|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | Benefits of early postoperative jejunal feeding in patients undergoing duodenohemipancreatectomy显示文摘瞄准:学习早手术后的肠内的营养是否减少复杂并发症的发生或改进营养的地位追随者 duodenohemipancreatectomy (DHP ) 。方法:我们学习了为一个 peri-ampullary 团经历了 DHP 的 39 个病人。23 个病人收到了全部的父母营养然后开始有在手术后的白天(邮政部门) 之间的营养的口头的吸入 7 和 14 [晚手术后的肠内的营养(LPEN ) 组] 。十六个病人开始有肠内的在手术以后整个空肠造口术导管日子喂[早手术后的肠内的营养(EPEN ) 组] 。在早手术后的阶段的复杂并发症和实验室数据的发生在在 LPEN 和 EPEN 组之间的比较被学习。结果:在 EPEN 组的白朊和全部的蛋白质的浆液层次比在 LPEN 组的那些显著地高。身体团索引的损失显著地作为与 LPEN 组相比在 EPEN 组被压制。在操作比在 LPEN 组在 EPEN 组更快显著地被恢复以后,淋巴细胞计数立即减少了。EPEN 组显著地比 LPEN 组显示出手术后的胰腺的管,以及住院的显著地更短的长度的更少发生。在在二个组之间的另外的手术后的复杂并发症的发生没有有效差量,例如推迟的胃的倒空,外科的地点感染,胆管炎,和小肠阻塞。结论:EPEN 是为为一个 peri-ampullary 团经历了 DHP 的病人的一个安全、有益的机会。 | Takehiro Okabayashi Michiya Kobayashi Isao Nishimori Tekeki Sugimoto Toyokazu Akimori Tsutomu Namikawa Ken Okamoto Saburo Onishi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，1： | 23 |
| 3 | Evaluation and treatment of malignant ascites secondary to gastric cancer显示文摘Malignant ascites affects approximately 10% of patients with gastric cancer(gC), and poses significant difficulties for both patients and clinicians. In addition to the dismal general condition of affected patients and the diversity of associated complications such as jaundice and ileus, problems in assessing scattered tumors have hampered the expansion of clinical trials for this condition. However, the accumulation of reported studies is starting to indicate that the weak response to treatment in g C patients with malignant ascites is more relevant to their poor prognosis rather than to the ascites volume at diagnosis. Therefore, precise assessment of initial state of ascites, repetitive evaluation of treatment efficacy, selection of suitable treatment, and swift transition to other treatment options as needed are paramount to maximizing patient benefit. Accurately determining ascites volume is the crucial first step in clinically treating a patient with malignant ascites. Ultrasonography is commonly used to identify the existence of ascites, and several methods have been proposed to estimate ascites volume. Reportedly, the sum of the depth of ascites at five points(named 'five-point method') on three panels of computed tomography images is well correlated to the actual ascites volume and/or abdominal girth. This method is already suited to repetitive assessment due to its convenience compared to the conventional volume rendering method. Meanwhile, a new concept, 'Clinical Benefit Response in g C(CBR-GC)', was recently introduced to measure the efficacy of chemotherapy for malignant ascites of g C. CBR-GC is a simple and reliable patient-oriented evaluation system based on changes in performance status and ascites, and is expected to become an important clinical endpoint in future clinical trials. The principal of treatment for g C patients with ascites is palliation and prevention of ascites-related symptoms. The treatment options are various, including a standard treatment based on the available guidelines, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(HIPEC), laparoscopic HIPEC alone, intravenous chemotherapy, intraperitoneal chemotherapy, and molecular targetingtherapy. Although each treatment option is valid,further research is imperative to establish the optima choice for each patient. | Hiromichi Maeda Michiya Kobayashi Junichi Sakamoto | 2015 | World Journal of Gastroenterology2015，21，39： | 23 |
