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| 1 | Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas显示文摘AIM: To observe the relationship between the expression of vascular endothelial growth factor (VEGF), microvascular density (MVD) and the pathological characteristics of esophageal and gastric carcinomas.METHODS: S-P immunohistochemical staining was used to investigate the expression of VEGF in all the specimens.The antibody against factor VIII-related antigen was used to display vascular endothelial cells, and MVD was examined by counting the factor VIII-positive vascular endothelial cells.RESULTS: The positive rates of VEGF expression in esophageal carcinoma and gastric carcinoma were 81.36 %and 67.5 % respectively, and the MVD averaged 41.81±8.44and 34.36±9.67 respectively, which were higher than those in benign diseases. The expression of VEGF and MVD were closely correlated with the degree of differentiation, lymphatic metastasis, but not related to depth of cancer invasion. In early stage gastric carcinoma, the rate of expression of VEGF and MVD was lower than that in progressive gastric carcinomas. CONCLUSION: The expression of VEGF is correlated with tumor angiogenesis, and VEGF plays an important role in new blood vessels formation, the expression of VEGF and MVD play an important role in tumor growth and metastasis.MVD and the expression of VEGF may be two important indexes for patients′ prognosis. | Jin-Rong Du Ying Jiang Yan-Mei Zhang Hong Fu, Department of Pathology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China | 2003 | World Journal of Gastroenterology2003，9，7： | 75 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | Effect of intracoronary administration of anisodamine on slow reflow phenomenon following primary percutaneous coronary intervention in patients with acute myocardial infarction显示文摘许多基本、临床的研究证明了那 anisodamine 的背景能在减轻 microvascular 痉挛上生产重要效果,改进并且挖出冠的 microcirculation。它可能对为尖锐心肌的梗塞( AMI )跟随经皮的冠的干预(一种总线标准)的慢回流现象( SRP )的改进有益我们调查了的 .So 梗塞的 SRP 上的 anisodamine 的 intracoronary 管理的效果联系了在病人跟随主要一种总线标准,圣片断提高了的动脉( IRA )尖锐心肌的梗塞( STEAMI ) .Methods 有从 148 个 STEAMI 病人的一个总数的 SRP 的 21 个病人相信主要一种总线标准从9月被注册进这研究当 SRP 发生了时,硝化甘油(200 g ) 是“大丸药”第一注入了 IRA 排除 epicardial 动脉的痉挛并且识别 SRP 以及一个基线和克制代理人追随者一种总线标准。十分钟以后,当冠的 angiography (CAG ) 被拿在前并且在时, anisodamine 的 1000 g 在 200 g/s 与 SRP 被注入 IRA 第一,第 10 分别地在硝化甘油或 anisodamine 的管理以后纪录的第三 and。改正的 TIMI 框架计数(cTFC ) , TIMI 心肌的灌注等级(TMPG ) 和 IRA 的直径被吉布森的 TIMI 框架计数方法用量的计算机 angiography (QCA ) 计算并且分析在冠的流动和容器腔上评估 anisodamine 的影响的系统。同时, intracoronary 和全身的动脉和心电图(ECG )( 收缩、心脏舒张、吝啬的压力) 的侵略血液动力学的参数被测量并且监视。室的性能参数和不利反应的变化被评估并且在在 cTFCs 和 TMPG 的重要变化都没被发现在的 1 月 post-PCI.Results 跟随起来第一,第 10 作为与基线控制(P0.05 ) 相比在硝化甘油的 intracoronary 管理以后纪录的第三 and。cTFCs 被 58.3% , 56.2% ,和 54.6% 减少,分别地(P0.001 ) ,并且 TMPG 从 1.13 被增加 ??????????? 呃 ???????? 偓 ?? 吗? | FU Xiang-hua FAN Wei-ze GU Xin-shun WEI Yong-yun JIANG Yun-fa WU Wei-li LI Shi-qiang HAO Guo-zhen WEI Qing-min XUE Ling | 2007 | Chinese Medical Journal2007，，14： | 37 |
