1.23(95%CI: 1.12-1.36, P < 0.0001). H. pylori eradication therapy demonstrated symptom improvement during long-term follow-up at ≥ 1 year(RR = 1.24; 95%CI: 1.12-1.37, P < 0.0001) but not during short-term follow-up at < 1 year(RR = 1.26; 95%CI: 0.83-1.92, P = 0.27). Seven studies showed no benefit of H. pylori eradication therapy on quality of life with an SMD of-0.01(95%CI:-0.11 to 0.08, P = 0.80). Six studies demonstrated that H. pylori eradication therapy reduced the development of peptic ulcer disease compared to no eradication therapy(RR = 0.35; 95%CI: 0.18-0.68, P = 0.002). Eight studies showed that H. pylori eradication therapy increased the likelihood of treatment-related side effects compared to no eradication therapy(RR = 2.02; 95%CI: 1.12-3.65, P = 0.02). Ten studies demonstrated that patients who received H. pylori eradication therapy were more likely to obtain histologic resolution of chronic gastritis compared to those who did not receive eradication therapy(RR = 7.13; 95%CI: 3.68-13.81, P < 0.00001).CONCLUSION: The decision to eradicate H. pylori in patients with functional dyspepsia requires individual assessment. | Li-Jun Du Bin-Rui Chen John J Kim Sarah Kim Jin-Hua Shen Ning Dai | 2016 | World Journal of Gastroenterology2016，22，12： | 30 |
| 2 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 3 | Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes显示文摘The Arabidopsis thaliana Calmodulin-binding Transcription Activator(CAMTA)transcription factors CAMTA1,CAMTA2,and CAMTA3(CAMTA123)serve as master regulators of salicylic acid(SA)-mediated immunity,repressing the biosynthesis of SA in healthy plants.Here,we show that CAMTA123 also repress the biosynthesis of pipecolic acid(Pip)in healthy plants.Loss of CAMTA123 function resulted in the induction of AGD2-like defense response protein 1(ALD1),which encodes an enzyme involved in Pip biosynthesis.Induction of ALD1 resulted in the accumulation of high levels of Pip,which brought about increased levels of the SA receptor protein NPR1 without induction of NPR1 expression or requirement for an increase in SA levels.Pip-mediated induction of ALD1 and genes regulating the biosynthesis of SA—CBP60g,SARD1,PAD4,and EDS1—was largely dependent on NPR1.Furthermore,Pip-mediated increase in NPR1 protein levels was associated with priming of Pip and SA biosynthesis genes to induction by low levels of SA.Taken together,our findings expand the role for CAMTA123 in regulating key immunity genes and suggest a working model whereby loss of CAMTA123 repression leads to the induction of plant defense genes and initiation of SAR. | Yongsig Kim Sarah J.Gilmour Lumen Chao Sunchung Park Michael F.Thomashow | 2020 | Molecular Plant2020，13，1： | 8 |
| 4 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 5 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 6 | Uncovering material deformations via machine learning combined with four-dimensional scanning transmission electron microscopy显示文摘Understanding lattice deformations is crucial in determining the properties of nanomaterials,which can become more prominent in future applications ranging from energy harvesting to electronic devices.However,it remains challenging to reveal unexpected deformations that crucially affect material properties across a large sample area.Here,we demonstrate a rapid and semi-automated unsupervised machine learning approach to uncover lattice deformations in materials.Our method utilizes divisive hierarchical clustering to automatically unveil multi-scale deformations in the entire sample flake from the diffraction data using four-dimensional scanning transmission electron microscopy(4D-STEM).Our approach overcomes the current barriers of large 4D data analysis without a priori knowledge of the sample.Using this purely data-driven analysis,we have uncovered different types of material deformations,such as strain,lattice distortion,bending contour,etc.,which can significantly impact the band structure and subsequent performance of nanomaterials-based devices.We envision that this data-driven procedure will provide insight into materials’intrinsic structures and accelerate the discovery of materials. | Chuqiao Shi Michael C.Cao Sarah M.Rehn Sang-Hoon Bae Jeehwan Kim Matthew RJones David A.Muller Yimo Han | 2022 | npj Computational Materials2022，，1： | 3 |
