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| 1 | Characterization of Hand,Foot,and Mouth Disease in China between 2008 and 2009显示文摘Objective To investigate the epidemiological and clinical features of hand,foot and mouth disease (HFMD) since several outbreaks of HFMD caused by enteroviruses were documented in China between 2007 and 2008.Methods HFMD cases reported to the National Infectious Disease Information Management System database between May 2008 and April 2009 were assessed.Clinical features in some of the severe and fatal cases were analyzed the etiology of the outbreaks was investigated.Results 89.1% of reported HFMD cases were found in children<5 year‐old with an age‐specific incidence rate of 834.1/100 000 in the first year as the notifiable disease in China from May 2008 to April 2009.The incidence,mortality and percentage of severe cases were studied for three regions of China and found to be highest in the central region.The incidence of severe cases and mortality in rural population were significantly higher than those in urban population.Among the laboratory confirmed EV17 positive cases there were 52.6% mild,83.5% severe,and 96.1% fatal cases.More myoclonic jerks were found in the severe case group than in group that died.Tachypnea,lip purpling,pink foaming and low limb temperature occurred more frequently in the fatal cases than in the severe cases.Conclusion The epidemic of HFMD in China was characterized predominantly by EV71 infections,had relatively high mortality rates especially in the central region,and was most prevalent in young,rural populations. | ZHANG Jing SUN JunLing CHANG ZhaoRui ZHANG WeiDong WANG ZiJun FENG ZiJian | 2011 | Biomedical and Environmental Sciences2011，24，3： | 74 |
| 2 | Chemical characterization of size-resolved aerosols in four seasons and hazy days in the megacity Beijing of China显示文摘Size-resolved aerosol samples were collected by MOUDI in four seasons in 2007 in Beijing. The PM10 and PM1.8mass concentrations were 166.0 ± 120.5 and 91.6 ± 69.7 μg/m^3, respectively,throughout the measurement, with seasonal variation: nearly two times higher in autumn than in summer and spring. Serious fine particle pollution occurred in winter with the PM1.8/PM10 ratio of 0.63, which was higher than other seasons. The size distribution of PM showed obvious seasonal and diurnal variation, with a smaller fine mode peak in spring and in the daytime. OM(organic matter = 1.6 × OC(organic carbon)) and SIA(secondary inorganic aerosol) were major components of fine particles, while OM, SIA and Ca_2+were major components in coarse particles. Moreover, secondary components, mainly SOA(secondary organic aerosol) and SIA,accounted for 46%–96% of each size bin in fine particles, which meant that secondary pollution existed all year. Sulfates and nitrates, primarily in the form of(NH_4)_2SO_4, NH_4NO_3, Ca SO_4, Na_2SO_4 and K_2SO_4, calculated by the model ISORROPIA II, were major components of the solid phase in fine particles. The PM concentration and size distribution were similar in the four seasons on non-haze days, while large differences occurred on haze days, which indicated seasonal variation of PM concentration and size distribution were dominated by haze days. The SIA concentrations and fractions of nearly all size bins were higher on haze days than on non-haze days, which was attributed to heterogeneous aqueous reactions on haze days in the four seasons. | Kang Sun Xingang Liu Jianwei Gu Yunpeng Li Yu Qu Junling An Jingli Wang Yuanhang Zhang Min Hu Fang Zhang | 2015 | Journal of Environmental Sciences2015，27，6： | 19 |
| 3 | Environmental magnetism and paleoclimatic interpretation of the Sanmenxia loess-paleosol sequence in the southeastern extremity of the Chinese Loess Plateau显示文摘这是多参数矿物质的一份报告在在间隔 ofL1 上的中国黄土高原(CLP ) 的 SE 极限的 Sanmenxialoess-paleosol 两行诗的磁性的结果 - 跨越最后 1 个妈的 L13。这些结果显示出那团特定的磁性的危险性(x) , Xarm 和 SIRM,他们的比率展出平行 stratigraphic 变化。Sincesuperparamagnetic (SP ) 粒子有重要贡献到到顽磁的 X 而是没有贡献,例如,手臂和 SIRM,在 x 之间的强壮的线性关联一(i 顽磁(例如, ARMand SIRM ) 建议生产成土作用的磁性的谷物是主要在里面小单个领域范围。因而,到想在以前的研究的体积 x 的 SP 粒子的重要贡献显然被过高估计。在 Sanmenxia 和中部的谷物尺寸的 2arm/X 数据从 CLP 显示的内地典型黄土节记录强壮的相似,暗示 Jarm/X 可以为监视变化 offerrimagnetic 谷物被认为是可靠指示物缩放。S 比率和 HIRM 的结果((SIRM+IRM_(.3T ))/2 ) 大小显示在与成土作用联系的 paleosols 有软磁铁矿 / 磁赤铁矿和 hardhematite/goethite 的重要改进。 | WANG Xisheng YANG Zhenyu Reidar Levlie SUN Zhiming PEI Junling | 2006 | Chinese Science Bulletin2006，51，22： | 15 |