| 4 | The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间活跃地对感染作为本地保护者参予母亲胎儿的有免疫力的忍耐和行为的建立和维护。然而, dNK 房间怎么在怀孕期间维持在忍耐和反感染免疫者回答之间的有免疫力的平衡,仍然保持未知。这里,我们证明禁止的分子 T 房间免疫球蛋白领域和粘蛋白包含域的 molecule-3 (Tim-3 ) 在超过 60 % 上被表示;dNK 房间。Tim-3 + dNK 房间显示更高的 interleukin (IL )-4 和更低的肿瘤坏死因素(TNF )-α并且 perforin 生产。人的 trophoblast 房间能经由 galectin-9 (Gal-9 ) 和在 Gal-9 和 Tim-3 之间的相互作用的分泌物导致外部 NK 房间的转变进象 dNK 一样显型。另外, trophoblasts 禁止导致的 lipopolysaccharide (LPS ) 由 dNK 房间的支持 inflammatory cytokine 和 perforin 生产,它能被抵销抗体的 Tim-3 稀释。有趣地, Tim-3-expressing dNK 房间的一个减少的百分比在人的流产和鼠科的流产容易的模型被观察。而且, T 助手(Th )2 类型 cytokines 被减少, Th1 类型 cytokines 从人和老鼠流产在 Tim-3 + 然而并非 Tim-3 − dNK 房间被增加。因此,我们的结果建议 Gal-9/Tim-3 信号为 dNK 房间功能的规定是重要的,它为正常怀孕的维护是有益的。 | Yan-Hong Li Wen-Hui Zhou Yu Tao Song-Cun Wang Yun-Lan Jiang Di Zhang Hai-Lan Piao Qiang Fu Da-Jin Li Mei-Rong Du | 2016 | Cellular & Molecular Immunology2016，13，1： | 40 |
| 5 | Different treatment strategies and molecular features between right-sided and left-sided colon cancers显示文摘The colon is derived from the embryological midgut and hindgut separately,with the right colon and left colon having different features with regards to both anatomical and physiological characteristics.Cancers located in the right and left colon are referred to as right colon cancer(RCC) and left colon cancer(LCC),respectively,based on their apparent anatomical positions.Increasing evidence supports the notion that not only are there differences in treatment strategies when dealing with RCC and LCC,but molecular features also vary between them,not to mention the distinguishing clinical manifestations.Disease-free survival after radical surgery of both RCC and LCC are similar.In the treatment of RCC,the benefit gained from adjuvant FOLFIRI chemotherapy is superior,or at least similar,to LCC,but inferior to LCC if FOLFOX regimen is applied.On the other hand,metastatic LCC exhibits longer survival than that of RCC in a palliative chemotherapy setting.For KRAS wild-type cancers,LCC benefits more from cetuximab treatment than RCC.Moreover,advanced LCC shows a higher sensitivity to bevacizumab treatment in comparison with advanced RCC.Significant varieties exist at the molecular level between RCC and LCC,which may serve as the cause of all apparent differences.With respect to carcinogenesis mechanisms,RCC is associated with known gene types,such as MMR,KRAS,BRAF,and mi RNA-31,while LCC is associated with CIN,p53,NRAS,mi RNA-146 a,mi RNA-147 b,and mi RNA-1288.Regarding protein expression,RCC is related to GNAS,NQO1,telomerase activity,P-PDH,and annexin A10,while LCC is related to Topo I,TS,and EGFR.In addition,separated pathways dominate progressionto relapse in RCC and LCC.Therefore,RCC and LCC should be regarded as two heterogeneous entities,with this heterogeneity being used to stratify patients in order for them to have the optimal,current,and novel therapeutic strategies in clinical practice.Additional research is needed to uncover further differences between RCC and LCC. | Hong Shen Jiao Yang Qing Huang Meng-Jie Jiang Yi-Nuo Tan Jian-Fei Fu Li-Zhen Zhu Xue-Feng Fang Ying Yuan | 2015 | World Journal of Gastroenterology2015，21，21： | 33 |
