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| 1 | Neuroimaging in the early diagnosis of neurodegenerative disease显示文摘Functional imaging may be useful for both the early diagnosis as well as preclinical detection of neurodegenerative disease.Additionally,while structural imaging has traditionally been regarded as a tool to exclude alternate diagnoses,recent advances in magnetic resonance show promise for greater diagnostic specificity.The role of MR and radionuclide imaging in early diagnosis and preclinical detection of dementia and parkinsonism are reviewed here. | A Jon Stoessl | 2012 | Translational Neurodegeneration2012，1，1： | 5 |
| 2 | The effects of exercise on cognition in Parkinson’s disease: a systematic review显示文摘Cognitive impairments are highly prevalent in Parkinson’s disease(PD)and can substantially affect a patient’s quality of life.These impairments remain difficult to manage with current clinical therapies,but exercise has been identified as a possible treatment.The objective of this systematic review was to accumulate and analyze evidence for the effects of exercise on cognition in both animal models of PD and human disease.This systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)statement.Fourteen original reports were identified,including six pre-clinical animal studies and eight human clinical studies.These studies used various exercise interventions and evaluated many different outcome measures;therefore,only a qualitative synthesis was performed.The evidence from animal studies supports the role of exercise to improve cognition in humans through the promotion of neuronal proliferation,neuroprotection and neurogenesis.These findings warrant more research to determine what roles these neural mechanisms play in clinical populations.The reports on cognitive changes in clinical studies demonstrate that a range of exercise programs can improve cognition in humans.While each clinical study demonstrated improvements in a marker of cognition,there were limitations in each study,including non-randomized designs and risk of bias.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was used and the quality of the evidence for human studies were rated from“low”to“moderate”and the strength of the recommendations were rated from“weak”to“strong”.Studies that assessed executive function,compared to general cognitive abilities,received a higher GRADE rating.Overall,this systematic review found that in animal models exercise results in behavioral and corresponding neurobiological changes in the basal ganglia related to cognition.The clinical studies showed that various types of exercise,including aerobic,resistance and dance can improve cognitive function,although the optimal type,amount,mechanisms,and duration of exercise are unclear.With growing support for exercise to improve not only motor symptoms,but also cognitive impairments in PD,health care providers and policy makers should recommend exercise as part of routine management and neurorehabilitation for this disorder. | Danielle K Murray Matthew A Sacheli Janice J Eng A Jon Stoessl | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 3 | The underlying mechanism of prodromal PD:insights from the parasympathetic nervous system and the olfactory system显示文摘Neurodegeneration of Parkinson’s disease(PD)starts in an insidious manner,30–50%of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis.Prodromal stage of the disease,during which the disease pathology has started but is insufficient to result in clinical manifestations,offers a valuable window for disease-modifying therapies.The most focused underlying mechanisms linking the pathological pattern and clinical characteristics of prodromal PD are the prion hypothesis of alpha-synuclein and the selective vulnerability of neurons.In this review,we consider the two potential portals,the vagus nerve and the olfactory bulb,through which abnormal alpha-synuclein can access the brain.We review the clinical,pathological and neuroimaging evidence of the parasympathetic nervous system and the olfactory system in the neurodegenerative process and using the two systems as models to discuss the internal homogeneity and heterogeneity of the prodromal stage of PD,including both the clustering and subtyping of symptoms and signs.Finally,we offer some suggestions on future directions for imaging studies in prodromal Parkinson’s disease. | Shu-Ying Liu Piu Chan A.Jon Stoessl | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 4 | Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL- PET study显示文摘 | Whone AL Watts RL Stoessl A J | 2003 | Ann Neurol2003，54，： | 1 |
| 5 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 6 | Invited Article: Functional imaging in Parkinson disease显示文摘 | R Nandhagopal Martin J. McKeown A Jon Stoessl | | 2008 (16,)0，，： | 1 |
| 7 | Double blind Study of Botulinum Toxin in Spasmodic Torticollis显示文摘 | Tsui JK Eisen A Stoessl AJ | 1986 | Lancet(S0140- 6736)1986，2，8501： | 1 |
| 8 | Positron emission tomography in premotor Parkinson's disease显示文摘 | Stoessl AJ | 2007 | Parkinsonism Related Disord2007，133，： | 1 |
| 9 | Functional imaging in Parkinson disease显示文摘 | Nandhagopal R McKeown MJ Stoessl AJ | 2008 | Neurology2008，70，： | 1 |
| 10 | The opiate antagonist naloxone suppresses a rodent model of tardive dyskinesia显示文摘 | Stoessl AJ Polanski E Frydryszak H | 1993 | Mov Disord1993，8，4： | 1 |
| 11 | Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity 显示文摘 | van Kampen JM McGeer EG Stoessl AJ | 2000 | Synaps2000，37，3： | 1 |
| 12 | Scans without evidence of dopamine deficiency : thetriumph of careful clinical assessment 显示文摘 | Stoessl AJ | 2010 | Mov Disord2010，25，5： | 1 |
| 13 | Slower progression of Parkinson's disease with ropinirole versus levodopa:the REAL-PET study显示文摘 | Whone AL Watts RL Stoessl A J | | 0，，： | 1 |
| 14 | Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study显示文摘 | Whone AL Watts RL Stoessl AJ | 2003 | Ann Nenrol2003，54，1： | 1 |
| 15 | Slower progression of Parkinson's disease with ropinirole versus levodopa:The REAL-PET study显示文摘 | WATTS RL STOESSL AJ | 2003 | Ann Neurol2003，54，1： | 1 |
| 16 | Imaging insights intobasal ganglia function, Parkinson's disease, and dystonia显示文摘 | Stoessl AJ Lehericy S Strafella AP | 2014 | Lancet2014，384，9942： | 1 |
| 17 | Imaging insights into basal ganglia function,Parkinson's disease,and dystonia显示文摘 | Stoessl AJ Lehericy S Strafella AP | 2014 | Lancet2014，384，9942： | 1 |
| 18 | Neuroimaging in Parkinson's disease 显示文摘 | Stoessl A J | 2011 | Neurotherapeuties: The Journal of the American Society for Experimental Neuro Therapeu- tics2011，8，1： | 1 |
| 19 | Positron emission tomography in premotor Parkinson’s disease显示文摘 | A. Jon Stoessl | 2007 | Parkinsonism and Related Disorders2007，，： | 1 |
| 20 | Double blind study of botulinum toxin in spasmodic torticollis 显示文摘 | Tsui JKC Eisen A Stoessl AJ | 1986 | Lancet1986，2，： | 1 |
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