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| 1 | The maximum coseismic vertical surface displacement and surface deformation pattern accompanying the Ms 8.0 Wenchuan earthquake显示文摘The amount of coseismic deformation and its distribution of the Wenchuan earthquake provide important scientific bases for revealing the mechanisms of earthquake preparation and characterizing the rupture propagation of the Wenchuan earthquake. The previous studies have indicated that the earthquake ruptured the middle-to-north segment of the Longmenshan central fault and the middle segment of the Longmenshan range-front fault, which are characterized by two surface rupture zones of 240 km and 90 km in length, respectively. Based on the pre-earthquake information and photos of landforms and buildings obtained through ge-ologic and geomorphic survey of the area around Shaba Village of Beichuan County, Sichuan Province and the extensive interview with local villagers, we measured the displacements of the major terrain features and the dislocated buildings by total station instruments and differential GPS and obtained the maximum vertical displacement of 9±0.5 m and right-lateral displacement of 2±0.5 m around the Zou’s house in Shaba Village. Though the near-surface deformation exhibits a normal faulting around Shaba Village, the dynamic environment has not changed on the whole. The NW wall of the fault uplifted but without gravity gliding as normally occurring on the hanging wall of a normal fault, which proves that the 9±0.5 m displacement should be the maximum coseismic vertical displacement of the May 12, 2008 Ms 8.0 Wenchuan earthquake. | Ran YongKang Shi Xiang Wang Hu Chen LiChun Chen Jie Liu RuiChun Gong Huiling | 2010 | Chinese Science Bulletin2010，55，9： | 9 |
| 2 | Ultra-stable Eu^(3+)-doped CsPbCl_(2)Br_(1) perovskite quantum dots glass for optical temperature sensing显示文摘In this work,Eu^(3+)-doped CsPbCl_(2)Br_(1) in borosilicate glass was successfully synthesized by the melt quenching annealing technique and crystallization method.This work reports a novel Eu^(3+)-doped CsPbCl_(2)Br_(1) perovskite quantum dots(QDs)glass with high sensitivity for optical temperature sensing.The relation of fluorescence intensity ratio(FIR)with the temperature was studied in the temperature range of 80-440 K.Notably,the maximum absolute temperature sensitivity(Sa)and relative temperature sensitivity(Sr)of Eu^(3+)-doped CsPbCl_(2)Br_(1) perovskite QDs glass can reach as high as 0.0315 K-1 and3.097%/K,respectively.Meanwhile,Eu^(3+)-doped CsPbCl_(2)Br_(1) QDs glass demonstrates good water resistance,excellent thermal and cold cycling stability performance,The Eu^(3+)-doped QDs glass materials can bring inspiration to the future exploration of rare earth ion-doped QDs glass material on the application of optical temperature sensing in the future. | Yanxia Yu Guangzhan Shao Ling Ding Huiling Zhang Xiaojuan Liang Jianping Liu Weidong Xiang | 2021 | Journal of Rare Earths2021，39，12： | 4 |
| 3 | Dielectric and piezoelectric properties of barium-modified Aurivillius-type Na 0.5 Bi 4.5 Ti 4 O 15显示文摘 | Huiling Du Xiang Shi | 2011 | Journal of Physics and Chemistry of Solids2011，，11： | 2 |
| 4 | Defect Structure and Electrical Conduction Behavior of Bi- based pyrochlores显示文摘 | Du Huiling Shi Xiang Cui Yu | 2010 | Solid State Communi Cations2010，150，： | 1 |
