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| 1 | A CIN-like TCP transcription factor(LsTCP4)having retrotransposon insertion associates with a shift from Salinas type to Empire type in crisphead lettuce(Lactuca sativa L.)显示文摘To improve several agronomic traits in crisphead lettuce(Lactuca sativa L.)under high-temperature growth conditions,we investigated the correlation among those traits in multiple cultivars and performed genetic mapping of their causal genes.In a field cultivation test of Empire type(serrated leaf)and Salinas type(wavy leaf)cultivars,Empire type cultivars showed increased tipburn susceptibility and late bolting compared with Salinas type cultivars.We attempted genetic mapping of leaf shape and bolting time by ddRAD-seq using the F2 population derived from a cross between‘VI185’(Empire type)and‘ShinanoGreen’(Salinas type).These analyses suggested that both traits are controlled by a single locus in LG5.Genotyping of 51 commercial lettuce cultivars with a tightly linked marker(LG5_v8_252.743Mbp)at this locus showed an association between its genotype and the serrated leaf phenotype.By further fine mapping and transcriptome analysis,a gene encoding putative CIN-like TCP transcription factor was determined to be a candidate gene at this locus and was designated as LsTCP4.An insertion of retrotransposable element was found in the allele of‘VI185’,and its transcript level in the leaves was lower than that in‘ShinanoGreen’.Because shapes of leaf epidermal cells in‘VI185’were similar to those in the TCP family mutant of Arabidopsis thaliana,the leaf shape phenotype was likely caused by reduced expression of LsTCP4.Furthermore,because it is known that the TCP family protein also controls flowering time via interaction with FT in A.thaliana,it was highly possible that LsTCP4 gave pleiotropic effects on both leaf shape and bolting time in lettuce. | Kousuke Seki Kenji Komatsu Keisuke Tanaka Masahiro Hiraga Hiromi Kajiya-Kanegae Hideo Matsumura Yuichi Uno | 2020 | Horticulture Research2020，7，1： | 7 |
| 2 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 3 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 4 | Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms显示文摘 | Daisuke Yamasaki Natsuko Kawabe Hitomi Nakamura Keisuke Tachibana Kenji Ishimoto Toshiya Tanaka Hiroyuki Aburatani Juro Sakai Takao Hamakubo Tatsuhiko Kodama Takefumi Doi | 2011 | European Journal of Cell Biology2011，，8： | 2 |
| 5 | Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma显示文摘Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended. | Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 6 | Cancer-derived VEGF plays no role in malignant ascites formation in the mouse显示文摘AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ascites.METHODS: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression knockdown.RESULTS: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ statistically.CONCLUSION: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF. | Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 7 | Expression of Δ6, Δ5 desaturase and GLELO elongase genes from Mortierella alpina for production of arachidonic acid in soybean [ Glycine max (L.) Merrill] seeds显示文摘 | Ren Chen Keisuke Matsui Miyuki Ogawa Mieko Oe Misa Ochiai Hiroshi Kawashima Eiji Sakuradani Sakayu Shimizu Masao Ishimoto Makoto Hayashi Yoshikatsu Murooka Yoshikazu Tanaka | 2005 | Plant Science2005，，2： | 1 |
