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| 1 | Early chronic obstructive pulmonary disease: Beyond spirometry显示文摘The significant healthcare burden associated with chronic obstructive pulmonary disease(COPD) is driving us to improve our understanding of the natural history of this disease. Historically, the focus has been largely centred on diagnosing and treating individuals with moderate and severe disease. However, it is now recognised that the speed of decline in lung function as measured by forced expiratory volume in 1 s occurs faster in the earlier stages of the disease process. As a result, a clearer understanding of the potential benefits of treatment in early COPD is needed. It is recognised that many patients with COPD remain undiagnosed in the community which has prompted global case-finding initiatives. In this review we discuss the difficulties in diagnosing COPD in its early stages, examine the roleof case-finding and look at the evidence for early intervention with therapeutic agents. There is a growing interest in the phenotypic variation amongst patients with COPD and we explore the role of phenotyping in early COPD and its potential benefits in providing a more individualised approach to COPD management. The majority of patients with COPD are known to die from non-respiratory causes such as cardiovascular disease. The mechanistic link is thought to relate to systemic inflammation, causing us to question whether earlier interventions could have a beneficial impact on the burden of co-morbidities for patients with COPD. | Judith A Brebner Alice M Turner | 2013 | World Journal of Respirology2013，3，3： | 5 |
| 2 | Gastroesophageal reflux disease related asthma:From preliminary studies to clinical practice显示文摘The diagnosis of asthma requires the presence of episodic respiratory difficulties characterized by variable and reversible airway obstruction. It has a high prevalence worldwide and is traditionally considered to be an allergic disease. Most cases are responsive to treatment with bronchodilators and anti-inflammatories, as recommendedby national and international guidelines; however, appro-ximately 10% of asthmatic patients are refractory even to optimal therapy. Gastroesophageal reflux disease(GERD) is a common disorder in asthmatic patients and the two disorders may be linked pathophysiologically. Here we review data from preliminary studies that suggest asthma could be induced or exacerbated by gastroesophageal reflux. The optimal strategies for the diagnosis of GERDrelated asthma and its therapy are still debated. However, there is evidence to suggest that antireflux treatment is effective and practical for asthmatic patients with welldefined reflux disease. | Zhi-Wei Hu Ji-Min Wu Wei-Tao Liang Zhong-Gao Wang | 2015 | World Journal of Respirology2015，5，1： | 5 |
| 3 | Pulmonary complications of transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘Transcatheter arterial chemoembolization(TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma(HCC). Post-TACE pulmonary complications resulting in acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous(AV) shunts within the hyper-vascular HCC. We review herein the literature on pulmonary complications related to TACE for HCC. Post-TACE pulmonary complications have included pulmonary oil embolism, interstitial pneumonitis, chemical pneumonitis, ALI, ARDS, lipoid pneumonia, acute eosinophilic and neutrophilic pneumonia, bilious pleuritis, pulmonary abscess, pulmonary tumor embolism, and possibly pulmonary metastasis with HCC. The risk factors associated with post-TACE pulmonary complications identified in the literature include large hyper-vascular HCC with AV shunts, large-volume Lipiodol infusion, and embolization via the right inferior phrenic artery. However, the absence of known risk factors is not a guarantee against serious complications. An astute awareness of the potential post-TACE pulmonary complications should expedite appropriate therapeutic interventions and increase potential for early recovery. | Quan M Nhu Harry Knowles Paul J Pockros Catherine T Frenette | 2016 | World Journal of Respirology2016，6，3： | 4 |
| 4 | Post splenectomy related pulmonary hypertension显示文摘Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management. | Atul V Palkar Abhinav Agrawal Sameer Verma Asma Iftikhar Edmund J Miller Arunabh Talwar | 2015 | World Journal of Respirology2015，5，2： | 3 |
| 5 | Pulmonary hypertension in patients with chronic obstructive pulmonary disease: Recent advances in pathophysiology and management显示文摘 | WATARUHIDA YETUN YOSHIHIROKIKUCHI SHINICHIOKABE KUNIOSHIRATO | 2002 | Respirology2002，，1： | 2 |
| 6 | Integrating the overlap of obstructive lung disease and obstructive sleep apnoea: OLDOSA syndrome显示文摘 | Octavian C. Ioachimescu Mihaela Teodorescu | 2013 | Respirology2013，，3： | 2 |
| 7 | Polymyxin B-immobilized fiber columns:A column to breathe new life into the treatment of interstitial lung disease?显示文摘Acute exacerbations of idiopathic pulmonary fibrosis(IPF) is a severe respiratory condition with high mortality rate. Direct hemoperfusion with polymyxin B-immobilized fiber columns(PMX-DHP) was originally introduced for the treatment of septic shock. Application of PMX-DHP to the treatment of acute exacerbations of IPF may improve oxygenation and survival of the patients with the disease. In addition to acute exacerbations of IPF, PMXDHP has been applied to acute respiratory failure fromvarious causes; an amyopathic dermatomyositis patient who developed rapidly progressive interstitial lung disease(ILD) with elevated anti-CADM-140/MDA5 autoantibody and a patient with severe amiodarone pulmonary toxicity. It is also demonstrated that PMX-DHP performed on the first day of steroid pulse therapy may improve the prognosis of patients with rapidly progressive ILDs in a case-control setting. PMX treatment decreases not only various circulating molecules but also inflammatory cells, in particular activated monocytes, producing such mediators. Although the incidence of acute exacerbations of IPF is too low for proper randomization, in order to test the effects of PMX-DHP on the disease, a cohort or casecontrol analytic study needs to be conducted, preferably from more than one center or research group. | Katsuaki Asakawa Toshinori Takada | 2015 | World Journal of Respirology2015，5，1： | 2 |