| 7 | Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer显示文摘 | Jie Liang Masayuki Nagahashi Eugene Y. Kim Kuzhuvelil B. Harikumar Akimitsu Yamada Wei-Ching Huang Nitai C. Hait Jeremy C. Allegood Megan M. Price Dorit Avni Kazuaki Takabe Tomasz Kordula Sheldon Milstien Sarah Spiegel | 2013 | Cancer Cell2013，，： | 3 |
| 8 | Management of borderline resectable pancreatic cancer显示文摘Pancreatic cancer is the fourth most common cause of cancer death in the United States. Surgery remains the only curative option; however only 20% of the patients have resectable disease at the time of initialpresentation. The definition of borderline resectable pancreatic cancer is not uniform but generally denotes to regional vessel involvement that makes it unlikely to have negative surgical margins. The accurate staging of pancreatic cancer requires triple phase computed tomography or magnetic resonance imaging of the pancreas. Management of patients with borderline resectable pancreatic cancer remains unclear. The data for treatment of these patients is primarily derived from retrospective single institution experience. The prospective trials have been plagued by small numbers and poor accrual. Neoadjuvant therapy is recommended and typically consists of chemotherapy and radiation therapy. The chemotherapeutic regimens continue to evolve along with type and dose of radiation therapy. Gemcitabine or 5-fluorouracil based chemotherapeutic combinations are administered. The type and dose of radiation vary among different institutions. With neoadjuvant treatment, approximately 50% of the patients are able to undergo surgical resections with negative margins obtained in greater than 80% of the patients. Newer trials are attempting to standardize the definition of borderline resectable pancreatic cancer and treatment regimens. In this review, we outline the definition, imaging requirements and management of patients with borderline resectable pancreatic cancer. | Amit Mahipal Jessica Frakes Sarah Hoffe Richard Kim | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 3 |
| 9 | Osteoblastic glucocorticoid signaling exacerbates high-fat-diet-induced bone loss and obesity显示文摘Chronic high-fat diet(HFD)consumption not only promotes obesity and insulin resistance,but also causes bone loss through mechanisms that are not well understood.Here,we fed wild-type CD-1 mice either chow or a HFD(43%of energy from fat)for 18 weeks;HFD-fed mice exhibited decreased trabecular volume(-28%)and cortical thickness(-14%)compared to chow-fed mice.In HFD-fed mice,bone loss was due to reduced bone formation and mineral apposition,without obvious effects on bone resorption.HFD feeding also increased skeletal expression of sclerostin and caused deterioration of the osteocyte lacunocanalicular network(LCN).In mice fed HFD,skeletal glucocorticoid signaling was activated relative to chow-fed mice,independent of serum corticosterone concentrations.We therefore examined whether skeletal glucocorticoid signaling was necessary for HFD-induced bone loss,using transgenic mice lacking glucocorticoid signaling in osteoblasts and osteocytes(HSD2^(OB/OCY)-tg mice).In HSD2^(OB/OCY)-tg mice,bone formation and mineral apposition rates were not suppressed by HFD,and bone loss was significantly attenuated.Interestingly,in HSD2^(OB/OCY)-tg mice fed HFD,both Wnt signaling(less sclerostin induction,increased P | Sarah Kim Holger Henneicke Lauryn L.Cavanagh Eugenie Macfarlane Lee Joanne Thai Daphne Foong Sylvia J.Gasparini Colette Fong-Yee Michael M.Swarbrick Markus J.Seibel Hong Zhou | 2021 | Bone Research2021，9，4： | 2 |
| 10 | The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis显示文摘 | Seung Up Kim Hyun Jung Oh Ian R. Wanless Sarah Lee Kwang-Hyub Han Young Nyun Park | 2012 | Journal of Hepatology2012，，3： | 2 |
| 11 | The I nhibitor of wax 1 locus ( I w1 ) prevents formation of β‐ and OH ‐β‐diketones in wheat cuticular waxes and maps to a sub‐c M interval on chromosome arm 2 BS显示文摘 | Nikolai M. Adamski Maxwell S. Bush James Simmonds Adrian S. Turner Sarah G. Mugford Alan Jones Kim Findlay Nikolai Pedentchouk Penny Wettstein‐Knowles Cristobal Uauy | 2013 | Plant J2013，，6： | 2 |
