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| 1 | DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling显示文摘endoplasmic 蜂窝胃(嗯) 由原子信封, perinuclear 表和一个外部管状的网络组成。外设嗯并且线粒体形式在特定的子域的紧密的接触,它协调二个细胞器的函数并且为象 Ca 2+ 转移和 apoptosis 那样的多重细胞的进程被要求。然而,它大部分是未知的怎么嗯形态学并且嗯线粒体发信号动态地在象 DNA 那样的不同生理或病理学的条件下面被调整损坏。这里,我们证明外设,管状嗯响应 DNA 经历重要扩展损坏,和那这个过程依赖于嗯塑造蛋白质 REEP1, REEP2 和 EI24 (别名 PIG8 ) 的调停 p53 的 transcriptional 激活。这通过 EI24 和 mitochondrial 支持嗯线粒体接触的形成外部膜蛋白质 VDAC2,便于 Ca 2+ 转移从嗯到线粒体并且支持 DNA 导致损坏的 apoptosis。因此,我们识别包含改变在的一条唯一的 DNA 损坏反应小径嗯形态学,发信号的嗯线粒体,和 apoptosis。 | Pengli Zheng Qingzhou Chen Xiaoyu Tian Nannan Qian Peiyuan Chai Bing Liu Junjie Hu Craig Blackstone Desheng Zhu Junlin Teng Jianguo Chen | 2018 | Cell Research2018，28，8： | 9 |
| 2 | Effects and safety of aspirin use in patients after cerebrovascular bypass procedures显示文摘Object Superficial temporal artery to middle cerebral artery(STA-MCA)bypass is the most effective treatment for Moyamoya disease(MMD).In this study,we aimed to assess whether aspirin improves STA-MCA bypass patency and is safe in patients with MMD.Methods We performed a retrospective medical record review of patients with ischaemic-onset MMD who had undergone STA-MCA bypass at two hospitals between January 2011 and August 2018,to clarify the effects and safety of aspirin following STA-MCA bypass.The neurological status at the last follow-up(FU)was compared between patients with FU bypass patency and occlusion.Results Among 217 identified patients(238 hemispheres),the mean age was 41.4±10.2 years,and 51.8%were male;the indications for STA-MCA bypass were stroke(48.2%),followed by a transient ischaemic attack(44.0%).Immediate bypass patency was confirmed in all cases.During the FU period(1.5±1.5 y),15 cases were occluded at FU imaging,resulting in an overall cumulative patency rate of 94%.The patency rates were 93%and 94%in the short-term FU group(n=131,mean FU time 0.5±0.2 years)and long-term FU group(n=107,mean FU time 4.1±3.5 years),respectively.The STA-MCA bypass patency rate in the aspirin group was higher than that in the non-aspirin group(98.7%vs 89.7%;HR 1.57;95%CI 1.106 to 2.235;p=0.012).No significant difference in the FU haemorrhagic events was observed between the aspirin and non-aspirin groups.Conclusions Among adult patients with ischaemic-onset MMD undergoing STA-MCA bypass procedures,aspirin might increase the bypass patency rate,without increasing the bleeding risk.FU bypass patency may be associated with a better outcome.Additional studies,especially carefully designed prospective studies,are needed to address the role of aspirin after bypass procedures. | Junlin Lu Guangchao Shi Yuanli Zhao Rong Wang Dong Zhang Xiaolin Chen Hao Wang Ji Zong Zhao | 2021 | Stroke & Vascular Neurology2021，6，4： | 7 |
| 3 | A New Material of Lindera (Lauraceae) of the Late Pliocene from Tengchong, Yunnan and the Genus' Biogeography Significance显示文摘Lindera is a large genus of graceful, pleasantly scented and common native trees and shrubs of southern China and neighboring regions of SE Asia. There is a well-documented Cenozoic fossil record not only in these regions but also from elsewhere. A new fossil leaf record has been found in diatomite beds from the Upper Pliocene Mangbang Formation of Tuantian, Tengchong County, Yunnan. The leaves are identified and assigned to Lindera acuminatissima K. Q. Dao et B. N. Sun sp. nov., by comparing their leaf architecture and epidermal characteristics with those of 51 extant Lauraceae species and with 15 known fossil Lindera taxa. The specimens have well-preserved cuticles, with typical leaf architecture and epidermal characteristics of the Lauraceae, including entire leaf margin, intramarginal veins, basal ternate acrodromous primary veins, one-cell trichome base, paracytic stomatal apparatus, sunken guard cells, subsidiary hardly staining cells and presence of oil cells. These characteristics are consistent with Lindera sect. Daphnidium but are different from reported fossil and extant species of Lindera. The cuticles of Lindera are fragile and delicate with only three Lindera fossils reported based on this tissue. In terms of paleobiogeography, the fossil record indicates that Lindera is distributed in high- to mid-latitude regions of the Late Cretaceous to Paleocene northern hemisphere. Coincidentally, the records of Lindera located on both sides of the Bering Land Bridge possibly support the hypothesis that ancient plants extended via transcontinental exchanges through the Bering Corridor. In the Eocene, ancient Lindera spread to Europe through the Northern Degeer Route and the Southern Thulian Route. At the same time, ancient Lindera spread into Central Asia. Climatic changes and