| 4 | STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line,GIST-T1显示文摘AIM:To estimate whether STI571 inhibits the expressionof vascular endothelial growth factor(VEGF)in thegastrointestinal stromal tumor(GIST)cells.METHODS:We used GIST cell line,GIST-T1.It hasa heterogenic 57-bp deletion in exon 11 to produce amutated c-KIT,which results in constitutive activationof c-KIT.Cells were treated with/without STI571 orstem cell factor(SCF).Transcription and expression ofVEGF were determined by RT-PCR and flow cytometryor Western blotting,respectively.Activated c-KIT wasestimated by immunoprecipitation analysis.Cell viabilitywas determined by MTT assay.RESULTS:Activation of c-KIT was inhibited bySTI571 treatment.VEGF was suppressed at both thetranscriptional and translational levels in a temporal anddose-dependent manner by STI571.SCF upregulatedthe expression of VEGF and it was inhibited by STI571.STI571 also reduced the cell viability of the GIST-T1cells,as determined by MTT assay.CONCLUSION:Activation of c-KIT in the GIST-T1regulated the expression of VEGF and it was inhibited bySTI571.STI571 has antitumor effects on the GIST cellswith respect to not only the inhibition of cell growth,butalso the suppression of VEGF expression. | Toufeng Jin Hajime Nakatani Takahiro Taguchi Takumi Nakano Takehiro Okabayashi Takeki Sugimoto Michiya Kobayashi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，5： | 14 |
| 5 | Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients显示文摘瞄准:由于源于先进胃的癌症的腹膜炎 carcinomatosa 与腹水在病人在它的静脉内的管理以后在血浆和腹水检验 paclitaxel 集中。方法:有腹水的二个病人在这研究由于源于胃的癌症的腹膜炎 carcinomatosa 被包括。在血浆和腹水的 paclitaxel 集中为 72 h 被调查以防 1 和 168 h 以防 2 在静脉内的管理以后。结果:在血浆的 paclitaxel 集中在管理以后立即达到顶点,在 24 h 以内在 0.1 微摩尔(85 ng/mL ) 的阀值价值下面由快速的减少列在后面。相反,在腹水的 paclitaxel 集中在管理以后为 24 h 逐渐地增加了到与在血浆发现的水平一致的水平。在 24 h 以后,在腹水和血浆的 paclitaxel 的水平变得类似,与被维持直到 72 h 追随者管理的最佳的水平。结论:在腹水的 paclitaxel 的集中在静脉内的管理以后为多达 72 h 为癌症房间的治疗在最佳的水平以内被维持。Paclitaxel 是为胃的癌症的恶意的腹水的治疗的有希望的药。 | Michiya Kobayashi Junichi Sakamoto Tsutomu Namikawa Ken Okamoto Takehiro Okabayashi Kengo Ichikawa Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，9： | 14 |
| 6 | Metastatic bone cancer as a recurrence of early gastric cancer - characteristics and possible mechanisms显示文摘The surgical outcome of most early gastric cancer (EGC)is usually satisfactory. Some cases show bone metastasis even though the depth of cancer invasion is confined to the mucosa. The most frequent site for recurrence of EGC is the liver. Cases of EGC with bone metastasis are reviewed to clarify the clinicopathological characteristics of EGC giving rise to bone metastasis. Possible mechanisms and risk factors underlying this rare condition are proposed.Forty-six cases of bone metastasis from EGC are reviewed from published reports and meeting proceedings in Japan.This investigation suggests that risk factors for bone metastasis from EGC include depressed-type signet-ring cell carcinoma, poorly differentiated carcinoma, and/or the likely involvement of lymph node metastasis, even though the cancer is confined to the gastric mucosa. The risk factors do not include recurrence of EGC in the liver. We speculate that the mechanism of bone metastasis from EGC is via lymphatic channels and systemic circulation. Postoperative follow-up of cases should consider the development of bone metastasis from EGC. We propose the use of elevated alkaline phosphatase levels for the detection of bone metastasis and recommend bone scintigraphy in positive cases. | Michiya Kobayashi Takehiro Okabayashi Takeshi Sano Keijiro Araki | 2005 | World Journal of Gastroenterology2005，11，36： | 9 |
