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| 1 | A half century (1961-2011) of applying microsurgery to experimental liver research显示文摘The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies. | Maria-Angeles Aller Natalia Arias Isabel Prieto Salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis Arias Jaime Arias | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | The ability of sperm selection techniques to remove single- or double-strand DNA damage显示文摘为精子的准备的许多技术当前是可得到的,哪个通常采用的大多数是密度坡度 centrifugation (DGC ) 和游泳起来(啜) 。迄今为止,这些方法看起来在为帮助繁殖技术(艺术) 选择功能的精子有效,但是他们可以在精子 DNA 上有否定效果。在这研究,处理技术消除单个海滨的包含的精子和双海滨 DNA 损坏的这些精液的能力被在 157 件精液样品的二尾巴的彗星试金和精子染色质分散测试从寻求帮助繁殖治疗的病人估计。我们显示的结果啜并且 DGC 在消除包含双海滨 DNA 损坏和精子与的精子是同等地有效的高度损坏了(降级) DNA 由存在描绘了单个海滨并且双海滨 DNA 裂缝。然而, DGC 比在选择从单个海滨的 DNA 损坏是免费的精子啜是更有效的。未来研究应该描述 DNA 损坏的各种各样的类型的重要性并且检验处理在每个实验室过去常决定他们的能力消除 DNA 损坏并且因此,经由艺术阻止基因变化的潜在的传播的协议的精子。 | Maria Enciso Miriam Iglesias Isabel Galan Jonas Sarasa Antonio Gosalvez Jaime Gosalvez | 2011 | Asian Journal of Andrology2011，13，5： | 2 |
| 3 | Flexible distributed feedback lasers based on nanoimprinted cellulose diacetate with efficient multiple wavelength lasing显示文摘Here we present the assembly of novel transparent all-polymer distributed feedback(DFB)lasers.Flexible and highly transparent cellulose diacetate(CdA)was employed as substrate on which gratings with different periods were engraved by thermal nanoimprinting with high fidelity.Highly luminescent conjugated polymers(CP),poly(9,9-dioctylfluorene)(PFO),poly(9,9-dioctylfluorene-alt-benzothiadiazole)(F8BT),and a blend of F8BT and poly(3-hexylthiophene)-poly(9,9-dioctylfluorene-altbenzothiadiazole)(P3HT:F8BT)were deposited by spin coating onto the nanostructured plastic surfaces,giving rise to perpendicular single-mode lasing emission in the blue,green,and red wavelength ranges,respectively.These lasers show linewidths below 1 nm and low thresholds(≈6μJcm^(−2) for blue and red lasing emission),comparable to other state-of-the-art lasers obtained from similar optical gain materials on rigid substrates.The followed strategy is scalable and versatile,enabling the development of large area nanoimprinted DFB lasers(>1cm^(2))on plastic,which is highly relevant for applications in various markets. | José R.Castro Smirnov Ahmad Sousaraei Manuel R.Osorio Santiago Casado Jaime J.Hernández Longfei Wu Qi Zhang Ruidong Xia Daniel Granados Reinhold Wannemacher Isabel Rodriguez Juan Cabanillas-Gonzalez | 2019 | npj Flexible Electronics2019，3，1： | 2 |
| 4 | Management of pancreatic cancer in the elderly显示文摘Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. The aging of the population will result in a rise in the incidence of pancreatic adenocarcinoma within the next years. Thus, the management of pancreatic cancer in the elderly population is gaining increasing relevance. Older cancer patients represent a heterogeneous group with different biological, functional and psychosocial characteristics that can modify the usual management of this disease, including pharmacokinetic and pharmacodynamic changes, polypharmacy, performance status, comorbidities and organ dysfunction. However, the biological age, not the chronological age, of the patient should be the limiting factor in determining the most appropriate treatment for these patients. Unfortunately, despite the increased incidence of this pathology in older patients, there is an underrepresentation of these patients in clinical trials, and the management of older patients is thus determined by extrapolation from the results of studies performed in younger patients. In this review, the special characteristics of the elderly, the multidisciplinary management of localized and advanced ductal adenocarcinoma of the pancreas and the most recent advances in the management of this condition will be discussed, focusing on surgery, chemotherapy, radiation and palliative care. | Oliver Higuera Ismael Ghanem Rula Nasimi Isabel Prieto Laura Koren Jaime Feliu | 2016 | World Journal of Gastroenterology2016，22，2： | 2 |
