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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Neil J. Stone Jennifer G. Robinson Alice H. Lichtenstein C. Noel Bairey Merz Conrad B. Blum Robert H. Eckel Anne C. Goldberg David Gordon Daniel Levy Donald M. Lloyd-Jones Patrick McBride J. Sanford Schwartz Susan T. Shero Sidney C. Smith Karol Watson Pet | 2014 | Circulation (_suppl_ Suppl)2014，，25： | 2 |
| 3 | Pleural effusion in patients with pulmonary embolism 显示文摘 | Elaine YAP Graeme Anderson Jennifer Donald | 2008 | Respirology2008，13，6： | 1 |
| 4 | Oriented astroglial cell growth on micropatterned polystyrene substrates显示文摘 | JENNIFER B RECKNOR JUSTIN C RECKNOR DONALD S SAKAGUCHI | 2004 | Biomaterials2004，25，： | 1 |
| 5 | Valuing Customers显示文摘 | Sunil Gupta Donald R Lehmann Jennifer Ames Stuart | 2004 | Journal of Marketing Research2004，，： | 1 |
| 6 | The ‘Image Gently’ campaign: increasing CT radiation dose awareness through a national education and awareness program显示文摘 | Marilyn J. Goske Kimberly E. Applegate Jennifer Boylan Penny F. Butler Michael J. Callahan Brian D. Coley Shawn Farley Donald P. Frush Marta Hernanz-Schulman Diego Jaramillo Neil D. Johnson Sue C. Kaste Gregory Morrison Keith J. Strauss Nora Tuggle | 2008 | Pediatric Radiology2008，，3： | 1 |
| 7 | Certification of SRM 1589a PCBs, pesticides, PBDEs, and dioxins/furans in human serum显示文摘 | Michele M. Schantz Jennifer M. Keller Stefan Leigh Donald G. Patterson Katherine E. Sharpless Andreas Sj?din Heather M. Stapleton Robert Swarthout Wayman E. Turner Stephen A. Wise | 2007 | Analytical and Bioanalytical Chemistry2007，，4： | 1 |
| 8 | Efficacy and Safety of Extended Release Metoprolol Succinate in Hypertensive Children 6 to 16 Years of Age: A Clinical Trial Experience显示文摘 | Donald L. Batisky Jonathan M. Sorof Jennifer Sugg Michaelene Llewellyn Michael Klibaner James W. Hainer Ronald J. Portman Bonita Falkner | 2007 | The Journal of Pediatrics2007，，2： | 1 |
| 9 | Genome-Wide Significance and Replication of the Chromosome 12p11.22 Locus Near the PTHLH Gene for Peripartum Cardiomyopathy显示文摘 | Benjamin D. Horne Kismet D. Rasmusson Rami Alharethi Deborah Budge Kimberly D. Brunisholz Torri Metz John F. Carlquist Jennifer J. Connolly T. Flint Porter Donald L. Lappé Joseph B. Muhlestein Robert Silver Josef Stehlik James J. Park Heidi T. May Tami L. | 2011 | Circulation: Cardiovascular Genetics2011，，4： | 1 |
| 10 | Newcomer Adjustment During Organizational Socialization : A Meta-Analytic Review of Antecedents, Outcomes and Methods 显示文摘 | Bauer Talya N Bodner Todd Erdogan Berrin Truxillo Donald M Tucker Jennifer S | 2007 | Journal of Applied Psychology2007，92，3： | 1 |
| 11 | Certification of SRM 1589a PCBs, pesticides, PBDEs, and dioxins/furans in human serum显示文摘 | Michele M. Schantz Jennifer M. Keller Stefan Leigh Donald G. Patterson Katherine E. Sharpless Andreas Sj?din Heather M. Stapleton Robert Swarthout Wayman E. Turner Stephen A. Wise | 2007 | Analytical and Bioanalytical Chemistry2007，，4： | 1 |
| 12 | Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus显示文摘AIM: To determine the safety profile of new hepatitis C virus(HCV) treatments in liver transplant(LT) recipients with recurrent HCV infection.METHODS: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events(SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIVinfected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite outcome. RESULTS: Median age of the 42 patients was 60 years [Interquartile Range(IQR): 56-65 years], 33%(14/42) were female, 21%(9/42) were Hispanic, and 9%(4/42) were Black. The median time from transplant to treatment initiation was 5.4 years(IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62%(8/13) patients, while 54%(7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31%(95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin(OR = 0.61 per g/d L, 95%CI: 0.40-0.88, P < 0.01), estimated glomerular filtration rate(OR = 0.95 per m L/min per 1.73 m^2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin(OR = 2.43 per mg/d L, 95%CI: 1.17-8.65, P < 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for cases.CONCLUSION: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge. | Neal Patel Kian Bichoupan Lawrence Ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng David Motamed Viktoriya Khaitova Nancy Bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch | 2016 | World Journal of Gastroenterology2016，22，9： | 1 |
| 13 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults显示文摘 | Neil J. Stone Jennifer Robinson Alice H. Lichtenstein C. Noel Bairey Merz Donald M. Lloyd-Jones Conrad B. Blum Patrick McBride Robert H. Eckel J. Sanford Schwartz Anne C. Goldberg Susan T. Shero David Gordon Sidney C. Smith Daniel Levy Karol Watson Peter | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 14 | Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology显示文摘 | Alexander Zimprich Saskia Biskup Petra Leitner Peter Lichtner Matthew Farrer Sarah Lincoln Jennifer Kachergus Mary Hulihan Ryan J. Uitti Donald B. Calne A.Jon Stoessl Ronald F. Pfeiffer Nadja Patenge Iria Carballo Carbajal Peter Vieregge Friedrich Asmus B | 2004 | Neuron2004，，4： | 1 |
| 15 | SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine显示文摘 | Warren S Alexander Robyn Starr Jennifer E Fenner Clare L Scott Emanuela Handman Naomi S Sprigg Jason E Corbin Ann L Cornish Rima Darwiche Catherine M Owczarek Thomas W.H Kay Nicos A Nicola Paul J Hertzog Donald Metcalf Douglas J Hilton | 1999 | Cell1999，，5： | 1 |
| 16 | Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography显示文摘 | Donald C. Hood Brad Fortune Stella N. Arthur Danli Xing Jennifer A. Salant Robert Ritch Jeffrey M. Liebmann | 2008 | Journal of Glaucoma2008，，7： | 1 |
| 17 | Relationships between stress, job satisfaction,coping strategies, and attribu- tional style among nurses显示文摘 | Jennifer LW Donald Tara AH | 2007 | J Vocat Behav2007，70，2： | 1 |
| 18 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Neil J. Stone Jennifer G. Robinson Alice H. Lichtenstein C. Noel Bairey Merz Conrad B. Blum Robert H. Eckel Anne C. Goldberg David Gordon Daniel Levy Donald M. Lloyd-Jones Patrick McBride J. Sanford Schwartz Susan T. Shero Sidney C. Smith Karol Watson Pet | 2014 | Circulation . 2014 (25_s)2014，，25： | 1 |
| 19 | Vigorous Achalasia: Original Description Requires Minor Change显示文摘 | Luciana Camacho-Lobato Philip O. Katz Jennifer Eveland Marcelo Vela Donald O. Castell | 2001 | Journal of Clinical Gastroenterology2001，，5： | 1 |
| 20 | Extracellular enzyme activity beneath temperate trees growing under elevated carbon dioxide and ozone 显示文摘 | Jennifer L L Donald R Z Robert L S | 2002 | Soil Science Society of America Journal2002，66，： | 1 |
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