| 6 | Multicenter follow-up study of ankle fracture surgery显示文摘在从流行病学、临床的大 multicenter 的中国的脚关节破裂上的很少数据学习的背景是这研究的 available.The 目的是由考察在这研究包括了的 China.Methods 在五所医院经历了脚关节骨折外科的 235 个病人评估流行病学的特征和脚关节破裂的外科的结果经历了脚关节的病人折断外科在到2009年7月 .Age 的从2000年1月的五所中国医院,性,损害的机制, Arbeitsgemeinschaft f | XU Hai-lin LIU Li-min LI Xuan ZHANG Dian-ying FU Zhong-guo WANG Tian-bing ZHANG Pei-xun JIANG Bao-guo SHEN Hui-liang WANG Gang WANG Guang-lin WU Xin-bao | 2012 | Chinese Medical Journal2012，，4： | 27 |
| 7 | Use of Controlled Release Fertilizer for Increasing N Efficiency of Direct Seeding Rice显示文摘Field trials on a silt-loamy paddy soil derived from shallow-sea deposit in direct seeding rice fields were conducted in Zhejiang, China, in 1996 to compare N efficiency of controlled release fertilizers (LP fertilizers) with the conventional urea. Six treatments including CK (no N fertilizer), conventional urea and different types of LP fertilizers at different rates were designed for two succeeding crops of early and late rice. A blend of different types of LP fertilizers as a single preplant 'co-situs' application released N in a rate and amount synchronizing with uptake pattern of direct seeding rice. A single preplant application of the LP fertilizers could meet the N requirement of rice for the whole growth period without need of topdressing. Using LP fertilizer blends, equivalent grain yields could be maintained even if the N fertilization rates were reduced by 25%~50% compared with the conventional urea. Agronomic efficiency of the LP fertilizers was 13.6%~ 86.4% higher than that of the conventional urea in early rice and 100%~164.1% in late rice, depending on the amounts of the LP fertilizers applied. N fertilizer recovery rate increased from 27.4% for the conventional application of urea to 41.7%~54.l% for the single preplant 'co-situs' application of the LP fertilizers. Use of the LP fertilizers was promising if the increase in production costs due to the high LP fertilizer prices could be compensated by increase in yield and N efficiency, reduction in labor costs and improvement in environment. | FU JIANRONG, ZHU YUANHONG and JIANG LINA Institute of Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021 (China) | 2001 | Pedosphere2001，11，4： | 27 |
| 8 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 9 | Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails显示文摘 | Yanbin Fu Chenwen Huang Xinxiu Xu Haifeng Gu Youqiong Ye Cizhong Jiang Zilong Qiu Xin Xie | 2015 | Cell Research2015，25，9： | 24 |
| 10 | Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘 | Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W | 2006 | 中国生物学文摘2006，20，8： | 23 |