| 5 | Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer显示文摘Herein, we designed a dual-response shape transformation and charge reversal strategy with chemo-photodynamic therapy to improve the blood circulation time, tumor penetration and retention,which finally enhanced the anti-tumor effect. In the system, hydrophobic photosensitizer chlorin e6(Ce6), hydrophilic chemotherapeutic drug berberrubine(BBR) and matrix metalloproteinase-2(MMP-2) response peptide(PLGVRKLVFF) were coupled by linkers to form a linear triblock molecule BBR-PLGVRKLVFF-Ce6(BPC), which can self-assemble into nanoparticles. Then, positively charged BPC and polyethylene glycol-histidine(PEG-His) were mixed to form PEG-His@BPC with negative surface charge and long blood circulation time. Due to the acidic tumor microenvironment, the PEG shell was detached from PEG-His@BPC attributing to protonation of the histidine, which achieved charge reversal, size reduction and enhanced tumor penetration. At the same time, enzyme cutting site was exposed, and the spherical nanoparticles could transform into nanofibers following the enzymolysis by MMP-2, while BBR was released to kill tumors by inducing apoptosis. Compared with original nanoparticles, the nanofibers with photosensitizer Ce6 retained within tumor site for a longer time. Collectively,we provided a good example to fully use the intrinsic properties of different drugs and linkers to construct tumor microenvironment-responsive charge reversal and shape transformable nanoparticles with synergistic antitumor effect. | Wenfeng Jia Rui Liu Yushan Wang Chuan Hu Wenqi Yu Yang Zhou Ling Wang Mengjiao Zhang Huile Gao Xiang Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 1 |
| 6 | Dielectric and piezoelectric properties of barium-modified Aurivillius-type Na 0.5 Bi 4.5 Ti 4 O 15显示文摘 | Huiling Du Xiang Shi | 2011 | Journal of Physics and Chemistry of Solids2011，，： | 1 |
| 7 | PDMS/MWCNT-based tactile sensor array with coplanar electrodes for crosstalk suppression显示文摘The severe crosstalk effect is widely present in tactile sensor arrays with a sandwich structure.Here we present a novel design for a resistive tactile sensor array with a coplanar electrode layer and isolated sensing elements,which were made from polydimethylsiloxane(PDMS)doped with multiwalled carbon nanotubes(MWCNTs)for crosstalk suppression.To optimize its properties,both mechanical and electrical properties of PDMS/MWCNT-sensing materials with different PDMS/MWCNT ratios were investigated.The experimental results demonstrate that a 4 wt% of MWCNTs to PDMS is optimal for the sensing materials.In addition,the pressure-sensitive layer consists of three microstructured layers(two aspectant PDMS/MWCNT-based films and one top PDMS-based film)that are bonded together.Because of this three-layer microstructure design,our proposed tactile sensor array shows sensitivity up to−1.10 kPa^(−1),a response time of 29 ms and reliability in detecting tiny pressures. | Luxian Wang Huiling Peng Xiaolin Wang Xiang Chen Chunsheng Yang Bin Yang Jingquan Liu | 2016 | Microsystems & Nanoengineering2016，2，1： | 1 |
| 8 | Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression显示文摘Poor tumor accumulation remains a serious challenge for nanomedicines to achieve ideal antitumor outcomes.The different size preferences for systematic circulation,tumor retention and deep permeation have attracted great attention when designing antineoplastic nano-delivery system.Herein,we developed a nano-system which can shrink its size in tumor microenvironment to achieve better tumor retention and penetration.In this work,the cationic bovine serum albumin-protected,doxorubicin-loaded gold nanoclusters(CAuNC-DOX)and amino-functionalized mesoporous silica nanoparticles(MSN)are connected by Fe^(2+)and are further coated with hyaluronic acid(HA)to obtain a core-satellite MSN-Fe-CAuNCDOX@HA nano system(MFADH).When reaching the tumor site,the HA shell,which endows the system with both