tectonization since the Neogene prevented the propagation of Lindera throughout Asia, North America and Europe, and hence the distribution areas have just regressed to the low-latitude regions in Asia and North America. From the Paleogene to the Neogene, Lindera has changed its distribution by surviving extreme climate changes. Quaternary glaciations ultimately led to Lindera becoming extinct in Europe. The new record from Tengchong, Yunnan, with its lower latitude located in tropical and subtropical regions, indicates that Lindera has lived in those regions since the late Pliocene. | DAO Kequn CHEN Junlin JIN Peihong DONG Chong YANG Yi XU Xiaohui WU Jingyu XIE Sanping LIN Zhicheng SUN Bainian | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 4 |
| 4 | Collection efficiency in a three-dimensional randomly arranged dual-layer granular bed filter显示文摘The dual-layer granular bed filter packed with randomly arranged granules was simulated to study the effects of bed depth of the lower layer of fine granules and the inlet gas velocity on the collection mechanism.The computational results show that the collection efficiency is much better from this granular bed than a single-layer granular bed,especially for particle diameters of 1-10μm.The inlet gas velocity has less effect on the grade collection efficiency of the dual-layer granular bed than of the single-layer granular bed.The dual-layer granular bed provides a high collection efficiency and low pressure drop.The relationship between the grade collection efficiency and the Stokes number(St)based on the inlet gas velocity is obtained.If St is below a threshold,the grade collection efficiency remains stable;if St is in value above threshold,the grade collection efficiency increases linearly with lg(St).As the bed depth of the lower layer of fine granules increases,the threshold for St shifts forward. | Junlin Chen Xunfeng Li Xiulan Huai Jingzhi Zhou | 2020 | Particuology2020，18，2： | 3 |
| 5 | Investigation on landing impact dynamic and low-gravity experiments for deep space lander显示文摘Herein symmetrical four-legged suspension lunar lander was used as the research object, the six-degree-of-freedom dynamic model was built and the model of the lunar soil friction coefficient was improved. For the low-gravity simulation on objects outside earth for future work, the law of dynamic similarity for detectors was deduced. A new method was proposed for simulating the low-gravity field on the surface of objects outside earth, which was achieved by changing initial conditions of the landing by the probe and by subsequent treatment of experimental data. The prototype tested the limitation of this method was verified. It is shown that the prototypes of detectors can be used in detectors low-gravity simulation test with this method, and equipments are simple and operationally effective. This method can be used for later lunar exploration, and low-gravity simulations on extraterrestrial objects. | CHEN JinBao NIE Hong WAN JunLin LIN Qing | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，10： | 3 |
| 6 | CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage显示文摘Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that play important roles in gene expression regulation.This study aimed to evaluate the potential role of circRNAs in decidual tissue of patients with early recurrent miscarriage(RM).We constructed circRNA expression profiles in decidual tissue using microarray data.A total of 123 differentially expressed circRNAs,including 78 upregulated and 45 downregulated circRNAs were detected in the early RM group compared with the control group(P<0.05).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis also revealed the enrichment of specific circRNAs.The verified circRNA-targeted miRNA-mRNA network was constructed,most of the circRNAs harbored miRNA binding sites.The network involved 3 circRNAs,27 microRNAs and 82 mRNAs.Hsa_circRNA_103092-miR-224-PRLR network was selected to verify by qRT-PCR.These results showed that circRNAs are aberrantly expressed in the decidual tissue in early RM patients and play potential roles in the development of early RM.It gives new insights into the mechanism of recurrent miscarriage. | Chunli Li Xuemei Chen Xueqing Liu Xiaoli Liu Junlin He Yubin Ding Chao Tong Chuan Peng Yingxiong Wang Rufei Gao | 2020 | Genes & Diseases2020，7，3： | 3 |
| 7 | Mechanism for the formation and microphysical characteristics of submicron aerosol during heavy haze pollution episode in the Yangtze River Delta, China显示文摘 | Honglei Wang Junlin An Lijuan Shen Bin Zhu Chen Pan Zirui Liu Xiaohui Liu Qing Duan Xuan Liu Yuesi Wang | 2014 | Science of the Total Environment2014，，： | 2 |