| 8 | A new noninvasive measurement system for wave intensity: evaluation of carotid arterial wave intensity and reproducibility显示文摘 | K. Niki Motoaki Sugawara Dehua Chang Akimitsu Harada Takashi Okada Ryoichi Sakai Keisuke Uchida Rie Tanaka Catherine E. Mumford | 2002 | Heart and Vessels2002，，1： | 1 |
| 9 | Early appendiceal adenocarcinoma. A review of the literature with special reference to optimal surgical procedures显示文摘 | Keisuke Hata Nobutaka Tanaka Yukihiro Nomura Ikuo Wada Hirokazu Nagawa | 2002 | Journal of Gastroenterology2002，，3： | 1 |
| 10 | IL-18 gene polymorphisms affect IL-18 production capability by monocytes显示文摘 | Junsuke Arimitsu Toru Hirano Shinji Higa Mari Kawai Tetsuji Naka Atsushi Ogata Yoshihito Shima Minoru Fujimoto Tomoki Yamadori Keisuke Hagiwara Tomoharu Ohgawara Yusuke Kuwabara Ichiro Kawase Toshio Tanaka | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 11 | Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer显示文摘 | Norimitsu Tanaka Shinichi Toyooka Junichi Soh Takafumi Kubo Hiromasa Yamamoto Yuho Maki Takayuki Muraoka Kazuhiko Shien Masashi Furukawa Tsuyoshi Ueno Hiroaki Asano Kazunori Tsukuda Keisuke Aoe Shinichiro Miyoshi | 2011 | Lung Cancer2011，，1： | 1 |
| 12 | Results of immunotherapy for patients with unexplained secondary recurrent abortions显示文摘 | Hiroshi Adachi Koichi Takakuwa Takuya Mitsui Keisuke Ishii Masaki Tamura Kenichi Tanaka | 2003 | Clinical Immunology2003，，3： | 1 |
| 13 | Modeling the trajectory of window flames with regard to flow attachment to the adjacent wall显示文摘 | Keisuke Himoto Tsuneto Tsuchihashi Yoshiaki Tanaka Takeyoshi Tanaka | 2008 | Fire Safety Journal2008，，2： | 1 |
| 14 | Notch effect on fatigue strength reduction of bearing steel in the very high cycle regime显示文摘 | Yoshiaki Akiniwa Nobuyuki Miyamoto Hirotaka Tsuru Keisuke Tanaka | 2006 | International Journal of Fatigue2006，，11： | 1 |
| 15 | Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression<.-- Doctopic: CAN -->显示文摘 | Yoshifumi Morita Takanori Sakaguchi Koji Ikegami Naoko Goto-Inoue Takahiro Hayasaka Vu Thi Hang Hiroki Tanaka Takashi Harada Yasushi Shibasaki Atsushi Suzuki Kazuhiko Fukumoto Keisuke Inaba Makoto Murakami Mitsutoshi Setou Hiroyuki Konno | 2013 | Journal of Hepatology2013，，2： | 1 |
| 16 | Development of a strain for efficient degradation of polychlorinated biphenyls by patchwork assembly of degradation pathways显示文摘 | Tsuneo Ohmori Hirokazu Morita Megumi Tanaka Keisuke Miyauchi Daisuke Kasai Kensuke Furukawa Kiyotaka Miyashita Naoto Ogawa Eiji Masai Masao Fukuda | 2010 | Journal of Bioscience and Bioengineering2010，，4： | 1 |
| 17 | Diffraction Measurements of Residual Macrotress and Microstress Using X-rays显示文摘 | Keisuke Tanaka Yoshiaki Akiniwa | 2004 | Synchrotron and Neutrons JSME International Journal Series A2004，147，3： | 1 |
| 18 | Reservoir monitoring by a 4D electrical technique显示文摘 | Keisuke Ushijima Hideki Mizunaga Toshuaki Tanaka | 1999 | The leading edge December1999，，： | 1 |
| 19 | Usefulness of Beta-Catenin Immunostaining for the Differential Diagnosis of Solid-Pseudopapillary Neoplasm of the Pancreas显示文摘 | Yukichi Tanaka Kenji Notohara Keisuke Kato Rieko Ijiri Shigeo Nishimata Tetsumi Miyake Masaharu Fukunaga Minoru Horisawa Yukio Nakatani | 2002 | The American Journal of Surgical Pathology2002，，： | 1 |
| 20 | A new noninvasive measurement system for wave intensity: evaluation of carotid arterial wave intensity and reproducibility显示文摘 | K. Niki Motoaki Sugawara Dehua Chang Akimitsu Harada Takashi Okada Ryoichi Sakai Keisuke Uchida Rie Tanaka Catherine E. Mumford | 2002 | Heart and Vessels2002，，1： | 1 |
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