| 7 | Laparoscopic splenectomy for splenic hamartoma:Case management and clinical consequences显示文摘Splenic hamartoma is a rare benign tumor,and although minimally invasive surgery may be suitable for this condition,there have only been 2 previous reports of laparoscopic surgery.Here we report the third case of splenic hamartoma managed by laparoscopic splenectomy.A 37-year-old male was incidentally diagnosed by abdominal ultrasonography with a hypoechoic mass measuring 2.5 cm × 2.4 cm in the spleen.Color Doppler sonography showed multiple flow signals within the mass and contrast-enhanced computed tomography revealed strong enhancement of the lesion.On T1-and T2-weighted magnetic resonance images,the splenic mass was demonstrated as isointense and hyperintense respectively.Although a malignant tumor could not be ruled out,a hand-assisted laparoscopic splenectomy was performed because the splenic mass was limited in size and had not invaded adjacent organs.The pathological diagnosis was splenic hamartoma.The postoperative course was uneventful and the patient was discharged by the seventh postoperative day.Although splenic hamartomas have some specific imaging features,more reports and analyses of these cases are required to increase the reliability of the diagnosis and management.Hand-assisted laparoscopic splenectomy may play a pivotal role in the postoperative diagnosis and management of this condition. | Tsutomu Namikawa Hiroyuki Kitagawa Jun Iwabu Michiya Kobayashi Manabu Matsumoto Kazuhiro Hanazaki | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 4 |
| 8 | Clinical experience of Pseudo-Meigs' Syndrome due to colon cancer显示文摘We report a rare case of Pseudo-Meigs' Syndrome caused by ovarian metastasis from sigmoid colon cancer, which was accompanied by peritoneal dissemination. A 58-year-old female patient presented with massive right pleural effusion, ascites and a huge pelvic mass. Under the diagnosis of an advanced ovarian tumor, bilateral oophorectomy was performed and sigmoidectomy was also carried out after intraoperative diagnosis of peritoneal dissemination involving the sigmoid colon. How- ever, immunohistochemical staining revealed that the ovarian lesions were metastasis from the primary advanced colon cancer. Postoperatively, ascites and pleural effusion subsided, and the diagnosis of Pseudo-Meigs' Syndrome due to a metastatic ovarian tumor from colon cancer was determined. The patient is now undergoing a regimen of chemotherapy for colon cancer without recurrence of ascites or hydrothorax 10 mo after the surgery. Pseudo-Meigs' Syndrome due to a metastaticovarian tumor from colon cancer is rare but clinically important because long-term alleviation of symptoms can be achieved by surgical resection. This case report suggests that selected patients, even with peritoneal dissemination, may obtain palliation from surgical resection of metastatic ovarian tumors. | Hiromichi Maeda Takehrio Okabayashi Kazuhiro Hanaza-ki Michiya Kobayashi | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 9 | Cetuximab and panitumumab in a patient with colon cancer and concomitant chronic skin disease:A potential beneficial effect on psoriasis vulgaris显示文摘Monoclonal antibodies against epidermal growth factor receptor(EGFR) are used in the treatment of advanced colorectal cancer. However, these agents can induce severe dermatological side effects that discourage their administration in patients with chronic dermatological disease. EGFR plays a key role in normal skin development and immunological function, and is expressed in various tissues and organs, although contrarily, it is overexpressed in psoriasis-related skin lesions. Thus, discussion is ongoing regarding the putative pathological role and therapeutic potential of this protein. We herein report on a patient