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| 1 | Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study显示文摘AIM: To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study. METHODS: We investigated the clinical outcomes and risk factors for the development of perforation in 98 consecutive gastric neoplasms undergoing ESD regarding. Demographic and clinical parameters including patient-, tumor-, and treatment-related factors, clinical parameters, and duration of hospital stay were analyzed for risk factors for perforation. In subgroup analysis, we also compared the clinical outcomes between perforation and 'silent' free air without endoscopically visible perforation detected only by computed tomography.RESULTS: Perforation was identified in 8.2% of patients. All patients were managed conservatively by the administration of antibiotics. The mean procedure time was significantly longer in patients with endoscopic perforation than in those without. According to the receiver-operating characteristic analysis, the resulting cutoff value of the procedure time for perforation was 115 min (87.5% sensitivity, 56.7% specificity). Prolonged procedure time (≥ 115 min) was associated with an increased risk of perforation (odds ratio 9.15; 95%CI: 1.08-77.54; P = 0.04). Following ESD, body temperature and C-reactive protein level were significantly higher in patients with perforation than in those without (P = 0.02), whereas there was no difference between these patient groups on the starting day of oral intake or of hospitalization. In subgroup analysis, the post-ESD clinical course was not different between endoscopic perforation and silent free air. CONCLUSION: Only prolonged procedure time (≥ 115 min) was significantly associated with perforation. The clinical outcomes of perforation are favorable and are comparable to those of patients with or without silent free air. | Jiro Watari Toshihiko Tomita Fumihiko Toyoshima Jun Sakurai Takashi Kondo Haruki Asano Takahisa Yamasaki Takuya Okugawa Hisatomo Ikehara Tadayuki Oshima Hirokazu Fukui Hiroto Miwa | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 17 |
| 2 | Pneumatosis cystoides intestinalis associated with massive free air mimicking perforated diffuse peritonitis显示文摘当时积气 cystoides 肠(一种总线标准) 一个稀罕疾病实体与许多胃肠、非胃肠的混乱,与巨大的内联系的一种总线标准和制动火箭腹被联系释放空气是极其不平常的,并且是困难的从穿孔腹膜炎诊断差别。我们在场一种总线标准的二个盒子把免费空气或模仿了穿孔腹膜炎的制动火箭腹空气与巨大的腹联系了。这些盒子强调模仿穿孔腹膜炎的一种总线标准的临床的重要性,它要求紧急情况外科。外科手术前的成像形式和诊断腹腔镜检查是有用的做精确诊断。 | Yoichi Sakurai Masahiro Hikichi Jun Isogaki Shinpei Furuta Risaburo Sunagawa Kazuki Inaba Yoshiyuki Komori Ichiro Uyama | 2008 | World Journal of Gastroenterology2008，14，43： | 6 |
| 3 | Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study显示文摘AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD. | Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，12： | 4 |
| 4 | Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study显示文摘AIM To assess the clinical characteristics of patients with complicated erosive esophagitis(EE) and their associated factors.METHODS This prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios(aO R) and 95%CI for the association with complicated EE.RESULTS During the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors(PPIs) were included. Of them, 143(8.2%) had EE complications. Esophageal bleeding occurred in 84(4.8%) patients, esophageal strictures in 45(2.6%) patients, and 14(0.8%) patients experienced both. Multivariate analysis showed that increased age(a OR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents(a OR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B(a OR: 2.69; 95%CI: 