| 8 | Respiratory physiotherapy in gastroesophageal reflux disease:A review article显示文摘Gastroesophageal reflux disease(GERD) is a frequen disorder which is expensive to diagnose and treat Initiating therapy with empiric trial of proton-pump inhibitor is a well established strategy; however symptoms of GERD do often persist regardless of effective medication. Nowadays, increasing interest concerning the efficacy and safety of chronic acid suppression with proton-pump inhibitors(PPIs), prompts a consideration fo GERD treatment strategies related to the basic physiology of the lower esophageal sphincter, including modulationof its tone and ending of spontaneous transient lower esophageal sphincter relaxation, which contributes to reflux. Together, the lower esophageal sphincter and the crural diaphragm represent the major antireflux barrier, protecting the esophagus from reflux of gastric content. In order to prevent the need for enduring PPIs therapy or surgical procedures, substitute therapeutics approaches are being researched. Recently, studies have focused on the response of the respiratory muscles to inspiratory muscle training. As a result, inspiratory muscle training has emerged as a potential alternative for treatment of gastroesophageal reflux. The present report reviews the physiologic factors contributing to GERD, and presents the newly developed therapies that can be applied either alone or in association with available efficient GERD therapy. | Renata Carvalho de Miranda Chaves Tomás Navarro-Rodriguez | 2015 | World Journal of Respirology2015，5，1： | 2 |
| 9 | New therapies for chronic obstructive pulmonary disease,lung regeneration显示文摘Chronic obstructive pulmonary disease(COPD) is characterized by the presence of airflow limitations that are not fully reversible and is a major cause of chronic morbidity and mortality worldwide. Although there has been extensive research examining the molecular mechanisms underlying the development of COPD, there is no proven clinically effective treatment for promoting recovery from established COPD. At present, regeneration is the only hope for a cure in patients with COPD. In this article, we review current treatments for COPD, focusing particularly on recent advances in lung regeneration based on two major approaches: regeneration-promoting agents and cell therapy. Retinoic acids are the majorfocus among regeneration-promoting agents, while mesenchymal stem cells are the main topic in the field of cell-based therapy. This article aims to provide valuable information for developing new therapies for COPD. | Masaki Fujita | 2015 | World Journal of Respirology2015，5，1： | 2 |
| 10 | Incidence of community‐acquired pneumonia in children caused by Mycoplasma pneumoniae: Serological results of a prospective, population‐based study in primary health care显示文摘 | MattiKorppi TarjaHeiskanen‐Kosma MarjaanaKleemola | 2004 | Respirology2004，，1： | 2 |
| 11 | Lung cancer screening: Should we be excluding people with previous malignancy?显示文摘The National Lung Screening Trial(NLST) was a large,randomized, controlled study showing a 20% reduction of lung cancer mortality and 7% reduction of all cause mortality using annual low dose computed tomography(LDCT) in a high risk population. NLST excluded people with a previous history of cancer treatment within the past 5 years and all people with a history lung cancer. The aim of this work is to review how lung cancer screening trials addressed the confounding effect of previous malignancy. We also review the subsequent recommendations by the United States Preventative Task Force Services, multiple professional societies and the Center for Medicaid and Medicare Services which defer either to NLST criteria or, clinician judgment or refrain from asserting any recommendation on the topic, respectively. Implications of lung cancer screening in the setting of previous malignancies, specifically lung, head and neck, esophageal, gastric, breast, colorectal cancer and lymphoma are also discussed. With lung cancer screening, an antecedent malignancy introduces the possibility of discovering metastasis as well as lung cancer. In some circumstances diagnosis and treatment of oligometastatic disease may confer a survival benefit. The survival benefit of treating either lung cancer or oligometastatic disease as result of lung cancer screening has yet to be determined. Further studies are needed to determine the role of lung cancer screening in the setting of previous malignancy. | Cherie P Erkmen Larry R Kaiser Ashley L Ehret | 2016 | World Journal of Respirology2016，6，1： | 2 |
| 12 | The prevalence of pulmonary fibrosis combined with emphysema in patients with lung cancer显示文摘 | KazuhiroUSUI ChiharuTANAI YoshiakiTANAKA HiromichiNODA TeruoISHIHARA | 2011 | Respirology2011，，2： | 2 |
| 13 | Population based standards for pulmonary function in non-smoking adults in Singapore显示文摘 | Ng TP Hui KP | 1997 | Respirology1997，2，2： | 1 |
| 14 | Clinical characteristics and efficacy of bronchoscopic intervention for tracheobronchial leiomyoma显示文摘 | Kwon YS Kim H Koh WJ | 2008 | Respirology2008，13，6： | 1 |
| 15 | Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats 显示文摘 | Cai S Chen P Zhang C | 2009 | Respirology2009，14，3： | 1 |
| 16 | HIV-associated Opportunistic Pneumo- nias显示文摘 | Huang L Crothers KA | 2009 | Respirology2009，14，4： | 1 |
| 17 | Non-surgical therapy for patients with advanced non-small celllung cancer 显示文摘 | Liao M L | 1998 | Respirology1998，3，： | 1 |
| 18 | Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease 显示文摘 | NAKAMURA S HASHIMOTO Y MIKAMI M | 2003 | Respirology2003，，8： | 1 |
| 19 | Prevalence of anxiety and depression among chronic bronchitis patients and the associated factors 显示文摘 | Miguel D J Hernandez BV Puente ML | 2011 | Respirology2011，16，7： | 1 |
| 20 | Effect of early pulmonary rehabilitation on health care utilization and health status in patients hospitalized with acute exacerbations of COPD 显示文摘 | Ko F W Dai D L Ngai J | 2011 | Respirology2011，16，4： | 1 |
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