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| 1 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 2 | Laparoscopic partial resection for hemangioma in the third portion of the duodenum显示文摘Benign duodenal tumors are rare and less commonthan malignant tumors.Furthermore,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal bleeding.This report describes a case with bleeding hemangiomas in the thirdportion of the duodenum and jejunum and their successful treatment using a laparoscopic approach.Thereis no report of totally laparoscopic resection for tumorin the third portion of duodenum.After performinga laparoscopic Kocher maneuver,the location of theduodenal hemangioma was confirmed by endoscopicand laparoscopic observation.The lesion was excisedusing ultrasonic coagulating shears and the defect inthe duodenal wall was sutured laparoscopically.Thehemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision.The operatingtime was 241 min and blood loss was negligible.Thepostoperative course was uneventful.For benign duodenal tumors in the third portion,if endoscopic resection is not adapted,this less invasive technique may be a standard treatment. | Shingo Kanaji Tetsu Nakamura Masayasu Nishi Masashi Yamamoto Kiyonori Kanemitu Kimihiro Yamashiita Tatsuya Imanishi Yasuo Sumi Satoshi Suzuki Kenichi Tanaka Yoshihiro Kakeji | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 3 | Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer显示文摘 | Ryota Nakanishi Jun Harada Munkhbold Tuul Yan Zhao Koji Ando Hiroshi Saeki Eiji Oki Takefumi Ohga Hiroyuki Kitao Yoshihiro Kakeji Yoshihiko Maehara | 2013 | International Journal of Clinical Oncology2013，，6： | 2 |
| 4 | Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer显示文摘AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric cancers.METHODS:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c PCR.Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing.RESULTS:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors.We found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation status.CONCLUSION:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of mutations.However, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis. | Eiji Oki Yan Zhao Rintaro Yoshida Takanobu Masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara | 2009 | World Journal of Gastroenterology2009，15，20： | 2 |
| 5 | Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis显示文摘 | Yasushi Toh Eiji Oki Kippei Ohgaki Yasuo Sakamoto Shuhei Ito Akinori Egashira Hiroshi Saeki Yoshihiro Kakeji Masaru Morita Yoshihisa Sakaguchi Takeshi Okamura Yoshihiko Maehara | 2010 | International Journal of Clinical Oncology2010，，2： | 2 |
| 6 | A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer显示文摘 | Kazuhiro Nishikawa Satoshi Morita Takanori Matsui Michiya Kobayashi Yoji Takeuchi Ikuo Takahashi Seiji Sato Yumi Miyashita Akira Tsuburaya Junichi Sakamoto Yoshihiro Kakeji Hideo Baba | 2012 | Gastric Cancer2012，，4： | 2 |
| 7 | Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis显示文摘Esophagectomy with extended lymphadenectomy and gastric conduit reconstruction is a radical procedure for the treatment of esophageal cancer that is associated with a high morbidity rate.Gastric conduit necrosis is a fatal complication that occurs in 2%of patients.Conventionally,two-stage salvage surgery consisting of removal of the necrotic gastric conduit followed by reconstruction has been performed;however,this procedure has a high morbidity rate.We describe a61-year-old man who underwent minimally invasive esophagectomy complicated by slowly progressive gastric conduit necrosis associated with complete neck drainage and a stable overall condition.There was a 2 cm gap in the anastomosis.Because there was no evidence of residual gastric conduit necrosis,a removable,covered self-expanding metal stent(SEMS)was inserted to bridge the anastomosis.The stent was fixed to the patient's ear with silk thread through the lasso on its proximal end to prevent migration.Eight weeks after insertion,the stent was removed easily without any associated complications.The anastomotic defect was completely bridged with granulation tissue,showing progressive epithelialization without leakage or stenosis.The patient was discharged home in good general health.This is the first report of the successful conservative management of esophago-gastric conduit anastomosis disruption with SEMS placement. | Taro Oshikiri Yoshinobu Yamamoto Ikuya Miki Masahiro Tsuda Tetsu Nakamura Yasuhiro Fujino Masahiro Tominaga Yoshihiro Kakeji | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 8 | Clinicopathologic significance of hypoxia-inducible factor lalpha overexpression in gastric carcinomas 显示文摘 | Mizokami K Kakeji Y Oda S | 2006 | J Surg Oncol2006，94，2： | 1 |
| 9 | Clinical significance of vascular endothelial growth factor expression in gastric cancer显示文摘 | KAKEJI Y KOGA T SUMIYOSHI Y | 2002 | J Exp Clin Cancer Res2002，21，： | 1 |
| 10 | Activation of PI3K/Akt signaling and hormone resistance in breast cancer显示文摘 | Tuoknaga E Kimura Y Mashino K Oki E Kataoka A Ohno S Morita M Kakeji Y Baba H Maehara Y | 2006 | Breast Cancer2006，13，2： | 1 |
| 11 | Clinicopathological Features and Overexpression of Matrix Metalloproteinases in Intramucosal Gastric Carcinoma with Lymph Node Metastasis显示文摘 | Kabashima A Maehara Y Kakeji Y | 2000 | Clinical Cancer Research2000，6，9： | 1 |
| 12 | DNA ploidy and clinical implications in gastric cancer 显示文摘 | Korenaga D Kakeji Y | 2002 | Surgery2002，131，1： | 1 |
| 13 | Development and assessment of morphologic criteria for diagnosing gastric cancer using confocal endomicroscopy: an ex vivo and in vivo study显示文摘 | Kakeji Y Yamaguchi S Yoshida D | 2006 | Endoscopy2006，38，： | 1 |
| 14 | Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer显示文摘 | Tsujitani S Kakeji Y Watanabe A | 1990 | Cancer1990，66，： | 1 |
| 15 | S-1 in the treatment of advanced and recurrent gastric cancer:current state and future prospects显示文摘 | Takahashi I Kakeji Y Emi Y | 2003 | Gastric Cancer2003，6，1： | 1 |
| 16 | S-1 in the treatment of ad-vanced and recurrent gastric cancer:current state and futureprospects显示文摘 | Takahashi I Kakeji Y Emi Y | 2003 | Gastric Cancer2003，61，： | 1 |
| 17 | Overexpression of vascular endothelial factor C is related to lymohogenous metassis in early gastric carcinoma显示文摘 | Kabashima A Maehara Y Kakeji Y | 2001 | Oncoogy2001，60，2： | 1 |
| 18 | Role of transforming growth factor-β1 in invasion and metastasis in gastric carcinoma显示文摘 | Kakeji Y Kabashima A | 1999 | J Clin Oncol1999，17，2： | 1 |
| 19 | Angiogenesis as a target for gastric cancer显示文摘 | Kakeji Y Maehara Y Sumiyoshi Y | 2002 | Surgery2002，131，1： | 1 |
| 20 | Clinicopathologic signifi- cance of hypoxia-inducible factor 1 alpha overexpression in gastric carcinomas显示文摘 | Mizokani K Kakeji Y Oda S | 2006 | J Surg 0ncol2006，94，2： | 1 |
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