| 5 | Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units显示文摘Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively included.Anemia was defined as hemoglobin<130 g/L in men and<120 g/L in women.The association between anemia and mortality or readmission at six months was assessed by the Cox regression method.Results A total of 629 patients were included.Mean age was 66.6 years.A total of 197 patients(31.3%)had anemia.Coronary angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score values.Patients with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement therapies.Both ICCU and hospital stay were significantly longer in patients with anemia.Both the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia.Most patients underwent coronary angiography.Anemia was independently associated to poorer outcomes at 6 months. | Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 | 2020 | Journal of Geriatric Cardiology2020，17，1： | 2 |
| 6 | Charaeterisation of Microeoecaeeae isolated from different varie- ties of chorizo显示文摘 | Moniea Gareia-Varona Eva M Santos Isabel Jaime | 2000 | International Journal of Food Microbiology2000，，54： | 1 |
| 7 | The shell microstructure, mineralogyy and isotopic composition of Amussiopecten baranensis (Pectinidae, Bivalvia) from the miocene of span: a valuable paleoenvironmental tool显示文摘 | Isabel Z Jaime D P Antonio V | 1996 | Geobios1996，29，6： | 1 |
| 8 | Effect of the packaging method and the storage time on lipid oxidation and colour stability on dry fermented sausage salchichón manufactured with raw material with a high level of mono and polyunsaturated fatty acids显示文摘 | Bego?a Rubio Beatriz Martínez M a Dolores García-Cachán Jordi Rovira Isabel Jaime | 2008 | Meat Science2008，，4： | 1 |
| 9 | Production of omega-3 polyunsaturated fatty acid concentrates: A review显示文摘 | NURIA RUBIO-RODRIGUEZ SAGRARIO BELTRN ISABEL JAIME | 2009 | Innovative Food Science and Emerging Technologies2009，11，2010： | 1 |
| 10 | Expanded Adipose-Derived Stem Cells for the Treatment of Complex Perianal Fistula: a Phase II Clinical Trial显示文摘 | Damian Garcia-Olmo Dolores Herreros Isabel Pascual José Antonio Pascual Emilio Del-Valle Jaime Zorrilla Paloma De-La-Quintana Mariano Garcia-Arranz Maria Pascual | 2009 | Diseases of the Colon & Rectum2009，，1： | 1 |
| 11 | Supercritical fluid extraction of fish oil from fish by-products: A comparison with other extraction methods显示文摘 | Nuria Rubio-Rodríguez Sara M. de Diego Sagrario Beltrán Isabel Jaime María Teresa Sanz Jordi Rovira | 2011 | Journal of Food Engineering2011，，2： | 1 |
| 12 | Efficacy and Safety of Mass Cataract Surgery Campaign in a Developing Country显示文摘 | Isabel Signes-Soler Jaime Javaloy Robert Montés-Micó Gonzalo Mu?oz César Albarrán-Diego | 2013 | Optometry and Vision Science2013，，2： | 1 |
| 13 | The effect of sugar concentration and starter culture on instrumental and sensory textural properties of chorizo -Spanish dry-cured sausage显示文摘 | Consuelo González-Fernández Eva M. Santos Jordi Rovira Isabel Jaime | 2006 | Meat Science2006，，3： | 1 |
| 14 | The discovery of SycO highlights a new function for type Ⅲ secretion effector chaperones显示文摘 | Michel Letzelter Isabel Sorg Luls Jaime Mota | 2006 | EMBO2006，25，13： | 1 |
| 15 | Supercritical fluid extraction of the omega-3 rich oil contained in hake ( Merluccius capensis–Merluccius paradoxus ) by-products: Study of the influence of process parameters on the extraction yield and oil quality显示文摘 | Nuria Rubio-Rodríguez Sara M. de Diego Sagrario Beltrán Isabel Jaime Maria Teresa Sanz Jordi Rovira | 2008 | The Journal of Supercritical Fluids2008，，2： | 1 |
| 16 | Proteolytic activity of isolated lamb calpains on myofibrils under the conditions of pH, Ca^2+ concentration and temperature existing in postmortem muscle显示文摘 | Pilar Cena Isabel Jaime Jose Antonio Beltran | 1991 | Z Lebensm Unters Forsch1991，194，： | 1 |
| 17 | Outcomes after thrombolysis in AIS according to prior statin use: A registry and review显示文摘 | Elena Meseguer Mikael Mazighi Bertrand Lapergue Julien Labreuche Gaia Sirimarco Jaime Gonzalez-Valcarcel Philippa C. Lavallée Lucie Cabrejo Céline Guidoux Isabelle F. Klein Jean-Marc Olivot Aymeric Rouchaud Jean-Philippe Desilles Pierre Amarenco | 2012 | Neurology2012，，17： | 1 |
