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| 1 | Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease显示文摘 | Xia Chen Kailin Yang Chen Wu Cheng Chen Can Hu Olga Buzovetsky Zefang Wang Xiaoyun Ji Yong Xiong Haitao Yang | 2016 | Cell Research2016，26，11： | 10 |
| 2 | Forty Years Development of China's Outward Foreign Direct Investment:Retrospect and the Challe nges Ahead显示文摘Outwardforeign direct investment(OFDI)has increasingly become an important method for China to integrate into the world economy.This paper comprehensively reviews and analyzes policy development and the changing pattern of China's OFDI over the past 40 years.We divide the development into'restricted”(1978-1999),'relaxed'(2000-2016)and'regulated',(2017 onwards)stages.This paper also reviews literature on the impact of Chinese OFDI on China and host countries.Despite its generally positive effects,large-scale and unbalanced OFDI activities have alarmed Chinese policymakers.Both developing and developed host countries have expressed their concern over national security and the misbehavior of some Chinese overseas enterprises.Therefore,greater supervision and adjustment from quantity to quality growth is necessary for the future development of China's OFDI. | Bijun Wang Kailin Gao | 2019 | China & World Economy2019，27，3： | 10 |
| 3 | Leak detection in pipelines by exclusively frequency domain method显示文摘A further development of exclusively inverse frequency domain method for leak detection in pipelines is presented and validated.The location and leakage can be determined by analyzing the difference of transient water head response between the simulated and measured data in frequency domain.The transient signals are generated by portion sharp closure of a valve from the small constant opening and it needs only a few meters of water.The discrete boundary conditions and observation data are both transformed in frequency domain by Laplace transform.Example in numerical simulation is studied for demonstration of this approach.The application of the method to an experimental pipeline confirms the analysis and illustrates successful detection of the single pipeline leak.The precalibration approach is presented to minimize the effect of data and model error and it splits the method into two parts.One uses data from a known state to fit the parameters of the model and the other uses data from the current state for the fitting of leak parameters using the now calibrated model.Some important practical parameters such as wave speed,friction in steady and unsteady state and the adaptability of the method are discussed.It was found that the nonlinearity errors associated with valve boundary condition could be prevented by consideration of the induced flow perturbation curve shape. | GUO XinLei YANG KaiLin GUO YongXin | 2012 | Science China(Technological Sciences)2012，55，3： | 8 |
| 4 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332显示文摘Dear Editor,Since December 2019,the pandemic of coronavirus disease 2019(COVID-19)has taken a heavy toll on global health,creating an urgent need to develop effective strategies for prevention and treatment.The etiological agent,known as severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected nearly 229.2 million people worldwide with more than 4.7 million deaths as of September 15,2021.Older age and preexisting health conditions are associated with worse clinical prognosis including higher mortality rates(Zhou et al.,2020).The global race to combat this pandemic has led to rapid deployment of numerous effective vaccines against SARS-CoV-2(Tregoning et al.,2021).However,the emergence of viral variants,including the Delta variant(B.1.617.2),compromised vaccine effectiveness with resurgence of SARS-CoV-2 infection among highly vaccinated population(Keehner et al.,2021).Therefore,development of therapeutics against the more conserved viral targets would be essential to contain the spread of COVID-19 and reduce mortality. | Yao Zhao Chao Fang Qi Zhang Ruxue Zhang Xiangbo Zhao Yinkai Duan Haofeng Wang Yan Zhu Lu Feng Jinyi Zhao Maolin Shao Xiuna Yang Leike Zhang Chao Peng Kailin Yang Dawei Ma Zihe Rao Haitao Yang | 2022 | Protein & Cell2022，13，9： | 6 |