good biocompatibility and preferable tumor targeting ability,was disintegrated,followed by acid-stimulated release of small-sized pharmacological unit—CAuNC-DOX for further tumor penetration.As demonstrated in both in vitro and in vivo results,MFADH showed excellent antitumor effect,providing a proof of concept for the feasibility of shrinkable nanoplatforms in tumor treatment. | Jiayi Sun Jingyang Li Xi Li Lu Yang Yitong Liu Huile Gao Li Xiang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 9 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 10 | Lattice-distorted Pt wrinkled nanoparticles for highly effective hydrogen electrocatalysis显示文摘Modulating Pt surfaces through the introduction of lattice distortion emerges as immensely effective strategy that enhances the kinetics of alkaline hydrogen evolution and oxidation processes.In this study,we fabricated lattice-distorted Pt wrinkled nanoparticles(LD-Pt WNPs)for efficient hydrogen electrocatalysis.The LD-Pt WNPs not only outperform the Pt/C benchmark in hydrogen oxidation reaction,achieving an excellent mass-specific current of 968.5 mA·mg_(Pt)^(-1)(9 times that of Pt/C),but also demonstrate outstanding hydrogen evolution reaction activity with a small overpotential of 58.0 mV.Comprehensive experiments and density functional theory calculations reveal that lattice defects introduce an abundance of unsaturated coordination atoms while modifying the d-band center of Pt.This dual effect optimizes the binding strength of crucial H and OH intermediates,leading to a significant reduction in the energy barrier of the reaction bottleneck,commonly known as the Volmer step.This work unveils a fresh viewpoint on projecting and developing high efficiency electrocatalysts through defect engineering. | Xue Li Xiang Han Zhenrui Yang Shun Wang Yun Yang Juan Wang Jiadong Chen Zhongwei Chen Huile Jin | 2024 | Nano Research2024，17，5： | 0 |
| 11 | Prevalence and risk factors for minimal hepatic encephalopathy in cirrhotic patients with different etiologies显示文摘Aims:Minimal hepatic encephalopathy(MHE)significantly affects the prognosis of patients with cirrhosis.This study was performed to determine whether there is a difference in the prevalence of MHE among patients with cirrhosis of different etiologies and whether the etiology directly influences the occurrence of MHE.Methods:This multicenter,cross-sectional study enrolled 1879 patients with confirmed cirrhosis at 40 hospitals from October 25,2021,to January 10,2023(Trial registration:http://gffzzd3f38a9638994581svn9vbwvvbuf96ubn.ffgz.tsg.suse.edu.cn/[NCT05140837]).The patients'demographics,etiologies of cirrhosis,and laboratory test results were collected.The psychometric hepatic encephalopathy score(PHES)was determined in all patients to screen for MHE.Multivariate logistic analyses were performed to identify the risk factors for MHE.Results:In total,736 patients with cirrhosis were analyzed.The prevalence of MHE was 42.0%(n=309).The primary etiology among all patients was hepatitis B virus(HBV)-related cirrhosis(71.9%[529/736]).The prevalence of MHE was significantly higher in patients with alcoholic cirrhosis(57.1%[40/70])than in those with HBV-related cirrhosis(40.6%[215/529],p=0.009)or hepatitis C virus(HCV)-related cirrhosis(38.2%[26/68],p=0.026).Age(odds ratio[OR],1.042;95%confidence interval[CI],1.024-1.059;p<0.001),duration of education(OR,0.935;95%CI,0.899-0.971;p=0.001),etiology(OR,1.740;95%CI,1.028-2.945;p=0.039),and high MELD-Na scores(OR,1.038;95%CI,1.009-1.067;p=0.009)were independent risk factors for MHE.When patients with cirrhosis of different etiologies were analyzed separately,the results showed that