with advanced colon cancer and concomitant long-standing psoriasis vulgaris who received antiEGFR antibody monotherapy as a third-line treatment for metastatic disease. One week after the initiation of treatment, the patient's skin lesions dramatically subsided and the improvement was sustained during therapy. Based on this case, we propose that anti-EGFR antibody therapy is not necessarily contraindicated in patients with psoriasis vulgaris. Moreover, the findings reaffirmed that EGFR is an important molecule in the pathology of psoriasis. | Ken Okamoto Hiromichi Maeda Takeo Shiga Mai Shiga Ken Dabanaka Kazuhiro Hanazaki Michiya Kobayashi | 2015 | World Journal of Gastroenterology2015，21，12： | 4 |
| 10 | Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study显示文摘AIM To assess the clinical characteristics of patients with complicated erosive esophagitis(EE) and their associated factors.METHODS This prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios(aO R) and 95%CI for the association with complicated EE.RESULTS During the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors(PPIs) were included. Of them, 143(8.2%) had EE complications. Esophageal bleeding occurred in 84(4.8%) patients, esophageal strictures in 45(2.6%) patients, and 14(0.8%) patients experienced both. Multivariate analysis showed that increased age(a OR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents(a OR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B(a OR: 2.69; 95%CI: 1.48-4.96), C(aO R: 15.38; 95%CI: 8.62-28.37), and D(aO R: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated(a OR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age(a OR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B(aO R: 3.60; 95%CI: 1.52-8.50), C(a OR: 27.61; 95%CI: 12.34-61.80), and D(a OR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age(a OR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom(aO R: 2.51; 95%CI: 1.39-4.51), concomitantuse of psychotropic agents(a OR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C(aO R: 7.35; 95%CI: 3.32-16.25), and D(a OR: 20.34; 95%CI: 8.36-49.53) and long-segment Barrett's esophagus(a OR: 4.63; 95%CI: 1.64-13.05).CONCLUSION Aging and severe EE were common associated factors, although there were more associated factors in esophageal strictures than esophageal ulcer bleeding. Despite the availability and widespread use of PPIs, EE complications are likely to remain a problem in Japan owing to the aging population and high-stress society. | Masahiro Sakaguchi Noriaki Manabe Nobuo Ueki Jun Miwa Tomoki Inaba Norimasa Yoshida Kouichi Sakurai Masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，2： | 3 |
| 11 | Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study显示文摘 | Kengo Ichikawa Takehiro Okabayashi Hiromichi Maeda Tsutomu Namikawa Tatsuo Iiyama Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2013 | Surgery Today2013，，7： | 2 |
| 12 | Clinicopathological study of cardiac tamponade due to pericardial metastasis originating from gastric cancer显示文摘AIM: To review the cases reported in the literature,examined their clinicopathological features, and evaluated the efficacy of different therapeutic modalities for this rare condition.METHODS: A search of the MEDLINE database revealed 16 cases of pericarditis carcinomatosa (PC)originating from GC reported in the literature between1982 and 2005. Additional detailed data were obtained from the authors of these studies for subsequent clinicopathological investigation. We have also described about a case study from our own clinic.RESULTS: The mean age of cases with pericarditis carcinomatosa originating