1.48-4.96), C(aO R: 15.38; 95%CI: 8.62-28.37), and D(aO R: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated(a OR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age(a OR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B(aO R: 3.60; 95%CI: 1.52-8.50), C(a OR: 27.61; 95%CI: 12.34-61.80), and D(a OR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age(a OR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom(aO R: 2.51; 95%CI: 1.39-4.51), concomitantuse of psychotropic agents(a OR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C(aO R: 7.35; 95%CI: 3.32-16.25), and D(a OR: 20.34; 95%CI: 8.36-49.53) and long-segment Barrett's esophagus(a OR: 4.63; 95%CI: 1.64-13.05).CONCLUSION Aging and severe EE were common associated factors, although there were more associated factors in esophageal strictures than esophageal ulcer bleeding. Despite the availability and widespread use of PPIs, EE complications are likely to remain a problem in Japan owing to the aging population and high-stress society. | Masahiro Sakaguchi Noriaki Manabe Nobuo Ueki Jun Miwa Tomoki Inaba Norimasa Yoshida Kouichi Sakurai Masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，2： | 3 |
| 5 | Laparoscopic repair of hiatal hernia with mesenterioaxial volvulus of the stomach显示文摘Although mesenterioaxial gastric volvulus is an uncommon entity characterized by rotation at the transverse axis of the stomach, laparoscopic repair procedures have still been controversial. We reported a case of mesenterioaxial intrathoracic gastric volvulus, which was successfully treated with laparoscopic repair of the diaphragmatic hiatal defect using a polytetrafluoroethylene mesh associated with Toupet fundoplication. A 70-year-old Japanese woman was admitted to our hospital because of sudden onset of upper abdominal pain. An upper gastrointestinal series revealed an incarcerated intrathoracic mesenterioaxial volvulus of the distal portion of the stomach and the duodenum. The complete laparoscopic approach was used to repair the volvulus. The laparoscopic procedures involved the repair of the hiatal hernia using polytetrafluoroethylene mesh and Toupet fundoplication. This case highlights the feasibility and effectiveness of the laparoscopic procedure, and laparoscopic repair of the hiatal defect using a polytetrafluoroethylene mesh associated with Toupet fundoplication may be useful for preventing postoperative recurrence of hiatal her-nia, volvulus, and gastroesophageal reflux. | Kazuki Inaba Yoichi Sakurai Jun Isogaki Yoshiyuki Komori Ichiro Uyama | 2011 | World Journal of Gastroenterology2011，17，15： | 3 |
| 6 | The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53显示文摘 | Hiroaki Higashitsuji Hisako Higashitsuji Katsuhiko Itoh Toshiharu Sakurai Toshikazu Nagao Haruhiko Sumitomo Tomoko Masuda Simon Dawson Yutaka Shimada R. John Mayer Jun Fujita | 2005 | Cancer Cell2005，，： | 2 |
| 7 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 8 | Nuclear survivin expression predicts poorer prognosis in glioblastoma显示文摘 | Katsuyuki Shirai Yoshiyuki Suzuki Kuniyuki Oka Shin-ei Noda Hiroyuki Katoh Yoshihiko Suzuki Jun Itoh Hideaki Itoh Shogo Ishiuchi Hideyuki Sakurai Masatoshi Hasegawa Takashi Nakano | 2009 | Journal of Neuro - Oncology2009，，3： | 1 |
| 9 | Monitoring the expression pattern of around 7,000 Arabidopsis genes under ABA treatments using a full-length cDNA microarray显示文摘 | Motoaki Seki Junko Ishida Mari Narusaka Miki Fujita Tokihiko Nanjo Taishi Umezawa Asako Kamiya Maiko Nakajima Akiko Enju Tetsuya Sakurai Masakazu Satou Kenji Akiyama Kazuko Yamaguchi-Shinozaki Piero Carninci Jun Kawai Yoshihide Hayashizaki Kazuo Shinozaki | 2002 | Functional & Integrative Genomics2002，，6： | 1 |