age(OR,1.035;95%CI,1.014-1.057;p=0.001)and duration of education(OR,0.924;95%CI,0.883-0.966;p=0.001)were risk factors for MHE among patients with HBV-related cirrhosis,whereas age(OR,1.138;95%CI,1.033-1.254;p=0.009)and creatinine concentration(OR,16.487;95%CI,1.113-244.160;p=0.042)were risk factors for MHE in patients with HCV-related cirrhosis.No risk factors for MHE were found in patients with autoimmune cirrhosis.For patients with alcoholic cirrhosis,the platelet count(OR,1.014;95%CI,1.000-1.027;p=0.045)was a risk factor for MHE.The PHES subtest results were inconsistent among patients who had MHE with cirrhosis of different etiologies.Patients with HBV-related cirrhosis performed better on Number Connection Test B and the serial dotting test than those with alcoholic cirrhosis(p=0.007 and p<0.001),better on Number Connection Test B than those with HCV-related cirrhosis(p=0.020),and better on the line tracing test than those with autoimmune cirrhosis(p=0.037).Conclusion:The etiology of cirrhosis affected the prevalence of MHE and risk factors for MHE.The domains of major cognitive impairment varied among patients with cirrhosis of different etiologies.Further studies are required to verify these findings. | Xiaoyan Li Shanghao Liu Huiling Xiang Qingge Zhang Ying Guo Hongmei Zu Jing Wang Jiaojian Lv Xiaoning Zhang Fanping Meng Jiahuan Li Jie Li Yangzhen Bianba Jia Shang Guo Zhang Fei Liu Zhaowei Tong Chuang Lei Wei Ye Qiaohua Yang Ningning Wang Ying Song Wei Fu Ziyue Li Yanjing Gao Yongping Zhang Jiafang Chen Caiyun Wu Qi Zheng Fang Wang Jiali Yu Lianjie Lin Chuanlong Yang Xiaoting Yang Xiaomin Ye Xiangmei Wang Xuelan Zhao Xiaolong Qi Fusheng Wang Junliang Fu | 2023 | Portal Hypertension & Cirrhosis2023，2，4： | 0 |
| 12 | Immunogenicity and safety of a booster COVID-19 vaccination in patients with chronic liver disease:A multicenter study显示文摘Aim:Patients with chronic liver disease(CLD),especially cirrhosis,are at a high risk of severe illness or death from coronavirus disease-2019(COVID-19)and may have a suboptimal immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine.This study aimed to evaluate the safety and immunogenicity of the COVID-19 booster vaccination in patients with CLD.Methods:The study protocol was prospectively registered at ClinicalTrials.gov(No.NCT05204602)after approval by the Ethics Committee.Adult participants with CLD were enrolled in this multicenter prospective study.They completed two doses of the inactivated COVID-19 vaccine and received booster doses at least 6 months later.Adverse reactions were recorded within 14 days after the booster dose.Serum samples of the enrolled patients were collected before and after booster vaccination and tested for SARS-CoV-2 receptor-binding domain(RBD)immunoglobulin G and neutralizing anti-bodies.The chi-squared or Fisher's exact test was used to compare categorical data,and the Mann-Whitney U test was used to compare continuous variables.Two-sided p<0.05 were considered statistically significant.Results:In total,63 patients were enrolled from four hospitals in China,including 29 patients with cirrhosis.The median age of all patients was 55 years,and 61.9%(39/63)were male.The vaccines were well tolerated;most adverse reactions were mild and transient,and injection site pain(6.4%;4/63)and fatigue(3.2%,2/63)were the most frequent local and systemic adverse events.Following the booster vaccination,our results showed that in the whole cohort,the levels and positive rates of anti-RBD IgG and neutralizing antibodies were significantly higher than baseline levels(all p<0.05).Conclusions:The inactivated COVID-19 booster vaccine was safe and significantly increased antibody levels and positivity rates following standard vaccination regimens in patients with CLD,especially those with cirrhosis. | Jitao Wang Jingwen Ai Huiling Xiang Yanliang Zhang Zhiyun Hou Qiran Zhang Jiaojian Lv Shubo Chen Chuan Liu Qianqian Li Jing Liang Faren Xie Shujun Jiang Nina Zhang Aiguo Zhang Xiaolin Lan Xuying Zhang Jinlong Li Dengxiang Liu Wenchuan Wang Wei Rao Zhang Qun Qiuju Tian Xiaolong Qi Wenhong Zhang | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 13 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