| 4 | Characteristics and formation mechanism of regional haze episodes in the Pearl River Delta of China显示文摘To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Heshan of Guangdong province.Five haze episodes occurred in October and November 2014 in the Pearl River Delta(PRD)region. The meteorological parameters, gas data, chemical compositions, and optical parameters of the aerosols were obtained. Among these events, the second haze episode,with the highest concentration of PM2.5 of 187.51 μg/m^3, was the most severe. NO^3-was always higher than SO_4^(2-), which indicated that motor vehicles played an important role in the haze, even though the oxidation rate from SO_2 to SO_4^(2-)was faster than that of NOXto NO_3^-. The difference between the hourly averages of Na+and K+during the haze episode and clean days was small, implying that straw combustion and sea salt had no significant effect on the occurrence of haze, and the backward trajectories of the air masses also conformed with this result. The air pollutants were difficult to disperse because of the significant decrease in the planetary boundary layer(PBL) height. Relative humidity played a crucial role in the formation of haze by leading to hygroscopic growth of the diameter of aerosols. | Wenguang Li Xingang Liu Yuanhang Zhang Kang Sun Yusheng Wu Rui Xue Limin Zeng Yu Qu Junling An | 2018 | Journal of Environmental Sciences2018，30，1： | 11 |
| 5 | Velvet antler polypeptide is able to induce differentiation of neural stem cells towards neurons in vitro显示文摘OBJECTIVE: To investigate the neural differentiation capacity of water extraction of velvet antler.METHODS: Velvet antler(Cervus Nippon Temminck) polypeptide(VAP) was used to differentiate neural stem cells(NSCs) towards neurons in the study. Firstly, we obtain the polypeptides of VAP by water extraction. Secondly, we observed the morphology, assayed the factors in the media by enzyme-linked immunosorbent assay, and detected the special neural molecules by immuno fl uorescence staining. NSCs were cultured on the cell climbing film. After neuronal differentiation, differentiated NSCs were mounted for immunocytochemistry with immunofluorescence technique.RESULTS: The differentiating cells look like neuron,some special factors, such as Glial cell line-derived neurotrophic factor, nerve growth factor, in the media can be detected while differentiated neuron-like cells can express the special neural molecules.CONCLUSION: Differentiation of NSCs towards neurons can be induced by velvet antler polypeptide. | Zhang Lihong Zhuang Zhihong Sun Yanan Ma Shuhua Yang Weifeng Lei Hongtao Zuo Junling Ouyang Jingfeng Wang Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 6 | Bamboo Leaf and Pollen Fossils from the Late Miocene of Eastern Zhejiang,China and their Phytogeological Significance显示文摘Fossil bamboo leaves and pollen from Upper Miocene deposits of the Shengxian Formation in Tiantai and Ninghai counties,eastern Zhejiang,China represent a rare record in Asia.The distinctive pseudopetiole and parallel venation of the leaf blades and the clearly thickened annulus of the pollen aperture place them in the subfamily Bambusoideae.Morphological analysis supports the determination of these fossil leaves as belonging to the genus Bambusium and two new species are described.Bambusium latipseudopetiolus Q.J.Wang et B.N.Sun sp.nov.has a distinctly wide pseudopetiole of 0.23 cm in width and 0.40 cm in length,several vascular bundles on parallel veins,and 5–8 lateral veins on both sides of the midrib.Bambusium longipseudopetiolus Q.J.Wang et B.N.Sun sp.nov.has a distinctly long pseudopetiole of 0.60 cm in length and 0.10 cm in width,several vascular bundles on the pseudopetiole,and 6 lateral veins on both sides of the midrib.Pollen grains from the same layer provide additional evidence of bamboos.They are characterized by 32.0–51.0 μm in diameter,a round pore 3.0–4.0 μm in diameter with a broad thickened annulus 2.5–3.5 μm around,and several conspicuous secondary folds on the exine surface.The morphological analysis leads to their assignment to Graminidites bambusoides Stuchlik.These fossils are important for the study of bamboo phytogeography in China.They demonstrate that there were bamboos growing in southeastern China during the Late Miocene and that bamboos in Zhejiang begin to diversify no later than the Late Miocene.In combination with bamboo fossils from other places,it seems that bamboos had a wide distribution across southern China during the Miocene,ranging from southwestern Yun'nan to southeastern Zhejiang. | WANG Qiujun MA Fujun YANG Yi DONG Junling WANG Haofei LI Ruiyun XU Xiaohui SUN Bainian | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 7 |