| 10 | Drug interaction between voriconazole and tacrolimus and its association with the bioavailability of oral voriconazole in recipients of allogeneic hematopoietic stem cell transplantation显示文摘 | Takehiko Mori Jun Kato Akiko Yamane Masatoshi Sakurai Sumiko Kohashi Taku Kikuchi Yukako Ono Shinichiro Okamoto | 2012 | International Journal of Hematology2012，，5： | 1 |
| 11 | Effect of unsaturated bonds in the sn -2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes显示文摘 | Masahiro Nagahama Akiko Otsuka Masataka Oda Rajesh K. Singh Zyta M. Ziora Hiroshi Imagawa Mugio Nishizawa Jun Sakurai | 2007 | BBA - Biomembranes2007，，11： | 1 |
| 12 | Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice显示文摘 | Tomoko Masuda Katsuhiko Itoh Hiroaki Higashitsuji Hisako Higashitsuji Noa Nakazawa Toshiharu Sakurai Yu Liu Hiromu Tokuchi Takanori Fujita Yan Zhao Hiroyuki Nishiyama Takashi Tanaka Manabu Fukumoto Masahito Ikawa Masaru Okabe Jun Fujita | 2012 | Proceedings of the National Academy of Sciences2012，，27： | 1 |
| 13 | Pulmonary Artery Pseudoaneurysm Related to Radiofrequency Ablation of Lung Tumor显示文摘 | Jun Sakurai Hidefumi Mimura Hideo Gobara Takao Hiraki Susumu Kanazawa | 2010 | CardioVascular and Interventional Radiology2010，，2： | 1 |
| 14 | Cirp protects against tumor necrosis factor-α-induced apoptosis via activation of extracellular signal-regulated kinase显示文摘 | Toshiharu Sakurai Katsuhiko Itoh Hiroaki Higashitsuji Kohsuke Nonoguchi Yu Liu Hirohiko Watanabe Tadasu Nakano Manabu Fukumoto Tsutomu Chiba Jun Fujita | 2006 | BBA - Molecular Cell Research2006，，3： | 1 |
| 15 | Non-erosive reflux disease rather than cervical inlet patch involves globus显示文摘 | Kazutoshi Hori Yongmin Kim Jun Sakurai Jiro Watari Toshihiko Tomita Tadayuki Oshima Chizuko Kondo Takayuki Matsumoto Hiroto Miwa | 2010 | Journal of Gastroenterology2010，，11： | 1 |
| 16 | Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection显示文摘 | Toshihiko Tomita Yongmin Kim Takahisa Yamasaki Takuya Okugawa Takashi Kondo Fumihiko Toyoshima Jun Sakurai Junji Tanaka Tsuyoshi Morita Tadayuki Oshima Hirokazu Fukui Kazutoshi Hori Jiro Watari Takayuki Matsumoto Hiroto Miwa | 2012 | Journal of Gastroenterology and Hepatology2012，，9： | 1 |
| 17 | Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1显示文摘 | Yu Liu Hiroaki Higashitsuji Hisako Higashitsuji Katsuhiko Itoh Toshiharu Sakurai Kazuhiko Koike Kiichi Hirota Manabu Fukumoto Jun Fujita | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 18 | Monitoring the expression pattern of around 7,000 Arabidopsis genes under ABA treatments using a full-length cDNA microarray显示文摘 | Motoaki Seki Junko Ishida Mari Narusaka Miki Fujita Tokihiko Nanjo Taishi Umezawa Asako Kamiya Maiko Nakajima Akiko Enju Tetsuya Sakurai Masakazu Satou Kenji Akiyama Kazuko Yamaguchi-Shinozaki Piero Carninci Jun Kawai Yoshihide Hayashizaki Kazuo Shinozaki | 2002 | Functional & Integrative Genomics2002，，6： | 1 |
| 19 | Longitudinal follow-up of height up to five years of age in infants born preterm small for gestational age; comparison to full-term small for gestational age infants显示文摘 | Kazuo Itabashi Jun Mishina Hiroshi Tada Motoichiro Sakurai Yuko Nanri Yuko Hirohata | 2006 | Early Human Development2006，，5： | 1 |
| 20 | A recombinant carboxy‐terminal domain of alpha‐toxin protects mice against Clostridium perfringens显示文摘 | Masahiro Nagahama Masataka Oda Keiko Kobayashi Sadayuki Ochi Teruhisa Takagishi Masahiro Shibutani Jun Sakurai | 2013 | Microbiol Immunol2013，，5： | 1 |
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