| 11 | Effect of tirofiban plus clopidogrel and aspirin on primary percutaneous coronary intervention via transradial approach in patients with acute myocardial infarction显示文摘背景:阿司匹林和 clopidogrel 能改进心肌的灌注并且在经皮的冠的干预(一种总线标准) 期间减轻心肌的损害。静脉内的 tirofiban 的增加是否在这个过程期间生产进一步的利益,没在圣片断举起被澄清心肌的梗塞(STEMI ) 病人。我们在经由 transradial 动脉途径经历了主要一种总线标准(p 一种总线标准) 的 STEMI 病人上评估了这。方法:连续病人被使随机化进 tirofiban 组(n=72 ) 或安慰剂组(n=78 ) 。起始的包括的 Angiographic 分析和在心肌的梗塞(TIMI ) 的最后的血栓溶解流动等级(TFG ) ,改正的 TIMI 框架计数(CTFC ) 和血栓形成容器的心肌的灌注分级的 TIMI (TMPG ) 。血小板聚集率(同等) ,肌酸磷酸激酶(CPK ) , CPK isoenzyme MB (CPK-MB ) 和我铺平的 troponin 被测量, TIMI 定义被用来估计流血复杂并发症。左室的表演参数与平衡放射性核种脑室造影术被调查。主要不利心脏的事件(向) 被跟随在上面为 6 个月。结果:TFG 0 的案例并且 1 在一种总线标准前, TFG 0 指南电线的十字路口什么时候首先是在一种总线标准以后的 TFG 3 的更少,和案例,比在安慰剂组的那些是在 tirofiban 组的更多。最后的 CTFC 是少数和发生不回流现象更低,也最后的 TFG 3 的百分比比在安慰剂组(所有 P<0.05 ) 的那些在 tirofiban 组是更高的。吝啬的山峰 CPK-MB 显著地更低,当时左室的性能参数在一种总线标准以后的 1 个星期更在安慰剂组比那些在 tirofiban 组被改进。同等显著地立即在 tirofiban 注入以后被减少。在 tirofiban 组的 6 月的向的发生在安慰剂组显然是比那低的。没有统计差别关于为复杂并发症放血在二个组之间被注意。结论:除了在有经由 transradial 动脉存取的 p 一种总线标准的 STEMI 病人的阿司匹林和 clopidogrel,静脉内的 tirofiban 注入能快速禁止血小板聚集,松开闭塞的血栓,改进心肌的灌注并且减少有容器存取的很少复杂并发症的向的发生并且流血。 | FU Xiang-hua HAO Qing-qing JIA Xin-wei FAN Wei-ze GU Xin-shun WU Wei-li HAO Guo-zhen LI Shi-qiang JIANG Yun-fa GENG Wei | 2008 | Chinese Medical Journal2008，，6： | 22 |
| 12 | Intensive cholesterol lowering with statin improves the outcomes of percutaneous coronary intervention in patients with acute coronary syndrome显示文摘背景发生不回流现象限制经皮的冠的干预(一种总线标准) 的临床的结果。这使随机化的控制研究被设计总共在 PCI.Methods 期间在心肌的灌注和心肌的 ischemic 损害上评估集中的 stalin 预告的处理的立即的保护的效果有急性冠的症候群(交流)的 228 个病人随机被分到标准 stalin 组( SS 组, n=115 )并且集中的 statin 组(组, n=113 )。在 SS 组的病人收到了 20 mg simvastatin,在 IS 组的病人在一种总线标准前收到了 80 mg simvastatin 7 天。在心肌的梗塞(TIMI ) 的 Thrombolysis 流动等级(TFG ) ,改正的 TIMI 框架计数(CTFC ) 和 TIMI 干涉容器的心肌的灌注等级(TMPG ) 在 stent 推广前后被记录。肌酸 kinase ( CK ) isoenzyme MB ,我和血浆高 sensitive-C 铺平的 troponin 反应蛋白质( hs-CRP ), P-selectin 和细胞间的粘附分子( ICAM )以前被测量并且在 procedure.Results 以后的 24 个小时在 stent 推广以后的 TFG 显著地与更少的 TIMI 0-1 和更多的 TIMI 3 血流动被改进在比在 SS 组是组(所有 P < 0.05 )。病人没有回流现象是更少在是组(P < 0.001 ) 。CTFC 比在 SS 组在 IS 组是更低的(P < 0.001 ) 。TMPG 也比在 SS 组(P=0.001 ) 在 IS 组被改进。尽管一种总线标准在过程以后在 CK-MB 24 小时引起了重要增加,提高的 CK-MB 价值是更低的在组比在 SS 组(18.74 吗?? | JIA Xin-wei FU Xiang-hua ZHANG Jing GU Xin-shun FAN Wei-ze WU Wei-li HAO Guo-zhen LI Shi-qiang JIANG Yun-fa | 2009 | Chinese Medical Journal2009，，6： | 22 |
| 13 | Effect of intestinal ischemia-reperfusion on expressions of endogenous basic fibroblast growth factor and transforming growth factor β in lung and its relation with lung repair显示文摘AIM To study the changes of endogenoustransforming growth factor β(TGFβ)and basicfibroblast growth factor(bFGF)in lung followingintestinal ischemia and reperfusion injury andtheir effects on lung injury and repair.METHODS Sixty Wistar rats were divided intofive groups,which underwent sham-operation,ischemia(45 minutes),and reperfusion(6,24and 48 hours,respectively)after ischemia(45minutes).Immunohistochemical method wasused to observe the localization and amounts ofboth growth factors.RESULTS Positive signals of both growthfactors could be found in normal lung,mainly inalveolar cells and endothelial cells of vein.Afterischemia and reperfusion insult,expressions ofboth growth factors were increased and theiramounts