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| 1 | Doxorubicin-eluting bead vs conventional transcatheter arterial chemoembolization for hepatocellular carcinoma before liver transplantation显示文摘AIM:To assess the possible effect of two different types of preoperative transcatheter arterial chemoembolization(TACE)on recurrence-free survival after liver transplantation(LT)in patients with hepatocellular carcinoma(HCC)and to analyze the effects of TACE on tumor histology.METHODS:We retrospectively analyzed the histological features of 130 HCC nodules in 63 native livers removed at transplantation.Patients who received any other type of treatment such as radiofrequency tumor ablation,percutaneous ethanol ablation or who were not treated at all were excluded.All patients in the present study were within the Milan Criteria at the last imaging findings before transplantation.Doxorubicineluting bead TACE(DEB-TACE)was performed in 22patients(38 nodules),and conventional TACE(c-TACE)in 16(25 nodules).Patients’and tumors’characteristics were retrospectively reviewed.We performed a pernodule analysis of the explanted livers to establish the mean percentage of necrosis of any nodule treated by TACE(conventional or DEB)and a per-patient analysis to establish the percentage of necrosis in the cumulative tumor area,including 21 nodules not reached by TACE.Inflammatory and fibrotic changes in the tissue surrounding the tumor nodule were analyzed and categorized as poor/absent,moderate and enhanced reaction.Uni-and multivariate analysis of risk factors for HCC-recurrence were performed.RESULTS:The number and diameter of the nodules,the time spent on the waiting list and the number of treatments were similar in the two groups.A trend towards higher appropriate response rates(necrosis≥90%)was observed in the DEB-TACE group(44.7%vs32.0%,P=0.2834).The mean percentage of necrosis in the cumulative tumor area was 58.8%±36.6%in the DEB-TACE group and 50.2%±38.1%in the c-TACE group(P=0.4856).Fibrotic and inflammatory reactions surrounding the tumor nodule were markedly more common in the DEB-TACE group(P<0.0001,for both the parameters).The three-year recurrence-free survival was higher in DEB-TACE-treated patients than in conventionally treated patients(87.4%vs 61.5%,P=0.0493).Other factors affecting recurrence-free survival included viable tumor beyond Milan Criteria on histopathological examination,the percentage of necrosis on CTA≤50%and a pre-transplant serum-fetoprotein level greater than 70 ng/mL.On multivariate analysis,the lack of treatment with DEB-TACE,high levels of-fetoprotein and viable tumor beyond Milan Criteria at histology examination were identified as independent predictors of tumor recurrence.CONCLUSION:DEB-TACE can effectively promote tumor necrosis and improves recurrence-free survival after LT in HCC. | Daniele Nicolini Gianluca Svegliati-Baroni Roberto Candelari Cinzia Mincarelli Alessandra Mandolesi Italo Bearzi Federico Mocchegiani Andrea Vecchi Roberto Montalti Antonio Benedetti Andrea Risaliti Marco Vivarelli | 2013 | World Journal of Gastroenterology2013，19，34： | 12 |
| 2 | A practical approach to the diagnosis of autoimmune pancreatitis显示文摘Autoimmune pancreatitis is a disease characterized by specific pathological features,different from those of other forms of pancreatitis,that responds dramatically to steroid therapy.The pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging,mimicking pancreatic cancer.Clinically,the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic cancer.Since in the presence of a pancreatic mass the probability of tumour is much higher than that of pancreatitis,the physician should be aware that in focal autoimmune pancreatitis the first step before using steroids is to exclude pancreatic adenocarcinoma.In this review,we briefly analyse the strategies to be followed for a correct diagnosis of autoimmune pancreatitis. | Luca Frulloni Antonio Amodio Anna Maria Katsotourchi Italo Vantini | 2011 | World Journal of Gastroenterology2011，17，16： | 8 |
| 3 | Optimal management of a patient with recurrent nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma is rare in western countries, accounting for less than 1% of all malignancies. Despite prognosis is satisfactory for newly diagnosed, non-metastatic disease, management of recurrent disease is challenging, with a survival expectancy of approximately 6 mo with the use of chemotherapy as the sole salvage treatment. We report a case of recurrent nasopharyngeal carcinoma treated with a combination of chemotherapy, radiotherapy and surgery in the context of a multidisciplinary approach. A durable complete response was achieved. | Francesco Perri Italo Dell’Oca Paolo Muto Concetta Schiavone Corrado Aversa Franco Fulciniti Raffaele Solla Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Caponigro | 2014 | World Journal of Clinical Cases2014，2，7： | 8 |