| 6 | Effect of rock composition microstructure and pore characteristics on its rock mechanics properties显示文摘This paper is to study the influence of composition, microstructure and pore characteristics on the rock mechanical properties. Five kinds of sandstone compositions were analyzed by using X-ray diffraction instrument. And the microstructure was observed by using scanning electron microscope. Then the pore distribution characteristic was investigated by using the low field nuclear magnetic resonance equipment. Finally, the uniaxial compression test was carried out to investigate the mechanical characteristics by using RMT150C mechanics experimental system and the uniaxial compressive strength, Poisson's ratio and elastic modulus were obtained. Compared to the analysis of the composition, structure and pore distribution and mechanical properties of the five kinds of sandstones, the relationship among composition,structure, pore distribution and mechanical properties was obtained. The results show that the composition, microstructure, pore distribution and mechanical properties of sandstone are closely related.With the decrease of feldspar and quartz particles, the compressive strength and elastic modulus increase, while the porosity decreases. | Li Huamin Li Huigui Wang Kailin Liu Chuang | 2018 | International Journal of Mining Science and Technology2018，28，2： | 6 |
| 7 | Combined remediation of DDT congeners and cadmium in soil by Sphingobacterium sp.D-6 and Sedum alfredii Hance显示文摘Combined pollution of 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (DDT) and cadmium (Cd) in agricultural soils is of great concern because they present serious risk to food security and human health.In order to develop a cost-effective and safe method for the removal of DDTs and Cd in soil,combined remediation of DDTs and Cd in soil by Sphingobacterium sp.D-6 and the hyperaccumulator,Sedum alfredii Hance was investigated.After treatment for 210 days,the degradation half-lives of DDTs in soils treated by strain D-6 decreased by 8.1% to 68.0% compared with those in the controls.The inoculation of strain D-6 into soil decreased the uptake of DDTs by pak choi and S.alfredii.The shoots/roots ratios of S.alfredii for the Cd accumulation ranged from 12.32 to 21.75.The Cd concentration in soil decreased to 65.8%-71.8% for S.alfredii treatment and 14.1%-58.2% for S.alfredii and strain D-6 combined treatment,respectively,compared with that in the control.The population size of the DDTs-degrading strain,Simpson index (1/D) and soil respiratory rate decreased in the early stage of treatment and then gradually increased,ultimately recovering to or exceeding the initial level.The results indicated that synchronous incorporation of strain D-6 and S.alfredii into soil was found to significantly (p 0.05) enhance the degradation of DDTs in soil and the hyperaccumulation of Cd in S.alfredii.It was concluded that strain D-6 and S.alfredii could be used successfully to control DDTs and Cd in contaminated soil. | Hua Fang Wei Zhou Zhengya Cao Feifan Tang Dandan Wang Kailin Liu Xiangwei Wu Xiao'e Yang Yongge Sun Yunlong Yu | 2012 | Journal of Environmental Sciences2012，24，6： | 5 |
| 8 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 9 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 10 | FORCED WAVE PROPAGATION IN VISCOELASTIC CABLE WITH SMALL SAG显示文摘Based on the linear viscoelastic differential constitutive law and cable structural model, the coupled longitudinal-transverse waves that propagate along a viscoelastic cable with small curvature is investigated. A mathematical model is presented that describes the three-dimensional nonlinear response of a viscoelastic cable. An asymptotic form of this model is obtained for the linear response of cables having small equihbrium curvature. The spectral relation governing the propagating waves is derived using transform methods. The spectral relation is employed in deriving a Green's function that is then used to construct solutions for in-plane response under distributed harmonic excitation. Analysis of forced response reveals the existence of two types of periodic waves that propagate through the cable, one characterizing extension-comprehensive deformation and the other characteristic transverse deformation. | Li Yinghui Jian Kailin~1 Gao Qing Yin Xuegang~1 (Department of Applied Mechanics and Engineering, Southwest Jiaotong University, Chengdu 610031, China) (1 State Key Laboratory of Mechanical Transmission, Chongqing University, Chongqing 400044, China) | 2001 | Acta Mechanica Solida Sinica2001，14，2： | 4 |