| 8 | Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity显示文摘 | Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen | 2012 | Cell Research2012，22，9： | 2 |
| 9 | Numerical study of collection efficiency and heat-transfer characteristics of packed granular filter显示文摘The collection mechanism and heat-transfer characteristics of a packed granular filter were investigated using a three-dimensional randomly packed granular filter model. The bridging method was introduced to optimize the grids of contact points between granules. The influences of granular bed depth, gas velocity, and gas temperature on grade collection efficiency were investigated. The results indicated that a decrease of temperature improved collection efficiency when the particle diameter was greater than 5 |xm. The grade collection efficiency maintained a stable value when the Stokes number, St, was less than 0.009, but increased linearly with ig(St) when St > 0.009. A logarithmic mean temperature difference method was used to obtain overall heat-transfer coefficients of gas-solid two-phase flow through the packed granular filter. The results showed that convective heat transfer was enhanced due to the intro-duction of solid particles in the bed. The overall heat-transfer coefficient increased approximately linearly with an increase in particle loading ratio. The Nusselt number was related to the Reynolds number, the Archimedes number, and the particle loading ratio. | Junlin Chen Xunfeng Li Xiulan Huai Yongwei Wang Jingzhi Zhou | 2019 | Particuology2019，17，5： | 2 |
| 10 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 11 | Uniqueness and asymptotically stable periodic solutions of lienard type equation显示文摘 | Chen H B Qin Junlin | | submitted0，，： | 1 |
| 12 | Effect of varying NaCl doses on flavonoid production in suspension cells of Ginkgo biloba : relationship to chlorophyll fluorescence, ion homeostasis, antioxidant system and ultrastructure显示文摘 | Ying Chen Fangzhi Lin Hua Yang Li Yue Fei Hu Junlin Wang Yongya Luo Fuliang Cao | 2014 | Acta Physiologiae Plantarum2014，，12： | 1 |
| 13 | Quantitative angiographic haemodynamic evaluation of bypasses for complex aneurysms: a preliminary study显示文摘Objective Open microsurgery,often with bypass techniques,is indispensable for complex aneurysms.To date,it remains unknown whether arterial anatomy or quantitative blood flow measurements can predict insufficient flow-related stroke(IRS).The present study aimed to evaluate the risk factors for IRS in patients treated with open microsurgery with bypass procedures for complex internal carotid artery aneurysms.Methods Patients with complex aneurysms undergoing bypass surgery were retrospectively reviewed.The recipient/donor flow index(RDFI)was preoperatively evaluated using colour-coding angiography.RDFI was defined as the ratio of the cerebral blood volume of the recipient and donor arteries.The sizes of the recipient and donor arteries were measured.The recipient/donor diameter index(RDDI)was then calculated.IRS was defined as the presence of new postoperative neurological deficits and infarction on postoperative CT scans.We assessed the association between RDFI and other variables and the IRS.Results Twenty patients(38±12 years)were analysed.IRS was observed in 12 patients(60%).Patients with postoperative IRS had a higher RDFI than those without postoperative IRS(p<0.001).RDDI was not significantly different between patients with and without IRS(p=0.905).Patients with RDFI>2.3 were more likely to develop IRS(p<0.001).Conclusion Quantitative digital subtraction angiography enables preoperative evaluation of cerebral blood volume.RDFI>2.3,rather than RDDI,was significantly associated with postoperative IRS.This preoperative evaluation allows appropriate decisions regarding the treatment strategy for preventing postoperative IRS. | Junlin Lu Chao Xue Xulin Hu Yuanli Zhao Dong Zhang Xiaolin Chen Ji Zong Zhao | 2022 | Stroke & Vascular Neurology2022，7，1： | 1 |
| 14 | Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery显示文摘Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue. | Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu Xu Ziqiang Xu Bingbing Jiang Cao Li | 2021 | Nano Research2021，14，11： | 1 |
| 15 | Observation of aerosol optical properties and particulate pollution at background station in the Pearl River Delta region显示文摘 | CHEN Jianshan XIN Jinyuan AN Junlin | 2008 | Atmospheric Research2008，47，27： | 1 |
| 16 | Accessory Lobe of Right Liver Mimicking a Pulmonary Tumor in an Adult Male显示文摘 | Wang Yi Junlin Liao Zhang Wei-guo Chen Jin-hua He Yong Chen Jian-ming | 2010 | The Annals of Thoracic Surgery2010，，2： | 1 |