| 14 | Sub-percent precision measurement of neutrino oscillation parameters with JUNO显示文摘JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the experiment.The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector.It is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data collection.In the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering hypothesis.The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters. | Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem 安丰鹏 安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩 蔡啸 蔡严克 蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚 曹国富 曹俊 Rossella Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明 陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学 陈羽 陈志源 陈梓康 程捷 程雅苹 Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智 邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然 杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan 樊磊 方建 方文兴 Marco Fargetta Dmitry Fedoseev 费政勇 Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 高峰 Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar 龚光华 宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov 顾旻皓 谷肖飞 古宇 关梦云 管宇铎 Nunzio Guardone 郭聪 郭竞渊 郭万磊 Xinheng Guo 郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强 侯少静 Yee Hsiung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊 胡守扬 胡涛 胡宇翔 胡焯钧 黄桂鸿 黄翰雄 黄凯旋 黄文昊 Xin Huang 黄性涛 黄永波 惠加琪 霍雷 霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐 贾慧慧 贾俊基 蹇司玉 蒋荻 蒋炜 江晓山 荆小平 Cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Khanchai Khosonthongkee Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Victor Lebrin Frederic Lefevre 雷瑞庭 Rupert Leitner Jason Leung Daozheng Li 李德民 李飞 李福乐 李高嵩 Huiling Li 李梦朝 李民 李楠 Nan Li 李清江 李茹慧 李瑞 黎山峰 李涛 李腾 李卫东 李卫国 李笑梅 李小男 李兴隆 李仪 李依宸 李玉峰 Zepeng Li 李兆涵 李志兵 李紫源 李宗海 梁浩 梁昊 廖佳军 Ayut Limphirat Guey-Lin Lin 林盛鑫 林韬 凌家杰 Ivano Lippi 刘芳 刘海东 刘昊天 刘宏邦 刘红娟 刘洪涛 Hui Liu 刘江来 刘金昌 刘敏 刘倩 刘钦 Runxuan Liu 刘树彬 刘术林 刘小伟 刘熙文 Yan Liu Yunzhe Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo 陆川 路浩奇 陆景彬 吕军光 路书祥 Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Arslan Lukanov Daibin Luo Fengjiao Luo 罗光 罗舒 罗武鸣 罗晓杰 Vladimir Lyashuk 马帮争 马冰 马秋梅 马斯 马骁妍 马续波 Jihane Maalmi 麦景宇 Yury Malyshkin Roberto Carlos Mandujano Fabio Mantovani Francesco Manzali 冒鑫 冒亚军 Stefano M.Mari Filippo Marini Cristina Martellini Gisele Martin-Chassard Agnese Martini Matthias Mayer Davit Mayilyan Ints Mednieks Artur Meinusch 孟月 Anselmo Meregaglia Emanuela Meroni David Meyhö Mauro Mezzetto Jonathan Miller Lino Miramonti Marta Colomer Molla Paolo Montini Michele Montuschi Axel Müller Massimiliano Nastasi Dmitry V.Naumov Elena Naumova Diana Navas-Nicolas Igor Nemchenok Minh Thuan Nguyen Thi 宁飞鹏 宁哲 Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Rainer Othegraven Alessandro Paoloni Sergio Parmeggiano 裴亚田 Luca Pelicci Nicomede Pelliccia 彭安国 彭海平 彭宇 彭昭缘 Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Oliver Pilarczyk Luis Felipe Piñeres Artyom Popov Pascal Poussot Ezio Previtali 齐法制 祁鸣 钱森 钱小辉 钱圳 乔浩 秦中华 丘寿康 Gioacchino Ranucci Neill Raper Reem Rasheed Alessandra Re Henning Rebber Abdel Rebii Mariia Redchuk 任斌 任杰 Barbara Ricci Mariam