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| 1 | High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection显示文摘AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori infection.METHODS: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify HBD-2.RESULTS: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected subjects.CONCLUSION: Our results place the β-defensins, especially HBD-2, in the front line of innate immune defence.Moreover, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator. | Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya Hirayama Masamitsu Nakazato Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，31： | 10 |
| 2 | Clinical impact of serum exosomal microRNA‐21 as a clinical biomarker in human esophageal squamous cell carcinoma显示文摘 | Youhei Tanaka Hidenobu Kamohara Kouichi Kinoshita Junji Kurashige Takatsugu Ishimoto Masaaki Iwatsuki Masayuki Watanabe Hideo Baba | 2012 | Cancer2012，，6： | 2 |
| 3 | Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms显示文摘 | Daisuke Yamasaki Natsuko Kawabe Hitomi Nakamura Keisuke Tachibana Kenji Ishimoto Toshiya Tanaka Hiroyuki Aburatani Juro Sakai Takao Hamakubo Tatsuhiko Kodama Takefumi Doi | 2011 | European Journal of Cell Biology2011，，8： | 2 |
| 4 | Sugar, Uric Acid, and the Etiology of Diabetes and Obesity显示文摘 | Richard J. Johnson Takahiko Nakagawa L. Gabriela Sanchez-Lozada Mohamed Shafiu Shikha Sundaram Myphuong Le Takuji Ishimoto Yuri Y. Sautin Miguel A. Lanaspa | 2013 | Diabetes2013，，10： | 2 |
| 5 | CD44v6 expression is related to mesenchymal phenotype and poor prognosisin patients with colorectal cancer显示文摘 | Seiya Saito Hirohisa Okabe Masayuki Watanabe Takatsugu Ishimoto Masaaki Iwatsuki Yoshifumi Baba Youhei Tanaka Junji Kurashige Yuji Miyamoto Hideo Baba | 2013 | Oncology Reports2013，，4： | 2 |
| 6 | The MicroRNA-21/PTEN Pathway Regulates the Sensitivity of HER2-Positive Gastric Cancer Cells to Trastuzumab显示文摘 | Kojiro Eto Masaaki Iwatsuki Masayuki Watanabe Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2014 | Annals of Surgical Oncology2014，，1： | 2 |
| 7 | Cause and Management of Recurrent Primary Spontaneous Pneumothorax After Thoracoscopic Stapler Blebectomy显示文摘 | Takashi Muramatsu Mie Shimamura Motohiko Furuichi Tatsuhiko Nishii Shinji Takeshita Shinichiro Ishimoto Hiroaki Morooka Yoko Tanaka Chiyoshi Yagasaki Kazumitsu Ohmori Motomi Shiono | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 8 | Analysis of circulating tumor cells derived from advanced gastric cancer显示文摘 | Kosei Toyoshima Akira Hayashi Masahide Kashiwagi Naoko Hayashi Masaaki Iwatsuki Takatsugu Ishimoto Yoshifumi Baba Hideo Baba Yoshikazu Ohta | 2015 | Int. J. Cancer2015，，4： | 2 |
| 9 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc ? and Thereby Promotes Tumor Growth显示文摘 | Takatsugu Ishimoto Osamu Nagano Toshifumi Yae Mayumi Tamada Takeshi Motohara Hiroko Oshima Masanobu Oshima Tatsuya Ikeda Rika Asaba Hideki Yagi Takashi Masuko Takatsune Shimizu Tomoki Ishikawa Kazuharu Kai Eri Takahashi Yu Imamura Yoshifumi Baba Mitsuyo O | 2011 | Cancer Cell2011，，3： | 2 |
| 10 | Integrated simulation of the atomization process of a liquid jet through a cylindrical nozzle显示文摘 | ISHIMOTO J HOSHINA H TSUCHIYAMA T | 2007 | Interdiscipli-nary Information Sciences2007，13，1： | 1 |
| 11 | Designing chiral quaternary ammonium polymers:novel type of polymeric catalyst for asymmetric alkylation reaction 显示文摘 | hsuno S Paul D K Ishimoto M | 2010 | Chemistry Letters2010，9，2： | 1 |
| 12 | Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73 显示文摘 | Ishimoto O Kawahara C Enjo K | 2002 | Cancer Res2002，62，3： | 1 |
| 13 | Plasma natriuretic peptide as a biochemical marker for atrioventricular sequence in patients with pacemakers 显示文摘 | Horie H Tsutamoto T Ishimoto N | 1999 | PACE1999，22，2： | 1 |
| 14 | Expression of Δ6, Δ5 desaturase and GLELO elongase genes from Mortierella alpina for production of arachidonic acid in soybean [ Glycine max (L.) Merrill] seeds显示文摘 | Ren Chen Keisuke Matsui Miyuki Ogawa Mieko Oe Misa Ochiai Hiroshi Kawashima Eiji Sakuradani Sakayu Shimizu Masao Ishimoto Makoto Hayashi Yoshikatsu Murooka Yoshikazu Tanaka | 2005 | Plant Science2005，，2： | 1 |
| 15 | Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy显示文摘 | LANASPA M A ISHIMOTO T CICERCHI C | 2014 | J Am Soc Nephrol2014，25，11： | 1 |
| 16 | Direct hemoperfusion using immobilized polymyxin B in patients with rapidly progressive interstitial pneumonias: a retrospective study显示文摘 | Hara S Ishimoto H Sakamoto N et ai | 2011 | Respiration2011，81，2： | 1 |
| 17 | Plasma brain natriuretic peptideas a biochemical marker for at- rioventricular sequence in patients with pacemakers显示文摘 | Horie H Tsutamoto T Ishimoto N | 1999 | Pacing Clin Electrophysiol1999，22，2： | 1 |
| 18 | Isolation of human beta- defensin-4 in lung tissue and its increase in lower respiratory tract infection显示文摘 | Yanagi S Ashitani J Ishimoto H | 2005 | Respir Res2005，6，： | 1 |
| 19 | Current perspectives towards the identification of key players in gastric cancer micro RNA dysregulation显示文摘 | Ishimoto T Baba H Izumi D | 2015 | Int J Cancer2015，，： | 1 |
| 20 | Numerical analysis of cavitating flow of liquid helium in a converging-divering nozzle显示文摘 | Ishimoto J Kamijo K | 2003 | Journal of Fluids Engineering2003，125，74： | 1 |
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