| 18 | Tumor Necrosis Factor-α, Interleukin-1β and Nitric Oxide: Induction of Liver Megamitochondria in Prehepatic Portal Hypertensive Rats显示文摘 | Isabel Prieto Ph.D. Fulgencio Jiménez M.D. Maria-Angeles Aller Ph.D. Maria-Paz Nava Ph.D. Elena Vara PhD. Cruz Garcia Ph.D. Jaime Arias Ph.D | 2005 | World Journal of Surgery2005，，7： | 1 |
| 19 | New approach to assess sperm DNA fragmentation dynamics: Fine-tuning mathematical models显示文摘Background: Sperm DNA fragmentation(sDF) has been proved to be an important parameter in order to predict in vitro the potential fertility of a semen sample. Colloid centrifugation could be a suitable technique to select those donkey sperm more resistant to DNA fragmentation after thawing. Previous studies have shown that to elucidate the latent damage of the DNA molecule, sDF should be assessed dynamically, where the rate of fragmentation between treatments indicates how resistant the DNA is to iatrogenic damage. The rate of fragmentation is calculated using the slope of a linear regression equation. However, it has not been studied if s DF dynamics fit this model. The objectives of this study were to evaluate the effect of different after-thawing centrifugation protocols on sperm DNA fragmentation and elucidate the most accurate mathematical model(linear regression, exponential or polynomial) for DNA fragmentation over time in frozen-thawed donkey semen.Results: After submitting post-thaw semen samples to no centrifugation(UDC), sperm washing(SW) or single layer centrifugation(SLC) protocols, sD F values after 6 h of incubation were significantly lower in SLC samples than in SW or UDC.Coefficient of determination(R^2) values were significantly higher for a second order polynomial model than for linear or exponential. The highest values for acceleration of fragmentation(aSDF) were obtained for SW, fol owed by SLC and UDC.Conclusion: SLC after thawing seems to preserve longer DNA longevity in comparison to UDC and SW. Moreover,the fine-tuning of models has shown that sDF dynamics in frozen-thawed donkey semen fit a second order polynomial model, which implies that fragmentation rate is not constant and fragmentation acceleration must be taken into account to elucidate hidden damage in the DNA molecule. | Isabel Ortiz Jesus Dorado Jane Morrell Jaime Gosalvez Francisco Crespo Juan M.Jimenez Manuel Hidalgo | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 0 |
| 20 | Embrionary way to create a fatty liver in portal hypertension显示文摘Portal hypertension in the rat by triple partial portal vein ligation produces an array of splanchnic and systemic disorders, including hepatic steatosis. In the current review these alterations are considered components of a systemic inflammatory response that would develop through three overlapping phenotypes: The neurogenic, the immune and the endocrine. These three inflammatory phenotypes could resemble the functions expressed during embryonic development of mammals. In turn, the inflammatory phenotypes would be represented in the embryo by two functional axes, that is, a coelomic-amniotic axis and a trophoblastic yolk-sac or vitelline axis. In this sense, the inflammatory response developed after triple partial portal vein ligation in the rat would integrate both functional embryonic axes on the liver interstitial space of Disse. If so, this fact would favor the successive development of steatosis, steatohepatitis and fibrosis. Firstly, these recapitulated embryonic functions would produce the evolution of liver steatosis. In this way, this fat liver could represent a yolk-sac-like in portal hypertensive rats. After that, the systemic recapitulation of these embryonic functions in experimental prehepatic portal hypertension would consequently induce a gastrulationlike response in which a hepatic wound healing reaction or fibrosis occur. In conclusion, studying the mechanisms involved in embryonic development could provide key results for a better understanding of the nonalcoholic fatty liver disease etiopathogeny. | Maria-Angeles Aller Natalia Arias Isabel Peral Sara García-Higarza Jorge-Luis Arias Jaime Arias | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 0 |
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