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| 1 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 2 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 3 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 4 | Magnetic Resonance Spectroscopy显示文摘 | Sachin K Gujar Sharad Maheshwari Isabella Bj?rkman-Burtscher Pia C Sundgren | 2005 | Journal of Neuro-Ophthalmology2005，，3： | 2 |
| 5 | Electrosynthesis of aromatic aldehydes by palladium-catalyzed carbonyla- tion of aryl iodies in the presence of formic acid 显示文摘 | Italo C Isabella C Sandro C | 1999 | J Org Chem1999，，： | 1 |
| 6 | Alliance management: a view from the past and a look to the future显示文摘 | Spckman R E Forbes T M Isabella L A Macavoy T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 7 | Creating strategic alliances which endure 显示文摘 | Spekman R E Isabella L A Thomas C | 1996 | Long Range Plan- ning1996，29，3： | 1 |
| 8 | Hierarchically as- sembled ZnO nanocrystallites for high-efficiency dye-sensi- tized solar cells显示文摘 | Nafiseh M Isabella C Antonio B | 2011 | Angew Chem2011，123，12： | 1 |
| 9 | Alliances Management: a View from Past and a Look to the Future显示文摘 | Spekman R E Isabella L A Macavor T C | 1998 | Journal of Management Studies1998，，6： | 1 |
| 10 | Alliance management: A view from the past and a look to the future 显示文摘 | SPEKMAN R E FORBES T M ISABELLA L A MACAVOR T C | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 11 | Quantitative assessments of indoor air pollution and respiratory health in a population-based sample of French dwellings显示文摘 | Cécile Billionnet Emilie Gay Séverine Kirchner Bénédicte Leynaert Isabella Annesi-Maesano | 2011 | Environmental Research2011，，3： | 1 |
| 12 | Creating Strategic Alliances which Edure显示文摘 | Spekman R E Isabella L A MacAvoy T C | 1996 | Long Range Planning1996，，29： | 1 |
| 13 | A comparative study of the NH3-SCR reactions over a Cu-zeolite and a Fe-zeolite catalyst 显示文摘 | MASSIMO C ISABELLA N ENRICO T | 2010 | Catalysis Today2010，151，： | 1 |
| 14 | Novel autoantigens in autoimmune hypophysitis显示文摘 | Isabella L Karl W B Tzou S C | 2008 | Clinical Endoerinol2008，69，： | 1 |
| 15 | A comprehensive multilocus phylogeny for the wood-warblers and a revised classification of the Parulidae (Aves)显示文摘 | Irby J. Lovette Jorge L. Pérez-Emán John P. Sullivan Richard C. Banks Isabella Fiorentino Sergio Córdoba-Córdoba María Echeverry-Galvis F. Keith Barker Kevin J. Burns John Klicka Scott M. Lanyon Eldredge Bermingham | 2010 | Molecular Phylogenetics and Evolution2010，，2： | 1 |
| 16 | Optimal Design of Survivable Mesh Networks Based on Line Switched WDM Self-healing Rings显示文摘 | Andrea F Isabella C Marco T | | 0，，03： | 1 |
| 17 | Alliance Management: A View from the Past and a Look to the Future显示文摘 | Spekman R E Forbes T M Isabella L A Macavor T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 18 | An overview of the open modeling interface environment (the OpenMI)显示文摘 | ROGER V MOORE ISABELLA C | | 0，，： | 1 |
| 19 | Ethanol production in immobilized-cell bioreaetors from mixed sugar syrups and enzymatic hydrolysates of steam-exploded biomass显示文摘 | Isabella D B Daniela C Francesco N | 2004 | Applied Biochemistry and Biotechnology2004，，： | 1 |
| 20 | Alliance management : a view from the past and a look to the future 显示文摘 | SPEKMAN R E FORBES Ⅲ T M ISABELLA L A MACAVOY T C | | Journal Of Management Studies0，35，6： | 1 |
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