at 6 hours were larger than those ofnormal control or of 24 and 48 hours after insult.CONCLUSION The endogenous bFGF and TGF βexpression appears to be up-regulated in thelung following intestinal ischemia andreperfusion,suggesting that both growth factorsmay be involved in the process of lung injury andrepair. | Xiao Bing Fu Yin Hui Yang Tong Zhu Sun Xiao Man Gu Li Xian Jiang Xiao Oing Sun Zhi Yong Sheng Research Laboratory,304th Hospital of PLA,Beijing 100037,China | 2000 | World Journal of Gastroenterology2000，6，3： | 21 |
| 14 | Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014显示文摘Dengue has been well recognized as a global public health threat,but only sporadic epidemics and imported cases were reported in recent decades in China.Since July 2014,an unexpected large dengue outbreak has occurred in Guangdong province,China,resulting in more than 40000 patients including six deaths.To clarify and characterize the causative agent of this outbreak,the acute phase serum from a patient diagnosed with severe dengue was subjected to virus isolation and high-throughput sequencing(HTS).Traditional real-time RT-PCR and HTS with Ion Torrent PGM detected the presence of dengue virus serotype 2(DENV-2).A clinical DENV-2 isolate GZ05/2014 was obtained by culturing the patient serum in mosquito C6/36 cells.The complete genome of GZ05/2014 was determined and deposited in Gen Bank under the access number KP012546.Phylogenetic analysis based on the complete envelope gene showed that the newly DENV-2 isolate belonged to Cosmopolitan genotype and clustered closely with other Guangdong strains isolated in the past decade.No amino acid mutations that are obviously known to increase virulence or replication were identified throughout the genome of GZ05/2014.The high homology of Guangdong DENV-2 strains indicated the possibility of establishment of local DENV-2 circulation in Guangdong,China.These results help clarify the origin of this epidemic and predict the future status of dengue in China. | ZHAO Hui ZHAO Ling Zhai JIANG Tao LI Xiao Feng FAN Hang HONG Wen Xin ZHANG Yu ZHU Qin YE Qing TONG Yi Gang CAO Wu Chun ZHANG Fu Chun QIN Cheng Feng | 2014 | Science China(Life Sciences)2014，57，12： | 21 |
| 15 | Non-alcoholic fatty liver disease:An early mediator predicting metabolic syndrome in obese children?显示文摘AIM:To investigate if non-alcoholic fatty liver disease (NAFLD) is an early mediator for prediction of metabolic syndrome,and if liver B-ultrasound can be used for its diagnosis.METHODS:We classified 861 obese children (6-16 years old) into three subgroups:group 0 (normal liver in ultrasound and normal transaminases);group 1 (fatty liver in ultrasound and normal transaminases);and group 2 (fatty liver in ultrasound and elevated transaminases).We measured the body mass index,waist and hip circumference,blood pressure,fasting blood glucose,insulin,homeostasis model assessment of insulin resistance (HOMA-IR),whole-body insulin sensitivity index (WBISI),lipid profile and transaminases in all the