| 4 | Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy:demographic,virological,and clinical features显示文摘Background:The data on hepatitis b virus(HBV)infection in immigrants population are scanty.The porpoise of this study was to define the demographic,virological,and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples,Italy.Methods:A screening for HBV infection was offered to 1,331 immigrants,of whom 1,212(91%)(831 undocumented immigrants and 381 refugees)accepted and were screened for hepatitis B surface antigen(HBsAg)and anti-hepatitis B core antibody(HBc).Those found to be HBsAg positive were further investigated at third-level infectious disease units.Results:Of the 1,212 immigrants screened,116(9.6%)were HBsAg positive,490(40.4%)were HBsAg negative/anti-HBc positive,and 606(50%)were seronegative for both.Moreover,21(1.7%)were anti-human immunodeficiency virus positive and 45(3.7%)were anti-hepatitis C virus positive.The logistic regression analysis showed that male sex(OR:1.79;95%CI:1.28-2.51),Sub-Saharan African origin(OR:6.18;95%CI:3.37-11.36),low level of schooling(OR:0.96;95%CI:0.94-0.99),and minor parenteral risks for acquiring HBV infection(acupuncture,tattoo,piercing,or tribal practices,OR:1.54;95%CI:1.1-2.16)were independently associated with ongoing or past HBV infection.Of the 116 HBsAg-positive immigrants,90(77.6%)completed their diagnostic itinerary at a third-level infectious disease unit:29(32.2%)were asymptomatic non-viremic HBsAg carriers,43(47.8%)were asymptomatic viremic carriers,14(15.6%)had chronic hepatitis,and four(4.4%)had liver cirrhosis,with superimposed hepatocellular carcinoma in two.Conclusions:The data illustrate the demographic,clinical and virological characteristics of HBV infection in immigrants in Italy and indicate the need for Italian healthcare authorities to enhance their support for providing screening,HBV vaccination,treatment,and educational programs for this populations. | Nicola Coppola Loredana Alessio Luciano Gualdieri Mariantonietta Pisaturo Caterina Sagnelli Carmine Minichini Giovanni Di Caprio Mario Starace Lorenzo Onorato Giuseppe Signoriello Margherita Macera Italo Francesco Angelillo Giuseppe Pasquale Evangelista Sagnelli | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 5 | Effective bowel cleansing before colonoscopy: a randomized study of split-dosage versus non-split dosage regimens of high-volume versus low-volume polyethylene glycol solutions显示文摘 | Riccardo Marmo Gianluca Rotondano Giovanni Riccio Armando Marone Maria Antonia Bianco Italo Stroppa Anna Caruso Nicola Pandolfo Stefano Sansone Elena Gregorio Giuseppe D’Alvano Nicoletta Procaccio Pina Capo Clelia Marmo Livio Cipolletta | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 6 | The silk road economic belt: balance of interests显示文摘The article makes an analogy between the Great Silk Road and the modern Belt and Road Initiative(BRI,also known as‘One Belt,One Road’[OBOR])of China in the context of their significance for the development of international trade,as well as the Central Asian region.The historical role of the Silk Road is considered from the viewpoint of mutual benefit of states along the trade route.The authors consider the concept as the co-development of states,suggested by China within the framework of the BRI,which involves international cooperation on the basis of mutual benefits for all participants,promotion of economic growth and welfare,development of modern infrastructure through joint investments.An attempt is made to assess the interests of Central Asian countries in the Silk Road Economic Belt(SREB)projects.Common interests include construction of modern road infrastructure,exploration and extraction of mineral deposits,transportation of energy resources,establishment of logistics and industrial zones.There is an increase in the transit role of the Central Asian countries within the framework of the BRI,as well an increase in investments from China.The countries along SREB are concerned about potential threats of the inflow of Chinese labour,the use of technologies that can cause environmental problems,the loss of control over strategic assets,and general growth of financial dependence on China.The article analyses Russia’s perception of the Chinese initiative.It is concluded that the main mutual interest of the two countries is opposing the US’s attempts to establish a dominating role in the region and thus ensuring the security of the transport system through the institutions of the Eurasian Economic Union(EAEU)and the Shanghai Cooperation Organisation(SCO).The authors reveal a trend of changing the role of Russia as the main