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| 1 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 2 | Efficacy of texture analysis of pre-operative magnetic resonance imaging in predicting microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Presence of microvascular invasion(MVI)indicates poorer prognosis postcurative resection of hepatocellular carcinoma(HCC),with an increased chance of tumour recurrence.By present standards,MVI can only be diagnosed postoperatively on histopathology.Texture analysis potentially allows identification of patients who are considered‘high risk’through analysis of pre-operative magnetic resonance imaging(MRI)studies.This will allow for better patient selection,improved individualised therapy(such as extended surgical margins or adjuvant therapy)and pre-operative prognostication.AIM This study aims to evaluate the accuracy of texture analysis on pre-operative MRI in predicting MVI in HCC.METHODS Retrospective review of patients with new cases of HCC who underwent hepatectomy between 2007 and 2015 was performed.Exclusion criteria:No preoperative MRI,significant movement artefacts,loss-to-follow-up,ruptured HCCs,previous hepatectomy and adjuvant therapy.Fifty patients were divided into MVI(n=15)and non-MVI(n=35)groups based on tumour histology.Selected images of the tumour on post-contrast-enhanced T1-weighted MRI were analysed.Both qualitative(performed by radiologists)and quantitative data(performed by software)were obtained.Radiomics texture parameters were extracted based on the largest cross-sectional area of each tumor and analysed using MaZda software.Five separate methods were performed.Methods 1,2 and 3 exclusively made use of features derived from arterial,portovenous and equilibrium phases respectively.Methods 4 and 5 made use of the comparatively significant features to attain optimal performance.RESULTS Method 5 achieved the highest accuracy of 87.8%with sensitivity of 73%and specificity of 94%.CONCLUSION Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC with accuracies of up to 87.8%and can potentially impact clinical management. | Jordan Zheng Ting Sim Terrence Chi Hong Hui Tong Kuan Chuah Hsien Min Low Cher Heng Tan Vishal GShelat | 2022 | World Journal of Clinical Oncology2022，13，11： | 3 |
| 3 | Real-time dynamics and cross-correlation gating spectroscopy of free-carrier Drude slow-light solitons显示文摘Optical solitons—stable waves balancing delicately between nonlinearities and dispersive effects—have advanced the field of ultrafast optics and dynamics,with contributions spanning from supercontinuum generation to soliton fission,optical event horizons,Hawking radiation and optical rogue waves,among others.Here,we investigate picojoule soliton dynamics in silicon slow-light,photonic-bandgap waveguides under the influence of Drude-modeled,free-carrier-induced nonlinear effects.Using real-time and single-shot amplified dispersive Fourier transform spectroscopy simultaneously with high-fidelity cross-correlation frequency resolved optical gating at femtojoule sensitivity and femtosecond resolution,we examine the soliton stability limits,the soliton dynamics including free-carrier quartic slow-light scaling and acceleration,and the Drude electron–hole plasma-induced perturbations in the Cherenkov radiation and modulation instability.Our real-time single-shot and time-averaged cross-correlation measurements are matched with our detailed theoretical modeling,examining the reduced group velocity free-carrier kinetics on solitons at the picojoule scale. | Heng Zhou Shu-Wei Huang Xiujian Li James F McMillan Chi Zhang Kenneth Kin-Yip Wong Mingbin Yu Guo-Qiang Lo Dim-Lee Kwong Kun Qiu Chee Wei Wong | 2017 | Light(Science & Applications)2017，6，1： | 1 |
| 4 | Intratypic variants of human papillomavirus type 16 and risk of cervical Neoplasia in Taiwan显示文摘 | Ya‐Ju Chang Hui‐Chi Chen Mei‐Hung Pan Bor‐Heng Lee San‐Lin You Ching‐Yu Lin Yi‐Chun Chou Chang‐Yao Hsieh Yu‐Juen Cheng Kai‐Li Liaw Ann W. Hsing Mark Schiffman Chien‐Jen Chen | 2013 | J. Med. Virol2013，，： | 1 |
| 5 | Prednisone monotherapy in asymptomatic hormone refractory prostate cancer 显示文摘 | Heng DY Chi KN | 2006 | Can J Urol2006，13，6： | 1 |
| 6 | Timeliness and earnings quality 显示文摘 | Chi - Wen Jevons Lee Heng Yue | 2004 | Working paper from American Accounting Association 2004 annual meeting2004，，： | 1 |
| 7 | Study on the direction identification and alignment of garlic scaly bud显示文摘 | Gao Chi Zhang Heng | 2012 | Advanced Materials Research2012，，： | 1 |
| 8 | Study of apartmentblock optimal configuration based on up-peak traffic-flow iteration显示文摘 | Zhou Ming Wan Jianru Chi Heng | 2006 | Elevator World2006，，3： | 1 |
| 9 | A Double-Blinded Randomized Controlled Trial of Laparoendoscopic Single-Site Access Versus Conventional 3-Port Appendectomy显示文摘 | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Tiffany Cho Lam Wong Michael Chi Ming Poon Simon Kin Hung Wong Heng Tat Leong Paul Bo San Lai Enders Kwok Wai Ng | 2012 | Annals of Surgery2012，，6： | 1 |