participants.The risk of developing metabolic syndrome (MS) was assessed according to the degree of liver fatty infiltration based on the B-ultrasound examination.RESULTS:Among the 861 obese children,587 (68.18%) were classified as having NAFLD,and 221 (25.67%) as having MS.The prevalence of MS in NAFLD children (groups 1 and 2) was 37.64% (221/587),which was much higher than that in non-NAFLD group (group 0,12.04%) (P < 0.01).There were significantly higher incidences concerning every component of MS in group 2 compared with group 0 (P < 0.05).The incidence of NAFLD in MS patients was 84.61% (187/221),which was significantly higher than that of hypertension (57.46%,127/221) and glucose metabolic anomalies (22.62%,50/221),and almost equal to the prevalence of dyslipidemia (89.14%,197/221).Based on the B-ultrasound scales,the presence of moderate and severe liver fatty infiltration carried a high risk of hypertension [odds ratio (OR):2.18,95% confidence interval (95% CI):1.27-3.75],dyslipidemia (OR:7.99,95% CI:4.34-14.73),impaired fasting glucose (OR:3.65,95% CI:1.04-12.85),and whole MS (OR:3.77;95% CI:1.90-7.47,P < 0.01).The state of insulin resistance (calculated by HOMA-IR and WBISI) deteriorated as the degree of fatty infiltration increased.CONCLUSION:NAFLD is not only a liver disease,but also an early mediator that reflects metabolic disorder,and liver B-ultrasound can be a useful tool for MS screening. | Jun-Fen Fu Hong-Bo Shi Li-Rui Liu Ping Jiang Li Liang Chun-Lin Wang Hong-Bo Shi Ping Jiang Xi-Yong Liu | 2011 | World Journal of Gastroenterology2011，17，6： | 20 |
| 16 | An Ammonia-Hydrogen Energy Roadmap for Carbon Neutrality:Opportunity and Challenges in China显示文摘1.Opportunities and a bottleneck in the hydrogen energy industry Hydrogen(H_(2))is a carbon-free energy carrier with a wide range of application scenarios that was first emphasized in the Report on the Work of the Government in 2019 in China.In March 2021,President Xi Jinping reiterated that China pledges to achieve the goals of peak carbon emissions by 2030 and carbon neutrality by 2060. | Lilong Jiang Xianzhi Fu | 2021 | Engineering2021，7，12： | 20 |
| 17 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 18 | Effect of multiple-phase regional intra-arterial infusion chemotherapy on patients with resectable pancreatic head adenocarcinoma显示文摘背景地区性的intra动脉的注入化疗( RIAC )是更珍贵的与不能实行的胰腺的腺癌改进病人的生活的预后和质量,并且辅助 RIAC 在延长幸存并且在胰腺的癌症的激进的切除术以后减少肝转移的风险起一个重要作用,但是外科手术前或多重阶段的 RIAC 的效果(外科手术前与手术后的 RIAC 结合了)为 resectable ,胰腺的癌症没被调查。在这未来的研究,为有 resectable 的病人的多重阶段的 RIAC 的效果胰腺的头腺癌被评估,并且它与手术后的 RIAC 作比较的安全和有效性也是有胰腺的头癌症随机被分到二个组的 resectable 的 assessed.Methods 病人。在组 A (n=50 ) 的病人与与多重阶段的 RIAC 相结合的扩大 pancreaticoduodenectomy 的新治疗学的模式被对待,并且那些在组 B (n=50 ) 被对待,扩大 pancreaticoduodenectomy 在一样的时期与手术后的 RIAC 结合了。新治疗学的模式的可行性,依从和效率被 RIAC 的肿瘤尺寸,浆液肿瘤标记,临床的利益反应(CBR ) ,外科的复杂并发症,死亡和毒性评估。没有疾病的幸存时间,中部的幸存时间,肝转移的发生,在 1, 2, 3 和 5 年的幸存率也被观察。生活曲线被在组 A 的疼痛消除率和 CBR 是的 Kaplan-Meier method.Results 产生 80% 和 84% 分别地。浆液肿瘤标记显然减少了,肿瘤尺寸在组 A 在外科手术前的 RIAC 以后在 26% 病人减少了。不再外科的复杂并发症,死亡或严重全身的副作用与组 B 相比在组 A 被观察。在组 A 的肝转移的发生是 34% 它在组 B 是比 50% 低的。在组 A 的没有疾病的幸存时间和中部的幸存时间分别地是 15.5 个月和 18 个月。1- , 2- , 3 年、 5 年的幸存率分别地是 54.87% , 34.94% , 24.51% 和 12.25% 。没有在多重阶段的 RIAC 是的二 groups.Conclusions 之间的幸存时间或幸存率的重要差别在 resectable 的联合治疗有效由提高肿瘤生长和肝转移的减小的抑制的胰腺的头癌,没有病人的安全或外科的过程上的否定效果。 | JIN Chen YAO Lie LONG Jiang FU De-liang YU Xian-jun XU Jin YANG Feng NI Quan-xing | 2009 | Chinese Medical Journal2009，，3： | 17 |
