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| 1 | Dehiscence following successful endoscopic closure of gastric perforation during endoscopic submucosal dissection显示文摘Gastric perforation is one of the most serious complications that can occur during endoscopic submucosal dissection(ESD).In terms of the treatment of such perforations,we previously reported that perforations immediately observed and successfully closed with endoclips during endoscopic resection could be managed conservatively.We now report the first case in our medical facility of a gastric perforation during ESD that was ineffectively treated conservatively even after successful endoscopic closure.In December 2006,we performed ESD on a recurrent early gastric cancer in an 81-year-old man with a medical history of laparotomy for cholelithiasis.A perforation occurred during ESD that was immediately observed and successfully closed with endoclips so that ESD could be continued resulting in an en-bloc resection.Intensive conservative management was conducted following ESD,however,an endoscopic examination five days after ESD revealed dehiscence of the perforation requiring an emergency laparotomy. | Masau Sekiguchi Haruhisa Suzuki Ichiro Oda Shigetaka Yoshinaga Satoru Nonaka Makoto Saka Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2012 | World Journal of Gastroenterology2012，18，31： | 7 |
| 2 | ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status显示文摘AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas.The results were further correlated with clinicopathological variables.RESULTS:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas. | Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima | 2015 | World Journal of Gastroenterology2015，21，7： | 7 |
| 3 | Bone metastasis from early gastric cancer following non-curative endoscopic submucosal dissection显示文摘A 67-year-old male underwent endoscopic submucosal dissection(ESD)to treat early gastric cancer(EGC)in 2001.The lesion(50 mm × 25 mm diameter)was histologically diagnosed as poorly differentiated adenocarcinoma,with an ulcer finding.Although the tumor was confined to the mucosa with no evidence of lymphovascular involvement,the ESD was regarded as a noncurative resection due to the histological type,tumor size,and existence of an ulcer finding(as indicated by the 2010 Japanese gastric cancer treatment guidelines,ver.3).Despite strong recommendation for subsequent gastrectomy,the patient refused surgery.An alternative follow-up routine was designed,which included five years of biannual clinical examinations to detect and measure serum tumor markers and perform visual assessment of recurrence by endoscopy and computed tomography scan after which the examinations were performed annually.The patient's condition remained stable for eight years,until a complaint of back pain in 2010 prompted further clinical investigation.Bone scintigraphy indicated increased uptake.Histological examination of biopsy specimens taken from the lumbar spine revealed adenocarcinoma resembling the carcinoma cells from the EGC that had been treated previously by ESD,and which was consistent with immunohistochemical findings of gastrointestinal tract cancer.Thus,the diagnosis of bone metastasis from EGC was made.The reported rates of EGC recurrence in surgically resected cases range 1.4%-3.4%,but among these bone metastasis is very rare.To our knowledge,this is the first reported case of bone metastasis from EGC following a non-curative ESD and occurring after an eight-year disease-free interval. | Hiroyuki Kawabata Ichiro Oda Haruhisa Suzuki Satoru Nonaka Shigetaka Yoshinaga Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2013 | World Journal of Gastroenterology2013，19，30： | 2 |
| 4 | Calcium Fortification of Soy Milk with Calcium-Lecithin Liposome System显示文摘 | Motohiko hirotsuka Hitoshi taniguchi Hiroshi narita Makoto kito | 1984 | Journal of Food Science1984，，49： | 1 |
| 5 | The value of narrow band imaging for early detection of laryngeal cancer显示文摘 | Akihito Watanabe Masanobu Taniguchi Hitoshi Tsujie Masao Hosokawa Masahiro Fujita Shigeyuki Sasaki | 2009 | European Archives of Oto - Rhino - Laryngology2009，，7： | 1 |
| 6 | Comparison of HER2 status between surgically resected specimens and matched biopsy specimens of gastric intestinal-type adenocarcinoma显示文摘 | Hiroshi Yoshida Noriko Yamamoto Hirokazu Taniguchi Ichiro Oda Hitoshi Katai Ryoji Kushima Hitoshi Tsuda | 2014 | Virchows Archiv2014，，2： | 1 |