Rifai Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec 阮锡超 Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Simone Sanfilippo Anut Sangka Utane Sawangwit Julia Sawatzki Michaela Schever Cédric Schwab Konstantin Schweizer Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Zhuang Shao Vladislav Sharov Arina Shaydurova 石京燕 史娅楠 Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Sergey Sokolov Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov OndřejŠrámek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin 苏俊 孙世峰 孙希磊 孙勇杰 孙永昭 孙正阳 Narumon Suwonjandee Michal Szelezniak 唐健 唐强 唐泉 唐晓 Vidhya Thara Hariharan Eric Theisen Alexander Tietzsch Igor Tkachev Tomas Tmej Marco Danilo Claudio Torri Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Alexandros Tsagkarakis Cristina Tuve Nikita Ushakov Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cornelius Moritz Vollbrecht Cristina Volpe Katharina Von Sturm Vit Vorobel Dmitriy Voronin Lucia Votano Pablo Walker 王彩申 Chung-Hsiang Wang 王恩 王国利 王坚 王俊 汪璐 Meifen Wang 王孟 Meng Wang 王瑞光 王思广 王维 王为 王文帅 王玺 王湘粤 王仰夫 王耀光 王毅 王义 王贻芳 王元清 Yuman Wang 王喆 王铮 王志民 Zongyi Wang Apimook Watcharangkool 魏微 魏巍 韦雯露 魏亚东 温凯乐 温良剑 Christopher Wiebusch 黄振辉 Bjoern Wonsak 吴帝儒 吴群 吴智 Michael Wurm Jacques Wurtz Christian Wysotzki 习宇飞 夏冬梅 Xiang Xiao 谢小川 谢宇广 Zhangquan Xie 辛钊 邢志忠 续本达 徐程 徐东莲 徐繁荣 许杭锟 徐吉磊 徐晶 徐美杭 徐音 闫保军 Taylor Yan Wenqi Yan 严雄波 Yupeng Yan 杨长根 杨成峰 Huan Yang 杨洁 杨雷 杨晓宇 Yifan Yang 姚海峰 叶佳璇 叶梅 叶子平 Frédéric Yermia Na Yin 尤郑昀 俞伯祥 余炽业 喻纯旭 余泓钊 于淼 于向辉 于泽源 于泽众 袁岑溪 袁成卓 袁影 袁振雄 岳保彪 Noman Zafar Vitalii Zavadskyi 曾珊 曾婷轩 曾裕达 占亮 张爱强 张斌 张斌婷 张飞洋 Guoqing Zhang 张宏浩 张家梁 张家文 张杰 Jin Zhang 张景波 张金楠 Mohan Zhang 张鹏 张清民 张石其 张澍 张涛 张晓梅 张鑫 张玄同 Xueyao Zhang 张银鸿 张易于 张永鹏 张宇 张圆圆 张玉美 张振宇 张志坚 Fengyi Zhao 赵洁 赵荣 赵润泽 赵书俊 Dongqin Zheng 郑华 郑阳恒 Weirong Zhong 周静 周莉 周楠 周顺 周彤 周详 朱江 朱景森 朱康甫 朱科军 朱志航 庄博 庄红林 宗亮 邹佳恒 | 2022 | Chinese Physics C2022，46，12： | 0 |
| 15 | Calycosin attenuates the inflammatory damage of microglia induced by oxygen and glucose deprivation through the HMGB1/TLR4/NF-κB signaling pathway显示文摘Stroke seriously threatens human life and health worldwide,but only very few effective stroke medicines are currently available.Our previous studies have indicated that the phytoestrogen calycosin exerts neuroprotective effects in cerebral ischemia and reperfusion injury rats.Therefore,the objective of this study is to further explore the protective effect of calycosin on inflammatory injury in microglia after oxygen-glucose deprivation/reoxygenation(OGD/R)and to clarify whether its protective effect is related to the HMGB1/TLR4/NF-κB signaling pathway.Here,the OGD/R model of rodent microglia is established in vitro to simulate cerebral ischemia-reperfusion injury.Through the CCK-8 test,ELISA,qRT-PCR,and western blot analysis,we find that the activity of microglia is decreased,the expressions of HMGB1 and TLR4 and the phosphorylation of NF-κB(p-NF-κB)are increased,and the releases of the inflammatory factors IL-6,IL-1β,and TNF-αare increased after OGD/R.Pretreatment with calycosin could ameliorate these states,increase cell viability,reduce HMGB1,TLR4 and p-NF-κB expression,and reduce inflammatory cytokine production.In addition,the effect of calycosin is similar to that of TAK-242(an inhibitor of TLR4),and the effect of the combined treatment is better than that of the single treatment.The results indicate that calycosin protects microglia from OGD/R injury and reduces the inflammatory response.Calycosin might alleviate cerebral ischemiareperfusion injury by inhibiting the HMGB1/TLR4/NF-κB pathway. | Xiang Li Xin Yang Huiling Lu Wenbo Wang Le Cai Jian Chen Yong Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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