from GC was 54 years.Females were diagnosed at a younger age (46.3 years)compared to males (58 years). The mean survival period after diagnosis was 4.5 mo. No statistical differences in the length of survival time were found between different therapeutic modalities, such as drainage, and local and/or systemic chemotherapy after drainage. However,three cases who underwent systemic chemotherapy survived for more than 10 mo. Cases that developed metachronous cardiac tamponade for more than 2years after the diagnosis of GC generally survived for a longer period of time, although this was not statistically significant. Multivariate analysis revealed that low levels of carcinoembryonic antigen (CEA), and CEA and/or cancer antigen 19-9 (CA 19-9) were associated with longer survival.CONCLUSION: Cases with low levels of CEA, and CEA and/or CA 19-9 should undergo systemic chemotherapy with or without local chemotherapy after drainage. | Michiya Kobayashi Takehiro Okabayashi Ken Okamoto Tsutomu Namikawa Keijiro Araki | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 13 | Hydrogen-Rich University of Wisconsin Solution Attenuates Renal Cold Ischemia–Reperfusion Injury显示文摘 | Toyofumi Abe Xiao-Kang Li Koji Yazawa Naoyuki Hatayama Lin Xie Bunpei Sato Yoichi Kakuta Koichi Tsutahara Masayoshi Okumi Hidetoshi Tsuda Jun-ya Kaimori Yoshitaka Isaka Michiya Natori Shiro Takahara Norio Nonomura | 2012 | Transplantation Journal2012，，1： | 2 |
| 14 | Impact of jejunal pouch interposition reconstruction after proximal gastrectomy for early gastric cancer on quality of life: short- and long-term consequences显示文摘 | Tsutomu Namikawa Toyokazu Oki Hiroyuki Kitagawa Takehiro Okabayashi Michiya Kobayashi Kazuhiro Hanazaki | 2012 | The American Journal of Surgery2012，，2： | 2 |
| 15 | 缓激肽对左室收缩和舒张功能作用的实验研究显示文摘抑制缓激肽(BK)降解可以产生转换酶抑制剂的临床效益,然而,它对心功能的作用尚不清楚。为此,我们对6只清醒犬通过压力-容积关系,分析自主神经阻滞前后缓激肽对左室功能的影响。结果显示:阻滞自主神经前,静脉注射缓激肽引起总外周阻力减小,而使左室收缩末期压力下降;心率、每搏量、冠状动脉流量、左室充盈率和左室舒张速率均增加。缓激肽还增加了左室收缩末期压-容积关系、dp/dtmax-舒张末期容积(VED)关系和心搏功-VED关系的斜率,表示心肌收缩力增加。阻滞自主神经后,这些变化仍然存在。结果显示:在清醒动物,静脉注射缓激肽引起动脉扩张,加强左室收缩和舒张功能,此作用不受自主神经影响。 | 李为民 Michiya Ohno Che-Ping Cheng 黄永麟 高黎平 郭小兵 | 1996 | 中华心血管病杂志1996，24，3： | 2 |
| 16 | A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer显示文摘 | Kazuhiro Nishikawa Satoshi Morita Takanori Matsui Michiya Kobayashi Yoji Takeuchi Ikuo Takahashi Seiji Sato Yumi Miyashita Akira Tsuburaya Junichi Sakamoto Yoshihiro Kakeji Hideo Baba | 2012 | Gastric Cancer2012，，4： | 2 |
| 17 | Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride显示文摘 | Kengo Ichikawa Takehiro Okabayashi Yasuo Shima Tatsuo Iiyama Yuka Takezaki Masaya Munekage Tsutomu Namikawa Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2012 | Molecular Biology Reports2012，，12： | 1 |
| 18 | Adenosquamous carcinoma of the extrahepatic biliary tract: clinicopathological analysis of Japanese cases of this uncommon disease显示文摘 | Takehiro Okabayashi Michiya Kobayashi Isao Nishimori Tsutomu Namikawa Ken Okamoto Saburo Onishi Keijiro Araki | 2005 | Journal of Gastroenterology2005，，2： | 1 |
| 19 | A case with synchronous multiple liver metastases from gastric carcinoma: postoperative long-term disease-free survival显示文摘 | Masaya Munekage Takehiro Okabayashi Norihiro Hokimoto Takeki Sugimoto Hiromichi Maeda Tsutomu Namikawa Ken Dabanaka Michiya Kobayashi Keijiro Araki Kazuhiro Hanazaki | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
| 20 | The Estimation of Energy Consumption and CO2 Emission Due to Housing Construction in Japan显示文摘 | Michiya Suzuki Tatsuo Oka Kiyoshi Okada | 1995 | Energy and Buildings1995，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员