| 17 | Existence and uniqueness of periodic solutions of an equation of Duffing type显示文摘 | CHEN Hongbin WANG Lihe QIN Junlin | | 0，，： | 1 |
| 18 | Effects of V-pits covering layer position on the optoelectronic performance of InGaN green LEDs显示文摘The impact of the V-pits covering layer(VCL) position on the optoelectronic performance of InGaN-based green light-emitting diodes(LEDs) was investigated. It is found that earlier covering of V-pits will hinder the hole injection via the sidewall of V-pits, and then result in less quantum wells(QWs) participating in radioluminescence. The current-voltage characteristics show that the LEDs with earlier covering of V-pits have higher operating voltage at room temperature, and a more dramatic voltage rise with the reduction of temperature. Meanwhile, more manifested emission peaks for sidewall QWs and deeper QWs near to ntype layer was observed in the sample with earlier coveing of V-pits at cryogenic temperatures, for the reason that the holes being injected via V-pits sidewall have higher kinetic energy and could transport to deeper QWs. | Chen Xu Changda Zheng Xiaoming Wu Shuan Pan Xingan Jiang Junlin Liu Fengyi Jiang | 2019 | Journal of Semiconductors2019，40，5： | 1 |
| 19 | Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma显示文摘The long non-coding RNA,Negative Regulator of Antiviral Response(NRAV)has been identified as a participant in both respiratory virus replication and immune checkpoints,however,its involvement in pan-cancer immune regulation and prognosis,particularly those of hepatocellular carcinoma(HCC),remains unclear.To address this knowledge gap,we analyzed expression profiles obtained from The Cancer Genome Atlas(TCGA)database,comparing normal and malignant tumor tissues.We found that NRAV expression is significantly upregulated in tumor tissues compared to adjacent nontumor tissues.Kaplan-Meier(K-M)analysis revealed the prognostic power of NRAV,wherein overexpression was significantly linked to reduced overall survival in a diverse range of tumor patients.Furthermore,noteworthy associations were observed between NRAV,immune checkpoints,immune cell infiltration,genes related to autophagy,epithelial-mesenchymal transition(EMT),pyroptosis,tumor mutational burden(TMB),and microsatellite instability(MSI)across different cancer types,including HCC.Moreover,NRAV upregulation expression was associated with multiple pathological stages by clinical observations.Furthermore,our investigation revealed a substantial elevation in the expression of NRAV in both HCC tumor tissues and cells compared to normal tissues and cells.The inhibition of NRAV resulted in the inhibition of cell proliferation,migration,and invasion in HCC cells,while also influencing the expression of CD274(PD-L1)and CD44,along with various biomarkers associated with EMT,autophagy,and pyroptosis.The aforementioned results propose NRAV as a promising prognostic biomarker for HCC. | JUN LIU WENLI LI RUYUE LU JIAQING XU CHUNHUI JIANG JUNLIN DUAN LINGZHI ZHANG GUANFU WANG JIAXI CHEN | 2024 | Oncology Research2024，32，4： | 0 |
| 20 | Effects of zeolite application on grain yield,water use and nitrogen uptake of rice under alternate wetting and drying irrigation显示文摘With the increasing scarcity of water resources and growing population,the dual goal of saving irrigation water and increasing grain yield has become a major challenge in rice production around the world.A two-year lysimetric experiment was conducted to assess the effects of zeolite application(Z_(0):0 and Z1:15 t/hm^(2) and water regimes(W_(0):continuous flooding irrigation,W1:energy-controlled irrigation,W2:alternate wetting and drying irrigation)on grain yield,water use and total nitrogen uptake of rice.Zeolite addition to paddy field significantly increased grain yield,total N uptake,and water use efficiency(WUE),despite a negligible effect on amount of irrigation water used.Compared with W_(0),the separate use of W_(1) and W_(2) each considerably decreased irrigation water.However,W2-grown rice showed a significant decline in grain yield.In contrast,W1 showed comparable grain yield with W_(0),and achieved the highest WUE.Correlation analysis revealed that grain yield was significantly and positively correlated with effective panicles,spikelets per panicle,water consumption,and total N uptake.It is concluded that the combination of zeolite application at the rate of 15 t/hm^(2) and energy-controlled irrigation could be recommended to benefit farmers by reducing irrigation water while improving grain yield on a clay loam soil. | Junlin Zheng Taotao Chen Guimin Xia Wei Chen Guangyan Liu Daocai Chi | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 0 |
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