| 11 | 27-Hydroxycholesterol-induced EndMT acts via STAT3 signaling to promote breast cancer cell migration by altering the tumor microenvironment显示文摘Objective:The endothelial to mesenchymal transition(EndMT)plays a major role in cancer metastasis by regulating the complexity of the tumor microenvironment(TME).Here,we investigated whether 27-hydroxycholesterol(27 HC)induces EndMT in endothelial cells(ECs).Methods:EndMT markers in the human microvascular endothelial cell-1(HMEC-1)cell line and human umbilical vein endothelial cells(HUVECs)stimulated with 27 HC were evaluated with Western blot.Epithelial to mesenchymal transition(EMT)markers in breast cancer(BC)cells cultured in conditioned medium were investigated with quantitative real time polymerase chain reaction(qRT-PCR).The MMP-2 and MMP-9 mRNA expression and activity were detected with qRT-PCR and gelatin zymography assays,respectively.The effect of activated STAT3 on 27 HC-induced EndMT was validated by Western blot,immunofluorescence staining,and cell transfection assays.The migration ability of BC cells was evaluated with Transwell assays.Results:We found that 27 HC induced EndMT in HMEC-1 and HUVECs,and 27 HC-induced EndMT facilitated EMT and BC cell migration.The 27 HC-induced EMT of BC cells also promoted EndMT and HUVEC migration.Investigation of the underlying molecular mechanisms revealed that STAT3 knockdown repressed EndMT in HUVECs as well as migration in BC cells induced with 27 HC.In addition,C646 and resveratrol,inhibitors of STAT3 acetylation,repressed the expression of Ac-STAT3,p-STAT3,and EndMT markers in HUVECs exposed to 27 HC;these HUVECs in turn attenuated the migration ability of BC cells in 27 HC-induced EndMT.Conclusions:Cross-talk between 27 HC-induced EndMT and EMT was observed in the TME.Moreover,activation of STAT3 signaling was found to be involved in 27 HC-induced EndMT. | Kailin Jiao Jing Zhen Maoxuan Wu Mengying Teng Keke Yang Qian Zhou Chunyan Hu Ming Zhou Yuan Li Zhong Li | 2020 | Cancer Biology & Medicine2020，17，1： | 3 |
| 12 | Sensitivities of Tornadogenesis to Drop Size Distribution in a Simulated Subtropical Supercell over Eastern China显示文摘Numerical simulations with the Advanced Regional Prediction System(ARPS) model were performed to investigate the impact of microphysical drop size distribution(DSD) on tornadogenesis in a subtropical supercell thunderstorm over Anhui Province, eastern China. Sensitivity experiments with different intercept parameters of rain, hail and snow DSDs in a Lin-type microphysics scheme were conducted. Results showed that rain and hail DSDs have a significant impact on the simulated storm both microphysically and dynamically. DSDs characterized by larger(smaller) intercepts have a smaller(larger) particle size and a lower(higher) mass-weighted mean fall velocity, and produce relatively stronger(weaker) and wider(narrower)cold pools through enhanced(reduced) rain evaporation and hail melting processes, which are then less favorable(favorable)for tornadogenesis. However, tornadogenesis will also be suppressed by the weakened mid-level mesocyclone when the cold pool is too weak. When compared to a U.S. Great Plain case, the two microphysical processes are more sensitive to DSD variations in the present case with a higher melting level and deeper warm layer. This suggests that DSD-related cloud microphysics has a stronger influence on tornadogenesis in supercells over the subtropics than the U.S. Great Plains. | ZHENG Kailin CHEN Baojun | 2014 | Advances in Atmospheric Sciences2014，31，3： | 3 |
| 13 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 14 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 15 | Structural characterizations of protonated homodimers of amino acids:Revealed by infrared multiple photon dissociation(IRMPD) spectroscopy and theoretical calculations显示文摘Infrared multiple photon dissociation(IRMPD) spectroscopic and theoretical studies of protonated homodimers of amino acids generated by electrospray ionization in the gas phase have been reviewed.Results show that proton affinity(PA) may be applied as a probe to predict their structural type: saltbridged or charge-solvated. Proline can be viewed as a reference. For an amino acid with a PA value higher than that of proline, the most stable conformation of its protonated homodimer tends to prefer saltbridged conformation; otherwise, charge-solvated conformation is expected to be the most stable.However, side chain effects may cause the inaccuracy in structural determination due to the strong interactions with the charge, which makes the charge-solvated structure more stable even for species with high PA values. Temperature effect on distribution of different isomers is also very important. In lots of cases, the coexistence of multiple isomers is general, which makes the explanation of an overall IRMPD spectrum difficult. So a statistical view on the distribution of optimized isomers is very helpful. | Lifu Ma Juan Ren Ruxia Feng Kailin Zhang Xianglei Kong | 2018 | Chinese Chemical Letters2018，29，9： | 3 |