| 19 | Ti/(Ti,Cr)N/CrN multilayer coated 316L stainless steel by arc ion plating as bipolar plates for proton exchange membrane fuel cells显示文摘Arc ion plating(AIP) is applied to form Ti/(Ti,Cr)N/Cr N multilayer coating on the surface of 316 L stainless steel(SS316L) as bipolar plates for proton exchange membrane fuel cells(PEMFCs). The characterizations of the coating are analyzed by scanning electron microscopy(SEM) and X-ray diffraction(XRD). Interfacial contact resistance(ICR) between the coated sample and carbon paper is 4.9 m cm^2 under 150 N/cm^2,which is much lower than that of the SS316 L substrate. Potentiodynamic and potentiostatic tests are performed in the simulated PEMFC working conditions to investigate the corrosion behaviors of the coated sample. Superior anticorrosion performance is observed for the coated sample, whose corrosion current density is 0.12 μA/cm2. Surface morphology results after corrosion tests indicate that the substrate is well protected by the multilayer coating. Performances of the single cell with the multilayer coated SS316 L bipolar plate are improved significantly compared with that of the cell with the uncoated SS316 L bipolar plate, presenting a great potential for PEMFC application. | Shengli Wang Ming Hou Qing Zhao Yongyi Jiang Zhen Wang Huizhe Li Yu Fu Zhigang Shao | 2017 | Journal of Energy Chemistry2017，26，1： | 17 |
| 20 | A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle显示文摘Traditional Chinese herbs(TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test(TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized. The relationship between the concentration of quinine and animal preference index(PI) was obtained. Then the PI of TCH was measured through TBP, and bitterness results were converted into a unified numerical system using the relationship of concentration and PI. To verify the authenticity and sensitivity of quantified results,human sensory testing and electronic tongue testing were applied. The quantified results showed a good discrimination ability. For example, the bitterness of Coptidis Rhizoma was equal to 0.0579 mg/mL quinine, and Nelumbinis Folium was equal to 0.0001 mg/mL. The validation results proved that the newassessment method for TCH was objective and reliable. In conclusion, this study provides an option for the quantification of bitterness and the evaluation of taste masking effects. | Xue Han Hong Jiang Li Han Xi Xiong Yanan He Chaomei Fu Runchun Xu Dingkun Zhang Junzhi Lin Ming Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 17 |
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