| 7 | The First Quantitative Slip-Rate Estimated Along the Ashikule Fault at the Western Segment of the Altyn Tagh Fault System显示文摘As one of the longest strike-slip fault in Asia,the Altyn Tagh Fault(ATF)defines the northern boundary of the Tibetan Plateau and plays a significant role inaccommodating the deformation resulting from the IndiaAsia convergence.Slip-rate and seismic behavior of the fault are critical to understand the present-day | PAN Jiawei LI Haibing VAN DER WOERD Jerome SUN Zhiming SI Jialiang PEI Junling WU Fuyao CHEVALIER Marie-Luce | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 5 |
| 8 | Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis显示文摘Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis. | Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang Tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 9 | Observation of Wind Shear during Evening Transition and an Estimation of Submicron Aerosol Concentrations in Beijing Using a Doppler Wind Lidar显示文摘The wind speed and direction measured over six months by a Doppler wind lidar(Windcube-8)were compared with wind cup anemometers mounted on the 325-m Beijing meteorological tower(BMT).Five mountain–plain wind cases characterized by wind direction shear were selected based on the high-frequency(1.1 s)wind profile of the Windcube-8 and analyzed with 1-h mesoscale surface weather charts.Also analyzed was the relationship between insitu PM_1(aerodynamic diameter≤1μm)concentrations measured at 260 m on BMT and the carrier-to-noise ratio(CNR)of the co-located Windcube-8.The results showed that the 10-min averaged wind speed and direction were highly correlated(R=0.96–0.99)at three matched levels(80,140,and 200 m).The evening transition duration was1–3 h,with an average wind speed of 1 m s^(–1) at 80 m above the ground.In addition,there was a zero horizontalwind-speed zone along the wind direction shear line,and in one case,the wind speed was characterized by a Kelvin–Helmholtz gravity wave.The variability of the PM_1 concentrations was captured by the CNR of the Windcube-8 in a fair weather period without the long-range transport of dust. | Yong CHEN Junling AN Xiquan WANG Yele SUN Zifa WANG Jing DUAN | 2017 | Journal of Meteorological Research2017，31，2： | 5 |
| 10 | Development of BCPDA-Eu^3+-BAS Labeled Hepatitis B Surface Antibodies显示文摘 | TAN Wenjia SUN Zhixia XUAN Lili LI Junling XIE Wenbing HE Chengyan PAN Lihua | 2018 | Chemical Research in Chinese Universities2018，34，1： | 4 |
| 11 | Development of EST-SSR primers and their practicability test for Laminaria显示文摘Laminaria (Saccharina) is one of the economic important seaweeds.Through sequence analysis of 4 099 ESTs from Laminaria (971 were generated from our own cDNA laboratories and 3 128 were downloaded from updated EST databases) with SSRIT software,two hundred and fifty-four SSRs in 206 ESTs were found.From the 254 SSRs,sixty-three SSR primer-pairs were designed. In order to test their practicability, the 63 primer-pairs were tested in commonly used SSR reaction conditions using 12 Laminara DNA samples as templates. The results show that 23 SSR primer-pairs gave good amplification patterns on most (more than 80%) of the 12 Laminara DNA templates. Genetic diversity study of 12 Laminaria lines,which were widely used in breeding and economic cultivation in China,was performed based on the obtained SSR data. | WANG Guoliang TAN Xiaolong SHEN Junling LI Jian ZHANG Lei SUN Jianwei WANG Bin WENG Manli LIU Tao | 2011 | Acta Oceanologica Sinica2011，30，3： | 3 |
| 12 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 13 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 14 | Nocturnal Low-levelWinds and Their Impacts on Particulate Matter over the Beijing Area显示文摘Three-month wind profiles, 260 m PM_1 concentrations [i.e., particulate matter(PM) with an aerodynamic diameter ≤1μm], and carrier-to-noise ratio data at two Beijing sites 55 km apart(urban and suburban) were collected to analyze the characteristics of low-level nocturnal wind and PM in autumn and winter. Three mountain-plain wind events with wind shear were selected for analysis. The measurements indicated that the maximum wind speeds of the northerly weak low-level jet(LLJ) below 320 m at the suburban site were weaker than those at the urban site, and the LLJ heights and depths at the