| 16 | NONLINEAR VIBRATION ANALYSIS OF VISCOELASTIC CABLE WITH SMALL SAG显示文摘Both the inplane and out-of-plane transverse vibrations of a viscoelastic cable subjected to aninitial stress distributing uniform on the cross section are studied.The constitution of the cable material is as-sumed to be of the hereditary integral type.The partial differential-integral equations of motion are derivedfirst.Then by applying Galerkin’s method,the governing equations are reduced to a set of second-order non-linear differential-integral equations which are solved by finite difference numerical integration procedures.Finally,the effects of the viscosity parameter and the elaslic parameter on the transient amplitudes of the firstmode are investigated by numerical simulation. | Li Yinghui Jian Kailin Gao Qing Yin Xuegang | 2001 | Acta Mechanica Solida Sinica2001，14，4： | 3 |
| 17 | Global interpolating meshless shape function based on generalized moving least-square for structural dynamic analysis显示文摘A global interpolating meshless shape function based on the generalized moving least-square(GMLS) is formulated by the transformation technique. Both the shape function and its derivatives meet the Kronecker delta function property. With the interpolating GMLS(IGMLS) shape function, an improved element-free Galerkin(EFG)method is proposed for the structural dynamic analysis. Compared with the conventional EFG method, the obvious advantage of the proposed method is that the essential boundary conditions including both displacements and derivatives can be imposed by the straightforward way. Meanwhile, it can greatly improve the ill-condition feature of the standard GMLS approximation, and provide good accuracy at low cost. The dynamic analyses of the Euler beam and Kirchhoff plate are performed to demonstrate the feasibility and effectiveness of the improved method. The comparison between the numerical results of the conventional method and the improved method shows that the proposed method has better stability, higher accuracy, and less time consumption. | Dan XIE Kailin JIAN Weibin WEN | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，9： | 2 |
| 18 | Incoherent pulse Doppler lidar as the velocimeter system显示文摘This note reports a new type of incoherent pulse laser Doppler lidar velocimeter with iodine molecular filter as a frequency discriminator. Its transmitter subsystem applies a Nd:YAG pulse laser which is injected with a single longitudinal-mode diode pumped continuous seeder laser. The field experiment proved that this velocimeter measurement results are consistent with those measured by photoelectric velocimeter. Measurements of eight different velocities show that the standard deviation is 0.56m/s, the range resolution is 3.75m. | Zhishen Liu Xiaoquan Song Jintao Liu Kailin Zhang | 2002 | Chinese Science Bulletin2002，47，6： | 2 |
| 19 | Single Radar Measurement Method for Antiaircraft Projectile Miss Distance显示文摘To measure miss distance for antiaircraft projectile,a radial velocity identification and positioning method with a single radar is proposed. By analyzing the spatial resolution of multi-frequency ranging radar,the discrimination and testing model of this radar for multi-targets( projectile and target) is established to analyze the systematic error of antiaircraft miss distance. Then through the aerial target flight test and contrast test with optical test equipment,the validity of the measurement method is verified. This newmethod has the potential to be used in the measurement of antiaircraft projectile miss distance. | Wanjun Zhang Guohui Li Xiaoying Wu Kailin Wang Xuebing Leng | 2017 | Journal of Beijing Institute of Technology2017，26，4： | 2 |
| 20 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
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