| 7 | The value of narrow band imaging for early detection of laryngeal cancer显示文摘 | Akihito Watanabe Masanobu Taniguchi Hitoshi Tsujie Masao Hosokawa Masahiro Fujita Shigeyuki Sasaki | 2009 | European Archives of Oto - Rhino - Laryngology2009，，7： | 1 |
| 8 | Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer显示文摘 | Yutaka Sugihara Hirokazu Taniguchi Ryoji Kushima Hitoshi Tsuda Daisuke Kubota Hiroshi Ichikawa Kano Sakamoto Yukiko Nakamura Takeshi Tomonaga Shin Fujita Tadashi Kondo | 2012 | Journal of Proteomics2012，，17： | 1 |
| 9 | Small undifferentiated intramucosal gastric cancer with lymph-node metastasis:Case report显示文摘It has been reported recently that small undifferentiated intramucosal early gastric cancer(EGC) < 20 mm in size without any lymphovascular involvement or ulcerative findings had virtually no risk of lymph-node(LN) metastasis.Consequently,the indications for endoscopic resection were expanded to include such undifferentiated EGC lesions.We describe herein a case of a small undifferentiated intramucosal EGC < 20 mm in size without lymphovascular involvement or ulcerative findings that involved lymph-node metastasis.A 57-year-old female underwent pylorus preserving gastrectomy as standard treatment for an undifferentiated EGC 15 mm in size without any ulcerative finding.The surgical specimen revealed a signet-ring cell carcinoma with a moderately to poorly differentiated adenocarcinoma limited to the mucosa that was 15 mm in size with no lymphovascular involvement or ulcerative findings.This case involved LN metastasis,however,and the lesion was diagnosed as pathological stage ⅡA(T1N2M0) according to the Japanese Classification of Gastric Carcinoma. | Tomoyuki Odagaki Haruhisa Suzuki Ichiro Oda Shigetaka Yoshinaga Satoru Nonaka Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2013 | World Journal of Gastroenterology2013，19，20： | 1 |
| 10 | Association between plasma ghrelin and motilin levels during MMC cycle in conscious dogs显示文摘 | Aaron Zietlow Hitoshi Nakajima Hiroshi Taniguchi Kirk Ludwig Toku Takahashi | 2010 | Regulatory Peptides2010，，2： | 1 |
| 11 | Functionality and Digestibility of a Highly Phosphorylated Soybean Protein 显示文摘 | Motohiko Hirotsuka Hitoshi Taniguchi Hiroshi Narita Mako | 1984 | Agric Chem1984，48，1： | 1 |
| 12 | Usefulness of Transient Elastography for Noninvasive and Reliable Estimation of Right-Sided Filling Pressure in Heart Failure显示文摘 | Tatsunori Taniguchi Yasushi Sakata Tomohito Ohtani Isamu Mizote Yasuharu Takeda Yoshihiro Asano Masaharu Masuda Hitoshi Minamiguchi Machiko Kanzaki Yasuhiro Ichibori Hiroyuki Nishi Koichi Toda Yoshiki Sawa Issei Komuro | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 13 | His-Asp phosphorelay signaling: a communication avenue be- tween plants and their enviroment 显示文摘 | Hitoshi Sakakibara Mitsutaka Taniguchi and Tatsuo Sugiyama | 2000 | Plant Molecular Biology2000，42，： | 1 |
| 14 | Optimal Extent of Lymph Node Dissection for Siewert Type II Esophagogastric Junction Carcinoma显示文摘 | Hiroharu Yamashita Hitoshi Katai Shinji Morita Makoto Saka Hirokazu Taniguchi Takeo Fukagawa | 2011 | Annals of Surgery2011，，2： | 1 |
| 15 | FunetionaliTy and digestibility of a highly phosphorylated soybean protein显示文摘 | Motohiko Hirotsuka Hitoshi Taniguchi Hiroshi Narita | 1984 | Agrie Biol Chem1984，48，1： | 1 |
| 16 | Functionality and digestibility of a highly phosphorylated soybean pritein显示文摘 | MOTOHIKO HIROSTUKA HITOSHI TANIGUCHI HIROSHI NARTTA | 1984 | Agric Biol Chem1984，48，1： | 1 |
| 17 | Functionality and Digestibility of a Highly Phosphorylated Soybean Protein显示文摘 | Motohiko Hirotsuka Hitoshi Taniguchi Hiroshi Narita and Mako | 1984 | Agric Chem1984，48，1： | 1 |
| 18 | Bcl‐2, B cl‐6, and the I nternational P rognostic I ndex are prognostic indicators in patients with diffuse large B ‐cell lymphoma treated with rituximab‐containing chemotherapy显示文摘 | Akiko Miyagi Maeshima Hirokazu Taniguchi Suguru Fukuhara Noriyuki Morikawa Wataru Munakata Dai Maruyama Sung‐Won Kim Takashi Watanabe Yukio Kobayashi Kensei Tobinai Hitoshi Tsuda | 2012 | Cancer Sci2012，，： | 1 |
| 19 | Pre-procedural evaluation of the left atrial anatomy in patients referred for catheter ablation of atrial fibrillation显示文摘 | Yoshihisa Kanaji Shinsuke Miyazaki Jin Iwasawa Noboru Ichihara Takamitsu Takagi Akio Kuroi Hiroaki Nakamura Hiroshi Taniguchi Hitoshi Hachiya Yoshito Iesaka | 2015 | Journal of Cardiology2015，，： | 1 |
| 20 | Functionality and digestibility of a highly phosphorylated soybean protein显示文摘 | Motohiko Hirotsuka Hitoshi Taniguchi Hiroshi Narita | 1984 | Journal of the American Chemical Society1984，48，1： | 1 |
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