| 12 | A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease显示文摘 | Evan S. Dellon Hannah P. Kim Sarah L.W. Sperry David A. Rybnicek John T. Woosley Nicholas J. Shaheen | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 13 | IM-412 inhibits transforming growth factor β-induced fibroblast differentiation in human lung fibroblast cells显示文摘 | Sarah Park Ji-Yeon Ahn Min-Jin Lim Mi-Hyoung Kim Sae-lo-oom Lee Yeon-Sook Yun Gajin Jeong Jie-Young Song | 2010 | Biochemical and Biophysical Research Communications2010，，2： | 2 |
| 14 | Just-in-Time Teaching Exercises to Engage Students in an Introductory-Level Dinosaur Course显示文摘 | Laura A. Guertin Sarah E. Zappe Heeyoung Kim | 2007 | Journal of Science Education and Technology2007，，6： | 1 |
| 15 | Adjuvant Treatment for Gastric Cancer: Chemotherapy Versus Radiation显示文摘 | Noman Ashraf Sarah Hoffe Richard Kim | 2013 | The Oncologist2013，，9： | 1 |
| 16 | Reti-noids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators显示文摘 | Kintscher Ulrich Kim Sarah | 2001 | Arteriosclerosis Thrombosis & Vascular Biology2001，21，5： | 1 |
| 17 | Ig SF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95显示文摘Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand(RANKL)stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast maturation.Here, we demonstrate that immunoglobulin superfamily member 11(Ig SF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95(PSD-95), a scaffold protein with multiple protein interaction domains. Ig SF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, Ig SF11-deficient mice exhibit increased bone mass.Using in vitro osteoclast culture systems, we show that Ig SF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in Ig SF11-deficient cells is rescued by full-length Ig SF11 and that the Ig SF11-PSD-95 interaction requires the 75 C-terminal amino acids of Ig SF11. Our findings reveal a critical role for Ig SF11 during osteoclast differentiation and suggest a role for Ig SF11 in a receptor-and signal transduction molecule-containing protein complex. | Hyunsoo Kim Noriko Takegahara Matthew CWalsh Sarah AMiddleton Jiyeon Yu Jumpei Shirakawa Jun Ueda Yoshitaka Fujihara Masahito Ikawa Masaru Ishii Junhyong Kim Yongwon Choi | 2020 | Bone Research2020，8，1： | 1 |
| 18 | RNA-seq analysis of Rubus idaeus cv. Nova: transcriptome sequencing and de novo assembly for subsequent functional genomics approaches显示文摘 | Tae Kyung Hyun Sarah Lee Dhinesh Kumar Yeonggil Rim Ritesh Kumar Sang Yeol Lee Choong Hwan Lee Jae-Yean Kim | 2014 | Plant Cell Reports2014，，10： | 1 |
| 19 | Investigating the factors influencing professional identity of first year health and social care students显示文摘 | Kim AM Sarah HP Patrick SP | 2006 | Learning in Health and Social Care2006，5，2： | 1 |
| 20 | Mapping ideas from cyberspace to realspace: visualizing the spatial context of keywords from web page search results显示文摘We introduce a new method for visualizing and analyzing information landscapes of ideas and events posted on public web pages through customized web-search engines and keywords.This research integrates GIScience and web-search engines to track and analyze public web pages and their web contents with associated spatial relationships.Web pages searched by clusters of keywords were mapped with real-world coordinates(by geolocating their Internet Protocol addresses).The resulting maps represent web information landscapes consisting of hundreds of populated web pages searched by selected keywords.By creating a Spatial Web Automatic Reasoning and Mapping System prototype,researchers can visualize the spread of web pages associated with specific keywords,concepts,ideas,or news over time and space.These maps may reveal important spatial relationships and spatial context associated with selected keywords.This approach may provide a new research direction for geographers to study the diffusion of human thought and ideas.A better understanding of the spatial and temporal dynamics of the‘collective thinking of human beings’over the Internet may help us understand various innovation diffusion processes,human behaviors,and social movements around the world. | Ming-Hsiang Tsou Ick-Hoi Kim Sarah Wandersee Daniel Lusher Li An Brian Spitzberg Dipak Gupta Jean Mark Gawron Jennifer Smith Jiue-An Yang Su Yeon Han | 2014 | International Journal of Digital Earth2014，7，4： | 1 |
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