| 10 | Association between sex hormone-binding globulin and kidney function in men: results from the SPECT-China study显示文摘Background::The association between sex hormone-binding globulin(SHBG)and renal function has rarely been reported in men.We aimed to investigate the above association in a community-based Chinese population.Methods::A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors,which is a population-based study conducted from 2014 to 2016 in Eastern China.The estimated glomerular filtration rate(eGFR)was calculated according to the chronic kidney disease Epidemiology Collaboration equation.Low eGFR was defined as eGFR<60 mL·min-1·1.73 m-2.Results::After adjusting for age,smoking,metabolic factors,and testosterone,through increasing quartiles of SHBG,a significantly positive association between SHBG quartiles and eGFR was detected in men(Q1 vs.Q4,β-2.53,95%confidence interval-3.89,-1.17,Ptrend<0.001).Compared with the highest quartile of SHBG,SHBG in the lowest quartile was associated with 96%higher odds of low eGFR(odds ratio 1.96,95%confidence interval 1.10,3.48)in the model after full adjustment.According to the stratified analyses,the associations between a 1-standard deviation increase in serum SHBG and the prevalence of low eGFR were significant in men aged≥60 years old,waist circumference<90 cm,diabetes(no),hypertension(yes),dyslipidemia(no),and nonalcoholic fatty liver disease(no).Conclusions::Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics,lifestyle,metabolic-related risk factors,and testosterone.Large prospective cohort and basic mechanistic studies are warranted in the future. | Haojie Zhang Chi Chen Xuan Zhang Yuying Wang Heng Wan Yi Chen Wen Zhang Fangzhen Xia Yingli Lu Ningjian Wang | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 11 | A population-based study evaluating the impact of sunitinib on overall survival in the treatment of patients with metastatic renal cell cancer 显示文摘 | Heng DY Chi KN Murray N | 2009 | Cancer2009，11，5： | 1 |
| 12 | A population-based study evaluating the impact of sunitinib on overall survival in the treatment of patients with metastatic renal cell cancer显示文摘 | Heng D Y Chi K N Murray N | 2009 | Cancer2009，115，4： | 1 |
| 13 | A Double-Blinded Randomized Controlled Trial of Laparoendoscopic Single-Site Access Versus Conventional 3-Port Appendectomy显示文摘 | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Tiffany Cho Lam Wong Michael Chi Ming Poon Simon Kin Hung Wong Heng Tat Leong Paul Bo San Lai Enders Kwok Wai Ng | 2012 | Annals of Surgery2012，，6： | 1 |
| 14 | A population-based study evaluating the impact of sunitinib on overall survival in the treatment of patients with metastatic renal cell cancer显示文摘 | Heng DY Chi KN Murray N | 2009 | Cancer2009，115，4： | 1 |
| 15 | Risk Factors of Postoperative Infections in Adults with Complicated Appendicitis显示文摘 | Poon Chi Ming Tsang Yvonne Yee Yan Leong Heng Tat | 2009 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2009，，3： | 1 |
| 16 | An integrated framework for customer value and customer-relationship-management performance: a customerbased perspective from china 显示文摘 | Yonggui Wang Hing Po Lo Renyong Chi Heng Y | 2004 | Managing Service Quality2004，114，： | 1 |
| 17 | A population-based study eval- uating the impact of sunitinib on overall survival in the treatment of patients with metastatic renal cell cancer 显示文摘 | Heng DY Chi KN Murray N | 2009 | Cancer2009，115，4： | 1 |
| 18 | Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains显示文摘Non-structural protein 1(NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication.The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently.In the present study,the NS1 protein from the A/Shantou/602/06(H3N2) virus(herein abbreviated as NS32) was found to interact with NS1 from A/Shantou/169/06(H1N1),A/Chicken/Guangdong/1/05(H5N1) and A/Quail/Hong Kong/G1/97(H9N2)(abbreviated as NS11,NS51 and NS92,respectively) viruses,although NS32 shares 17.4% 20.9% sequence diversity with NS11,NS51 and NS92.This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains may be a common event during co-infection. | LI WeiZhong ZHANG Heng WANG GeFei ZHANG Chi ZENG XiangXing LIU Hui CHEN XiaoXuan XU YanXuan LI KangSheng | 2012 | Science China(Life Sciences)2012，55，6： | 0 |
| 19 | Parents making surgical decisions for their children:a pilot study显示文摘Parents play a key role in medical decision-making for their children,who are limited by their intellectual development in under-standing their own health status and treat-ment plans.1 These decisions are challenging as they may have a lifelong impact on patients'physical and mental well-being,and a signif-icant portion of parents are not satisfied with the informed consent process.Various factors affecting parental satisfaction with the informed consent process have been identi-fied,including parents'knowledge base,the specific types of decisions and the presence of decisional conflicts. | Adrian Chi Heng Fung Kenneth Kak Yuen Wong | 2023 | World Journal of Pediatric Surgery2023，6，2： | 0 |
| 20 | Recurrent inverted papilloma coexisted with skull base lymphoma: A case report显示文摘BACKGROUND Inverted papilloma is an uncommon neoplasm in the nasal cavity.It is a histologically benign tumor,but has a high recurrence and local invasion rate.In addition,nasal or skull base lymphoma is another rare neoplasm.The coexistence of these two tumors in one case makes the diagnosis and related treatment difficult.CASE SUMMARY We report a case of an immunocompetent patient,who had a history of inverted papilloma 20 years ago.The patient presented with an infiltrated mass lesion in the nasal cavity with extension to the frontal base.The repeated biopsies revealed inverted papilloma without any malignant transformation.After the patient underwent a frontobasal craniotomy with total tumor excision,the final pathological examination revealed nasal inverted papilloma coexisting with diffuse large B-cell lymphoma of the skull base.CONCLUSION Based on this case report,while managing a case of an aggressive recurrent inverted papilloma,not only squamous cell carcinoma transformation,but also other invasive malignancy,such as lymphoma,should be considered. | Heng Juei Hsu Chi Chen Huang Ming Tsung Chuang Chih Hao Tien Jung Shun Lee Po-Hsuan Lee | 2021 | World Journal of Clinical Cases2021，9，2： | 0 |
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