transit corridor for Chinese goods exported to Europe and European ones imported to China.The key long-term economic interests of China implementing the BRI have been identified:expansion of foreign markets,access to critical resources in the countries of Central Asia,export of capital,transfer of production abroad,increased exports of high-tech products and services,expansion of the RMB currency area and initiation of structural changes in the global management system.The assessment of China’s initiative by the US and Europe is given as a claim to economic leadership and the struggle to balance the country’s geopolitical position with its economic strength.The authors identify the areas of mutual and opposing interests of some European countries and China.It is concluded that,despite high risks and existing threats,the projects of the BRI can be implemented successfully that achieve the balance of interests and long-term mutual benefits of the countries involved. | Yakov Silin Larisa Kapustina Italo Trevisan Andrei Drevalev | 2018 | Economic and Political Studies2018，6，3： | 2 |
| 7 | Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome显示文摘 | Roy Freeman Wouter Wieling Felicia B. Axelrod David G. Benditt Eduardo Benarroch Italo Biaggioni William P. Cheshire Thomas Chelimsky Pietro Cortelli Christopher H. Gibbons David S. Goldstein Roger Hainsworth Max J. Hilz Giris Jacob Horacio Kaufmann Jens | 2011 | Autonomic Neuroscience: Basic and Clinical2011，，1： | 2 |
| 8 | Equilibrium selection in a nonlinear duopoly game with adaptive expectations显示文摘 | Gian Italo Bischi Michael Kopel | 2001 | Journal of Economic Behavior & Organization2001，46，： | 2 |
| 9 | Prevalence and natural history of hepatitis B and C infections in a large population of IBD patients treated with anti-tumor necrosis factor-α agents显示文摘 | Alfredo Papa Carla Felice Manuela Marzo Gianluca Andrisani Alessandro Armuzzi Marcello Covino Giammarco Mocci Daniela Pugliese Italo De Vitis Antonio Gasbarrini Gian Lodovico Rapaccini Luisa Guidi | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 10 | Incidence of cancer in the course of chronic pancreatitis显示文摘 | Giorgio Talamini Massimo Falconi Claudio Bassi Nora Sartori Roberto Salvia Erminia Caldiron Luca Frulloni Vincenzo Di Francesco Bruna Vaona Paolo Bovo Italo Vantini Paolo Pederzoli Giorgio Cavallini | 1999 | The American Journal of Gastroenterology1999，，5： | 2 |
| 11 | Static and rotational intensity modulated techniques for head-neck cancer radiotherapy: A planning comparison显示文摘 | Sara Broggi Lucia Perna Francesco Bonsignore Giuseppe Rinaldin Claudio Fiorino Anna Chiara Cristina Frigerio Ivana Butti Giulia Sangalli Italo Dell’Oca Nadia Di Muzio Giovanni Mauro Cattaneo Fausto Declich | 2014 | Physica Medica2014，，： | 1 |
| 12 | Overbalanced Perforating Yields Negative Skins in Layered Reservoir显示文摘 | Italo P Steve G | 2006 | SPE1040992006，，： | 1 |
| 13 | Electrosynthesis of aromatic aldehydes by palladium-catalyzed carbonyla- tion of aryl iodies in the presence of formic acid 显示文摘 | Italo C Isabella C Sandro C | 1999 | J Org Chem1999，，： | 1 |
| 14 | Comparison of mandibular rami width in patients with prognathism and retrognathia显示文摘 | Danilo PB Italo HA Paulo J | | 0，，10： | 1 |
| 15 | Identification of 4,5 -Dihydro-1H-pyrazolo quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors 显示文摘 | Italo B Dario B | 2010 | J Med Chem2010，53，9： | 1 |
| 16 | Epigenetic regulation of EBV persistence and oncogenesis显示文摘 | Italo Tempera Paul M. Lieberman | 2014 | Seminars in Cancer Biology2014，，： | 1 |
| 17 | Intensity-Modulated Proton Therapy Versus Helical Tomotherapy in Nasopharynx Cancer: Planning Comparison and NTCP Evaluation显示文摘 | Lamberto Widesott Alessio Pierelli Claudio Fiorino Italo Dell’Oca Sara Broggi Giovanni Mauro Cattaneo Nadia Di Muzio Ferruccio Fazio Riccardo Calandrino Marco Schwarz | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，： | 1 |
| 18 | Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension显示文摘 | ordan Jens Biaggioni Italo | 2002 | J Clin Hypertens (Greenwich)2002，4，2： | 1 |
| 19 | Relation of Myocardial Blush Grade to Microvascular Perfusion and Myocardial Infarct Size After Primary or Rescue Percutaneous Coronary Intervention显示文摘 | Italo Porto Francesco Burzotta Marta Brancati Carlo Trani Antonella Lombardo Enrico Romagnoli Giampaolo Niccoli Luigi Natale Lorenzo Bonomo Filippo Crea | 2007 | The American Journal of Cardiology2007，，12： | 1 |
| 20 | Droxidopa for neurogenic orthostatic hypotension: A randomized, placebo-controlled, phase 3 trial显示文摘 | Horacio Kaufmann Roy Freeman Italo Biaggioni Phillip Low Simon Pedder L. Arthur Hewitt Joe Mauney Michael Feirtag Christopher J. Mathias | 2014 | Neurology2014，，4： | 1 |
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