suburban site were lower than those at the urban site. The nocturnal 140 m mean vertical velocities and the variations in vertical velocity at the urban site were larger than those at the suburban site. A nocturnal breeze with a weak LLJ of ~3 m s^(-1) noticeably offset nocturnal PM transport due to southerly flow and convergence within the northern urban area of Beijing. Characteristics of the nocturnal LLJ, such as start-up time, structure, intensity, and duration, were important factors in determining the decrease in the nocturnal horizontal range and site-based low-level variations in PM. | Yong CHEN Junling AN Yele SUN Xiquan WANG Yu QU Jingwei ZHANG Zifa WANG Jing DUAN | 2018 | Advances in Atmospheric Sciences2018，35，12： | 2 |
| 15 | Flexible artificial synapse based on single-crystalline BiFeO_(3) thin film显示文摘Realization of functional flexible artificial synapse is a significant step toward neuromorphic computing.Herein,a flexible artificial synapse based on ferroelectric tunnel junctions(FTJs)is demonstrated,using BiFeO_(3)(BFO)thin film as the functional layer.The inorganic single crystalline FTJs grown on rigid perovskite substrates at high temperatures are integrated with the flexible plastic substrates,by using the water-soluble Sr_(3)Al_(2)O_(6)(SAO)as the sacrificial layer and the following transfer.The transferred freestanding BFO thin film exhibits excellent ferroelectric properties.Moreover,the memristive properties and the brain-like synaptic learning performance of the flexible FTJs are investigated.The results show that multilevel resistance states were maintained well of the flexible artificial synapse,together with their stable synaptic learning properties.Our work indicates the promising opportunity of ferroelectric thin film based flexible synapse used in the future neuromorphic computing system. | Zhen Zhao Amr Abdelsamie Rui Guo Shu Shi Jianhui Zhao Weinan Lin Kaixuan Sun Jingjuan Wang Junling Wang Xiaobing Yan Jingsheng Chen | 2022 | Nano Research2022，15，3： | 2 |
| 16 | Cloning and characterization of a novel CBL-interacting protein kinase from maize显示文摘 | Jinfeng Zhao Zhenfei Sun Jun Zheng Xiying Guo Zhigang Dong Junling Huai Mingyue Gou Junguang He Yongsheng Jin Jianhua Wang Guoying Wang | 2009 | Plant Molecular Biology2009，，6： | 2 |
| 17 | Buxus Leaves from the Oligocene of Guangxi, China and Their Biogeographical Significance显示文摘The present paper reports two new species of Buxus from the Oligocene Ningming Formation of Guangxi, South China, on the basis of several compressed fossil leaves.Buxus ningmingensis sp.nov.is characterized by an elliptic to ovate shape; pinnate venation with marginal secondary, long hairs on the adaxial side of the midvein base; and amphistomatic, anomocytic stomata with a prominent outer ring.All of these characteristics suggest a closest affinity to the living Buxus microphylla subsp.sinica.Another new species identified as Buxus preaustro-yunnanensis sp.nov.is characterized by the diagnostic formation of its admedially branched tertiaries, the trunks of which are often strongly thickened by sclereides.This species is most similar to the extant Buxus austroyunnanensis.The co-occurrence of Buxus ningmingensis sp.nov.and Buxus preaustro-yunnanensis sp.nov.suggests that these two Buxus lived during the Oligocene under a warm, tropical to subtropical climate, similar to the current climate of Ningming.Our findings provide the earliest fossil evidence of Buxus leaves with detailed illustrations of leaf architectural and cuticular features.The occurrence of these two species indicates that Buxus began to diversify in Guangxi no later than the Oligocene. | MA Fujun WANG Qiujun DONG Junling YANG Yi WANG Wenjia YAN Defei SUN Bainian | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 18 | Comparative study on adjuvanticity of compound Chinese herbal medicinal ingredients 显示文摘 | Wang Deyun Hu Yuanliang Sun Junling | 2005 | Vaccine2005，23，28： | 1 |
| 19 | The APOE ε2 allele may decrease the age at onset in patients with spinocerebellar ataxia type 3 or Machado-Joseph disease from the Chinese Han population显示文摘 | Huirong Peng Chunrong Wang Zhao Chen Zhanfang Sun Bin Jiao Kai Li Fengzhen Huang Xuan Hou Junling Wang Lu Shen Kun Xia Beisha Tang Hong Jiang | 2014 | Neurobiology of Aging2014，，9： | 1 |
| 20 | Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments显示文摘 | Jia Yinhua Sun Xiwei Sun Junling | 2014 | Plos One2014，9，5： | 1 |
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