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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Effects of exogenous enzymes, Lactobacillus acidophilus or their combination on feed performance response and carcass characteristics of rabbits fed sugarcane bagasse显示文摘The aim of this study was to evaluate the effect of Lactobacillus acidophilus(LAC), exogenous enzymes of ZAD(exogenous enzyme preparation) or their combination on feed conversion, and dressing of rabbits fed different treatments of sugarcane bagasse(SCB). Five rations were allotted randomly to five groups of New-Zealand White(NZW) rabbits(n=10) with initial live body weight of(838±42.4) g and 5 weeks of age. Rabbits were fed on diets with different sources of fiber as follows,(i) a control diet composed of 100% berseem hay and 0% SCB,(ii) 50% berseem hay and 50% untreated SCB(USCB),(iii) 50% berseem hay and 50% SCB treated with L. acidophilus(LAC),(iv) 50% berseem hay and 50% SCB treated with ZAD(ZAD), and(v) 50% berseem hay and 50% SCB treated with a combination of LAC+ZAD(LZ). Treatments of SCB with L. acidophilus, ZAD and LAC+ZAD had the highest feed conversion ratio than both USCB and control. The dressing percentage of rabbits that fed the LAC and LZ diets was higher(P<0.05) compared with that in the other groups. Performance index(PI) for LAC group was improved(P<0.05) compared to that for the other groups; however, PI for USCB group was the lowest(P<0.05). It could be concluded that treating SCB with L. acidophilus, exogenous enzymes of ZAD or their combination improved feed conversion and performance with more positive effects with L. acidophilus than the other treatments. | Nahla A Abdel-Aziz Mounir El-Adawy Maria A Mariezcurrena-Berasain Abdelfattah Z M Salem Jaime Olivares-Pérez Ahmed E Kholif Borhami E Borhami | 2015 | Journal of Integrative Agriculture2015，14，3： | 5 |
| 4 | Impact of PRRSV on activation and viability of antigen presenting cells显示文摘Porcine reproductive and respiratory syndrome(PRRS) is one of the most important diseases of swine industry. The causal agent, PRRS-virus(PRRSV), is able to evade the host immune response and survive in the organism causing transient infections. Despite all scientific efforts, there are still some gaps in the knowledge of the pathogenesis of this disease. Antigen presenting cells(APCs), as initiators of the immune response, are located in the first line of defense against microorganisms, and are responsible for antigen recognition, processing and presentation. Dendritic cells(DCs) are the main type of APC involved in antigen presentation and they are susceptible to PRRSV infection. Thus, PRRSV replication in DCs may trigger off different mechanisms to impair the onset of a host effective immune response against the virus. On the one side, PRRSV may impair the basic functions of DCs by regulating the expression of major histocompatibility complex class Ⅱ and CD80/86. Other strategy followed by the virus is the induction of cell death of APCs by apoptosis, necrosis or both of them. The impairment and/or cell death ofAPCs could lead to a failure in the onset of an efficient immune response, as long as cells could not properly activate T cells. Future aspects to take into account are also discussed in this review. | Irene M Rodríguez-Gómez Jaime Gómez-Laguna Librado Carrasco | 2013 | World Journal of Virology2013，2，4： | 4 |
| 5 | Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer显示文摘Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy.FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings.Here,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression.This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor.In addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed. | Jaime Ceballos-Viro José M López-Picazo José L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 6 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 7 | Effects of Low Temperature on Dormancy Release in Lily Bulbs显示文摘 | Sun H M Jaime A T S Li Y F | 2007 | Floriculture and Ornamental Biotechnology2007，，1： | 1 |
| 8 | An RTP/RTCP based approach for multimedia group and inter stream synchronization显示文摘 | FERNANDO B S JUAN C G C JAIME L M | 2008 | Multimedia Tools and Applications2008，40，2： | 1 |
| 9 | Influence of starter cultures and sugar concentrations on biogenic amine contents in chorizo dry sausage显示文摘 | GONZALEZ-FERNANDEZ C SANTOS E M JAIME I | 2003 | Food Microbiology2003，，20： | 1 |
| 10 | Investigation of the effects of salinity and dietary protein level on growth and survival of pacific white shrimp, Litopenaeus vannamei显示文摘 | Perez-Velazquez M L Gonzalea-Felix M Jaimes Busta- mente F | 2007 | J World Aquacult Soc2007，38，4： | 1 |
| 11 | Methods of analysis and separation of chiral flavonoids显示文摘 | JAIME A Y ANDREWS P K DAVIES N M | 2007 | Journal of Chromatography B2007，848，： | 1 |
| 12 | Photo-catalytic Degradation of Cellulose Bleaching Effluent by Supported TiO2and ZnO显示文摘 | M Cristina Yeber Jaime R odriguez Juanita Freer | 2000 | Chemosphere2000，41，11： | 1 |
| 13 | Seeding rate influence on yield and yield components of irrigated winter wheat in a Mediterranean climate显示文摘 | Jaime L Josep M Javier V | 2004 | Agronomy Journal2004，96，： | 1 |
| 14 | Population genetic structure of the Humboldt squid ( Dosidicus gigas d' Orbigny, 1835 ) inferred by mitochondrial DNA analysis 显示文摘 | Sandoval-Castellanos E Uribe-Alcocer M Dfaz- Jaimes P | 2010 | Experimental Marine Biology and Ecology2010，385，12： | 1 |
| 15 | Advanced oxidation of a pulp mill bleaching wastewater显示文摘 | Yeber Cristina M Jaime Rodríguez Juanita Freer | 1999 | Chemosphere1999，39，10： | 1 |
| 16 | Mg as a main source for the diverse magnetotransport properties of MgB2显示文摘 | Betts J B Jaime M | 2002 | Phys Rev2002，66，5： | 1 |
| 17 | Modification to physicochemical and nutritional proper-ties of hard-to-cook beans(Phaseolus vulgaris L)by extrusion cooking显示文摘 | Martin-Cabrejas M A Jaime L Karanja C | 1999 | Journal of Agricultural and Food Chemistry1999，，47： | 1 |
| 18 | Charaeterisation of Microeoecaeeae isolated from different varie- ties of chorizo显示文摘 | Moniea Gareia-Varona Eva M Santos Isabel Jaime | 2000 | International Journal of Food Microbiology2000，，54： | 1 |
| 19 | Choosing the location of corneal incision based on preexisting astigmatism in phacoemulsification显示文摘 | Jaime TJ Juan M | | 0，，05： | 1 |
| 20 | Mg-Fe hydrotalcite as a catalyst for the reduction of aromatic nitro compounds with hydrazine hydrate显示文摘 | Pramod S Kumbhar Jaime Sanchez-Valente Jean Marc M Millet | 2000 | Journal of Catalysis2000，191，： | 1 |
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